Xinmin Li

Summary

Affiliation: University of Chicago
Country: USA

Publications

  1. ncbi request reprint An integrated strategy for the optimization of microarray data interpretation
    Xinmin Li
    Functional Genomics Facility, Division of Biological Sciences, The University of Chicago, 5841 S Maryland Ave, Chicago, IL 60637, USA
    Gene Expr 12:223-30. 2005
  2. ncbi request reprint Connective tissue growth factor (CTGF) is regulated by Wnt and bone morphogenetic proteins signaling in osteoblast differentiation of mesenchymal stem cells
    Qing Luo
    Molecular Oncology Laboratory, Department of Surgery, The University of Chicago Medical Center, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    J Biol Chem 279:55958-68. 2004
  3. pmc CCN1/Cyr61 is regulated by the canonical Wnt signal and plays an important role in Wnt3A-induced osteoblast differentiation of mesenchymal stem cells
    Weike Si
    Molecular Oncology Laboratory, University of Chicago Medical Center, 5841 South Maryland Avenue, MC3079, Chicago, IL 60637
    Mol Cell Biol 26:2955-64. 2006
  4. pmc Hey1 basic helix-loop-helix protein plays an important role in mediating BMP9-induced osteogenic differentiation of mesenchymal progenitor cells
    Katie A Sharff
    Molecular Oncology Laboratory, Department of Surgery, The University of Chicago Medical Center, Chicago, Illinois 60637, USA
    J Biol Chem 284:649-59. 2009
  5. pmc miR-17-92 cluster accelerates adipocyte differentiation by negatively regulating tumor-suppressor Rb2/p130
    Qiang Wang
    Department of Medicine, Biological Sciences Division, University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 105:2889-94. 2008
  6. ncbi request reprint Inhibitor of DNA binding/differentiation helix-loop-helix proteins mediate bone morphogenetic protein-induced osteoblast differentiation of mesenchymal stem cells
    Ying Peng
    Molecular Oncology Laboratory, Department of Surgery, and Committe on Genetics, University of Chicago, IL 60637, USA
    J Biol Chem 279:32941-9. 2004
  7. pmc MicroRNA-377 is up-regulated and can lead to increased fibronectin production in diabetic nephropathy
    Qiang Wang
    Section of Nephrology, Department of Medicine, The University of Chicago, 5841 South Maryland Ave, MC5100, AMB S523, Chicago, IL 60637, USA
    FASEB J 22:4126-35. 2008
  8. ncbi request reprint Cardiac hypertrophy in vitamin D receptor knockout mice: role of the systemic and cardiac renin-angiotensin systems
    Wei Xiang
    Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Am J Physiol Endocrinol Metab 288:E125-32. 2005
  9. ncbi request reprint Transcriptional characterization of bone morphogenetic proteins (BMPs)-mediated osteogenic signaling
    Ying Peng
    Molecular Oncology Laboratory, Department of Surgery, The University of Chicago Medical Center, Chicago, Illinois 60637, USA
    J Cell Biochem 90:1149-65. 2003
  10. ncbi request reprint Role of GADD34 in modulation of cisplatin cytotoxicity
    Melissa L Fishel
    Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Biochem Pharmacol 71:239-47. 2006

