S Kevin Li

Summary

Affiliation: University of Cincinnati
Country: USA

Publications

  1. ncbi request reprint Assessment of PLGA-PEG-PLGA copolymer hydrogel for sustained drug delivery in the ear
    Liang Feng
    3225 Eden Avenue, Rm 136 HPB, University of Cincinnati, Cincinnati, OH 45267 0004, USA
    Curr Drug Deliv 11:279-86. 2014
  2. pmc MRI study of subconjunctival and intravitreal injections
    S Kevin Li
    Division of Pharmaceutical Sciences, James L Winkle College of Pharmacy, University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Pharm Sci 101:2353-63. 2012
  3. pmc Effective electrophoretic mobilities and charges of anti-VEGF proteins determined by capillary zone electrophoresis
    S Kevin Li
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, 3225 Eden Ave, 136 HPB, Cincinnati, OH 45267, United States
    J Pharm Biomed Anal 55:603-7. 2011
  4. pmc MRI in ocular drug delivery
    S Kevin Li
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, Cincinnati, OH 45267, USA
    NMR Biomed 21:941-56. 2008
  5. pmc Iontophoretic transport of charged macromolecules across human sclera
    Poonam Chopra
    Division of Pharmaceutical Sciences, James L Winkle College of Pharmacy, University of Cincinnati, Cincinnati, OH 45267, USA
    Int J Pharm 388:107-13. 2010
  6. pmc Ion-exchange membrane assisted transdermal iontophoretic delivery of salicylate and acyclovir
    Qingfang Xu
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, Cincinnati, OH 45267, USA
    Int J Pharm 369:105-13. 2009
  7. pmc Time-dependent electrical properties of human nail upon hydration in vivo
    Jinsong Hao
    Division of Pharmaceutical Sciences, James L Winkle College of Pharmacy, University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Pharm Sci 99:107-18. 2010
  8. pmc Influence of drug lipophilicity on drug release from sclera after iontophoretic delivery of mixed micellar carrier system to human sclera
    Poonam Chopra
    Division of Pharmaceutical Sciences, James L Winkle College of Pharmacy, University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Pharm Sci 102:480-8. 2013
  9. pmc Characterization of human sclera barrier properties for transscleral delivery of bevacizumab and ranibizumab
    He Wen
    Division of Pharmaceutical Sciences, James L Winkle College of Pharmacy, University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Pharm Sci 102:892-903. 2013
  10. pmc Sustained release micellar carrier systems for iontophoretic transport of dexamethasone across human sclera
    Poonam Chopra
    Division of Pharmaceutical Sciences, James L Winkle College of Pharmacy, University of Cincinnati, Cincinnati, OH 45267, USA
    J Control Release 160:96-104. 2012

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Assessment of PLGA-PEG-PLGA copolymer hydrogel for sustained drug delivery in the ear
    Liang Feng
    3225 Eden Avenue, Rm 136 HPB, University of Cincinnati, Cincinnati, OH 45267 0004, USA
    Curr Drug Deliv 11:279-86. 2014
    ..In summary, the PLGA-PEG-PLGA copolymer did not show toxicity to the inner ear at the 0.05-mL dose and could provide sustained release that could be controlled by using the additives for inner ear applications. ..
  2. pmc MRI study of subconjunctival and intravitreal injections
    S Kevin Li
    Division of Pharmaceutical Sciences, James L Winkle College of Pharmacy, University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Pharm Sci 101:2353-63. 2012
    ..MRI continues to provide insights into the transport barriers and clearance pathways of hydrophilic molecules in ocular delivery...
  3. pmc Effective electrophoretic mobilities and charges of anti-VEGF proteins determined by capillary zone electrophoresis
    S Kevin Li
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, 3225 Eden Ave, 136 HPB, Cincinnati, OH 45267, United States
    J Pharm Biomed Anal 55:603-7. 2011
    ..The present study demonstrated that capillary electrophoresis could be used to characterize the mobility and charge properties of drug candidates in the development of iontophoretic drug delivery...
