W Li

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi Role of the liver in peripheral tolerance: induction through oral antigen feeding
    Wei Li
    Division of Transplantation, Department of Surgery, University of Washington Medical Center, Seattle, WA, USA
    Am J Transplant 4:1574-82. 2004
  2. pmc Immunostimulating properties of intragastrically administered Acetobacter-derived soluble branched (1,4)-beta-D-glucans decrease murine susceptibility to Listeria monocytogenes
    Wei Li
    Division of Host Defense, Research Center for Prevention of Infectious Diseases, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812 8582, Japan
    Infect Immun 72:7005-11. 2004
  3. ncbi CTLA4 engagement is required for induction of murine liver transplant spontaneous tolerance
    Wei Li
    Department of Surgery, Division of Transplantation, University of Washington Medical Center, Seattle, WA, USA
    Am J Transplant 5:978-86. 2005
  4. ncbi The role of Foxp3+ regulatory T cells in liver transplant tolerance
    W Li
    Department of Surgery, Division of Transplantation, University of Washington Medical Center, Seattle, Washington 98195, USA
    Transplant Proc 38:3205-6. 2006
  5. pmc Thymic selection pathway regulates the effector function of CD4 T cells
    Wei Li
    Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Exp Med 204:2145-57. 2007
  6. ncbi Anti-CD25 mAb administration prevents spontaneous liver transplant tolerance
    W Li
    Division of Transplantation, Department of Surgery, University of Washington Medical Center, Seattle, Washington 98195, USA
    Transplant Proc 38:3207-8. 2006
  7. ncbi New insights into mechanisms of spontaneous liver transplant tolerance: the role of Foxp3-expressing CD25+CD4+ regulatory T cells
    W Li
    Division of Transplantation, Department of Surgery, University of Washington Medical Center, Seattle, WA, USA
    Am J Transplant 8:1639-51. 2008
  8. pmc CCR2 regulates monocyte recruitment as well as CD4 T1 allorecognition after lung transplantation
    A E Gelman
    Department of Surgery, Washington University in St Louis, St Louis, MO, USA
    Am J Transplant 10:1189-99. 2010
  9. ncbi gammadeltaT cells are involved in liver transplant tolerance
    F Malone
    Division of Pediatric Transplantation, Children s Hospital and Regional Medical Center, Seattle, Washington 98195, USA
    Transplant Proc 41:233-5. 2009
  10. pmc Lung transplant acceptance is facilitated by early events in the graft and is associated with lymphoid neogenesis
    W Li
    Department of Surgery, Washington University in St Louis, St Louis, Missouri, USA
    Mucosal Immunol 5:544-54. 2012

Detail Information

Publications69

  1. ncbi Role of the liver in peripheral tolerance: induction through oral antigen feeding
    Wei Li
    Division of Transplantation, Department of Surgery, University of Washington Medical Center, Seattle, WA, USA
    Am J Transplant 4:1574-82. 2004
    ..Our results suggest that the liver plays an important role in inducing peripheral tolerance in a mucosal tolerance model, especially feeding high-dose OVA...
  2. pmc Immunostimulating properties of intragastrically administered Acetobacter-derived soluble branched (1,4)-beta-D-glucans decrease murine susceptibility to Listeria monocytogenes
    Wei Li
    Division of Host Defense, Research Center for Prevention of Infectious Diseases, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812 8582, Japan
    Infect Immun 72:7005-11. 2004
    ..monocytogenes via augmentation of Th1 responses. These results suggest that infectious processes driven by intracellular microorganisms could be prevented to develop by the (1,4)-beta-D-glucan...
  3. ncbi CTLA4 engagement is required for induction of murine liver transplant spontaneous tolerance
    Wei Li
    Department of Surgery, Division of Transplantation, University of Washington Medical Center, Seattle, WA, USA
    Am J Transplant 5:978-86. 2005
    ..CTLA4 blockade promotes donor specific T-cell activation, cytotoxicity and Th1 polarization; protects alloreactive T cells from apoptotic death and induces liver allograft acute rejection...
