Peng Li

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint Mechanism of the inhibitory effect of electroacupuncture on experimental arrhythmias
    Peng Li
    School of Medicine, University of California, Irvine, CA 92697, USA
    J Acupunct Meridian Stud 6:69-81. 2013
  2. ncbi request reprint Excitatory projections from arcuate nucleus to ventrolateral periaqueductal gray in electroacupuncture inhibition of cardiovascular reflexes
    Peng Li
    Department of Medicine, Susan Samueli Center for Integrative Medicine, UCI School of Medicine, University of California Irvine, CA 92697 4075, USA
    Am J Physiol Heart Circ Physiol 290:H2535-42. 2006
  3. pmc Long-loop pathways in cardiovascular electroacupuncture responses
    Peng Li
    Department of Medicine, University of California, Irvine, CA, USA
    J Appl Physiol (1985) 106:620-30. 2009
  4. pmc An arcuate-ventrolateral periaqueductal gray reciprocal circuit participates in electroacupuncture cardiovascular inhibition
    Peng Li
    Department of Medicine, Susan Samueli Center for Integrative Medicine, School of Medicine, University of California, Irvine, CA 92697 4075, United States
    Auton Neurosci 158:13-23. 2010
  5. pmc Neural mechanism of electroacupuncture's hypotensive effects
    Peng Li
    Department of Medicine, Susan Samueli Center for Integrative Medicine, University of California, Irvine, California 92697, USA
    Auton Neurosci 157:24-30. 2010
  6. pmc Nucleus raphe pallidus participates in midbrain-medullary cardiovascular sympathoinhibition during electroacupuncture
    Peng Li
    Susan Samueli Center for Integrative Medicine, Department of Medicine, School of Medicine, University of California, Irvine, Irvine, California 92697 4075, USA
    Am J Physiol Regul Integr Comp Physiol 299:R1369-76. 2010
  7. ncbi request reprint Effect of electroacupuncture on pressor reflex during gastric distension
    Peng Li
    Department of Internal Medicine, College of Medicine, University of California, Irvine, California 92697 4075, USA
    Am J Physiol Regul Integr Comp Physiol 283:R1335-45. 2002
  8. ncbi request reprint Inhibitory effect of electroacupuncture (EA) on the pressor response induced by exercise stress
    Peng Li
    Dept of Medicine, University of California, Irvine Medical Science I, C235, Irvine, CA 92697 4075, USA
    Clin Auton Res 14:182-8. 2004
  9. ncbi request reprint Role of medullary GABA, opioids, and nociceptin in prolonged inhibition of cardiovascular sympathoexcitatory reflexes during electroacupuncture in cats
    Stephanie C Tjen-A-Looi
    Department of Medicine, Susan Samueli Center for Integrative Medicine, School of Medicine, University of California Irvine, CA 92697 4075, USA
    Am J Physiol Heart Circ Physiol 293:H3627-35. 2007
  10. ncbi request reprint Midbrain vlPAG inhibits rVLM cardiovascular sympathoexcitatory responses during electroacupuncture
    Stephanie C Tjen-A-Looi
    Department of Medicine, Susan Samueli Center for Integrative Medicine, UCI School of Medicine, University of California Irvine, CA 92697 4075, USA
    Am J Physiol Heart Circ Physiol 290:H2543-53. 2006

Collaborators

Detail Information

Publications64

  1. doi request reprint Mechanism of the inhibitory effect of electroacupuncture on experimental arrhythmias
    Peng Li
    School of Medicine, University of California, Irvine, CA 92697, USA
    J Acupunct Meridian Stud 6:69-81. 2013
    ..These experimental data explore the mechanism of acupuncture's effect on arrhythmias and are useful for clinical application...