  4. pmc MRI in ocular drug delivery
    S Kevin Li
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, Cincinnati, OH 45267, USA
    NMR Biomed 21:941-56. 2008
    ..Different MR contrast agents and MRI techniques for ocular drug-delivery research are compared. Ocular drug-delivery studies using MRI are reviewed...
  5. pmc Iontophoretic transport of charged macromolecules across human sclera
    Poonam Chopra
    Division of Pharmaceutical Sciences, James L Winkle College of Pharmacy, University of Cincinnati, Cincinnati, OH 45267, USA
    Int J Pharm 388:107-13. 2010
    ..Both electroosmosis and electrophoresis affected iontophoretic fluxes of the macromolecules; the relative contributions of electroosmosis and electrophoresis were a function of molecular size and charge of the macromolecules...
  6. pmc Ion-exchange membrane assisted transdermal iontophoretic delivery of salicylate and acyclovir
    Qingfang Xu
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, Cincinnati, OH 45267, USA
    Int J Pharm 369:105-13. 2009
    ..The present study has demonstrated the potential of a new approach using a positively charged ion-exchange membrane to enhance transdermal iontophoretic transport of negatively charged drugs...
  7. pmc Time-dependent electrical properties of human nail upon hydration in vivo
    Jinsong Hao
    Division of Pharmaceutical Sciences, James L Winkle College of Pharmacy, University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Pharm Sci 99:107-18. 2010
    ..The in vitro and in vivo correlation suggests that the in vitro nail plate can be a model in the research and development of transungual iontophoretic delivery...
  8. pmc Influence of drug lipophilicity on drug release from sclera after iontophoretic delivery of mixed micellar carrier system to human sclera
    Poonam Chopra
    Division of Pharmaceutical Sciences, James L Winkle College of Pharmacy, University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Pharm Sci 102:480-8. 2013
    ..These results suggest that the combination of transscleral iontophoresis and micellar carriers is more effective in sustaining transscleral delivery of the more lipophilic drugs studied in this investigation...
  9. pmc Characterization of human sclera barrier properties for transscleral delivery of bevacizumab and ranibizumab
    He Wen
    Division of Pharmaceutical Sciences, James L Winkle College of Pharmacy, University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Pharm Sci 102:892-903. 2013
    ..Thus, the polysaccharides may not be good surrogate permeants to model transscleral transport of therapeutic proteins in transscleral delivery studies...
  10. pmc Sustained release micellar carrier systems for iontophoretic transport of dexamethasone across human sclera
    Poonam Chopra
    Division of Pharmaceutical Sciences, James L Winkle College of Pharmacy, University of Cincinnati, Cincinnati, OH 45267, USA
    J Control Release 160:96-104. 2012
    ..These micellar carrier systems can be efficiently delivered into and across the sclera by iontophoresis for drug delivery...
  11. pmc Influence of pH on transungual passive and iontophoretic transport
    Kelly A Smith
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, 3225 Eden Ave, 136 HPB, Cincinnati, Ohio 45267, USA
    J Pharm Sci 99:1955-67. 2010
    ..Hydronium and hydroxide ion competition in iontophoretic transport was generally negligible at pH 3-11 was significant at the extreme pH conditions studied...
  12. pmc Effects of chemical enhancers on human epidermal membrane: Structure-enhancement relationship based on maximum enhancement (E(max))
    Sarah A Ibrahim
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Pharm Sci 98:926-44. 2009
    ..Based on the E(max) results, some common topical ingredients were found to be more potent enhancers than a number of well-known chemical enhancers...
  13. pmc Evaluation of intratympanic formulations for inner ear delivery: methodology and sustained release formulation testing
    Hongzhuo Liu
    Division of Pharmaceutical Sciences, James L Winkle College of Pharmacy, University of Cincinnati, Cincinnati, OH, USA
    Drug Dev Ind Pharm 40:896-903. 2014
    ....