  4. ncbi The role of Foxp3+ regulatory T cells in liver transplant tolerance
    W Li
    Department of Surgery, Division of Transplantation, University of Washington Medical Center, Seattle, Washington 98195, USA
    Transplant Proc 38:3205-6. 2006
    ..CTLA4, IL-4, and apoptosis of alloreactive T cells appear to contribute to the function of Treg and regulation of graft outcome...
  5. pmc Thymic selection pathway regulates the effector function of CD4 T cells
    Wei Li
    Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Exp Med 204:2145-57. 2007
    ..Our results imply that this thymic selection pathway plays an important role in determining the effector function of the resulting CD4 cells and in regulating immune response...
  6. ncbi Anti-CD25 mAb administration prevents spontaneous liver transplant tolerance
    W Li
    Division of Transplantation, Department of Surgery, University of Washington Medical Center, Seattle, Washington 98195, USA
    Transplant Proc 38:3207-8. 2006
    ..This was associated with enhanced anti-donor immune reactivity, downregulated Treg gene expression, and reduced T cell apoptosis in the grafts and host spleens...
  7. ncbi New insights into mechanisms of spontaneous liver transplant tolerance: the role of Foxp3-expressing CD25+CD4+ regulatory T cells
    W Li
    Division of Transplantation, Department of Surgery, University of Washington Medical Center, Seattle, WA, USA
    Am J Transplant 8:1639-51. 2008
    ..CTLA4, IL-4, TGF-beta and apoptosis of graft-infiltrating T cells are also associated with liver transplant tolerance and may contribute, at least in part, to the mechanisms of Treg-mediated immune regulation in this model...
  8. pmc CCR2 regulates monocyte recruitment as well as CD4 T1 allorecognition after lung transplantation
    A E Gelman
    Department of Surgery, Washington University in St Louis, St Louis, MO, USA
    Am J Transplant 10:1189-99. 2010
    ..Thus, CCR2 may be a potential target to attenuate alloimmune responses after lung transplantation...
  9. ncbi gammadeltaT cells are involved in liver transplant tolerance
    F Malone
    Division of Pediatric Transplantation, Children s Hospital and Regional Medical Center, Seattle, Washington 98195, USA
    Transplant Proc 41:233-5. 2009
    ..Our results suggested that gammadeltaT cells are involved in allogeneic immune responses. Whether gammadeltaT cells function as the causal or the effector cells in allograft tolerance rejection warrants further investigation...
  10. pmc Lung transplant acceptance is facilitated by early events in the graft and is associated with lymphoid neogenesis
    W Li
    Department of Surgery, Washington University in St Louis, St Louis, Missouri, USA
    Mucosal Immunol 5:544-54. 2012
    ..Thus, events contributing to lung transplant acceptance are established early in the graft and induction of bronchus-associated lymphoid tissue can be associated with an immune quiescent state...
  11. ncbi Costimulatory blockade-mediated lung allograft acceptance is abrogated by overexpression of Bcl-2 in the recipient
    M Okazaki
    Department of Surgery, Washington University in St Louis, St Louis, Missourri 63110 1013, USA
    Transplant Proc 41:385-7. 2009
    ..Thus, our results show that perioperative blockade of the CD40/CD40L and CD28/B7 costimulatory pathways markedly ameliorates acute rejection of lung allografts in wild type but not Bcl-2 transgenic recipients...
  12. pmc Lung cancer and occupational exposures other than cotton dust and endotoxin among women textile workers in Shanghai, China
    H Checkoway
    Department of Environmental and Occupational Health Sciences, University of Washington, Box 357234, Seattle, WA 98195 7234, USA
    Occup Environ Med 68:425-9. 2011
    ....
  13. pmc Transforming growth factor beta expression by human vascular cells inhibits interferon gamma production and arterial media injury by alloreactive memory T cells
    A H Lebastchi
    Department of Surgery, Interdepartmental Program in Vascular Biology and Therapeutics, Yale University School of Medicine, New Haven, CT, USA
    Am J Transplant 11:2332-41. 2011
    ....
