Qingyou Li

Summary

Affiliation: University of South Florida
Country: USA

Publications

  1. pmc Overcoming antigen masking of anti-amyloidbeta antibodies reveals breaking of B cell tolerance by virus-like particles in amyloidbeta immunized amyloid precursor protein transgenic mice
    Qingyou Li
    Department of Pharmacology University of South Florida, Tampa FL 33612 4799, USA
    BMC Neurosci 5:21. 2004
  2. pmc Improvement of a low pH antigen-antibody dissociation procedure for ELISA measurement of circulating anti-Abeta antibodies
    Qingyou Li
    Alzheimer s Research Laboratory, Department of Molecular Pharmacology and Physiology, University of South Florida, Tampa, FL 33612 4799, USA
    BMC Neurosci 8:22. 2007
  3. doi request reprint Chronological age impacts immunotherapy and monocyte uptake independent of amyloid load
    Qingyou Li
    USF Health Byrd Alzheimer s Institute, Tampa, FL 33613, USA
    J Neuroimmune Pharmacol 7:202-14. 2012
  4. pmc Suppression of amyloid deposition leads to long-term reductions in Alzheimer's pathologies in Tg2576 mice
    Rachel A Karlnoski
    Alzheimer s Research Laboratory, Department of Molecular Pharmacology and Physiology, School of Basic Biomedical Sciences, University of South Florida, Tampa, Florida 33612, USA
    J Neurosci 29:4964-71. 2009
  5. pmc Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden
    John C O'Leary
    Department of Molecular Medicine, Byrd Alzheimer s Research Institute, University of South Florida, Tampa, FL 33613, USA
    Mol Neurodegener 5:45. 2010
  6. doi request reprint Reelin supplementation recovers sensorimotor gating, synaptic plasticity and associative learning deficits in the heterozygous reeler mouse
    Justin T Rogers
    Department of Molecular Pharmacology and Physiology, University of South Florida, Tampa, FL 33612, USA
    J Psychopharmacol 27:386-95. 2013
  7. pmc Tau accumulation activates the unfolded protein response by impairing endoplasmic reticulum-associated degradation
    Jose F Abisambra
    Sanders Brown Center on Aging and Department of Physiology, College of Medicine, University of Kentucky, Lexington, Kentucky 40536, USA
    J Neurosci 33:9498-507. 2013
  8. pmc Trafficking CD11b-positive blood cells deliver therapeutic genes to the brain of amyloid-depositing transgenic mice
    Lori Lebson
    Department of Molecular Pharmacology and Physiology, University of South Florida, Tampa, Florida 33612, USA
    J Neurosci 30:9651-8. 2010
  9. ncbi request reprint Contrasting in vivo effects of two peptide-based amyloid-beta protein aggregation inhibitors in a transgenic mouse model of amyloid deposition
    Qingyou Li
    Alzheimer s Research Laboratory, Department of Molecular Pharmacology and Physiology, University of South Florida, Tampa, FL 33612 4799, USA
    Cell Transplant 17:397-408. 2008
  10. pmc The Hsp90 kinase co-chaperone Cdc37 regulates tau stability and phosphorylation dynamics
    Umesh K Jinwal
    Department of Molecular Medicine, USF Health Byrd Alzheimer s Institute, University of South Florida, Tampa, Florida 33613, USA
    J Biol Chem 286:16976-83. 2011

Collaborators

  • Dave Morgan
  • Chad A Dickey
  • Daniel C Lee
  • Chuanhai Cao
  • GABRIELLA D'ARCANGELO
  • Ying Jin
  • Umesh K Jinwal
  • Bo Zhang
  • Li Wang
  • HYANG SOOK HOE
  • Bryce Chackerian
  • Karen E Duff
  • Jose F Abisambra
  • John C O'Leary
  • Justin T Rogers
  • Edwin J Weeber
  • Laura J Blair
  • John Koren
  • Lori Lebson
  • Marcia N Gordon
  • Paul E Gottschall
  • Rachel A Karlnoski
  • Chantal E Guidi
  • Erika Donaldson
  • Ian Rusiana
  • G William Rebeck
  • Pengfei Li
  • Bryce A Nordhues
  • Christopher A Atkins
  • Matthew Cockman
  • Melinda M Peters
  • Amirthaa Suntharalingham
  • Justin H Trotter
  • Lisa Zhao
  • Jessica L Banko
  • Sarah Brady
  • Kathleen E Keenoy
  • Kevin Nash
  • Amelia G Johnson
  • Paul Marinec
  • Karoly Szekeres
  • Erin E Congdon
  • Jeffrey R Jones
  • Clara Kraft
  • Jason E Gestwicki
  • Melinda Peters
  • Siddharth Kamath
  • Nikisha Carty
  • Donna Herber
  • Jaume Pons
  • Mary Mercer
  • Arnon Rosenthal
  • Jennifer Alamed
  • Dione Kobayashi