  2. ncbi request reprint Excitatory projections from arcuate nucleus to ventrolateral periaqueductal gray in electroacupuncture inhibition of cardiovascular reflexes
    Peng Li
    Department of Medicine, Susan Samueli Center for Integrative Medicine, UCI School of Medicine, University of California Irvine, CA 92697 4075, USA
    Am J Physiol Heart Circ Physiol 290:H2535-42. 2006
    ..These results suggest that excitatory projections from the ARC to the vlPAG are essential to the EA inhibition of the reflex increase in BP induced by SN or gallbladder visceral afferent stimulation...
  3. pmc Long-loop pathways in cardiovascular electroacupuncture responses
    Peng Li
    Department of Medicine, University of California, Irvine, CA, USA
    J Appl Physiol (1985) 106:620-30. 2009
    ..Direct projections from the ARC to the rVLM, which serve as an important source of beta-endorphin, appear also to exist...
  4. pmc An arcuate-ventrolateral periaqueductal gray reciprocal circuit participates in electroacupuncture cardiovascular inhibition
    Peng Li
    Department of Medicine, Susan Samueli Center for Integrative Medicine, School of Medicine, University of California, Irvine, CA 92697 4075, United States
    Auton Neurosci 158:13-23. 2010
    ..Thus, a reciprocal excitatory glutamatergic neural circuit between the arcuate and vlPAG contributes to long-lasting EA cardiovascular inhibition. ACh in the arcuate but not in the vlPAG participates in the reciprocal excitation...
  5. pmc Neural mechanism of electroacupuncture's hypotensive effects
    Peng Li
    Department of Medicine, Susan Samueli Center for Integrative Medicine, University of California, Irvine, California 92697, USA
    Auton Neurosci 157:24-30. 2010
    ..Thus, a number of mechanisms underlying the long-lasting effect of EA on cardiovascular function have been identified but clearly further investigation is warranted...
  6. pmc Nucleus raphe pallidus participates in midbrain-medullary cardiovascular sympathoinhibition during electroacupuncture
    Peng Li
    Susan Samueli Center for Integrative Medicine, Department of Medicine, School of Medicine, University of California, Irvine, Irvine, California 92697 4075, USA
    Am J Physiol Regul Integr Comp Physiol 299:R1369-76. 2010
    ..These results indicate that EA activates the vlPAG, which excites the NRP to, in turn, inhibit rVLM presympathetic neurons and reflex cardiovascular sympathoexcitatory responses...
  7. ncbi request reprint Effect of electroacupuncture on pressor reflex during gastric distension
    Peng Li
    Department of Internal Medicine, College of Medicine, University of California, Irvine, California 92697 4075, USA
    Am J Physiol Regul Integr Comp Physiol 283:R1335-45. 2002
    ....
  8. ncbi request reprint Inhibitory effect of electroacupuncture (EA) on the pressor response induced by exercise stress
    Peng Li
    Dept of Medicine, University of California, Irvine Medical Science I, C235, Irvine, CA 92697 4075, USA
    Clin Auton Res 14:182-8. 2004
    ..We conclude that EA at specific acupoints improves exercise capacity and reduces the hemodynamic responses in approximately 70% of normal subjects...
  9. ncbi request reprint Role of medullary GABA, opioids, and nociceptin in prolonged inhibition of cardiovascular sympathoexcitatory reflexes during electroacupuncture in cats
    Stephanie C Tjen-A-Looi
    Department of Medicine, Susan Samueli Center for Integrative Medicine, School of Medicine, University of California Irvine, CA 92697 4075, USA
    Am J Physiol Heart Circ Physiol 293:H3627-35. 2007
    ..Furthermore, in the rVLM, opioids and GABA, but not nociceptin, participate in the long-term EA-related inhibition of sympathoexcitatory cardiovascular responses...