  14. ncbi Proanthocyanidin from grape seeds potentiates anti-tumor activity of doxorubicin via immunomodulatory mechanism
    Xiao Yu Zhang
    Department of Physiology, College of Basic Medicine, Lanzhou University, Gansu Province, 730000, People s Republic of China
    Int Immunopharmacol 5:1247-57. 2005
    ....
  15. ncbi Enhancement of NKT cells and increase in regulatory T cells results in improved allograft survival
    Wei Li
    Department of Surgery, Division of Transplantation, University of Washington Medical Center, Seattle, Washington 98195, USA
    J Surg Res 134:10-21. 2006
    ..We explored whether a subtherapeutic dose of FK506 could enhance the tolerizing effect of NKT cells induced by oral administration of donor spleen cells (SCs) in the pre-transplant period to prolong heart allograft survival...
  16. ncbi Constitutive expression of CIITA directs CD4 T cells to produce Th2 cytokines in the thymus
    Dipak R Patel
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Cell Immunol 233:30-40. 2005
    ....
  17. ncbi Identification of CD36 as a new surface marker of marginal zone B cells by transcriptomic analysis
    Ping Zhang
    State Key Laboratory of Cancer Biology, Department of Medical Genetics and Developmental Biology, Fourth Military Medical University, and Department of Dermatology, Xijng Hospital, Xi an 710032, China
    Mol Immunol 44:332-7. 2007
    ..These results revealed new phenotypic properties of MZ and FO B cells, and would facilitate further studies in the differentiation and functions of these mature B cells...
  18. ncbi Effects of B7-blocking agent and/or CsA on induction of platelet-specific T-cell anergy in chronic autoimmune thrombocytopenic purpura
    Jun Peng
    Department of Hematology, Qilu Hospital of Shandong University, Jinan, Shandong, People s Republic of China
    Blood 101:2721-6. 2003
    ..CTLA4-Ig may become a promising new therapeutic agent for the treatment of chronic AITP, and the combination of CTLA4-Ig and CsA would be a more powerful strategy for the management of refractory AITP...
  19. doi PD-L1/PD-1 signal deficiency promotes allogeneic immune responses and accelerates heart allograft rejection
    Weigang Wang
    Division of Transplantation, Department of Surgery, University of Washington Medical Center, Seattle, WA 98195, USA
    Transplantation 86:836-44. 2008
    ..PD-L1, a ligand for programmed death 1 (PD-1), delivers a negative costimulatory signal to T cells and plays a critical role in the regulation of peripheral tolerance...
  20. ncbi Immature and mature CD8alpha+ dendritic cells prolong the survival of vascularized heart allografts
    Peta J O'Connell
    Thomas E Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    J Immunol 168:143-54. 2002
    ..Mobilization of such a donor DC subset with capacity to modulate antidonor immunity may have significant implications for the therapy of allograft rejection...
  21. pmc Hermansky-Pudlak syndrome type 7 (HPS-7) results from mutant dysbindin, a member of the biogenesis of lysosome-related organelles complex 1 (BLOC-1)
    Wei Li
    Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Nat Genet 35:84-9. 2003
    ....
  22. ncbi Attenuation of aortic graft arteriosclerosis by systemic administration of Allotrap peptide RDP58
    Wei Li
    Thomas E Starzl Transplantation Institute and Department of Surgery, University of Pittsburgh Medical Center, E1540, Biomedical Science Tower, 200 Lothrop Street, Pittsburgh, PA 15261, Pennsylvania, USA
    Transpl Int 16:849-56. 2003
    ..These data suggest that the suppressive effect of RDP58 on allograft arteriosclerosis is due to multiple actions of the peptide, including induction of HO-1, inhibition of TNF-alpha, and a direct effect on SMC proliferation...
