YAN C LI

Summary

Affiliation: University of Chicago
Country: USA

Publications

  1. ncbi request reprint Effects of vitamin D receptor inactivation on the expression of calbindins and calcium metabolism
    Y C Li
    Department of Medicine, The University of Chicago, 5841 S Maryland Ave, Chicago, IL 60637, USA
    Am J Physiol Endocrinol Metab 281:E558-64. 2001
  2. ncbi request reprint Novel role of the vitamin D receptor in maintaining the integrity of the intestinal mucosal barrier
    Juan Kong
    Department of Medicine, The University of Chicago, Chicago, IL 60637, USA
    Am J Physiol Gastrointest Liver Physiol 294:G208-16. 2008
  3. pmc Vitamin D receptor signaling in podocytes protects against diabetic nephropathy
    Youli Wang
    Department of Medicine, Division of Biological Sciences, The University of Chicago, Chicago, IL 60637, USA
    J Am Soc Nephrol 23:1977-86. 2012
  4. pmc Vitamin D receptor signaling inhibits atherosclerosis in mice
    Frances L Szeto
    Department of Pathology, Division of Biological Sciences, The University of Chicago, Chicago, Illinois 60637, USA
    Mol Endocrinol 26:1091-101. 2012
  5. pmc Angiotensin II directly regulates intestinal epithelial NHE3 in Caco2BBE cells
    Mark W Musch
    Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    BMC Physiol 9:5. 2009
  6. doi request reprint Renoprotective effects of vitamin D analogs
    Yan Chun Li
    Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    Kidney Int 78:134-9. 2010
  7. ncbi request reprint Vitamin D and diabetic nephropathy
    Yan Chun Li
    Department of Medicine, The University of Chicago, Chicago, IL 60637, USA
    Curr Diab Rep 8:464-9. 2008
  8. ncbi request reprint Podocytes as target of vitamin D
    Yan Chun Li
    Department of Medicine, The University of Chicago, 900 E 57th Street, Chicago, IL 60637, USA
    Curr Diabetes Rev 7:35-40. 2011
  9. ncbi request reprint Vitamin D: a negative endocrine regulator of the renin-angiotensin system and blood pressure
    Yan Chun Li
    Department of Medicine, University of Chicago, MC 4076, 5841 S Maryland Avenue, Chicago, IL 60637, USA
    J Steroid Biochem Mol Biol 89:387-92. 2004
  10. pmc Molecular mechanism of vitamin D in the cardiovascular system
    Yan Chun Li
    Department of Medicine, The University of Chicago, Chicago, IL 60637, USA
    J Investig Med 59:868-71. 2011