Collaborators

Detail Information

Publications31

  1. ncbi request reprint An integrated strategy for the optimization of microarray data interpretation
    Xinmin Li
    Functional Genomics Facility, Division of Biological Sciences, The University of Chicago, 5841 S Maryland Ave, Chicago, IL 60637, USA
    Gene Expr 12:223-30. 2005
    ..In this review, we discuss an integrative approach, which can be used to prioritize microarray-derived candidate genes, define their functions, and place them in the context of the biological system being studied...
  2. ncbi request reprint Connective tissue growth factor (CTGF) is regulated by Wnt and bone morphogenetic proteins signaling in osteoblast differentiation of mesenchymal stem cells
    Qing Luo
    Molecular Oncology Laboratory, Department of Surgery, The University of Chicago Medical Center, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    J Biol Chem 279:55958-68. 2004
    ....
  3. pmc CCN1/Cyr61 is regulated by the canonical Wnt signal and plays an important role in Wnt3A-induced osteoblast differentiation of mesenchymal stem cells
    Weike Si
    Molecular Oncology Laboratory, University of Chicago Medical Center, 5841 South Maryland Avenue, MC3079, Chicago, IL 60637
    Mol Cell Biol 26:2955-64. 2006
    ..These findings suggest that tightly regulated CCN1/Cyr61 expression may play an important role in Wnt3A-induced osteoblast differentiation of mesenchymal stem cells...
  4. pmc Hey1 basic helix-loop-helix protein plays an important role in mediating BMP9-induced osteogenic differentiation of mesenchymal progenitor cells
    Katie A Sharff
    Molecular Oncology Laboratory, Department of Surgery, The University of Chicago Medical Center, Chicago, Illinois 60637, USA
    J Biol Chem 284:649-59. 2009
    ..Thus, our findings suggest that Hey1, through its interplay with Runx2, may play an important role in regulating BMP9-induced osteoblast lineage differentiation of MSCs...
  5. pmc miR-17-92 cluster accelerates adipocyte differentiation by negatively regulating tumor-suppressor Rb2/p130
    Qiang Wang
    Department of Medicine, Biological Sciences Division, University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 105:2889-94. 2008
    ..These data indicate that miR-17-92 promotes adipocyte differentiation by targeting and negatively regulating Rb2/p130...
  6. ncbi request reprint Inhibitor of DNA binding/differentiation helix-loop-helix proteins mediate bone morphogenetic protein-induced osteoblast differentiation of mesenchymal stem cells
    Ying Peng
    Molecular Oncology Laboratory, Department of Surgery, and Committe on Genetics, University of Chicago, IL 60637, USA
    J Biol Chem 279:32941-9. 2004
    ....
  7. pmc MicroRNA-377 is up-regulated and can lead to increased fibronectin production in diabetic nephropathy
    Qiang Wang
    Section of Nephrology, Department of Medicine, The University of Chicago, 5841 South Maryland Ave, MC5100, AMB S523, Chicago, IL 60637, USA
    FASEB J 22:4126-35. 2008
    ..Thus, overexpression of miR-377 in diabetic nephropathy indirectly leads to increased fibronectin protein production; as such, miR-377 can have a critical role in the pathophysiology of this prevalent human disease...
  8. ncbi request reprint Cardiac hypertrophy in vitamin D receptor knockout mice: role of the systemic and cardiac renin-angiotensin systems
    Wei Xiang
    Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Am J Physiol Endocrinol Metab 288:E125-32. 2005
    ....
  9. ncbi request reprint Transcriptional characterization of bone morphogenetic proteins (BMPs)-mediated osteogenic signaling
    Ying Peng
    Molecular Oncology Laboratory, Department of Surgery, The University of Chicago Medical Center, Chicago, Illinois 60637, USA
    J Cell Biochem 90:1149-65. 2003
    ..Further functional characterization of these downstream target genes should provide important insights into the molecular mechanisms behind BMP-mediated bone formation...
  10. ncbi request reprint Role of GADD34 in modulation of cisplatin cytotoxicity
    Melissa L Fishel
    Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Biochem Pharmacol 71:239-47. 2006
    ..Elucidation of these molecular pathways will aid in our goal of synthesizing more powerful modulators to increase efficacy of platinum agents...
  11. ncbi request reprint Altered gene expression profile in the kidney of vitamin D receptor knockout mice