  23. pmc CapG(-/-) mice have specific host defense defects that render them more susceptible than CapG(+/+) mice to Listeria monocytogenes infection but not to Salmonella enterica serovar Typhimurium infection
    Shefal S Parikh
    Department of Medicine, University of Florida College of Medicine, Gainesville, Florida 32610, USA
    Infect Immun 71:6582-90. 2003
    ..Our findings suggest that specific motility deficits in macrophages, dendritic cells, and neutrophils render CapG(-/-) mice more susceptible than CapG(+/+) mice to Listeria infection...
  24. ncbi Retroviral delivery of transforming growth factor-beta1 to myeloid dendritic cells: inhibition of T-cell priming ability and influence on allograft survival
    Takuya Takayama
    Thomas E Starzl Transplantation Institute, and Department of Surgery, University of Pittsburgh, Pennsylvania 15213, USA
    Transplantation 74:112-9. 2002
    ....
  25. ncbi Activation of platelet alphaIIbbeta3 by an exogenous peptide corresponding to the transmembrane domain of alphaIIb
    Hang Yin
    Department of Biochemistry and Biophysics, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 281:36732-41. 2006
    ..These observations demonstrate that transmembrane domain interactions regulate integrin function in situ and that it is possible to target intra-membranous protein-protein interactions in a way that can have functional consequences...
  26. pmc A hierarchical network of transcription factors governs androgen receptor-dependent prostate cancer growth
    Qianben Wang
    Division of Molecular and Cellular Oncology, Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    Mol Cell 27:380-92. 2007
    ..These collaborating factors, together with AR, form a regulatory hierarchy that governs androgen-dependent gene expression and prostate cancer growth and offer potential new opportunities for therapeutic intervention...
  27. ncbi [The proteomics study of apoptotic NB4 cells induced by sodium butyrate]
    Wei Li
    Department of Hematology Oncology, First Hospital of Jilin University, Changchun 130021, China
    Zhonghua Xue Ye Xue Za Zhi 27:436-40. 2006
    ..To explore the molecular mechanisms of apoptotic NB4 cells induced by the histone deacetylase inhibitor, sodium butyrate(SB)...
  28. pmc Identification of human STAT5-dependent gene regulatory elements based on interspecies homology
    Erik A Nelson
    Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 281:26216-24. 2006
    ..This strategy may be an effective way to identify functional binding regions for transcription factors with known cognate binding sites anywhere in the genome...
  29. ncbi Rosuvastatin attenuates monocyte-endothelial cell interactions and vascular free radical production in hypercholesterolemic mice
    Wei Li
    Division of Cardiovascular Medicine, Stanford University School of Medicine, CA 94305 5246, USA
    J Pharmacol Exp Ther 313:557-62. 2005
    ..Thus, treatment with rosuvastatin has acute anti-inflammatory actions that likely participate in its beneficial actions during atherogenesis...
  30. ncbi Effects of heat shock protein gp96 on human dendritic cell maturation and CTL expansion
    Yuxia Zhang
    Molecular Virology Research Center, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, PR China
    Biochem Biophys Res Commun 344:581-7. 2006
    ..In HLA-A2.1/Kb transgenic mice, gp96 and the recombinant fragments were found to augment CTL response specific for the HBcAg(18-27) FLPSDFFPSV peptide of hepatitis B virus...
  31. ncbi New T cell epitopes identified from an anti-idiotypic antibody mimicking ovarian cancer associated antigen
    Wei Li
    Gynecologic Oncology Center, Peking University People s Hospital, 11 Xi Zhi Men South Street, Xi Cheng District, Beijing, China
    Cancer Immunol Immunother 57:143-54. 2008
    ..Our study provided the structural basis of antigenicity of 6B11. The identification of antigen-specific T cell eptitopes in 6B11 should facilitate the design of epitope-based vaccine against human ovarian cancer...
  32. ncbi Establishment of customized mouse stem cell lines by sequential nuclear transfer
    Chunli Zhao
    State Key Laboratory of Reproductive Biology, Chinese Academy of Sciences, Beijing 100080, China
    Cell Res 17:80-7. 2007
    ..This indicates that the therapeutic cloning process using sequential NT-ESCs may not rescue the developmental deficiencies that resided in previous donor generations...
