Rong Li

Summary

Affiliation: University of Texas Health Science Center
Country: USA

Publications

  1. pmc Interleukin 6 secreted from adipose stromal cells promotes migration and invasion of breast cancer cells
    M Walter
    Department of Molecular Medicine, Institute of Biotechnology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78245, USA
    Oncogene 28:2745-55. 2009
  2. pmc Mouse cofactor of BRCA1 (Cobra1) is required for early embryogenesis
    Asma Amleh
    Department of Molecular Medicine, Institute of Biotechnology, University of Texas, Health Science Center at San Antonio, San Antonio, TX, USA
    PLoS ONE 4:e5034. 2009
  3. pmc Concerted transcriptional regulation by BRCA1 and COBRA1 in breast cancer cells
    Sarah E Aiyar
    1 Department of Biochemistry, Molecular Genetics, University of Virginia, Charlottesville, VA 22908, USA
    Int J Biol Sci 3:486-92. 2007
  4. pmc Association of radiotherapy with preferential depletion of luminal epithelial cells in a BRCA1 mutation carrier
    Huai Chin Chiang
    Department of Molecular Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78245, USA
    Exp Hematol Oncol 1:31. 2012
  5. pmc IKKbeta mediates cell shape-induced aromatase expression and estrogen biosynthesis in adipose stromal cells
    Sagar Ghosh
    Department of Molecular Medicine, Institute of Biotechnology, Division of Diabetes, University of Texas Health Science Center at San Antonio, San Antonio, TX 78245, USA
    Mol Endocrinol 23:662-70. 2009
  6. ncbi request reprint Modulation of aromatase expression by BRCA1: a possible link to tissue-specific tumor suppression
    Yanfen Hu
    Department of Biochemistry and Molecular Genetics, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA
    Oncogene 24:8343-8. 2005
  7. pmc Cell density is a critical determinant of aromatase expression in adipose stromal cells
    Sagar Ghosh
    Department of Molecular Medicine, Institute of Biotechnology, 15335 Lambda Drive, University of Texas, Health Science Center at San Antonio, San Antonio, TX 78245, USA
    J Steroid Biochem Mol Biol 118:231-6. 2010
  8. pmc Regulation of adipose oestrogen output by mechanical stress
    Sagar Ghosh
    Department of Molecular Medicine Institute of Biotechnology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA
    Nat Commun 4:1821. 2013
  9. pmc Cofactor of BRCA1 modulates androgen-dependent transcription and alternative splicing
    Jianlong Sun
    Department of Molecular Medicine, Institute of Biotechnology, 15355 Lambda Drive, University of Texas Health Science Center at San Antonio, San Antonio, TX 78245, USA
    J Steroid Biochem Mol Biol 107:131-9. 2007
  10. pmc Mechanical phenotype is important for stromal aromatase expression
    Sagar Ghosh
    Department of Molecular Medicine, Institute of Biotechnology, University of Texas, San Antonio, TX 78245, USA
    Steroids 76:797-801. 2011