  10. ncbi request reprint Midbrain vlPAG inhibits rVLM cardiovascular sympathoexcitatory responses during electroacupuncture
    Stephanie C Tjen-A-Looi
    Department of Medicine, Susan Samueli Center for Integrative Medicine, UCI School of Medicine, University of California Irvine, CA 92697 4075, USA
    Am J Physiol Heart Circ Physiol 290:H2543-53. 2006
    ..We conclude that the inhibitory influence of EA involves vlPAG stimulation, which, in turn, inhibits rVLM neurons in the EA-related attenuation of the cardiovascular excitatory response during visceral afferent stimulation...
  11. ncbi request reprint Atrial natriuretic peptide-dependent modulation of hypoxia-induced pulmonary vascular remodeling
    Yiu Fai Chen
    Vascular Biology and Hypertension Program, Department of Medicine, Division of Cardiovascular Disease, University of Alabama at Birmingham, 35296, USA
    Life Sci 79:1357-65. 2006
    ....
  12. ncbi request reprint Atrial natriuretic peptide inhibits transforming growth factor beta-induced Smad signaling and myofibroblast transformation in mouse cardiac fibroblasts
    Peng Li
    Vascular Biology and Hypertension Program, Department of Medicine, University of Alabama at Birmingham, AL 35294, USA
    Circ Res 102:185-92. 2008
    ..We postulate that this process contributes to the antifibrogenic effects of the natriuretic peptide in heart...
  13. pmc Modulation of cardiopulmonary depressor reflex in nucleus ambiguus by electroacupuncture: roles of opioids and γ-aminobutyric acid
    Stephanie C Tjen-A-Looi
    School of Medicine, Univ of California, Irvine, CA 92697 4075, USA
    Am J Physiol Regul Integr Comp Physiol 302:R833-44. 2012
    ..Thus EA at P5-6 decreases PBG evoked hypotension and bradycardia as well as the NAmb PBG-sensitive preganglionic cardiac vagal outflow through opioid and GABA neurotransmitter systems...
  14. ncbi request reprint Medullary substrate and differential cardiovascular responses during stimulation of specific acupoints
    Stephanie C Tjen-A-Looi
    Medical Science 1 C240, College of Medicine, Univ of California, Irvine, California 92697 4075, USA
    Am J Physiol Regul Integr Comp Physiol 287:R852-62. 2004
    ....
  15. pmc Inhibition of transforming growth factor-beta signaling induces left ventricular dilation and dysfunction in the pressure-overloaded heart
    Jason A Lucas
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Am J Physiol Heart Circ Physiol 298:H424-32. 2010
    ....
  16. pmc cGMP inhibits TGF-beta signaling by sequestering Smad3 with cytosolic beta2-tubulin in pulmonary artery smooth muscle cells
    Kaizheng Gong
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Mol Endocrinol 25:1794-803. 2011
    ....
  17. pmc Hypoxia induces downregulation of PPAR-γ in isolated pulmonary arterial smooth muscle cells and in rat lung via transforming growth factor-β signaling
    Kaizheng Gong
    Vascular Biology and Hypertension Program, Department of Medicine, University of Alabama at Birmingham, 35294, USA
    Am J Physiol Lung Cell Mol Physiol 301:L899-907. 2011
    ..These data provide strong evidence that activation of TGF-β/Smad signaling, via transcriptional suppression of PPAR-γ expression, mediates chronic hypoxia-induced downregulation of PPAR-γ expression in lung...
  18. ncbi request reprint Prolonged inhibition of rostral ventral lateral medullary premotor sympathetic neurons by electroacupuncture in cats
    Stephanie C Tjen-A-Looi
    Department of Internal Medicine, University of California at Irvine, Irvine, CA 92697 4075, USA
    Auton Neurosci 106:119-31. 2003
    ..Through an opioid mechanism, EA inhibits splanchnic nerve-induced excitatory responses of these rVLM neurons. Many of these neurons receiving convergent visceral and somatic input exhibit long-lasting inhibition by EA...