  33. pmc The SLAM-associated protein signaling pathway is required for development of CD4+ T cells selected by homotypic thymocyte interaction
    Wei Li
    Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Immunity 27:763-74. 2007
    ..Thus, in contrast to epithelial cell-selected CD4(+) T cells, the two distinct lineages of T cells selected by thymocytes--i.e., T-CD4 and NKT cells--both utilize the SAP-Fyn-PKCtheta pathway for their development and function...
  34. ncbi Selenium deficiency induced an altered immune response and increased survival following influenza A/Puerto Rico/8/34 infection
    Wei Li
    Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7461, USA
    Exp Biol Med (Maywood) 232:412-9. 2007
    ..This altered immune response was beneficial for protecting the mice from influenza virus-induced mortality...
  35. ncbi Tyk2 signaling in host environment plays an important role in contraction of antigen-specific CD8+ T cells following a microbial infection
    Wei Li
    Division of Host Defense and Digital Medicine Initiative, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, Japan
    J Immunol 178:4482-8. 2007
    ..These results suggest that Tyk2 signaling for IFN-gamma production in host environment plays an important role in contraction of effector CD8+ T cells following a microbial infection...
  36. doi Induction of immune response and anti-tumor activities in mice with a DNA vaccine encoding human mucin 1 variable-number tandem repeats
    Shuzi Zhang
    Vaccine Research Center, College of Life Science, Jilin University, Changchun, People s Republic of China
    Hum Immunol 69:250-8. 2008
    ..The combination of the MUC1 VNTR DNA vaccine and the IL-2 adjuvant plasmid provides an attractive alternative for prophylactic and therapeutic vaccinations against MUC1(+) tumors...
  37. ncbi Artificial phosphatidylserine liposome mimics apoptotic cells in inhibiting maturation and immunostimulatory function of murine myeloid dendritic cells in response to 1-chloro-2,4-dinitrobenze in vitro
    Dongmei Shi
    Dermatology Center of Chinese PLA, Xijing Hospital, The Fourth Military Medical University, Xi an 710032, China
    Arch Dermatol Res 299:327-36. 2007
    ..These data demonstrate that PS liposomes have therapeutic potential in allergic contact dermatitis (ACD)...
  38. pmc Localization of A20 to a lysosome-associated compartment and its role in NFkappaB signaling
    Lianyun Li
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Biochim Biophys Acta 1783:1140-9. 2008
    ..Interestingly, A20 mutants defective in membrane association also contain reduced NFkappaB inhibitory activity. These findings suggest the involvement of a lysosome-associated mechanism in A20-dependent termination of NFkappaB signaling...
  39. ncbi [C3d enhances immune response to the secreted form of Coxsackie virus B3 VP1 DNA vaccine]
    Na Zhao
    Department of Pathogenic Biology, Hebei Medical University, Shijiazhuang 050017, China
    Zhonghua Yi Xue Za Zhi 87:2561-3. 2007
    ..To explore a strategy to enhance the specific immune response induced by secreted form of Coxsackie virus B3 (CVB3) capsid protein 1 (sVP1) gene vaccination against Coxsackie virus infection...
  40. ncbi Grifolin, a potential antitumor natural product from the mushroom Albatrellus confluens, induces cell-cycle arrest in G1 phase via the ERK1/2 pathway
    Mao Ye
    Cancer Research Institute, Xiangya School of Medicine, Central South University, Changsha, Hunan 410078, PR China
    Cancer Lett 258:199-207. 2007
    ..These results are significant in that they provide a mechanistic framework for further exploring the use of grifolin as a novel antitumor agent...