Collaborators

Detail Information

Publications31

  1. pmc Interleukin 6 secreted from adipose stromal cells promotes migration and invasion of breast cancer cells
    M Walter
    Department of Molecular Medicine, Institute of Biotechnology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78245, USA
    Oncogene 28:2745-55. 2009
    ..Thus, our study uncovers a link between a cytoskeleton-based pathway in ASCs and the stromal impact on breast cancer cells...
  2. pmc Mouse cofactor of BRCA1 (Cobra1) is required for early embryogenesis
    Asma Amleh
    Department of Molecular Medicine, Institute of Biotechnology, University of Texas, Health Science Center at San Antonio, San Antonio, TX, USA
    PLoS ONE 4:e5034. 2009
    ..However, the physiological significance of NELF function is not clear due to the lack of any genetic systems for studying NELF...
  3. pmc Concerted transcriptional regulation by BRCA1 and COBRA1 in breast cancer cells
    Sarah E Aiyar
    1 Department of Biochemistry, Molecular Genetics, University of Virginia, Charlottesville, VA 22908, USA
    Int J Biol Sci 3:486-92. 2007
    ..The data shown herein support the notion that COBRA1 and BRCA1 may engage in common gene regulatory pathways to suppress breast cancer progression...
  4. pmc Association of radiotherapy with preferential depletion of luminal epithelial cells in a BRCA1 mutation carrier
    Huai Chin Chiang
    Department of Molecular Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78245, USA
    Exp Hematol Oncol 1:31. 2012
    ....
  5. pmc IKKbeta mediates cell shape-induced aromatase expression and estrogen biosynthesis in adipose stromal cells
    Sagar Ghosh
    Department of Molecular Medicine, Institute of Biotechnology, Division of Diabetes, University of Texas Health Science Center at San Antonio, San Antonio, TX 78245, USA
    Mol Endocrinol 23:662-70. 2009
    ..We suggest that IKKbeta-dependent aromatase induction due to changes in cellular architecture in adipose tissue may contribute to the breast cancer risks associated with high mammagraphic density and obesity...
  6. ncbi request reprint Modulation of aromatase expression by BRCA1: a possible link to tissue-specific tumor suppression
    Yanfen Hu
    Department of Biochemistry and Molecular Genetics, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA
    Oncogene 24:8343-8. 2005
    ....
  7. pmc Cell density is a critical determinant of aromatase expression in adipose stromal cells
    Sagar Ghosh
    Department of Molecular Medicine, Institute of Biotechnology, 15335 Lambda Drive, University of Texas, Health Science Center at San Antonio, San Antonio, TX 78245, USA
    J Steroid Biochem Mol Biol 118:231-6. 2010
    ..Our finding highlights the impact of increased cell number on estrogen biosynthesis as in the case of excessive adiposity...
  8. pmc Regulation of adipose oestrogen output by mechanical stress
    Sagar Ghosh
    Department of Molecular Medicine Institute of Biotechnology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA
    Nat Commun 4:1821. 2013
    ..This novel mechanotransduction pathway underlies communications between extracellular matrix, stromal hormone output, and cancer cell growth within the same microenvironment...
  9. pmc Cofactor of BRCA1 modulates androgen-dependent transcription and alternative splicing
    Jianlong Sun
    Department of Molecular Medicine, Institute of Biotechnology, 15355 Lambda Drive, University of Texas Health Science Center at San Antonio, San Antonio, TX 78245, USA
    J Steroid Biochem Mol Biol 107:131-9. 2007
    ..These findings suggest that COBRA1 may coordinate multiple steps in ligand-dependent gene expression, which in turn ensures both the quantity and quality of hormone-stimulated gene products...
  10. pmc Mechanical phenotype is important for stromal aromatase expression
    Sagar Ghosh
    Department of Molecular Medicine, Institute of Biotechnology, University of Texas, San Antonio, TX 78245, USA
    Steroids 76:797-801. 2011
    ..Further exploration of the in vitro model system may advance understanding of an important problem in breast cancer biology...
  11. pmc Cell density-dependent transcriptional activation of endocrine-related genes in human adipose tissue-derived stem cells
    Sagar Ghosh
    Department of Molecular Medicine, Institute of Biotechnology, 15355 Lambda Drive, University of Texas, Health Science Center at San Antonio, San Antonio, TX 78245, USA
    Exp Cell Res 316:2087-98. 2010
    ..Thus, our work suggests that cell density is an important determinant of the endocrine potential of ASCs...
  12. pmc Human negative elongation factor activates transcription and regulates alternative transcription initiation