  19. doi request reprint Molecular imaging of interstitial alterations in remodeling myocardium after myocardial infarction
    Susanne W M van den Borne
    University of California, Irvine School of Medicine, Irvine, California, USA
    J Am Coll Cardiol 52:2017-28. 2008
    ..The purpose of this study was to evaluate interstitial alterations in myocardial remodeling using a radiolabeled Cy5.5-RGD imaging peptide (CRIP) that targets myofibroblasts...
  20. ncbi request reprint Afferent mechanisms underlying stimulation modality-related modulation of acupuncture-related cardiovascular responses
    Wei Zhou
    Department of Medicine, College of Medicine, University of California, Irvine, CA 92697, USA
    J Appl Physiol (1985) 98:872-80. 2005
    ..The similarity of the responses to EA and MA and the lack of cardiovascular response to high-frequency EA appear to be largely a function of somatic afferent responses...
  21. pmc Processing cardiovascular information in the vlPAG during electroacupuncture in rats: roles of endocannabinoids and GABA
    Stephanie C Tjen-A-Looi
    School of Medicine, University of California, Irvine, CA 92697 4075, USA
    J Appl Physiol (1985) 106:1793-9. 2009
    ..Reduction of GABA release disinhibits vlPAG cells, which, in turn, modulate the activity of rVLM neurons to attenuate the sympathoexcitatory reflex responses...
  22. pmc Transforming growth factor-β inhibits myocardial PPARγ expression in pressure overload-induced cardiac fibrosis and remodeling in mice
    Kaizheng Gong
    Vascular Biology and Hypertension Program, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
    J Hypertens 29:1810-9. 2011
    ..This study tested the hypothesis that there is a functional interaction between transforming growth factor-β (TGF-β) signaling and endogenous PPARγ expression in cardiac fibroblasts and pressure overloaded heart...
  23. ncbi request reprint ANP signaling inhibits TGF-beta-induced Smad2 and Smad3 nuclear translocation and extracellular matrix expression in rat pulmonary arterial smooth muscle cells
    Peng Li
    Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Appl Physiol (1985) 102:390-8. 2007
    ..Blocking nuclear translocation and subsequent binding of pSmad2 and pSmad3 to TGF-beta-Smad response elements in ECM genes may be responsible for the inhibitory effects of ANP on TGF-beta-induced expression of ECM molecules...
  24. ncbi request reprint Hypoxia-responsive growth factors upregulate periostin and osteopontin expression via distinct signaling pathways in rat pulmonary arterial smooth muscle cells
    Peng Li
    Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Appl Physiol (1985) 97:1550-8; discussion 1549. 2004
    ..These differences in signaling suggest that PN and OPN may play different roles in pulmonary vascular remodeling under pathophysiological conditions...
  25. ncbi request reprint Nociceptin in rVLM mediates electroacupuncture inhibition of cardiovascular reflex excitatory response in rats
    Melissa M Crisostomo
    Medical Science 1, C240, College of Medicine, University of California Irvine, Irvine, CA 92697 4075, USA
    J Appl Physiol (1985) 98:2056-63. 2005
    ..Thus, in addition to the classical opioid system, nociceptin, through opioid receptor-like-1 receptor stimulation in the rVLM, participates in the modulatory influence of EA on reflex-induced increases in blood pressure...
  26. pmc Endothelial cells overexpressing interleukin-8 receptors reduce inflammatory and neointimal responses to arterial injury
    Dongqi Xing
    Department of Medicine, University of Alabama at Birmingham, 703 19th Street S, Birmingham, AL 35294, USA
    Circulation 125:1533-41. 2012
    ..We tested the hypothesis that targeted delivery of ECs by overexpressing IL8RA and IL8RB receptors prevents inflammatory responses and promotes structural recovery of arteries after endoluminal injury...
  27. ncbi request reprint Dominant negative mutation of the TGF-beta receptor blocks hypoxia-induced pulmonary vascular remodeling
    Yiu Fai Chen
    Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, Dept of Medicine, Univ of Alabama at Birmingham, UAB Station, Birmingham, AL 35294 0007, USA
    J Appl Physiol (1985) 100:564-71. 2006
    ....