  41. ncbi An important role of Tyk2 in APC function of dendritic cells for priming CD8+ T cells producing IFN-gamma
    Keiji Aizu
    Division of Host Defense, Research Center of Prevention of Infectious Diseases, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    Eur J Immunol 36:3060-70. 2006
    ..These results suggest that Tyk2 signaling is also important for DC function in the induction of MHC class Ia- and class Ib-restricted CD8+ Tc1 cells following L. monocytogenes infection...
  42. ncbi Activation of individual alphaIIbbeta3 integrin molecules by disruption of transmembrane domain interactions in the absence of clustering
    Rustem I Litvinov
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Biochemistry 45:4957-64. 2006
    ....
  43. ncbi Murine Hermansky-Pudlak syndrome genes: regulators of lysosome-related organelles
    Wei Li
    Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Bioessays 26:616-28. 2004
    ..Studies of the molecular functions of HPS proteins will reveal important details of vesicle trafficking and may lead to therapies for HPS...
  44. ncbi Fluorescence spectroscopy studies on 5-aminosalicylic acid and zinc 5-aminosalylicylate interaction with human serum albumin
    Feng Ling Cui
    Key Laboratory of Environmental Science and Engineering for Colleges and Universities of Henan Province, School of Chemistry and Environmental Science, Henan Normal University, Xinxiang, Henan 453002, PR China
    J Pharm Biomed Anal 34:189-97. 2004
    ..8-2.9%. A practical method was proposed for the determination of 5-ASA or 5-ASZ in human serum samples...
  45. ncbi The Hermansky-Pudlak syndrome 3 (cocoa) protein is a component of the biogenesis of lysosome-related organelles complex-2 (BLOC-2)
    Rashi Gautam
    Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    J Biol Chem 279:12935-42. 2004
    ..Interaction of the Hps5 and Hps6 proteins within BLOC-2 is abolished by the three-amino acid deletion in the Hps6(ru) mutant allele, indicating that these three amino acids are important for normal BLOC-2 complex formation...
  46. ncbi The effect of follicle-stimulating hormone on follicular development, granulosa cell apoptosis and steroidogenesis and its mediation by insulin-like growth factor-I in the goat ovary
    Yuansong Yu
    College of Animal Science and Veterinary Medicine, Shandong Agricultural University, Tai an City 271018, PR China
    Theriogenology 60:1691-704. 2003
    ..These results indicated that FSH mainly enhanced the development of medium sized follicles in the goat by suppressing the apoptosis of granulosa cells via increasing production of IGF-I and steroids, possibly through the PKA pathway...
  47. ncbi The Role of zinc in the disulphide stress-regulated anti-sigma factor RsrA from Streptomyces coelicolor
    Wei Li
    School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK
    J Mol Biol 333:461-72. 2003
    ..Redox stress induces disulphide bond formation amongst zinc-ligating residues, expelling the metal ion and stabilising a structure incapable of binding the sigma factor...
  48. ncbi [Influence of different doses of fentanyl on T-lymphocyte subpopulations and natural killer cells of patients with esophageal tumor during preoperation and postoperation]
    Wei Li
    Department of Anesthesiology, Cancer Center, Sun Yat Sen University, Guangzhou, Guangdong, PR China
    Ai Zheng 22:634-6. 2003
    ..This study was designed to investigate the effects of different doses of fentanyl on T-lymphocyte subpopulations and natural killer cells during esophageal cancer surgery under general anesthesia...
  49. pmc Differential T-cell activation by B7-1 expression
    Wei Li
    Department of Ophthalmology, University of Miami School of Medicine, FL, USA
    Immunology 109:336-42. 2003
    ..Based on these findings, the possible mechanism of differential B7-1 costimulation on peptide-specific and viral antigen-specific T-cell activation is discussed...
  50. pmc 3-Aminopropanal, formed during cerebral ischaemia, is a potent lysosomotropic neurotoxin
    Wei Li
    Division of Pathology II, Linkoping University Hospital, Sweden
    Biochem J 371:429-36. 2003
    ..These results may have implications for the development of new therapeutics designed to lessen secondary damage arising from focal cerebral ischaemia...
