Yu Long Li
Affiliation: University of Nebraska Medical Center
Tu H, Zhang D, Li Y. Cellular and Molecular Mechanisms Underlying Arterial Baroreceptor Remodeling in Cardiovascular Diseases and Diabetes. Neurosci Bull. 2018;: pubmed publisher
..Arterial baroreceptors can be considered as a potential therapeutic target to improve the prognosis of patients with cardiovascular diseases and diabetes. ..
Zhang D, Liu J, Tu H, Muelleman R, Cornish K, Li Y. In vivo transfection of manganese superoxide dismutase gene or nuclear factor ?B shRNA in nodose ganglia improves aortic baroreceptor function in heart failure rats. Hypertension. 2014;63:88-95 pubmed publisher
..The present study suggests that superoxide-NF?B signaling contributes to CHF-induced baroreceptor dysfunction and resultant impairment of baroreflex function. ..
Zhang D, Tu H, Wadman M, Li Y. Substrates and potential therapeutics of ventricular arrhythmias in heart failure. Eur J Pharmacol. 2018;833:349-356 pubmed publisher
Zhang D, Tu H, Cao L, Zheng H, Muelleman R, Wadman M, et al
. Reduced N-Type Ca2+ Channels in Atrioventricular Ganglion Neurons Are Involved in Ventricular Arrhythmogenesis. J Am Heart Assoc. 2018;7: pubmed publisher
..A decrease in N-type Ca2+ channels in AVG neurons attenuates vagal control of ventricular myocardium, thereby initiating ventricular arrhythmias. ..
Li Y, Tran T, Muelleman R, Schultz H. Blunted excitability of aortic baroreceptor neurons in diabetic rats: involvement of hyperpolarization-activated channel. Cardiovasc Res. 2008;79:715-21 pubmed publisher
..These results indicate that the HCN channels influence the excitability of AB neurons, and more importantly, contribute to the decreased excitability of AB neurons in T1D rats. ..
Li Y, Zhang D, Tu H, Muelleman R. Altered ENaC is Associated With Aortic Baroreceptor Dysfunction in Chronic Heart Failure. Am J Hypertens. 2016;29:582-9 pubmed publisher
..Baroreceptors should be a potential therapeutic target for reducing mortality in CHF. ..