  28. doi request reprint Adenine nucleotide translocase 1 deficiency results in dilated cardiomyopathy with defects in myocardial mechanics, histopathological alterations, and activation of apoptosis
    Nupoor Narula
    Center for Mitochondrial and Molecular Medicine and Genetics MAMMAG, University of California, Irvine, California, USA
    JACC Cardiovasc Imaging 4:1-10. 2011
    ....
  29. doi request reprint Molecular imaging for efficacy of pharmacologic intervention in myocardial remodeling
    Susanne W M van den Borne
    Division of Cardiology and Department of Pathology, University of California Irvine School of Medicine, Irvine, CA 92697, USA
    JACC Cardiovasc Imaging 2:187-98. 2009
    ..Using molecular imaging techniques, we examined interstitial alterations during postmyocardial infarction (MI) remodeling and assessed the efficacy of antiangiotensin and antimineralocorticoid intervention, alone and in combination...
  30. ncbi request reprint Effect of cardiac resynchronization therapy on longitudinal and circumferential left ventricular mechanics by velocity vector imaging: description and initial clinical application of a novel method using high-frame rate B-mode echocardiographic images
    Mani A Vannan
    Division of Cardiology, Department of Medicine, University of California, Irvine, Orange, 92868 4080, USA
    Echocardiography 22:826-30. 2005
    ..We describe a case in which VVI was used to assess the left ventricular dynamics in a patient with heart failure who did not respond to CRT...
  31. ncbi request reprint Fibroblast growth factor mediates hypoxia-induced endothelin-- a receptor expression in lung artery smooth muscle cells
    Peng Li
    Department of Medicine, University of Alabama at Birmingham at Alabama, Birmingham, AL 35294, USA
    J Appl Physiol (1985) 95:643-51; discussion 863. 2003
    ....
  32. pmc Decreased arteriolar tetrahydrobiopterin is linked to superoxide generation from nitric oxide synthase in mice fed high salt
    Timothy R Nurkiewicz
    Center for Cardiovascular and Respiratory Sciences, West Virginia University, School of Medicine, Morgantown, WV 26506 9105, USA
    Microcirculation 17:147-57. 2010
    ..We explored the possibility that "uncoupled" endothelial nitric oxide synthase (eNOS) is the source of this O(2) (-)...
  33. pmc A mouse model of mitochondrial disease reveals germline selection against severe mtDNA mutations
    Weiwei Fan
    Center for Molecular and Mitochondrial Medicine and Genetics, University of California, Irvine, CA 92697, USA
    Science 319:958-62. 2008
    ..Thus, severe mtDNA mutations appear to be selectively eliminated from the female germ line, thereby minimizing their impact on population fitness...
  34. ncbi request reprint Effects of pressure overload on extracellular matrix expression in the heart of the atrial natriuretic peptide-null mouse
    Dajun Wang
    Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Hypertension 42:88-95. 2003
    ..These results support the hypothesis that atrial natriuretic peptide protects against pressure overload-induced cardiac hypertrophy and remodeling by negative modulation of genes involved in extracellular matrix deposition...
  35. ncbi request reprint Assessment of mitral regurgitation and clinical decision-making
    Geu Ru Hong
    University of California Irvine, Orange, CA 92868 4080, USA
    Heart Fail Clin 2:425-33. 2006
  36. ncbi request reprint Anatomic and hemodynamic imaging using a new vector phased-array intracardiac catheter
    Peng Li
    Division of Cardiology, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI, USA
    J Am Soc Echocardiogr 15:349-55. 2002
    ..We used a new vector, phased-array intracardiac catheter (AcuNav) with complete 2-dimensional imaging and Doppler capabilities to describe a systematic approach for a detailed anatomic and hemodynamic cardiac assessment...