  14. pmc Evaluation of skin permeation of β-blockers for topical drug delivery
    Doungdaw Chantasart
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, 3225 Eden Avenue, 136 HPB, Cincinnati, Ohio 45267, USA
    Pharm Res 30:866-77. 2013
    ..To develop an effective topical skin delivery system for the β-blockers, the present study evaluated skin permeation of β-blockers propranolol, betaxolol, timolol, and atenolol...
  15. ncbi request reprint Mechanistic study of chemical skin permeation enhancers with different polar and lipophilic functional groups
    Ning He
    Department of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy, University of Utah, 30 S 2000 E, Room 213, Salt Lake City, Utah 84112, USA
    J Pharm Sci 93:1415-30. 2004
    ....
  16. pmc Transscleral iontophoretic and intravitreal delivery of a macromolecule: study of ocular distribution in vivo and postmortem with MRI
    Sarah A Molokhia
    Department of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy, University of Utah, UT 84112, USA
    Exp Eye Res 88:418-25. 2009
    ..In the intravitreal injection study, the diffusion coefficient of Galbumin in the vitreous humor was estimated to be close to that of free aqueous diffusion...
  17. pmc Chemical method to enhance transungual transport and iontophoresis efficiency
    Jinsong Hao
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, Cincinnati, OH 45267, USA
    Int J Pharm 357:61-9. 2008
    ..The effect of TGA on the nail plates was irreversible. The present study shows the possibility of using a chemical enhancer to reduce transport hindrance in the nail plate and thus enhance passive and iontophoretic transungual transport...
  18. pmc Effects of ionic strength on passive and iontophoretic transport of cationic permeant across human nail
    Kelly A Smith
    Division of Pharmaceutical Sciences, James L Winkle College of Pharmacy, University of Cincinnati, Cincinnati, OH 45267, USA
    Pharm Res 26:1446-55. 2009
    ..The present study investigated the effects of ionic strength upon transungual passive and iontophoretic transport...
  19. pmc Iontophoretically enhanced ciclopirox delivery into and across human nail plate
    Jinsong Hao
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Pharm Sci 98:3608-16. 2009
    ..The results demonstrate that iontophoresis was able to deliver an effective amount of CIC into and across the nails, and this suggests the feasibility of a constant voltage battery-powered transungual iontophoretic device...
  20. pmc Chemical enhancer solubility in human stratum corneum lipids and enhancer mechanism of action on stratum corneum lipid domain
    Sarah A Ibrahim
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, Cincinnati, OH 45267, USA
    Int J Pharm 383:89-98. 2010
    ..These results suggest that the enhancer mechanism of action is through enhancer intercalation into SC intercellular lipids and subsequent lipid lamellae fluidization related to enhancer lipid concentration...
  21. pmc Efficiency of fatty acids as chemical penetration enhancers: mechanisms and structure enhancement relationship
    Sarah A Ibrahim
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, 3225 Eden Avenue, Rm 136 HPB, Cincinnati, Ohio 45267 0004, USA
    Pharm Res 27:115-25. 2010
    ....
  22. pmc Effects of solvent deposited enhancers on transdermal permeation and their relationship with Emax
    Sarah A Ibrahim
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, Cincinnati, OH 45267, USA
    J Control Release 136:117-24. 2009
    ....
  23. ncbi request reprint Model analysis of flux enhancement across hairless mouse skin induced by chemical permeation enhancers
    Ning He
    Department of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy, University of Utah, 30 S 2000 E, Rm 213, Salt Lake City, UT 84112, USA
    Int J Pharm 297:9-21. 2005
    ....
  24. pmc Effects of alternating current frequency and permeation enhancers upon human epidermal membrane
    Qingfang Xu
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, Cincinnati, Ohio, USA
    Int J Pharm 372:24-32. 2009
    ..The enhancers reversibly reduced the AC voltage required to sustain a constant state of pore induction in HEM during AC iontophoresis, consistent with the mechanism of lipid lamellae electroporation in the stratum corneum...
