Yong Li

Summary

Affiliation: University of Louisville
Country: USA

Publications

  1. pmc The p53 Pathway Encounters the MicroRNA World
    Apana Takwi
    Department of Biochemistry and Molecular Biology and Center for Genetics and Molecular Medicine, School of Medicine, University of Louisville 319 Abraham Flexner Way, Louisville, KY 40202, USA
    Curr Genomics 10:194-7. 2009
  2. pmc Negative regulation of the tumor suppressor p53 gene by microRNAs
    M Kumar
    Department of Biochemistry and Molecular Biology, Center for Genetics and Molecular Medicine, School of Medicine, University of Louisville, Louisville, KY, USA
    Oncogene 30:843-53. 2011
  3. pmc Deciphering RNA structural diversity and systematic phylogeny from microbial metagenomes
    Yanglong Zhu
    Department of Biochemistry and Molecular Biology, and Center for Genetics and Molecular Medicine, School of Medicine, University of Louisville, Louisville, KY 40202, USA
    Nucleic Acids Res 35:2283-94. 2007
  4. pmc A systematic screen reveals MicroRNA clusters that significantly regulate four major signaling pathways
    Lindsey E Becker
    Department of Biochemistry and Molecular Biology, School of Medicine, University of Louisville, Louisville, KY, USA
    PLoS ONE 7:e48474. 2012
  5. pmc Differential expression of microRNA expression in tamoxifen-sensitive MCF-7 versus tamoxifen-resistant LY2 human breast cancer cells
    Tissa T Manavalan
    Department of Biochemistry and Molecular Biology, Center for Genetics and Molecular Medicine, University of Louisville School of Medicine, Louisville, KY 40292, USA
    Cancer Lett 313:26-43. 2011
  6. pmc Zinc-induced formation of a coactivator complex containing the zinc-sensing transcription factor MTF-1, p300/CBP, and Sp1
    Yong Li
    Department of Biochemistry and Molecular Biology, Mail Stop 3030, University of Kansas Medical Center, 39th and Rainbow Blvd, Kansas City, KS 66160 7421, USA
    Mol Cell Biol 28:4275-84. 2008
  7. pmc Interaction of the oncogenic miR-21 microRNA and the p53 tumor suppressor pathway
    Xiaodong Ma
    Department of Biochemistry and Molecular Biology, School of Medicine, University of Louisville, 319 Abraham Flexner Way, Louisville, KY 40202, USA
    Carcinogenesis 34:1216-23. 2013
  8. ncbi request reprint The role of 14-3-3 dimerization in its modulation of the CaV2.2 channel
    Yong Li
    Department of Neurobiology, Evelyn F McKnight Brain Institute and Civitan International Research Center, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Channels (Austin) 1:1-2. 2007
  9. pmc A statin-regulated microRNA represses human c-Myc expression and function
    Apana A L Takwi
    Department of Biochemistry and Molecular Biology, School of Medicine, University of Louisville, KY, USA
    EMBO Mol Med 4:896-909. 2012
  10. pmc Sequence analysis of RNase MRP RNA reveals its origination from eukaryotic RNase P RNA
    Yanglong Zhu
    Department of Biochemistry and Molecular Biology, and Center for Genetics and Molecular Medicine, School of Medicine, University of Louisville, Kentucky 40202, USA
    RNA 12:699-706. 2006