  37. ncbi request reprint Detection of resting myocardial perfusion defects by SonoVue myocardial contrast echocardiography
    Tamanna Nahar
    Department of Medicine, Division of Cardiology, University of Michigan Health System, Ann Arbor, Michigan, USA
    Echocardiography 20:511-7. 2003
    ..Each patient also had SPECT nuclear perfusion imaging performed. Segmental assessment of myocardial perfusion from SonoVue MCE images were compared with corresponding SPECT nuclear images...
  38. ncbi request reprint Rate-dependent AV delay optimization in cardiac resynchronization therapy
    Christoph Scharf
    Division of Cardiology, University of Michigan, Ann Arbor, MI, USA
    Pacing Clin Electrophysiol 28:279-84. 2005
    ..During cardiac resynchronization therapy (CRT), cardiac performance is dependent on an optimized atrioventricular delay (AVD). However, the optimal AVD at different heart rates has not been defined yet during CRT...
  39. ncbi request reprint [Problems in studies of acupuncture for treatment of ischemic cerebrovascular diseases in recent years]
    Peng Li
    The First Affiliated Hospital of Tianjin University of TCM, Tianjin 300193, China
    Zhongguo Zhen Jiu 27:150-4. 2007
    ....
  40. ncbi request reprint Caudal ventrolateral medulla mediates the depressor response elicited by the greater splanchnic nerve afferent stimulation in rats
    Ying Jie Peng
    Department of Physiology, Medical Center of Fudan University, Shanghai 200032, China
    Neurosci Lett 325:134-8. 2002
    ..These results suggest the involvement of CVLM neurons and activation of glutamate receptors in the CVLM in mediating the depressor response induced by the GSPL afferent stimulation in rats...
  41. ncbi request reprint Using BRFSS data to estimate prevalence of obesity and physical activities in Oklahoma
    Peng Li
    Chronic Disease Services, 1000 NE 10th Street, Oklahoma City, OK 73117, USA
    J Okla State Med Assoc 97:404-8; quiz 409-10. 2004
    ..Obesity has risen at an epidemic rate during the past two decades in the United States...
  42. ncbi request reprint Identification of novel non-phosphorylated ligands, which bind selectively to the SH2 domain of Grb7
    Stephanie C Pero
    Department of Surgery and the Vermont Cancer Center, University of Vermont School of Medicine, Burlington, Vermont 05405, USA
    J Biol Chem 277:11918-26. 2002
    ..These peptides will be useful in the development of targeted molecular therapeutics for cancers overexpressing Grb7 and in the development of Grb7-specific inhibitors to gain a complete understanding of the physiological role of Grb7...
  43. ncbi request reprint [Pressurized solvent extraction in quality control of Chinese herb]
    Peng Li
    Institute of Chinese Medical Sciences, University of Macau, Macau, China
    Zhongguo Zhong Yao Za Zhi 29:723-6. 2004
    ..This article attempts to review the basic principle, methods, apparatus and main characteristics of PSE and its applications to quality control of Chinese herb...
  44. doi request reprint Expanding the realm of ultrafast protein folding: gpW, a midsize natural single-domain with alpha+beta topology that folds downhill
    Adam Fung
    Department of Chemistry and Biochemistry, and Center for Biomolecular Structure and Organization, University of Maryland, College Park, Maryland 20742, USA
    J Am Chem Soc 130:7489-95. 2008
    ..These special features, together with a complex functional role in bacteriophage lambda assembly, suggest that gpW has been engineered to fold downhill by natural selection...
  45. ncbi request reprint GDNF augments survival and differentiation of TH-positive neurons in neural progenitor cells
    Zhao Hui Sun
    Department of Biological Sciences and Biotechnology, Institute of Neuroscience, Tsinghua University, State Key Laboratory of Biomembranes, Beijing 100084, China
    Cell Biol Int 28:323-5. 2004
    ..They might thus become beneficial sources of donor cells in the treatment of neurological disorders...