  25. pmc Electrically assisted delivery of macromolecules into the corneal epithelium
    Jinsong Hao
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, 3225 Eden Ave, HPB 136, Cincinnati, OH 45267, USA
    Exp Eye Res 89:934-41. 2009
    ..These results illustrate the feasibility of electrically assisted delivery of macromolecules such as siRNA into the cornea...
  26. pmc Gene delivery to cornea
    Jinsong Hao
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, Cincinnati, OH 45267, USA
    Brain Res Bull 81:256-61. 2010
    ..The combination of iontophoresis and electroporation was found to be effective in delivering siRNA but not plasmid DNA into the corneal epithelium. Nanocarriers such as polymeric micelles are promising methods of corneal gene delivery...
  27. pmc Mechanistic study of electroosmotic transport across hydrated nail plates: effects of pH and ionic strength
    Jinsong Hao
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Pharm Sci 97:5186-97. 2008
    ..Under the studied pH and ionic strength conditions, the effects of electroosmosis were small compared to the direct-field effects in transungual iontophoretic transport of small to moderate size permeants...
  28. pmc Influence of permeant lipophilicity on permeation across human sclera
    He Wen
    Division of Pharmaceutical Sciences James L Winkle College of Pharmacy, University of Cincinnati, 3225 Eden Avenue 136 HPB, Cincinnati, Ohio 45267, USA
    Pharm Res 27:2446-56. 2010
    ..The objectives of this study were to determine the effects of permeant lipophilicity on permeant uptake into and transport across human sclera for transscleral delivery...
  29. ncbi request reprint Enhanced transscleral lontophoretic transport with ion-exchange membrane
    S Kevin Li
    Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, Utah 84112, USA
    Pharm Res 23:1857-67. 2006
    ....
  30. doi request reprint Ocular delivery of pRNA nanoparticles: distribution and clearance after subconjunctival injection
    Liang Feng
    Division of Pharmaceutical Sciences James L Winkle College of Pharmacy, University of Cincinnati, 3225 Eden Avenue 136 HPB, Cincinnati, Ohio, 45267, USA
    Pharm Res 31:1046-58. 2014
    ....
  31. doi request reprint Study of drug release and tablet characteristics of silicone adhesive matrix tablets
    Gaurav Tolia
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, OH 45267 0004, USA
    Eur J Pharm Biopharm 82:518-25. 2012
    ..No routinely used excipients such as binders, granulating agents, glidants, or lubricants were required for making an acceptable tablet matrix of APAP using silicone PSA...
  32. pmc Distribution of propranolol in periocular tissues: a comparison of topical and systemic administration
    Jinsong Hao
    Division of Pharmaceutical Sciences, James L Winkle College of Pharmacy, University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Ocul Pharmacol Ther 27:453-9. 2011
    ..The objective of this study was to investigate the distribution of propranolol in periocular tissues and in plasma after topical application of propranolol as compared with intravenous and oral administration of propranolol...
  33. ncbi request reprint Transport behavior of hairless mouse skin during constant current DC iontophoresis I: baseline studies
    Mark R Liddell
    Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, Utah 84112 College of Pharmacy, University of Cincinnati, Cincinnati, Ohio 45267
    J Pharm Sci 100:1475-87. 2011
    ....
  34. ncbi request reprint Correlation of transdermal iontophoretic phenylalanine and mannitol transport: test of the internal standard concept under DC iontophoresis and constant resistance AC iontophoresis conditions
    Guang Yan
    Department of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy, University of Utah, 30 S 2000 E, Skaggs Hall 213, Salt Lake City 84112, USA
    J Control Release 98:127-38. 2004
    ....
  35. pmc Transungual iontophoretic transport of polar neutral and positively charged model permeants: effects of electrophoresis and electroosmosis
    Jinsong Hao
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Pharm Sci 97:893-905. 2008
    ..The present results with hydrated nail plates are consistent with electrophoresis-dominant (the direct field effect) transungual iontophoretic transport of small ionic permeants with small contribution from electroosmosis...