    Xinmin Li
    Functional Genomics Facility, University of Chicago, Chicago, Illinois 60637, USA
    J Cell Biochem 89:709-19. 2003
    ..These data provide a basis for further investigations into the molecular bases underlying the physiological abnormalities associated with VDR- and vitamin D-deficiency...
  12. ncbi request reprint Anti-diabetic effect of ginsenoside Re in ob/ob mice
    Jing Tian Xie
    Tang Center for Herbal Medicine Research, The Pritzker School of Medicine, The University of Chicago, MC 4028, IL 60637, USA
    Biochim Biophys Acta 1740:319-25. 2005
    ..Preliminary microarray analysis revealed differential expression of skeletal muscle genes associated with lipid metabolism and muscle function. The results suggest that ginsenoside Re may prove to be useful in treating type 2 diabetes...
  13. ncbi request reprint Genetic regulation by non-coding RNAs
    Liwang Qi
    Laboratory of Cell Biology, Research Institute of Forestry, Chinese Academy of Forestry, Beijing 100091, China
    Sci China C Life Sci 49:201-17. 2006
    ....
  14. pmc Effects of carbonic anhydrase VIII deficiency on cerebellar gene expression profiles in the wdl mouse
    Jian Yan
    Department of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States
    Neurosci Lett 413:196-201. 2007
    ..Several of the upregulated genes encode proteins that function in the Golgi apparatus which suggests that Car8 deficiency has important effects on synaptic vesicle formation and transport...
  15. ncbi request reprint TP508 accelerates fracture repair by promoting cell growth over cell death
    Xinmin Li
    College of Animal Science and Technology, Shanxi Agricultural University, Taigu, Shanxi 030801, China
    Biochem Biophys Res Commun 364:187-93. 2007
    ..This appears to occur through the stimulation of several bone healing pathways including cell cycle-G1/S checkpoint regulation, apoptosis, JAK/STAT, NF-kappaB, PDGF, PI3K/AKT, PTEN, and ERK/MAPK...
  16. doi request reprint Clinical and molecular responses in lung cancer patients receiving Romidepsin
    David S Schrump
    Thoracic Oncology Section Surgery Branch, Center for Cancer Research and Cancer Therapy Evaluation Program, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Clin Cancer Res 14:188-98. 2008
    ..A phase II trial was done to examine clinical and molecular responses mediated by this histone deacetylase inhibitor in lung cancer patients...
  17. pmc A deletion mutation in Slc12a6 is associated with neuromuscular disease in gaxp mice
    Yan Jiao
    Department of Orthopaedic Surgery Campbell Clinic, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Genomics 91:407-14. 2008
    ..The causative role of the exon 4 mutation within Slc12a6 in the gaxp phenotype was further confirmed by screening multiple inbred strains and by excluding the mutation of nearby genes within the gaxp locus...
  18. pmc Carbonic anhydrase-related protein VIII deficiency is associated with a distinctive lifelong gait disorder in waddles mice
    Yan Jiao
    Department of Orthopedic Surgery Campbell Clinic and Pathology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    Genetics 171:1239-46. 2005
    ..These data indicate that the wdl mouse is a Car8 null mutant and that CAR8 plays a central role in motor control...
  19. ncbi request reprint Thrombin peptide (TP508) promotes fracture repair by up-regulating inflammatory mediators, early growth factors, and increasing angiogenesis
    Hali Wang
    Research and Development, OrthoLogic Corp, Tempe, AZ 85281, USA
    J Orthop Res 23:671-9. 2005
    ..This study therefore suggests that TP508 promotes fracture repair through a mechanism that involves an increased induction of a number of growth factors, enhanced expression of inflammatory mediators, and angiogenesis-related genes...
  20. ncbi request reprint Chromosomal regions harboring genes for the work to femur failure in mice
    Xinmin Li
    Molecular Genetics Division, Musculoskeletal Disease Center, JL Pettis VA Medical Center, 11201 Benton Street 151, Loma Linda, CA 92357, USA
    Funct Integr Genomics 1:367-74. 2002
    ..If this is also true in humans, this finding will challenge the predictive value of BMD for the risk of fracture...
  21. ncbi request reprint Gene expression between a congenic strain that contains a quantitative trait locus of high bone density from CAST/EiJ and its wild-type strain C57BL/6J