    Jianlong Sun
    Department of Molecular Medicine Institute of Biotechnology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78245, USA
    J Biol Chem 285:6443-52. 2010
    ..Taken together, our data suggest a diverse transcriptional consequence of NELF-mediated RNAPII pausing in the human genome...
  13. ncbi request reprint Deregulation of cofactor of BRCA1 expression in breast cancer cells
    Jianlong Sun
    Department of Molecular Medicine, Institute of Biotechnology, 15355 Lambda Drive, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78245, USA
    J Cell Biochem 103:1798-807. 2008
    ..Furthermore, a lack of COBRA1 expression in breast carcinoma may serve as a useful indicator for poor prognosis...
  14. ncbi request reprint Tumor suppressor BRCA1 inhibits a breast cancer-associated promoter of the aromatase gene (CYP19) in human adipose stromal cells
    Sagar Ghosh
    Univ of Virginia, Charlottesville, VA 22908, USA
    Am J Physiol Endocrinol Metab 292:E246-52. 2007
    ..Therefore, in addition to its well-characterized activities in breast epithelial cells, a role of BRCA1 in modulation of estrogen biosynthesis in ASCs may also contribute to its tissue-specific tumor suppressor function...
  15. ncbi request reprint Functional and physical interactions between autonomously replicating sequence-binding factor 1 and the nuclear transport machinery
    Christian M Loch
    Department of Biochemistry and Molecular Genetics, School of Medicine, PO Box 800733, University of Virginia, Charlottesville, VA 22908 0733, USA
    Traffic 5:925-35. 2004
    ..We propose that the link between Abf1p and the nuclear transport machinery may also be important for partitioning multiple Abf1p-mediated nuclear processes...
  16. pmc Attenuation of estrogen receptor alpha-mediated transcription through estrogen-stimulated recruitment of a negative elongation factor
    Sarah E Aiyar
    Department of Biochemistry and Molecular Genetics, School of Medicine, University of Virginia, Charlottesville, Virginia 22908 0733, USA
    Genes Dev 18:2134-46. 2004
    ..We suggest that this new level of regulation may be important to control the duration and magnitude of a rapid and reversible hormonal response...
  17. ncbi request reprint Cofactor of BRCA1: a novel transcription factor regulator in upper gastrointestinal adenocarcinomas
    Patricia A McChesney
    Department of Internal Medicine, University of Virginia, Charlottesville, VA, USA
    Cancer Res 66:1346-53. 2006
    ..Electrophoretic mobility shift assay showed that COBRA1 attenuates AP-1 binding to DNA. Our results suggest COBRA1 as a novel oncogene in UGCs that regulate AP-1 binding and the expression of TFF1 in upper gastric epithelia...
  18. ncbi request reprint Cyclic AMP-dependent modification of gonad-selective TAF(II)105 in a human ovarian granulosa cell line
    Yimin Wu
    Department of Biochemistry and Molecular Genetics, School of Medicine, PO Box 800733, University of Virginia, Charlottesville, Virginia 22908 0733, USA
    J Cell Biochem 96:751-9. 2005
    ..Thus, our work suggests that pre-mRNA processing and post-translational modification represent two important regulatory steps for the gonad-specific functions of human TAF(II)105...
  19. pmc Genetic and genomic analyses of RNA polymerase II-pausing factor in regulation of mammalian transcription and cell growth
    Jianlong Sun
    Department of Molecular Medicine Institute of Biotechnology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78245, USA
    J Biol Chem 286:36248-57. 2011
    ..Furthermore, Nelf-b deletion also resulted in increased apoptosis. Thus, the genetic and genomic studies provide new physiological and molecular insight into Nelf-mediated pol II pausing...
  20. ncbi request reprint Jun proteins modulate the ovary-specific promoter of aromatase gene in ovarian granulosa cells via a cAMP-responsive element
    Sagar Ghosh
    Department of Biochemistry and Molecular Genetics, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA
    Oncogene 24:2236-46. 2005
    ..Taken together, our work suggests that Jun proteins may attenuate estrogen biosynthesis by directly downregulating transcription of the aromatase gene in ovarian granulosa cells...
  21. ncbi request reprint Genome-wide analysis of ARS (autonomously replicating sequence) binding factor 1 (Abf1p)-mediated transcriptional regulation in Saccharomyces cerevisiae
    Tsuyoshi Miyake
    Department of Biochemistry and Molecular Genetics, School of Medicine, University of Virginia, Charlottesville, VA 22908 0733, USA
    J Biol Chem 279:34865-72. 2004
    ..Taken together, these results strongly suggest distinct underlying mechanisms by which Abf1p regulates gene expression...