Collaborators

Detail Information

Publications47

  1. ncbi request reprint Effects of vitamin D receptor inactivation on the expression of calbindins and calcium metabolism
    Y C Li
    Department of Medicine, The University of Chicago, 5841 S Maryland Ave, Chicago, IL 60637, USA
    Am J Physiol Endocrinol Metab 281:E558-64. 2001
    ....
  2. ncbi request reprint Novel role of the vitamin D receptor in maintaining the integrity of the intestinal mucosal barrier
    Juan Kong
    Department of Medicine, The University of Chicago, Chicago, IL 60637, USA
    Am J Physiol Gastrointest Liver Physiol 294:G208-16. 2008
    ..Therefore, vitamin D deficiency may compromise the mucosal barrier, leading to increased susceptibility to mucosal damage and increased risk of IBD...
  3. pmc Vitamin D receptor signaling in podocytes protects against diabetic nephropathy
    Youli Wang
    Department of Medicine, Division of Biological Sciences, The University of Chicago, Chicago, IL 60637, USA
    J Am Soc Nephrol 23:1977-86. 2012
    ..Taken together, these data provide strong evidence that vitamin D/VDR signaling in podocytes plays a critical role in the protection of the kidney from diabetic injury...
  4. pmc Vitamin D receptor signaling inhibits atherosclerosis in mice
    Frances L Szeto
    Department of Pathology, Division of Biological Sciences, The University of Chicago, Chicago, Illinois 60637, USA
    Mol Endocrinol 26:1091-101. 2012
    ..Taken together, these observations provide evidence that macrophage VDR signaling, in part by suppressing the local RAS, inhibits atherosclerosis in mice...
  5. pmc Angiotensin II directly regulates intestinal epithelial NHE3 in Caco2BBE cells
    Mark W Musch
    Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    BMC Physiol 9:5. 2009
    ..To determine if AII might have a direct effect on intestinal epithelial Na+ transport, we investigated its actions on Na+ transport in human intestinal epithelial Caco2BBE cells...
  6. doi request reprint Renoprotective effects of vitamin D analogs
    Yan Chun Li
    Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    Kidney Int 78:134-9. 2010
    ..The emerging experimental and clinical evidence has provided a solid foundation for the continuing exploration of vitamin D analogs in prevention and intervention in kidney disease...
  7. ncbi request reprint Vitamin D and diabetic nephropathy
    Yan Chun Li
    Department of Medicine, The University of Chicago, Chicago, IL 60637, USA
    Curr Diab Rep 8:464-9. 2008
    ..These most recent data demonstrate that vitamin D and its analogues have renoprotective and therapeutic potentials in DN through targeting the RAS...
  8. ncbi request reprint Podocytes as target of vitamin D
    Yan Chun Li
    Department of Medicine, The University of Chicago, 900 E 57th Street, Chicago, IL 60637, USA
    Curr Diabetes Rev 7:35-40. 2011
    ..Emerging experimental data suggest that vitamin D may protect podocytes by targeting multiple pathways, including the renin-angiotensin system, Wnt/β-catenin pathway and pro-apoptotic pathway...
  9. ncbi request reprint Vitamin D: a negative endocrine regulator of the renin-angiotensin system and blood pressure
    Yan Chun Li
    Department of Medicine, University of Chicago, MC 4076, 5841 S Maryland Avenue, Chicago, IL 60637, USA
    J Steroid Biochem Mol Biol 89:387-92. 2004
    ....
  10. pmc Molecular mechanism of vitamin D in the cardiovascular system
    Yan Chun Li
    Department of Medicine, The University of Chicago, Chicago, IL 60637, USA
    J Investig Med 59:868-71. 2011
    ..This review will discuss the mechanism underlying the connection between vitamin D and cardiovascular disease and its physiological and therapeutic implications...
  11. ncbi request reprint Vitamin D regulation of the renin-angiotensin system
    Yan Chun Li
    Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    J Cell Biochem 88:327-31. 2003
    ....
  12. pmc 1,25-Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system
    Yan Chun Li
    Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    J Clin Invest 110:229-38. 2002
    ..Its apparent critical role in electrolytes, volume, and blood pressure homeostasis suggests that vitamin D analogues could help prevent or ameliorate hypertension...
  13. ncbi request reprint Inhibition of renin: an updated review of the development of renin inhibitors
    Yan Chun Li
    The University of Chicago, Department of Medicine, MC 4076, 5841 S Maryland Avenue, Chicago, IL 60637, USA
    Curr Opin Investig Drugs 8:750-7. 2007
    ..This review covers the evolution of renin inhibitors and discusses the advantages of renin inhibition at the enzymatic and biosynthetic levels for blood pressure control...
  14. pmc Vitamin D: roles in renal and cardiovascular protection
    YAN C LI
    Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    Curr Opin Nephrol Hypertens 21:72-9. 2012
    ..The purpose of this review is to update the recent advance regarding the effects of vitamin D and its analogs on the renal and cardiovascular system...
  15. pmc Loss of vitamin D receptor produces polyuria by increasing thirst
    Juan Kong
    Department of Medicine and Committee on Molecular Metabolism and Nutrition, University of Chicago, Chicago, IL 60637, USA
    J Am Soc Nephrol 19:2396-405. 2008
    ....
  16. pmc Long-term therapeutic effect of vitamin D analog doxercalciferol on diabetic nephropathy: strong synergism with AT1 receptor antagonist
    Yan Zhang
    Division of Biological Sciences, Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    Am J Physiol Renal Physiol 297:F791-801. 2009
    ....
  17. doi request reprint Combined vitamin D analog and AT1 receptor antagonist synergistically block the development of kidney disease in a model of type 2 diabetes
    Dilip K Deb
    Department of Medicine, The University of Chicago, Chicago, Illinois, USA
    Kidney Int 77:1000-9. 2010
    ..Thus, our study further shows that vitamin D analogs can increase the efficacy of AT1 receptor blockade, leading to a more effective prevention of kidney disease in type 2 diabetes...