Collaborators

Detail Information

Publications23

  1. pmc The p53 Pathway Encounters the MicroRNA World
    Apana Takwi
    Department of Biochemistry and Molecular Biology and Center for Genetics and Molecular Medicine, School of Medicine, University of Louisville 319 Abraham Flexner Way, Louisville, KY 40202, USA
    Curr Genomics 10:194-7. 2009
    ..Equally, p53 and components of its pathway have been shown to be targeted by miRNA thereby affecting p53 activities. In this review, we focus our discussion on the biological and pathological roles of miRNAs in the p53 pathway...
  2. pmc Negative regulation of the tumor suppressor p53 gene by microRNAs
    M Kumar
    Department of Biochemistry and Molecular Biology, Center for Genetics and Molecular Medicine, School of Medicine, University of Louisville, Louisville, KY, USA
    Oncogene 30:843-53. 2011
    ..Thus, beyond miR-125b and miR-504, the human TP53 gene is negatively regulated by two more miRNAs: miR-25 and miR-30d...
  3. pmc Deciphering RNA structural diversity and systematic phylogeny from microbial metagenomes
    Yanglong Zhu
    Department of Biochemistry and Molecular Biology, and Center for Genetics and Molecular Medicine, School of Medicine, University of Louisville, Louisville, KY 40202, USA
    Nucleic Acids Res 35:2283-94. 2007
    ..e. some archaeal P RNAs have only one nucleotide in the J2/3 joint. We also discuss the phylogenetic analysis based on covariance model of P RNA that offers a few advantages over the one based on 16S rRNA...
  4. pmc A systematic screen reveals MicroRNA clusters that significantly regulate four major signaling pathways
    Lindsey E Becker
    Department of Biochemistry and Molecular Biology, School of Medicine, University of Louisville, Louisville, KY, USA
    PLoS ONE 7:e48474. 2012
    ..We also verify p53 as a direct target of miR-200a. This study is the first to provide a panoramic view of miRNA clusters' effects on cellular pathways...
  5. pmc Differential expression of microRNA expression in tamoxifen-sensitive MCF-7 versus tamoxifen-resistant LY2 human breast cancer cells
    Tissa T Manavalan
    Department of Biochemistry and Molecular Biology, Center for Genetics and Molecular Medicine, University of Louisville School of Medicine, Louisville, KY 40292, USA
    Cancer Lett 313:26-43. 2011
    ..Agreement in the direction of anticipated regulation was detected for 12 putative targets. These miRNAs with opposite expression between the two cell lines may be involved in endocrine resistance...
  6. pmc Zinc-induced formation of a coactivator complex containing the zinc-sensing transcription factor MTF-1, p300/CBP, and Sp1
    Yong Li
    Department of Biochemistry and Molecular Biology, Mail Stop 3030, University of Kansas Medical Center, 39th and Rainbow Blvd, Kansas City, KS 66160 7421, USA
    Mol Cell Biol 28:4275-84. 2008
    ....
  7. pmc Interaction of the oncogenic miR-21 microRNA and the p53 tumor suppressor pathway
    Xiaodong Ma
    Department of Biochemistry and Molecular Biology, School of Medicine, University of Louisville, 319 Abraham Flexner Way, Louisville, KY 40202, USA
    Carcinogenesis 34:1216-23. 2013
    ..These data suggest that inhibition of miR-21 would be beneficial in apoptosis-inducing cancer therapies directed against p53-deficient tumors...
  8. ncbi request reprint The role of 14-3-3 dimerization in its modulation of the CaV2.2 channel
    Yong Li
    Department of Neurobiology, Evelyn F McKnight Brain Institute and Civitan International Research Center, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Channels (Austin) 1:1-2. 2007
    ..2 channel inactivation. These studies will help to understand the molecular mechanism underlying 14-3-3-dependent modulation of Ca(V)2.2 channels...
  9. pmc A statin-regulated microRNA represses human c-Myc expression and function
    Apana A L Takwi
    Department of Biochemistry and Molecular Biology, School of Medicine, University of Louisville, KY, USA
    EMBO Mol Med 4:896-909. 2012
    ..This work presents a highly promising therapeutic option, using drug repurposing and a miRNA as a biomarker, against cancers that overexpress c-Myc...
  10. pmc Sequence analysis of RNase MRP RNA reveals its origination from eukaryotic RNase P RNA
    Yanglong Zhu
    Department of Biochemistry and Molecular Biology, and Center for Genetics and Molecular Medicine, School of Medicine, University of Louisville, Kentucky 40202, USA
    RNA 12:699-706. 2006
    ..These conserved nucleotides between the MRP and P RNAs strongly support the hypothesis that the MRP RNA is derived from the P RNA molecule in early eukaryote evolution...
  11. pmc A MicroRNA gene is hosted in an intron of a schizophrenia-susceptibility gene
    Yanglong Zhu
    Department of Biochemistry and Molecular Biology, University of Louisville, United States
    Schizophr Res 109:86-9. 2009
    ..017 and 0.086, respectively). However, the expression of miR-346 and GRID1 is less correlated in SZ patients than in bipolar patients or in normal controls. This study implicates the importance of a miRNA in SZ...
