Xiaohua Li

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. ncbi Review of pharmacological treatment in mood disorders and future directions for drug development
    Xiaohua Li
    Department of Psychiatry and Behavioral Neuroscience, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Neuropsychopharmacology 37:77-101. 2012
  2. ncbi Lithium regulates glycogen synthase kinase-3beta in human peripheral blood mononuclear cells: implication in the treatment of bipolar disorder
    Xiaohua Li
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294 0017, USA
    Biol Psychiatry 61:216-22. 2007
  3. ncbi Regulation of mouse brain glycogen synthase kinase-3 by atypical antipsychotics
    Xiaohua Li
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294 0017, USA
    Int J Neuropsychopharmacol 10:7-19. 2007
  4. ncbi Is glycogen synthase kinase-3 a central modulator in mood regulation?
    Xiaohua Li
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Neuropsychopharmacology 35:2143-54. 2010
  5. ncbi Synaptic, intracellular, and neuroprotective mechanisms of anticonvulsants: are they relevant for the treatment and course of bipolar disorders?
    Xiaohua Li
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294 4400, USA
    J Affect Disord 69:1-14. 2002
  6. ncbi Risperidone and haloperidol augmentation of serotonin reuptake inhibitors in refractory obsessive-compulsive disorder: a crossover study
    Xiaohua Li
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, 35294, USA
    J Clin Psychiatry 66:736-43. 2005
  7. ncbi In vivo regulation of glycogen synthase kinase-3beta (GSK3beta) by serotonergic activity in mouse brain
    Xiaohua Li
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294 0017, USA
    Neuropsychopharmacology 29:1426-31. 2004
  8. ncbi Regulation of FOXO3a by brain-derived neurotrophic factor in differentiated human SH-SY5Y neuroblastoma cells
    Wawa Zhu
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, 1075 Sparks Center, 1720 7th Avenue South Birmingham, AL 35294 0017, USA
    Brain Res Mol Brain Res 126:45-56. 2004
  9. ncbi Deficiency in the inhibitory serine-phosphorylation of glycogen synthase kinase-3 increases sensitivity to mood disturbances
    Abigail Polter
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294 0017, USA
    Neuropsychopharmacology 35:1761-74. 2010
  10. ncbi Regulation of Akt and glycogen synthase kinase-3 beta phosphorylation by sodium valproate and lithium
    Patrizia De Sarno
    Department of Psychiatry and Behavioral Neurobiology, Sparks Center 1057, University of Alabama at Birmingham, Birmingham, AL 35294-0017, USA
    Neuropharmacology 43:1158-64. 2002

Research Grants

  1. Regulation of GSK3beta by Mood Stabilizers
    Xiaohua Li; Fiscal Year: 2005
  2. GSK3: Neural Modulators and Mood Disorders
    Xiaohua Li; Fiscal Year: 2007
  3. Glucogen Synthase Kinase 3beta and Bipolar Disorder
    Xiaohua Li; Fiscal Year: 2007
  4. GSK3: Neural Modulators and Mood Disorders
    Xiaohua Li; Fiscal Year: 2009

Collaborators

  • RICHARD JOPE
  • Patrizia De Sarno
  • Mark A Frye
  • Qin Wang
  • Jean Martin Beaulieu
  • Karen L Gamble
  • Li Wang
  • Eleonore Beurel
  • Lori L Davis
  • Stanford L Peng
  • Ling Song
  • Courtney A Miller
  • Terence A Ketter
  • T van Groen
  • KEVIN AARON ROTH
  • JOHN SWEATT
  • Jun Wang
  • Abigail M Polter
  • Sufen Yang
  • Wenjun Zhou
  • Ligong Chen
  • Abigail Polter
  • Fuzeng Li
  • Christopher Cottingham
  • Nathan A Styles
  • Wawa Zhu
  • L Chen
  • SCOTT B HOYT
  • Hollis Reeves
  • Rusheng Zhang
  • Vincent T Lee
  • Zhengquan Mao
  • Liu Hong
  • Yong Huang
  • Alpaslan Dedeoglu
  • Hong Lin
  • Lian Mai
  • Jodi Paul
  • Karen Sampson
  • Jim R Woodgett
  • S Yang
  • W Zhou
  • I Gaisina
  • P C Chen
  • Lori McMahon
  • Rakesha Garner
  • Alfred A Bartolucci
  • Gregory D Salinas
  • Ronald A Depinho
  • Anna A Zmijewska
  • Ji Hye Paik
  • Michael H Fisher
  • Kathryn A Lyons
  • William H Parsons
  • Sachin Batra
  • Clare London
  • Birgit T Priest
  • Vivien A Warren
  • Daniel C Dahl
  • D Euan MacIntyre
  • Doreen E Cashen
  • Maria L Garcia
  • McHardy M Smith
  • Roberta S May
  • William J Martin
  • Matthew J Wyvratt
  • Gregory J Kaczorowski
  • Brande S Williams
  • John P Felix
  • Liqin Liu
  • Yu Han
  • Wei Guo
  • Hiromi Sato
  • Jin Huang
  • Stefan Pukatzki
  • Daiming Fan
  • Ying Han
  • Yunping Zhao
  • Dara W Frank
  • Anastasia A Kazimirova
  • Eriya Kikawada
  • Stephen Lory
  • Jonathan P Arm
  • Li Lai
  • Neil W Kowall
  • Gautam N Bijur
  • John Engstrom
  • Xudong Huang
  • Kerry Cormier
  • Jonathan N Kremsky