  18. ncbi request reprint Effect of ANG II type I receptor antagonist and ACE inhibitor on vitamin D receptor-null mice
    Juan Kong
    Dept of Medicine, University of Chicago, MC 4076, 5841 S Maryland Ave, Chicago, IL 60637, USA
    Am J Physiol Regul Integr Comp Physiol 285:R255-61. 2003
    ....
  19. pmc Combination therapy with AT1 blocker and vitamin D analog markedly ameliorates diabetic nephropathy: blockade of compensatory renin increase
    Zhongyi Zhang
    Department of Medicine, Division of Biological Sciences, University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 105:15896-901. 2008
    ..These data demonstrate that inhibition of the RAS with combination of vitamin D analogs and RAS inhibitors effectively prevents renal injury in diabetic nephropathy...
  20. pmc Vitamin D receptor attenuates renal fibrosis by suppressing the renin-angiotensin system
    Yan Zhang
    Department of Medicine, University of Chicago, 900 E 57th Street, KCBD, Mailbox 9, Chicago, IL 60637, USA
    J Am Soc Nephrol 21:966-73. 2010
    ..Taken together, these results suggest that the VDR attenuates obstructive renal injury at least in part by suppressing the renin-angiotensin system...
  21. pmc Involvement of the vitamin D receptor in energy metabolism: regulation of uncoupling proteins
    Kari E Wong
    Department of Medicine, Committee on Molecular Metabolism and Nutrition, The University of Chicago, MC 4076, 5841 S Maryland Ave, Chicago, IL 60637, USA
    Am J Physiol Endocrinol Metab 296:E820-8. 2009
    ..These data indicate that vitamin D is involved in energy metabolism and adipocyte biology in vivo in part through regulation of beta-oxidation and UCP expression...
  22. pmc 1,25-Dihydroxyvitamin D3 suppresses high glucose-induced angiotensinogen expression in kidney cells by blocking the NF-{kappa}B pathway
    Dilip K Deb
    Department of Medicine and Committee on Molecular Metabolism and Nutrition, Division of Biological Sciences, The University of Chicago, Chicago, Illinois, USA
    Am J Physiol Renal Physiol 296:F1212-8. 2009
    ..These data indicate that 1,25(OH)(2)D(3) suppresses hyperglycemia-induced AGT expression by blocking NF-kappaB-mediated pathway...
  23. ncbi request reprint A vitamin D analogue inhibits colonic carcinogenesis in the AOM/DSS model
    Alessandro Fichera
    Department of Surgery, University of Chicago, Chicago, Illinois 60637, USA
    J Surg Res 142:239-45. 2007
    ..Our aim was to evaluate the anti-inflammatory and chemopreventive efficacy of the vitamin D analogue Ro26-2198 in the AOM/DSS model and in vitro in HCA-7 colon cancer cells...
  24. ncbi request reprint Cardiac hypertrophy in vitamin D receptor knockout mice: role of the systemic and cardiac renin-angiotensin systems
    Wei Xiang
    Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Am J Physiol Endocrinol Metab 288:E125-32. 2005
    ....
  25. ncbi request reprint Critical role of vitamin D in sulfate homeostasis: regulation of the sodium-sulfate cotransporter by 1,25-dihydroxyvitamin D3
    Merry J G Bolt
    Department of Medicine, University of Chicago, IL 60637, USA
    Am J Physiol Endocrinol Metab 287:E744-9. 2004
    ....
  26. ncbi request reprint Altered gene expression profile in the kidney of vitamin D receptor knockout mice
    Xinmin Li
    Functional Genomics Facility, University of Chicago, Chicago, Illinois 60637, USA
    J Cell Biochem 89:709-19. 2003
    ..These data provide a basis for further investigations into the molecular bases underlying the physiological abnormalities associated with VDR- and vitamin D-deficiency...
  27. ncbi request reprint Regulation of IL-1 family cytokines IL-1alpha, IL-1 receptor antagonist, and IL-18 by 1,25-dihydroxyvitamin D3 in primary keratinocytes
    Juan Kong
    Department of Medicine, University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    J Immunol 176:3780-7. 2006
    ..Collectively, these results suggest that vitamin D modulates cutaneous inflammatory reactions, at least in part, by increasing the IL-1Ra to IL-1alpha ratio and suppressing IL-18 synthesis in keratinocytes...
  28. ncbi request reprint Molecular mechanism of 1,25-dihydroxyvitamin D3 inhibition of adipogenesis in 3T3-L1 cells
    Juan Kong
    Dept of Medicine, Univ of Chicago, 5841 S Maryland Ave, Chicago, IL 60637, USA
    Am J Physiol Endocrinol Metab 290:E916-24. 2006
    ....
  29. ncbi request reprint Targeted expression of human vitamin d receptor in the skin promotes the initiation of the postnatal hair follicle cycle and rescues the alopecia in vitamin D receptor null mice
    Juan Kong
    Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    J Invest Dermatol 118:631-8. 2002
    ..Taken together, these data provide direct evidence that vitamin D receptor is required for the initiation of the postnatal hair follicular cycle in mice...
  30. ncbi request reprint Analogs of 1alpha,25-dihydroxyvitamin D(3) as novel inhibitors of renin biosynthesis
    Guilin Qiao
    Department of Medicine, University of Chicago, MC 4076, 5841 S Maryland Avenue, Chicago, IL 60637, USA
    J Steroid Biochem Mol Biol 96:59-66. 2005
    ....
  31. doi request reprint Targeted vitamin D receptor expression in juxtaglomerular cells suppresses renin expression independent of parathyroid hormone and calcium
    Juan Kong
    Department of Medicine, Division of Biological Sciences, Committee on Molecular Metabolism and Nutrition, The University of Chicago, Chicago, Illinois 60637, USA
    Kidney Int 74:1577-81. 2008
    ..Our study shows that suppression of renin expression by 1,25-dihydroxyvitamin D in vivo is independent of parathyroid hormone and calcium...
  32. pmc Lithocholic acid down-regulation of NF-kappaB activity through vitamin D receptor in colonic cancer cells
    Jun Sun
    Department of Medicine, Gastroenterology and Hepatology, University of Rochester, Rochester, NY 14642, USA
    J Steroid Biochem Mol Biol 111:37-40. 2008
    ..Collectively, our data indicated that LCA activated the VDR to block inflammatory signals in colon cells...