  12. pmc Single nucleotide variation in the TP53 3' untranslated region in diffuse large B-cell lymphoma treated with rituximab-CHOP: a report from the International DLBCL Rituximab-CHOP Consortium Program
    Yong Li
    Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Brown Cancer Center, Louisville, KY 40202, USA
    Blood 121:4529-40. 2013
    ..This study is the first to demonstrate the prognostic value of the TP53 3'UTR in cancer...
  13. pmc Loss of the miR-21 allele elevates the expression of its target genes and reduces tumorigenesis
    Xiaodong Ma
    Department of Biochemistry and Molecular Biology, School of Medicine, University of Louisville, 319 Abraham Flexner Way, Louisville, KY 40202, USA
    Proc Natl Acad Sci U S A 108:10144-9. 2011
    ..These results provide in vivo evidence that miR-21 exerts its oncogenic function through negatively regulating its target genes...
  14. ncbi request reprint RNase MRP RNA and human genetic diseases
    Allison N Martin
    Department of Biochemistry and Molecular Biology, and Center for Genetics and Molecular Medicine, School of Medicine, University of Louisville, Louisville, KY 40202, USA
    Cell Res 17:219-26. 2007
    ..The relationship of the genotype (RMRP mutation), RNA processing deficiency of the RNase MRP complex, and the phenotype of CHH and other skeletal dysplasias is yet to be explored...
  15. pmc miR-301a as an NF-κB activator in pancreatic cancer cells
    Zhongxin Lu
    Department of Biochemistry and Molecular Biology, University of Louisville, Louisville, KY 40202, USA
    EMBO J 30:57-67. 2011
    ..Revealing this novel mechanism of NF-κB activation by an miRNA offers new avenues for therapeutic interventions against pancreatic cancer...
  16. pmc A surprisingly large RNase P RNA in Candida glabrata
    Rym Kachouri
    Department of Biochemistry and Molecular Biology, and Center for Genetics and Molecular Medicine School of Medicine, University of Louisville, 319 Abraham Flexner Way, Louisville, KY 40202, USA
    RNA 11:1064-72. 2005
    ..RNase P RNA, therefore, represents one of the most diversified noncoding RNAs in terms of size variation and structural diversity...
  17. pmc MicroRNAs in NF-kappaB signaling
    Xiaodong Ma
    Department of Biochemistry and Molecular Biology, School of Medicine, University of Louisville, 319 Abraham Flexner Way, Louisville, KY 40202, USA
    J Mol Cell Biol 3:159-66. 2011
    ....
  18. ncbi request reprint Protein phosphatase-1 modulates the function of Pax-6, a transcription factor controlling brain and eye development
    Qin Yan
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA
    J Biol Chem 282:13954-65. 2007
    ..These results demonstrate that protein phosphatase 1 acts as a major phosphatase to dephosphorylate Pax-6 and modulate its function...
  19. pmc Apoptosis and the target genes of microRNA-21
    Lindsey E Becker Buscaglia
    Department of Biochemistry and Molecular Biology, University of Louisville, Louisville, KY 40202, USA
    Chin J Cancer 30:371-80. 2011
    ..This suggests that miR-21 is an oncogene which plays a key role in resisting programmed cell death in cancer cells and that targeting apoptosis is a viable therapeutic option against cancers expressing miR-21...
  20. pmc Estradiol downregulates miR-21 expression and increases miR-21 target gene expression in MCF-7 breast cancer cells
    Nalinie S Wickramasinghe
    Department of Biochemistry and Molecular Biology, Center for Genetics and Molecular Medicine, University of Louisville School of Medicine, Louisville, KY 40292, USA
    Nucleic Acids Res 37:2584-95. 2009
    ..These results are the first to demonstrate that E(2) represses the expression of an oncogenic miRNA, miR-21, by activating estrogen receptor in MCF-7 cells...
  21. ncbi request reprint Modulation of inactivation properties of CaV2.2 channels by 14-3-3 proteins
    Yong Li
    Department of Neurobiology, Evelyn F McKnight Brain Institute and Civitan International Research Center, School of Medicine, University of Alabama at Birmingham, 35294, USA
    Neuron 51:755-71. 2006
    ..These results demonstrate that 14-3-3 proteins are important regulators of Ca(V)2.2 channel activities and through this mechanism may contribute to their regulation of synaptic transmission and plasticity...
  22. pmc The zinc-sensing mechanism of mouse MTF-1 involves linker peptides between the zinc fingers
    Yong Li
    Department of Biochemistry and Molecular Biology, Mail Stop 3030, University of Kansas Medical Center, 39th and Rainbow Blvd, Kansas City, KS 66160 7421, USA
    Mol Cell Biol 26:5580-7. 2006
    ..Zinc may modulate highly specific, linker-mediated zinc finger interactions in MTF-1, thus affecting its zinc- and DNA-binding activities, resulting in translocation to the nucleus and binding to the MT-I gene promoter...
  23. pmc The dichotomy of p53 regulation by noncoding RNAs
    Qipan Deng
    Department of Biochemistry and Molecular Biology, School of Medicine, University of Louisville, 319 Abraham Flexner Way, Louisville, KY 40202, USA
    J Mol Cell Biol 6:198-205. 2014
    ....