  22. pmc Motivation, exercise, and stress in breast cancer survivors
    Brandi T Cuevas
    Institute for Health Promotion Research, The University of Texas Health Science Center at San Antonio, 7411 John Smith Drive, Suite 1000, San Antonio, TX, 78229, USA
    Support Care Cancer 22:911-7. 2014
    ..We investigated the associations between motivational profile, self-reported levels of PA and stress, and mental functioning in 94 posttreatment breast cancer survivors who voluntarily enrolled in an exercise program...
  23. pmc The alternative noncoding exons 1 of aromatase (Cyp19) gene modulate gene expression in a posttranscriptional manner
    Hanzhou Wang
    Department of Molecular Medicine, Institute of Biotechnology, 15355 Lambda Drive, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78245, USA
    Endocrinology 150:3301-7. 2009
    ..3 and I.4 contain the cis-acting elements responsible for modulation of aromatase levels. Thus, our work uncovers an important role of the alternative exons 1 in posttranscriptional regulation of aromatase gene expression...
  24. ncbi request reprint BRCA1: a locus-specific "liaison" in gene expression and genetic integrity
    Sarah Aiyar
    Department of Biochemistry and Molecular Genetics, School of Medicine, P O Box 800733, University of Virginia, Charlottesville, Virginia 22908 0733, USA
    J Cell Biochem 94:1103-11. 2005
    ....
  25. pmc JunB potentiates function of BRCA1 activation domain 1 (AD1) through a coiled-coil-mediated interaction
    Yan Fen Hu
    Department of Biochemistry and Molecular Genetics, School of Medicine, University of Virginia, Charlottesville 22908, USA
    Genes Dev 16:1509-17. 2002
    ..Thus, the coiled-coil-mediated cooperation between BRCA1 and JunB may facilitate the function of these proteins in tissue-specific transcriptional regulation and tumor suppression...
  26. pmc Association of obesity and circulating adipose stromal cells among breast cancer survivors
    Sagar Ghosh
    Department of Molecular Medicine, Institute of Biotechnology, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA
    Mol Biol Rep 41:2907-16. 2014
    ..Our findings suggest that circulating ASCs can serve as a potential biomarker for future studies of the impacts of obesity and physical activity on breast cancer recurrence and survival...
  27. pmc Amplification of distant estrogen response elements deregulates target genes associated with tamoxifen resistance in breast cancer
    Pei Yin Hsu
    Department of Molecular Medicine Institute of Biotechnology, Cancer Therapy and Research Center, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78245, USA
    Cancer Cell 24:197-212. 2013
    ..These findings may extend to other DNA regulatory elements, the amplification of which can profoundly alter target transcriptome during tumorigenesis...
  28. pmc Amyloid-β signals through tau to drive ectopic neuronal cell cycle re-entry in Alzheimer's disease
    Matthew E Seward
    Department of Biology, University of Virginia, Charlottesville, VA 22904 4328, USA
    J Cell Sci 126:1278-86. 2013
    ..Tau-dependent CCR was also observed in vivo in an AD mouse model. CCR, a seminal step in AD pathogenesis, therefore requires signaling from Aβ through tau independently of their incorporation into plaques and tangles...
  29. ncbi request reprint BRCA1 modulates ionizing radiation-induced nuclear focus formation by the replication protein A p34 subunit
    Shailesh K Choudhary
    Department of Biochemistry and Molecular Genetics, Health Sciences Center, Box 800733, University of Virginia, Charlottesville, Virginia 22908, USA
    J Cell Biochem 84:666-74. 2002
    ..These data suggest that BRCA1 plays an important role in processing the RPA-associated intermediates during DSB repair...
  30. ncbi request reprint Interaction of N-WASP with hnRNPK and its role in filopodia formation and cell spreading
    Youngdong Yoo
    Department of Molecular Medicine, Cornell University, Ithaca, New York 14853, USA
    J Biol Chem 281:15352-60. 2006
    ..Together, these results identify hnRNPK as a new negative regulator of N-WASP and suggest that hnRNPK may regulate the initial stage of cell spreading by direct association with N-WASP in the spreading initiation center...
  31. ncbi request reprint Negative elongation factor controls energy homeostasis in cardiomyocytes
    Haihui Pan
    Department of Molecular Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Cell Rep 7:79-85. 2014
    ..Our findings strongly indicate that NELF is part of the PPARα-mediated transcription regulatory network that maintains metabolic homeostasis in cardiomyocytes...