Detail Information

Publications34

  1. ncbi Review of pharmacological treatment in mood disorders and future directions for drug development
    Xiaohua Li
    Department of Psychiatry and Behavioral Neuroscience, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Neuropsychopharmacology 37:77-101. 2012
    ..It is predicted that future drug development will identify new agents targeting the molecular mechanisms involved in the pathophysiology of mood disorders...
  2. ncbi Lithium regulates glycogen synthase kinase-3beta in human peripheral blood mononuclear cells: implication in the treatment of bipolar disorder
    Xiaohua Li
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294 0017, USA
    Biol Psychiatry 61:216-22. 2007
    ..We tested whether lithium modified GSK3beta in vivo or in vitro in peripheral blood mononuclear cells (PBMCs) from healthy control and bipolar disorder subjects...
  3. ncbi Regulation of mouse brain glycogen synthase kinase-3 by atypical antipsychotics
    Xiaohua Li
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294 0017, USA
    Int J Neuropsychopharmacol 10:7-19. 2007
    ..These findings may support the pharmacological mechanisms of atypical antipsychotics in the treatment of mood disorders...
  4. ncbi Is glycogen synthase kinase-3 a central modulator in mood regulation?
    Xiaohua Li
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Neuropsychopharmacology 35:2143-54. 2010
    ....
  5. ncbi Synaptic, intracellular, and neuroprotective mechanisms of anticonvulsants: are they relevant for the treatment and course of bipolar disorders?
    Xiaohua Li
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294 4400, USA
    J Affect Disord 69:1-14. 2002
    ..Understanding the mechanisms of anticonvulsant mood stabilizers, integrated with clinical observations, may ultimately provide important new insights into the pathophysiology and treatment of bipolar disorders...
  6. ncbi Risperidone and haloperidol augmentation of serotonin reuptake inhibitors in refractory obsessive-compulsive disorder: a crossover study
    Xiaohua Li
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, 35294, USA
    J Clin Psychiatry 66:736-43. 2005
    ..Patients with predominant obsessions are common in OCD and are often difficult to treat, necessitating adjunctive treatment...
  7. ncbi In vivo regulation of glycogen synthase kinase-3beta (GSK3beta) by serotonergic activity in mouse brain
    Xiaohua Li
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294 0017, USA
    Neuropsychopharmacology 29:1426-31. 2004
    ..These results raise the possibility that impaired inhibitory control of GSK3beta may occur in conditions where serotonergic activity is dysregulated, such as in mood disorders...
  8. ncbi Regulation of FOXO3a by brain-derived neurotrophic factor in differentiated human SH-SY5Y neuroblastoma cells
    Wawa Zhu
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, 1075 Sparks Center, 1720 7th Avenue South Birmingham, AL 35294 0017, USA
    Brain Res Mol Brain Res 126:45-56. 2004
    ..The regulatory effect of BDNF on FOXO3a and its target genes may play a significant role in the BDNF-mediated neuronal survival, differentiation, and plasticity...
  9. ncbi Deficiency in the inhibitory serine-phosphorylation of glycogen synthase kinase-3 increases sensitivity to mood disturbances
    Abigail Polter
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294 0017, USA
    Neuropsychopharmacology 35:1761-74. 2010
    ....
  10. ncbi Regulation of Akt and glycogen synthase kinase-3 beta phosphorylation by sodium valproate and lithium
    Patrizia De Sarno
    Department of Psychiatry and Behavioral Neurobiology, Sparks Center 1057, University of Alabama at Birmingham, Birmingham, AL 35294-0017, USA
    Neuropharmacology 43:1158-64. 2002
    ....
  11. ncbi Functional significance of glycogen synthase kinase-3 regulation by serotonin
    Abigail M Polter
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294, United States
    Cell Signal 24:265-71. 2012
    ....
  12. ncbi Phosphorylation and down-regulation of Bim by muscarinic cholinergic receptor activation via protein kinase C
    Nathan A Styles
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294 0017, USA
    Neurochem Int 47:519-27. 2005
    ....
  13. ncbi Behavioral stress-induced activation of FoxO3a in the cerebral cortex of mice
    Wenjun Zhou
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, 35294, USA
    Biol Psychiatry 71:583-92. 2012
    ..The transcription factor FoxO3a is highly expressed in brain, but little is known about the response of FoxO3a to behavioral stress and its impact in the associated behavioral changes...