Detail Information

Publications10

  1. pmc Overcoming antigen masking of anti-amyloidbeta antibodies reveals breaking of B cell tolerance by virus-like particles in amyloidbeta immunized amyloid precursor protein transgenic mice
    Qingyou Li
    Department of Pharmacology University of South Florida, Tampa FL 33612 4799, USA
    BMC Neurosci 5:21. 2004
    ....
  2. pmc Improvement of a low pH antigen-antibody dissociation procedure for ELISA measurement of circulating anti-Abeta antibodies
    Qingyou Li
    Alzheimer s Research Laboratory, Department of Molecular Pharmacology and Physiology, University of South Florida, Tampa, FL 33612 4799, USA
    BMC Neurosci 8:22. 2007
    ..In addition, we examined use of a less stringent low pH procedure at pH 3.5, to ascertain if it had the same effects as the pH 2.5 procedure...
  3. doi request reprint Chronological age impacts immunotherapy and monocyte uptake independent of amyloid load
    Qingyou Li
    USF Health Byrd Alzheimer s Institute, Tampa, FL 33613, USA
    J Neuroimmune Pharmacol 7:202-14. 2012
    ..We conclude that preclinical studies should be conducted in aged animal models as well as young mice to better prepare for unintended consequences in the human trial...
  4. pmc Suppression of amyloid deposition leads to long-term reductions in Alzheimer's pathologies in Tg2576 mice
    Rachel A Karlnoski
    Alzheimer s Research Laboratory, Department of Molecular Pharmacology and Physiology, School of Basic Biomedical Sciences, University of South Florida, Tampa, Florida 33612, USA
    J Neurosci 29:4964-71. 2009
    ..If anything, there was a slower rate of increase in the suppressed APP mice than the control mice, suggesting that a slow seeding mechanism likely precedes a rapid fibrillogenesis in determining the extent of amyloid deposition...
  5. pmc Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden
    John C O'Leary
    Department of Molecular Medicine, Byrd Alzheimer s Research Institute, University of South Florida, Tampa, FL 33613, USA
    Mol Neurodegener 5:45. 2010
    ..Thus, efforts to discover therapeutics for tauopathies emphasize soluble tau reductions as well as neuroprotection...
  6. doi request reprint Reelin supplementation recovers sensorimotor gating, synaptic plasticity and associative learning deficits in the heterozygous reeler mouse
    Justin T Rogers
    Department of Molecular Pharmacology and Physiology, University of South Florida, Tampa, FL 33612, USA
    J Psychopharmacol 27:386-95. 2013
    ..These results suggest that characteristics of HRM, similar to those observed in schizophrenia, are sensitive to Reelin levels and can be modified with Reelin supplementation in male and female adults...
  7. pmc Tau accumulation activates the unfolded protein response by impairing endoplasmic reticulum-associated degradation
    Jose F Abisambra
    Sanders Brown Center on Aging and Department of Physiology, College of Medicine, University of Kentucky, Lexington, Kentucky 40536, USA
    J Neurosci 33:9498-507. 2013
    ..The reversibility of this process, however, suggests that tau-based therapeutics could significantly delay this type of cell death and therefore disease progression...
  8. pmc Trafficking CD11b-positive blood cells deliver therapeutic genes to the brain of amyloid-depositing transgenic mice
    Lori Lebson
    Department of Molecular Pharmacology and Physiology, University of South Florida, Tampa, Florida 33612, USA
    J Neurosci 30:9651-8. 2010
    ..Moreover, these data support the results from bone marrow grafts that circulating CD11b+ cells can enter the CNS without requiring the use of lethal irradiation...
  9. ncbi request reprint Contrasting in vivo effects of two peptide-based amyloid-beta protein aggregation inhibitors in a transgenic mouse model of amyloid deposition
    Qingyou Li
    Alzheimer s Research Laboratory, Department of Molecular Pharmacology and Physiology, University of South Florida, Tampa, FL 33612 4799, USA
    Cell Transplant 17:397-408. 2008
    ..These data emphasize the need for evaluating potential Abeta aggregation inhibitors with in vivo models of amyloid deposition before assuming they will have benefit in treating Alzheimer's disease patients...
  10. pmc The Hsp90 kinase co-chaperone Cdc37 regulates tau stability and phosphorylation dynamics
    Umesh K Jinwal
    Department of Molecular Medicine, USF Health Byrd Alzheimer s Institute, University of South Florida, Tampa, Florida 33613, USA
    J Biol Chem 286:16976-83. 2011
    ..We propose that changes in the neuronal levels or activity of Cdc37 could dramatically alter the kinome, leading to profound changes in the tau phosphorylation signature, altering its proteotoxicity and stability...