    Weikuan Gu
    Musculoskeletal Disease Center, JL Pettis VA Medical Center, 11201 Benton Street 151, Loma Linda, CA 92357, USA
    Funct Integr Genomics 1:375-86. 2002
    ....
  22. ncbi request reprint Genetic dissection of femur breaking strength in a large population (MRL/MpJ x SJL/J) of F2 Mice: single QTL effects, epistasis, and pleiotropy
    Xinmin Li
    Molecular Genetics Division, Musculoskeletal Disease Center, JL Pettis VA Medical Center and Loma Linda University, Loma Linda, California 92357, USA
    Genomics 79:734-40. 2002
    ..Identification of the genes unique to FBS may have an impact on prediction of osteoporosis in human...
  23. ncbi request reprint Quantitative trait loci (QTL) for lean body mass and body length in MRL/MPJ and SJL/J F(2) mice
    Godfred L Masinde
    Molecular Genetics Division, Musculoskeletal Disease Center, J L Pettis VA Medical Center and Loma Linda University, 11201 Benton Street 151, CA 92357, USA
    Funct Integr Genomics 2:98-104. 2002
    ..Interacting loci on chr 2 may influence LBM by regulating body length. Therefore, epistatic interactions as well as single QTL effects play an important role in the regulation of LBM...
  24. ncbi request reprint Quantitative trait loci that harbor genes regulating muscle size in (MRL/MPJ x SJL/J) F(2) mice
    Godfred L Masinde
    Molecular Genetics Division, Musculoskeletal Disease Center, Jerry L Pettis VA Medical Center and Loma Linda University, CA 92357, USA
    Funct Integr Genomics 2:120-5. 2002
    ..Three significant epistatic interactions between different QTL positions from muscle size and body length were identified ( P <0.01) on chromosomes 2, 9, 14 and 17, which explained 16.1% of the variance in F(2) mice...
  25. pmc Mapping quantitative trait loci that influence serum insulin-like growth factor binding protein-5 levels in F2 mice (MRL/MpJ X SJL/J)
    Subburaman Mohan
    Musculoskeletal Disease Center, J L Pettis Veterans Administration Medical Center, Loma Linda, California 92357, USA
    Endocrinology 144:3491-6. 2003
    ....
  26. ncbi request reprint Gene expression profile changes in NB4 cells induced by realgar
    Huaiyu Wang
    Department of Hematology, First Hospital of Xi an Jiaotong University, Xi an 710061, China
    Chin Med J (Engl) 116:1074-7. 2003
    ..To compare the gene expression profiles of acute promyelocytic leukemia cell line NB(4) before and after 12 hours of realgar treatment using cDNA microarray...
  27. ncbi request reprint A deletion causing spontaneous fracture identified from a candidate region of mouse Chromosome 14
    Yan Jiao
    Department of Orthopedic Surgery Campbell Clinic, Center of Genomics and Bioinformatics and Center of Diseases of Connective Tissues, University of Tennessee Health Science Center, Memphis, Tennessee, 38163, USA
    Mamm Genome 16:20-31. 2005
    ....
  28. ncbi request reprint Early signals for fracture healing
    Xinmin Li
    Shanxi Agricultural University, Taigu, Shanxi, China 030801
    J Cell Biochem 95:189-205. 2005
    ..Knowledge acquired through this analysis of transcriptional activities at the early stage of bone healing will contribute to our understanding of fracture repair and bone-related pathological conditions...
  29. ncbi request reprint Isolation of wound healing/regeneration genes using restrictive fragment differential display-PCR in MRL/MPJ and C57BL/6 mice
    Godfred Masinde
    Musculoskeletal Disease Center, JL Pettis VA Medical Center, Loma Linda, CA 92357, USA
    Biochem Biophys Res Commun 330:117-22. 2005
    ....
  30. pmc Bayesian shrinkage estimation of quantitative trait loci parameters
    Hui Wang
    Department of Botany and Plant Sciences, University of California, Riverside, 92521, USA
    Genetics 170:465-80. 2005
    ..The method was also used to map QTL responsible for wound healing in a family of a (MRL/MPJ x SJL/J) cross with 633 F(2) mice derived from two inbred lines...
  31. ncbi request reprint DNA microarrays: their use and misuse
    Xinmin Li
    Molecular Genetics Division, Musculoskeletal Disease Center, J L Pettis VA Medical Center Loma Linda University, Loma Linda, CA 92357, USA
    Microcirculation 9:13-22. 2002
    ..The center theme of this review is to improve microarray reproducibility by addressing common technical problems. Finally, we briefly summarize microarray's applications in biomedical research...