  14. ncbi Forkhead box, class O transcription factors in brain: regulation and behavioral manifestation
    Abigail Polter
    Department of Psychiatry, University of Alabama at Birmingham, 1075 Sparks Center, 1720 7th Avenue South, Birmingham, AL35294 0017, USA
    Biol Psychiatry 65:150-9. 2009
    ..Here, we investigated whether brain FoxO1 and FoxO3a can be regulated by serotonin and antidepressant treatment and whether their genetic deletion affects behaviors...
  15. ncbi Efficacy of risperidone augmentation to antidepressants in the management of suicidality in major depressive disorder: a randomized, double-blind, placebo-controlled pilot study
    Hollis Reeves
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, AL 35294, USA
    J Clin Psychiatry 69:1228-336. 2008
    ..This pilot study was designed to investigate the efficacy of risperidone augmentation to antidepressants in the acute management of suicidality and other core symptoms in MDD with suicidality...
  16. ncbi In vivo regulation of GSK3 phosphorylation by cholinergic and NMDA receptors
    Patrizia De Sarno
    Department of Psychiatry and Behavioral Neurobiology, 1720 Seventh Ave South, Sparks Center 1057, University of Alabama at Birmingham, Birmingham, AL 35294 0017, USA
    Neurobiol Aging 27:413-22. 2006
    ..Thus, drugs in each class of therapeutic agents used for AD have the common property of increasing the regulatory serine-phosphorylation of GSK3 within common pools of the enzyme...
  17. ncbi Anesthesia and post-mortem interval profoundly influence the regulatory serine phosphorylation of glycogen synthase kinase-3 in mouse brain
    Xiaohua Li
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, 1720 7th Avenue South, Birmingham, AL 35294-0017, USA
    J Neurochem 92:701-4. 2005
    ....
  18. ncbi BDNF-mediated signal transduction is modulated by GSK3beta and mood stabilizing agents
    Lian Mai
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, 1075 Sparks Center, 1720 7th Avenue South, Birmingham, AL 35294-00017, USA
    J Neurochem 82:75-83. 2002
    ..Therefore, increased GSK3beta selectively attenuates BDNF-induced CREB phosphorylation, and lithium and carbamazepine can facilitate activation of CREB...
  19. ncbi The effects of glycogen synthase kinase-3beta in serotonin neurons
    Wenjun Zhou
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS ONE 7:e43262. 2012
    ..Therefore, results of this study demonstrated a serotonin neuron-targeting function of GSK3β by regulating 5-HT1B autoreceptors, which impacts serotonergic neuron firing, serotonin release, and serotonin-regulated behaviors...
  20. ncbi Lithium reduces FoxO3a transcriptional activity by decreasing its intracellular content
    Zhengquan Mao
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0017, USA
    Biol Psychiatry 62:1423-30. 2007
    ..Searching for therapeutic targets downstream of BDNF signaling will facilitate the development of new treatment approaches for mood disorders...
  21. ncbi Noradrenergic antidepressant responses to desipramine in vivo are reciprocally regulated by arrestin3 and spinophilin
    Christopher Cottingham
    Department of Physiology and Biophysics, University of Alabama at Birmingham, 986 MCLM 1918 University Blvd, Birmingham, AL 35294, USA
    Neuropharmacology 62:2354-62. 2012
    ....
  22. ncbi Regulation of serotonin 1B receptor by glycogen synthase kinase-3
    Ligong Chen
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Mol Pharmacol 76:1150-61. 2009
    ....
  23. ncbi Glycogen synthase kinase-3beta, mood stabilizers, and neuroprotection
    Xiaohua Li
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, 35294-0017, USA
    Bipolar Disord 4:137-44. 2002
    ....
  24. ncbi Glycogen Synthase Kinase-3 is an Intermediate Modulator of Serotonin Neurotransmission
    Abigail M Polter
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham Birmingham, AL, USA
    Front Mol Neurosci 4:31. 2011
    ....
  25. ncbi 5-HT1A receptor-regulated signal transduction pathways in brain
    Abigail M Polter
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294, United States
    Cell Signal 22:1406-12. 2010
    ....
  26. ncbi Glycogen synthase kinase-3β is a functional modulator of serotonin-1B receptors
    L Chen
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Mol Pharmacol 79:974-86. 2011
    ..Future studies may elucidate the significant roles of GSK3 in serotonin neurotransmission and implications of GSK3 inhibitors as functional selective modulators of 5-HT1BR...