  51. ncbi Selection of peptide ligands binding to fibroblast growth factor receptor 1
    Hongkuan Fan
    College of Life Science, Jilin University, Changchun, People s Republic of China
    IUBMB Life 54:67-72. 2002
    ..The synthetic peptide Ac-ValTyrMetSerProPhe-NH2 can inhibit mitogenic activity of aFGF and has the potential to become a therapeutic agent as an aFGF antagonist...
  52. ncbi Hyperglycemia-induced apoptosis in mouse myocardium: mitochondrial cytochrome C-mediated caspase-3 activation pathway
    Lu Cai
    Department of Medicine, University of Louisville, Louisville, Kentucky, USA
    Diabetes 51:1938-48. 2002
    ..Hyperglycemia-induced myocardial apoptosis is mediated, at least in part, by activation of the cytochrome c-activated caspase-3 pathway, which may be triggered by ROS derived from high levels of glucose...
  53. ncbi Up-regulated transcriptional repressors SnoN and Ski bind Smad proteins to antagonize transforming growth factor-beta signals during liver regeneration
    Marina Macias-Silva
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 277:28483-90. 2002
    ..Our data show that active TGF-beta/Smad signals are present during regeneration and suggest that SnoN/Ski induction might explain hepatocyte resistance to TGF-beta during the proliferative phase...
  54. pmc Lysosomal destabilization in p53-induced apoptosis
    Xi Ming Yuan
    Pathology II, Linkoping University, Linköping 581 85, Sweden
    Proc Natl Acad Sci U S A 99:6286-91. 2002
    ..These findings on the induction of p53-induced lysosomal destabilization can also help to formulate new therapies for diseases with apoptotic disorders...
  55. ncbi Human neuroblastoma (SH-SY5Y) cells are highly sensitive to the lysosomotropic aldehyde 3-aminopropanal
    Zhengquan Yu
    Divisions of Pathology II, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Brain Res 1016:163-9. 2004
    ..Perhaps secondary brain damage during a critical post injury period can be prevented by the use of drugs that temporarily raise lysosomal pH, inactivate intralysosomal 3-AP, or stabilize lysosomal membranes against oxidative stress...
  56. ncbi Estradiol 3-glucuronide is transported by the multidrug resistance-associated protein 2 but does not activate the allosteric site bound by estradiol 17-glucuronide
    Phillip M Gerk
    University of Kentucky, Graduate Center for Toxicology, Room 306 HSRB, Lexington, KY 40536 0305, USA
    Drug Metab Dispos 32:1139-45. 2004
    ..The noncholestatic E23G is an Mrp2 substrate and competes with E217G for transport, but does not activate the allosteric site...
  57. ncbi Ubiquitin-conjugating enzyme 3 delays human lens epithelial cells in metaphase
    Qing Liu
    Laboratory for Nutrition and Vision Research, JMUSDA HNRCA at Tufts University, Boston, Massachusetts 02111, USA
    Invest Ophthalmol Vis Sci 47:1302-9. 2006
    ..Expecting to find similar effects in human lens epithelial cells (HLECs), the authors explored roles for this ubiquitin-conjugating enzyme in regulation of the HLEC cycle...
  58. ncbi Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in immunosuppressed nonhuman primates
    Bernhard J Hering
    Diabetes Institute for Immunology and Transplantation, Department of Surgery, University of Minnesota, 424 Harvard Street SE, Minneapolis, Minnesota 55455, USA
    Nat Med 12:301-3. 2006
    ....
  59. ncbi A normal mucin-binding lectin from the sponge Craniella australiensis
    Chuannan Xiong
    Dalian Institute of Chemical Physics, Chinese Academy of Science, Liaoning Dalian 116023, PR China
    Comp Biochem Physiol C Toxicol Pharmacol 143:9-16. 2006
    ..The lectin reaction is independent of the presence of divalent cations Ca2+ and Mg2+. The sequence of N-terminal residues of CAL was determined as TSSCQSIVVE. The lectin showed a potent mitogenic response towards BALB/c splenocytes...