  46. ncbi request reprint The effect of time and of vasoactive drugs on capillary leakage induced during myocardial contrast echocardiography
    Douglas Miller
    Department of Radiology, University of Michigan Department of Cardiology, University of Michigan, Ann Arbor, Michigan 48109 0553, USA
    Echocardiography 21:125-32. 2004
    ..This study tested the hypothesis that the capillary leakage results from a physiological response to injury, which might be protracted and modulated by vasoactive drugs...
  47. ncbi request reprint Differentiation of mesenchymal stem cells into dopaminergic neuron-like cells in vitro
    Li Guo
    Department of Toxicology, School of Public Health, Jilin University, Changchun, Jilin 130021, China
    Biomed Environ Sci 18:36-42. 2005
    ..To explore the way to induce mesenchymal stem cells (MSCs) to differentiate into dopaminergic neurons in vitro...
  48. ncbi request reprint Small nonphosphorylated Grb2-SH2 domain antagonists evaluated by surface plasmon resonance technology
    Feng Di T Lung
    Department of Chemistry, Tunghai University, Taichung, Taiwan, Republic of China
    Biopolymers 80:628-35. 2005
    ..Results of these studies provide important information for further development of potent nonphosphorylated peptide inhibitors of the Grb2-SH2 domain...
  49. ncbi request reprint The molecular mechanism of interaction between sushi peptide and Pseudomonas endotoxin
    Peng Li
    Department of Biological Sciences, National University of Singapore, Singapore
    Cell Mol Immunol 3:21-8. 2006
    ..Furthermore, in the presence of LPS, the peptide transitions from a random structure into an alpha-helical conformation and it disrupts LPS aggregates, hence, neutralizing the LPS toxicity...
  50. ncbi request reprint Density-controlled growth of aligned ZnO nanowires sharing a common contact: a simple, low-cost, and mask-free technique for large-scale applications
    Xudong Wang
    School of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA
    J Phys Chem B 110:7720-4. 2006
    ....
  51. ncbi request reprint Eplerenone prevents adverse cardiac remodelling induced by pressure overload in atrial natriuretic peptide-null mice
    Veronica Franco
    Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, University of Alabama at Birmingham, AL 35294, USA
    Clin Exp Pharmacol Physiol 33:773-9. 2006
    ..The mechanism whereby ANP deficiency leads to excess hypertrophy, fibrosis and early failure following TAC is increased profibrotic signals resulting from excess or unopposed MR activation, rather than increased levels of aldosterone...
  52. ncbi request reprint Molecular mechanisms that govern the specificity of Sushi peptides for Gram-negative bacterial membrane lipids
    Peng Li
    Department of Biological Sciences, National University of Singapore, Singapore
    Biochemistry 45:10554-62. 2006
    ....
  53. ncbi request reprint Structure-based design of potent Grb2-SH2 domain antagonists not relying on phosphotyrosine mimics
    Sheng Jiang
    Laboratory of Medicinal Chemistry, NCI, NIH, Frederick, MD 21702, USA
    Biochem Biophys Res Commun 349:497-503. 2006
    ..This potent peptidomimetic provides a new template for the development of non-pTyr containing Grb2-SH2 domain antagonists and acts as a chemotherapeutic lead for the treatment of erbB2-related cancer...
  54. ncbi request reprint Cardiovascular dysfunction caused by cecal ligation and puncture is attenuated in CD8 knockout mice treated with anti-asialoGM1
    Weike Tao
    Dept of Anesthesiology, The University of Texas Medical Branch, Galveston, TX 77555 0591, USA
    Am J Physiol Regul Integr Comp Physiol 289:R478-R485. 2005
    ..These observations likely explain, in part, the previously observed survival advantage of CD8KO/alphaAsGM1 mice following CLP...
  55. ncbi request reprint Simultaneous determination of 11 saponins in Panax notoginseng using HPLC-ELSD and pressurized liquid extraction
    Jian Bo Wan
    Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau, PR China
    J Sep Sci 29:2190-6. 2006
    ..The validated method was successfully applied to quantify 11 saponins in 28 samples of P. notoginseng collected in different places, which is helpful to control the quality of P. notoginseng and its related products...
