Xiang Dong Li

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. ncbi Myosin Va becomes a low duty ratio motor in the inhibited form
    Osamu Sato
    Department of Physiology, University of Massachusetts Medical School, Worcester, Massachueetts 01655, USA
    J Biol Chem 282:13228-39. 2007
  2. ncbi The globular tail domain of myosin Va functions as an inhibitor of the myosin Va motor
    Xiang Dong Li
    Department of Physiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Biol Chem 281:21789-98. 2006
  3. ncbi F-actin and myosin II binding domains in supervillin
    Yu Chen
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Biol Chem 278:46094-106. 2003
  4. ncbi The globular tail domain puts on the brake to stop the ATPase cycle of myosin Va
    Xiang Dong Li
    Departments of Physiology and Cell Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Proc Natl Acad Sci U S A 105:1140-5. 2008
  5. ncbi Activation of myosin Va function by melanophilin, a specific docking partner of myosin Va
    Xiang Dong Li
    Department of Physiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Biol Chem 280:17815-22. 2005
  6. ncbi The tail binds to the head-neck domain, inhibiting ATPase activity of myosin VIIA
    Nobuhisa Umeki
    Department of Physiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Proc Natl Acad Sci U S A 106:8483-8. 2009
  7. ncbi Conformational change and regulation of myosin molecules
    Mitsuo Ikebe
    Department of Physiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Adv Exp Med Biol 565:61-72; discussion 72, 359-69. 2005
  8. ncbi Ca2+-induced activation of ATPase activity of myosin Va is accompanied with a large conformational change
    Xiang-Dong Li
    Department of Physiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Biochem Biophys Res Commun 315:538-45. 2004
  9. ncbi Two functional heads are required for full activation of smooth muscle myosin
    Xiang-Dong Li
    Department of Physiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Biol Chem 278:29435-41. 2003
  10. ncbi [In vivo endochondral bone formation by implanting human bone morphogenetic protein-2-producing fibroblasts into nude mouse muscle]
    Xiang-Dong Li
    Institute of Orthopedics, Xijing Hospital, Fourth Military Medical University, Xi'an Shaanxi, P. R. China 710032
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 17:177-9. 2003

Detail Information

Publications10

  1. ncbi Myosin Va becomes a low duty ratio motor in the inhibited form
    Osamu Sato
    Department of Physiology, University of Massachusetts Medical School, Worcester, Massachueetts 01655, USA
    J Biol Chem 282:13228-39. 2007
    ....
  2. ncbi The globular tail domain of myosin Va functions as an inhibitor of the myosin Va motor
    Xiang Dong Li
    Department of Physiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Biol Chem 281:21789-98. 2006
    ....
  3. ncbi F-actin and myosin II binding domains in supervillin
    Yu Chen
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Biol Chem 278:46094-106. 2003
    ..Taken together, these results suggest that supervillin may mediate actin and myosin II filament organization at cholesterol-rich membrane domains...
  4. ncbi The globular tail domain puts on the brake to stop the ATPase cycle of myosin Va
    Xiang Dong Li
    Departments of Physiology and Cell Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Proc Natl Acad Sci U S A 105:1140-5. 2008
    ..We propose that binding of the GTD to the motor domain prevents the movement of the converter/lever arm during ATP hydrolysis cycle, thus inhibiting the chemical cycle of the motor domain...
  5. ncbi Activation of myosin Va function by melanophilin, a specific docking partner of myosin Va
    Xiang Dong Li
    Department of Physiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Biol Chem 280:17815-22. 2005
    ..The present finding raises the idea that myosin motors are switched upon their binding to the cargo molecules, thus avoiding the waste of ATP consumption...
  6. ncbi The tail binds to the head-neck domain, inhibiting ATPase activity of myosin VIIA
    Nobuhisa Umeki
    Department of Physiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Proc Natl Acad Sci U S A 106:8483-8. 2009
    ..We concluded that unconventional myosin that may be present a monomer in the cell can be regulated by intramolecular interaction of the tail with the head...
  7. ncbi Conformational change and regulation of myosin molecules
    Mitsuo Ikebe
    Department of Physiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Adv Exp Med Biol 565:61-72; discussion 72, 359-69. 2005
  8. ncbi Ca2+-induced activation of ATPase activity of myosin Va is accompanied with a large conformational change
    Xiang-Dong Li
    Department of Physiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Biochem Biophys Res Commun 315:538-45. 2004
    ..This conformational transition is closely correlated to the actin-activated ATPase activity. These results suggest that the tail and neck domain play a role in the Ca(2+) dependent regulation of myosin Va...
  9. ncbi Two functional heads are required for full activation of smooth muscle myosin
    Xiang-Dong Li
    Department of Physiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Biol Chem 278:29435-41. 2003
    ..The present study supports an idea that the two heads of smooth muscle myosin II interact with each other and the presence of two active heads is required for full activation...
  10. ncbi [In vivo endochondral bone formation by implanting human bone morphogenetic protein-2-producing fibroblasts into nude mouse muscle]
    Xiang-Dong Li
    Institute of Orthopedics, Xijing Hospital, Fourth Military Medical University, Xi'an Shaanxi, P. R. China 710032
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 17:177-9. 2003
    ..Endochondral bone formation in vivo was observed at the site of implantation 4 weeks later. CONCLUSION: Fibroblasts transfected by hBMP-2 gene can be used to promote endochondral bone formation in vivo...