  60. ncbi [Antisense hypoxia inducible factor-1alpha and B7-1 combination gene therapy for mouse lymphoma]
    Xue Ying Sun
    Hepatosplenic Surgery Center of Heilongjiang Province, The First Clinical College of Harbin Medical University, Harbin 150001, China
    Zhonghua Zhong Liu Za Zhi 27:404-7. 2005
    ..To investigate the synergistic effects of antisense HIF-1alpha gene therapy combined with B7-1-mediated immunotherapy on cancer treatment...
  61. ncbi Anthrax lethal toxin paralyzes neutrophil actin-based motility
    Russell L During
    Department of Medicine Infectious Diseases, University of Florida, Gainesville, FL 32610, USA
    J Infect Dis 192:837-45. 2005
    ..We conclude that 2 h of exposure to LT markedly impairs PMN actin assembly, and reductions in actin filament content are accompanied by a profound paralysis of PMN chemotaxis...
  62. ncbi Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1
    Jason S Carroll
    Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, Massachusetts 02115, USA
    Cell 122:33-43. 2005
    ..Furthermore, knockdown of FoxA1 expression blocks the association of ER with chromatin and estrogen-induced gene expression demonstrating the necessity of FoxA1 in mediating an estrogen response in breast cancer cells...
  63. pmc Interleukin (IL)-4 inhibits IL-10 to promote IL-12 production by dendritic cells
    Yongxue Yao
    Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Exp Med 201:1899-903. 2005
    ..These data indicate that IL-4 plays a key role in inducing Th1 cell differentiation by instructing DCs to produce less IL-10...
  64. ncbi A hidden Markov model for analyzing ChIP-chip experiments on genome tiling arrays and its application to p53 binding sequences
    Wei Li
    Department of Biostatistics and Computational Biology, Dana Farber Cancer Institute, Harvard School of Public Health Boston, MA 02115, USA
    Bioinformatics 21:i274-82. 2005
    ..The massive dataset generated from these experiments pose great challenges for data analysis...
  65. pmc Soluble lumican glycoprotein purified from human amniotic membrane promotes corneal epithelial wound healing
    Lung Kun Yeh
    Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, Florida 33136, USA
    Invest Ophthalmol Vis Sci 46:479-86. 2005
    ..To purify and characterize the glycoprotein lumican, isolated from human amniotic membrane (AM), and to examine its efficacy in treating corneal epithelium debridement...
  66. ncbi Enhanced expression of natural resistance-associated macrophage protein 1 in atherosclerotic lesions may be associated with oxidized lipid-induced apoptosis
    Wei Li
    Division of Pathology II, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Ann N Y Acad Sci 1030:202-7. 2004
    ..This finding reveals a novel function of Nramp1 in atherogenesis...
  67. ncbi Regulation of connexin43-protein binding in astrocytes in response to chemical ischemia/hypoxia
    Wei Li
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 280:7941-8. 2005
    ..These results identify new binding partners for connexin43 and demonstrate that interactions between connexin43 and protein kinases and phosphatases are dynamically altered as a consequence of connexin43 phosphorylation...
  68. ncbi Low-dose radiation (LDR) induces hematopoietic hormesis: LDR-induced mobilization of hematopoietic progenitor cells into peripheral blood circulation
    Wei Li
    Department of Hematology and Oncology, First University Hospital, PR China
    Exp Hematol 32:1088-96. 2004
    ..The aim of this study was to investigate the stimulating effect of low-dose radiation (LDR) on bone marrow hematopoietic progenitor cell (HPC) proliferation and peripheral blood mobilization...
  69. ncbi Hermansky-Pudlak syndrome is caused by mutations in HPS4, the human homolog of the mouse light-ear gene
    Tamio Suzuki
    Human Medical Genetics Program, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Nat Genet 30:321-4. 2002
    ..In addition, the HPS1 protein is absent in tissues of le mutant mice. These results suggest that the HPS4 and HPS1 proteins may function in the same pathway of organelle biogenesis...