  56. ncbi request reprint Design and synthesis of redox stable analogues of sunflower trypsin inhibitors (SFTI-1) on solid support, potent inhibitors of matriptase
    Sheng Jiang
    Laboratory of Medicinal Chemistry, NCI, NIH, Frederick, Maryland 21702, USA
    Org Lett 9:9-12. 2007
    ..92 nM. On the basis of this result, we designed and synthesized its proteolytically stable analogues, SFTI-2 and SFTI-3. SFTI-3 exhibited very good binding affinity to matriptase, and it was metabolically stable...
  57. pmc Parallelization of multicategory support vector machines (PMC-SVM) for classifying microarray data
    Chaoyang Zhang
    School of Computing, University of Southern Mississippi, Hattiesburg, MS 39406, USA
    BMC Bioinformatics 7:S15. 2006
    ..Since the process of generating models in traditional multicategory support vector machines for large datasets is very computationally intensive, there is a need to improve the performance using high performance computing techniques...
  58. ncbi request reprint [A DSP-based design method for detecting fetal heart rate signals]
    Xiao Feng Yang
    Biomedical Engineering Dept, Xi an Jiatong University, Xi an
    Zhongguo Yi Liao Qi Xie Za Zhi 30:413-5. 2006
    ..Clinical practice has proved that this system is able to pick up the real-time fetal heart rate correctly and rapidly...
  59. ncbi request reprint Chronic morphine selectively impairs cued fear extinction in rats: implications for anxiety disorders associated with opiate use
    Chaoliang Gu
    Department of Physiology, College of Medicine, Nanhua University, Hengyang, Hunan, PR China
    Neuropsychopharmacology 33:666-73. 2008
    ..Chronic morphine selectively impairs extinction of cued fear response. This deficit in fear extinction may be one of those critical components that contribute to the high prevalence of anxiety disorders in opiate addicts...
  60. ncbi request reprint Mitochondrial proteomic analysis and characterization of the intracellular mechanisms of bis(7)-tacrine in protecting against glutamate-induced excitotoxicity in primary cultured neurons
    Hongjun Fu
    Department of Biochemistry, Hong Kong University of Science and Technology, Hong Kong, China
    J Proteome Res 6:2435-46. 2007
    ....
  61. ncbi request reprint [Multi-central randomized controlled trials of electroacupunture at Zhigou (TE 6) for treatment of constipation induced by stagnation or deficiency of qi]
    Zhi Long Zhang
    Section of Acupuncture and Moxibustion, Tianjin Hospital of TCM, Tianjin 300140, China
    Zhongguo Zhen Jiu 27:475-8. 2007
    ..To assess the therapeutic effect and safety of electroacupuncture (EA) at Zhigou (TE 6) on constipation induced by stagnation or deficiency of qi...
  62. ncbi request reprint Fingerprint analysis of Rhizoma chuanxiong by pressurized capillary electrochromatography and high-performance liquid chromatography
    Guoxiang Xie
    School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, People s Republic of China
    Biomed Chromatogr 21:867-75. 2007
    ..The fingerprints of Rhizoma chuanxiong established with pCEC and HPLC are suitable to identify samples from different sources and can be used to control the quality of raw herbs...
  63. ncbi request reprint Analysis of urinary metabolites for metabolomic study by pressurized CEC
    Guoxiang Xie
    School of Pharmacy, Shanghai Jiao Tong University, Shanghai, PR China
    Electrophoresis 28:4459-68. 2007
    ....
  64. ncbi request reprint The critical role of calpain versus caspase activation in excitotoxic injury induced by nitric oxide
    Christiane Volbracht
    Institute of Molecular and Cell Biology IMCB, Singapore
    J Neurochem 93:1280-92. 2005
    ....