  33. ncbi request reprint Vitamin D receptor is required for dietary calcium-induced repression of calbindin-D9k expression in mice
    Merry J G Bolt
    Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    J Nutr Biochem 16:286-90. 2005
    ..Calcium regulation of the CaBP-D9k level may represent an important mechanism by which animals maintain their calcium balance...
  34. ncbi request reprint Critical role of calbindin-D28k in calcium homeostasis revealed by mice lacking both vitamin D receptor and calbindin-D28k
    Wei Zheng
    Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 279:52406-13. 2004
    ..These results directly demonstrate that CaBP-D28k plays a critical role in maintaining calcium homeostasis and skeletal mineralization and suggest that its calcemic role can be mostly compensated by CaBP-D9k...
  35. pmc Involvement of the vitamin D receptor in the regulation of NF-kappaB activity in fibroblasts
    Frances L Szeto
    Committee on Molecular Metabolism and Nutrition, Biological Science Division, The University of Chicago, Chicago, IL 60637, USA
    J Steroid Biochem Mol Biol 103:563-6. 2007
    ..These data suggest that VDR plays an inhibitory role in the regulation of NF-kappaB activation...
  36. ncbi request reprint Increased NF-kappaB activity in fibroblasts lacking the vitamin D receptor
    Jun Sun
    Department of Pathology, The University of Chicago, Chicago, IL 60637, USA
    Am J Physiol Endocrinol Metab 291:E315-22. 2006
    ..Taken together, these data suggest that VDR plays an inhibitory role in the regulation of NF-kappaB activation...
  37. ncbi request reprint Expression of vitamin D3 receptor in kidney tumors
    Wenhua Liu
    Department of Pathology, The University of Chicago Hospitals, University of Chicago, 5841 S Maryland Avenue, Chicago, IL 60637, USA
    Hum Pathol 37:1268-78. 2006
    ..In addition, the focal and much weaker VDR expression in clear cell RCCs makes VDR valuable in distinguishing clear cell RCC from other types of RCCs...
  38. ncbi request reprint 1,25-dihydroxyvitamin D3 suppresses renin gene transcription by blocking the activity of the cyclic AMP response element in the renin gene promoter
    Weihua Yuan
    Department of Medicine, Division of Biological Sciences, The University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 282:29821-30. 2007
    ..These data indicate that 1,25(OH)(2)D(3) suppresses renin gene expression at least in part by blocking the formation of CRE-CREB-CBP complex...
  39. doi request reprint Ursodeoxycholic acid suppresses Cox-2 expression in colon cancer: roles of Ras, p38, and CCAAT/enhancer-binding protein
    Sharad Khare
    Department of Medicine, Loyola University Medical Center, Maywood, Illinois 60153, USA
    Nutr Cancer 60:389-400. 2008
    ..These signal transducers are novel targets of UDCA's chemopreventive actions...
  40. pmc miR-17-92 cluster accelerates adipocyte differentiation by negatively regulating tumor-suppressor Rb2/p130
    Qiang Wang
    Department of Medicine, Biological Sciences Division, University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 105:2889-94. 2008
    ..These data indicate that miR-17-92 promotes adipocyte differentiation by targeting and negatively regulating Rb2/p130...
  41. ncbi request reprint Upregulation of interleukin-18 expression in mouse primary keratinocytes induced to differentiate by calcium
    Juan Kong
    Department of Medicine, University of Chicago, 5841 S Maryland Avenue, Chicago, IL 60637, USA
    Arch Dermatol Res 294:370-6. 2002
    ..These findings suggest that IL-18 is synthesized in keratinocytes mainly in the inactive precursor form, and its expression is upregulated as basal keratinocytes differentiate in the epidermis...
  42. ncbi request reprint Vitamin D receptor is not required for the rapid actions of 1,25-dihydroxyvitamin D3 to increase intracellular calcium and activate protein kinase C in mouse osteoblasts
    Ramesh K Wali
    Evanston Northwestern Healthcare, Evanston, Illinois 60201, USA
    J Cell Biochem 88:794-801. 2003
    ..Thus, VDR is not essential for these rapid actions of 1,25(OH)(2)D(3) in osteoblasts...
  43. ncbi request reprint Differential effects of Vitamin D analogs on bone formation and resorption
    Masaki Nakane
    Abbott Laboratories, R4CM, AP52, 200 Abbott Park Rd, Abbott Park, IL 60064 6217, USA
    J Steroid Biochem Mol Biol 98:72-7. 2006
    ....
  44. ncbi request reprint Negative regulation of monocyte adhesion to arterial elastic laminae by signal regulatory protein alpha and Src homology 2 domain-containing protein-tyrosine phosphatase-1
    Shu Q Liu
    Biomedical Engineering Department, Northwestern University, Evanston, Illinois 60208 3107, USA
    J Biol Chem 280:39294-301. 2005
    ..These observations suggest that SIRP alpha and SHP-1 potentially mediate the inhibitory effect of elastic laminae on monocyte adhesion...
  45. ncbi request reprint Vitamin D and its analogues: do they protect against cardiovascular disease in patients with kidney disease?
    Adeera Levin
    Division of Nephrology, University of British Columbia, Vancouver, Canada
    Kidney Int 68:1973-81. 2005
    ..In light of recent observational studies showing an association of vitamin D therapy and survival benefit in hemodialysis patients, the effects of vitamin D on cardiovascular system have become a heavily debated issue...
  46. ncbi request reprint Mechanisms of disease: vitamin D and inflammatory bowel disease
    Wee Chian Lim
    Department of Gastroenterology, Tan Tock Seng Hospital, Singapore
    Nat Clin Pract Gastroenterol Hepatol 2:308-15. 2005
    ..Here, we review the role of vitamin D in regulation of the immune system, and evidence for its involvement in the pathogenesis of inflammatory bowel disease...
  47. pmc Rescue of odontogenesis in Dmp1-deficient mice by targeted re-expression of DMP1 reveals roles for DMP1 in early odontogenesis and dentin apposition in vivo
    Yongbo Lu
    Department of Oral Biology, School of Dentistry, University of Missouri Kansas City, 650 E 25th Street, Kansas City, MO 64108, USA
    Dev Biol 303:191-201. 2007
    ....