Research Grants20

  1. A Novel Corepressor of Estrogen Receptor
    Rong Li; Fiscal Year: 2005
    ..These studies promise to provide important insight into hormonal gene regulation and suppression of breast cancer development. ..
  2. BRCA1 IN GENE REGULATION AND TUMOR SUPPRESSION
    Rong Li; Fiscal Year: 2006
    ..Findings from these studies promise to offer important guidance to the development of more targeted and effective strategies for the prevention and treatment of BRCA1-associated cancers. ..
  3. BRCA1 IN GENE REGULATION AND TUMOR SUPPRESSION
    Rong Li; Fiscal Year: 2007
    ..Findings from these studies promise to offer important guidance to the development of more targeted and effective strategies for the prevention and treatment of BRCA1-associated cancers. ..
  4. A Novel Corepressor of Estrogen Receptor
    Rong Li; Fiscal Year: 2006
    ..These studies promise to provide important insight into hormonal gene regulation and suppression of breast cancer development. ..
  5. BRCA1 Function in Gene Regulation and Tumor Suppression
    Rong Li; Fiscal Year: 2004
    ..The proposed study promises to shed new insights into the functional connection between BRCAI and the Jun proteins. It will also provide potential therapeutic targets for correcting the defects caused by BRCAI mutations. ..
  6. BRCA1 IN GENE REGULATION AND TUMOR SUPPRESSION
    Rong Li; Fiscal Year: 2009
    ..Findings from these studies promise to offer important guidance to the development of more targeted and effective strategies for the prevention and treatment of BRCA1-associated cancers. ..
  7. BRCA1 IN GENE REGULATION AND TUMOR SUPPRESSION
    Rong Li; Fiscal Year: 2010
    ..Findings from these studies promise to offer important guidance to the development of more targeted and effective strategies for the prevention and treatment of BRCA1-associated cancers. ..
  8. BRCA1 Function in Gene Regulation and Tumor Suppression
    Rong Li; Fiscal Year: 2003
    ..The proposed study promises to shed new insights into the functional connection between BRCAI and the Jun proteins. It will also provide potential therapeutic targets for correcting the defects caused by BRCAI mutations. ..
  9. A Novel Corepressor of Estrogen Receptor
    Rong Li; Fiscal Year: 2004
    ..These studies promise to provide important insight into hormonal gene regulation and suppression of breast cancer development. ..
  10. BRCA1 Function in Gene Regulation and Tumor Suppression
    Rong Li; Fiscal Year: 2002
    ..The proposed study promises to shed new insights into the functional connection between BRCAI and the Jun proteins. It will also provide potential therapeutic targets for correcting the defects caused by BRCAI mutations. ..
  11. BRCA1 IN GENE REGULATION AND TUMOR SUPPRESSION
    Rong Li; Fiscal Year: 2006
    ..Findings from these studies promise to offer important guidance to the development of more targeted and effective strategies for the prevention and treatment of BRCA1-associated cancers. ..
  12. A Novel Corepressor of Estrogen Receptor
    Rong Li; Fiscal Year: 2007
    ..These studies promise to provide important insight into hormonal gene regulation and suppression of breast cancer development. ..
  13. A Novel Corepressor of Estrogen Receptor
    Rong Li; Fiscal Year: 2006
    ..These studies promise to provide important insight into hormonal gene regulation and suppression of breast cancer development. ..
  14. BRCA1 Function in Gene Regulation and Tumor Suppression
    Rong Li; Fiscal Year: 2005
    ..The proposed study promises to shed new insights into the functional connection between BRCAI and the Jun proteins. It will also provide potential therapeutic targets for correcting the defects caused by BRCAI mutations. ..