  27. ncbi A pharmacokinetic and clinical evaluation of switching patients with bipolar I disorder from delayed-release to extended-release divalproex
    Lori L Davis
    Research and Development Department, Tuscaloosa VA Medical Center, Tuscaloosa, AL 35404, USA
    J Clin Psychiatry 68:1546-51. 2007
    ..To determine the optimal strategy for converting stable bipolar patients from twice-daily divalproex delayed release (DR) to once-daily divalproex extended release (ER)...
  28. ncbi Liquid chromatographic-tandem mass spectrometric assay for the simultaneous determination of didanosine and stavudine in human plasma, bronchoalveolar lavage fluid, alveolar cells, peripheral blood mononuclear cells, seminal plasma, cerebrospinal fluid an
    Yong Huang
    Department of Biopharmaceutical Sciences, University of California San Francisco, 94117, San Francisco, CA, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 799:51-61. 2004
    ..The lower limits of quantitation for both ddI and d4T were 2.0 ng/ml in plasma; 0.5 ng/ml in CSF; 0.4 ng/ml in AC, PBMC, and BALF; 1.0 ng/ml in seminal plasma; and 0.01 ng/mg in tonsil tissue...
  29. ncbi Preliminary studies of a novel bifunctional metal chelator targeting Alzheimer's amyloidogenesis
    Alpaslan Dedeoglu
    Geriatric Research Education and Clinical Center, Bedford Veterans' Administration Medical Center, Bedford, MA 01730, USA
    Exp Gerontol 39:1641-9. 2004
    ..Collectively, these preliminary findings carry implication for XH1 being a BBB-permeable lead compound for AD therapeutics targeting Alzheimer's amyloidogenesis, although further studies are needed...
  30. ncbi Pseudolipasin A is a specific inhibitor for phospholipase A2 activity of Pseudomonas aeruginosa cytotoxin ExoU
    Vincent T Lee
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
    Infect Immun 75:1089-98. 2007
    ..This novel inhibitor of ExoU-specific PLA(2) activity, named pseudolipasin A, may provide a new lead for virulence factor-based therapeutic design...
  31. ncbi Maspin augments proteasome inhibitor-induced apoptosis in prostate cancer cells
    Xiaohua Li
    Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Cell Physiol 212:298-306. 2007
    ..Our results suggest that gene therapy involving ectopic maspin expression may dramatically improve the efficacy of proteasome inhibitors for the treatment of prostate cancer...
  32. ncbi Reversal of migraine symptoms by Helicobacter pylori eradication therapy in patients with hepatitis-B-related liver cirrhosis
    Liu Hong
    State Key Laboratory of Cancer Biology and Institute of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi an 710032, Shaanxi Province, China
    Helicobacter 12:306-8. 2007
    ..pylori has been eradicated. Thus, the study pushed further insight into the mechanisms of migraine pathogenesis...
  33. ncbi 3-Amino-1,5-benzodiazepinones: potent, state-dependent sodium channel blockers with anti-epileptic activity
    SCOTT B HOYT
    Department of Medicinal Chemistry, Merck Research Laboratories, PO Box 2000, RY 123 236, Rahway, NJ 07065 0900, USA
    Bioorg Med Chem Lett 18:1963-6. 2008
    ..One member of this series displayed subnanomolar, state-dependent sodium channel block, and was orally efficacious in a mouse model of epilepsy...
  34. ncbi Activation of the MEK/MAPK pathway is involved in bryostatin1-induced monocytic differenciation and up-regulation of X-linked inhibitor of apoptosis protein
    Hong Lin
    Division of Hematology-Oncology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Exp Cell Res 272:192-8. 2002
    ..These findings suggest that the expression of XIAP is linked to monocytic differentiation in bryo1-treated THP-1 cells and represents one of the potential antiapoptotic mechanisms acquired during this process...

Research Grants6

  1. Regulation of GSK3beta by Mood Stabilizers
    Xiaohua Li; Fiscal Year: 2005
    ..The data obtained from this proposal will be used to support a future R01 grant application to achieve our long-term goal of understanding the pathophysiology and improving the treatment of bipolar disorder. ..
  2. GSK3: Neural Modulators and Mood Disorders
    Xiaohua Li; Fiscal Year: 2007
    ..This research is expected to provide significant new insight into the pathophysiology and the treatment of mood disorders. ..
  3. Glucogen Synthase Kinase 3beta and Bipolar Disorder
    Xiaohua Li; Fiscal Year: 2007
    ....
  4. GSK3: Neural Modulators and Mood Disorders
    Xiaohua Li; Fiscal Year: 2009
    ..This research is expected to provide significant new insight into the pathophysiology and the treatment of mood disorders. ..