Research Grants8

  1. Cardiovascular Effect of the Vitamin D Endocrine System.
    Yan Chun Li; Fiscal Year: 2010
    ..These studies will further enhance our understanding of the novel physiology of the vitamin D endocrine system and its pharmacological applications in the regulation of the RAS and cardiovascular system. ..
  2. Cardiovascular Effect of the Vitamin D Endocrine System.
    Yan Chun Li; Fiscal Year: 2009
    ..These studies will further enhance our understanding of the novel physiology of the vitamin D endocrine system and its pharmacological applications in the regulation of the RAS and cardiovascular system. ..
  3. Cardiovascular Effect of the Vitamin D Endocrine System.
    Yan Chun Li; Fiscal Year: 2007
    ..These studies will further enhance our understanding of the novel physiology of the vitamin D endocrine system and its pharmacological applications in the regulation of the RAS and cardiovascular system. ..
  4. Vitamin D and Diabetic Nephropathy
    Yan Chun Li; Fiscal Year: 2007
    ..These exploratory studies will enhance our understanding of a novel aspect of vitamin D physiology and provide a basis for exploring the therapeutic potential of vitamin D analogs in prevention and treatment of diabetic nephropathy. ..
  5. Regulation of minerals and fluids excretion in vitamin D
    Yan Chun Li; Fiscal Year: 2005
    ..The third goal is to study the effect of VDR inactivation on ANP expression and sodium and body fluid balance, in order to test in vivo, the hypothesis that 1,25(OH)2D3 negatively regulates ANP expression. ..
  6. Vitamin D: A Negative Regulator of Renin Expression
    Yan Chun Li; Fiscal Year: 2003
    ..abstract_text> ..
  7. Preventive Role of VDR in Colorectal Carcinogenesis
    Yan Chun Li; Fiscal Year: 2006
    ....