PiLong Li

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi The feasibility of parameterizing four-state equilibria using relaxation dispersion measurements
    PiLong Li
    Department of Biochemistry and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 8816, USA
    J Biomol NMR 51:57-70. 2011
  2. ncbi Structural and energetic mechanisms of cooperative autoinhibition and activation of Vav1
    Bingke Yu
    Department of Biochemistry, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 8816, USA
    Cell 140:246-56. 2010
  3. ncbi Internal dynamics control activation and activity of the autoinhibited Vav DH domain
    PiLong Li
    Howard Hughes Medical Institute and Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 8816, USA
    Nat Struct Mol Biol 15:613-8. 2008
  4. ncbi Phase transitions in the assembly of multivalent signalling proteins
    PiLong Li
    Department of Biochemistry and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8812, USA
    Nature 483:336-40. 2012

Collaborators

  • Bingke Yu
  • Junko Umetani
  • Gaya K Amarasinghe
  • Martin E Fernandez-Zapico
  • Ilídio R S Martins
  • Michael K Rosen
  • Mischa Machius
  • Daniel D Billadeau
  • Diana R Tomchick

Detail Information

Publications4

  1. ncbi The feasibility of parameterizing four-state equilibria using relaxation dispersion measurements
    PiLong Li
    Department of Biochemistry and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 8816, USA
    J Biomol NMR 51:57-70. 2011
    ..The results show that in favorable conditions the combination of relaxation dispersion and biochemical manipulation allow the four-state equilibrium to be parameterized, and thus coupling strength between two processes to be determined...
  2. ncbi Structural and energetic mechanisms of cooperative autoinhibition and activation of Vav1
    Bingke Yu
    Department of Biochemistry, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 8816, USA
    Cell 140:246-56. 2010
    ..Our findings illustrate how the opposing requirements of strong suppression of activity and rapid kinetics of activation can be achieved in multidomain systems...
  3. ncbi Internal dynamics control activation and activity of the autoinhibited Vav DH domain
    PiLong Li
    Howard Hughes Medical Institute and Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 8816, USA
    Nat Struct Mol Biol 15:613-8. 2008
    ..Thus, internal dynamics are required for and control both basal activity and the rate of full activation of the autoinhibited DH domain...
  4. ncbi Phase transitions in the assembly of multivalent signalling proteins
    PiLong Li
    Department of Biochemistry and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8812, USA
    Nature 483:336-40. 2012
    ..The widespread occurrence of multivalent systems suggests that phase transitions may be used to spatially organize and biochemically regulate information throughout biology...