Ning Li

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Feasibility of biomarker studies for engineered nanoparticles: what can be learned from air pollution research
    Ning Li
    Division of NanoMedicine, Department of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    J Occup Environ Med 53:S74-9. 2011
  2. doi request reprint Adjuvant effects of ambient particulate matter monitored by proteomics of bronchoalveolar lavage fluid
    Xuedong Kang
    Department of Biological Chemistry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    Proteomics 10:520-31. 2010
  3. pmc Ambient ultrafine particles provide a strong adjuvant effect in the secondary immune response: implication for traffic-related asthma flares
    Ning Li
    Division of NanoMedicine, Department of Medicine, University of California, Los Angeles, California 90095, USA
    Am J Physiol Lung Cell Mol Physiol 299:L374-83. 2010
  4. pmc Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage
    Ning Li
    Department of Medicine, University of California, Los Angeles, California 90095, USA
    Environ Health Perspect 111:455-60. 2003
  5. pmc The role of oxidative stress in ambient particulate matter-induced lung diseases and its implications in the toxicity of engineered nanoparticles
    Ning Li
    Division of NanoMedicine, Department of Medicine, University of California, Los Angeles, CA 90095, USA
    Free Radic Biol Med 44:1689-99. 2008
  6. pmc Correlation of cough with disease activity and treatment with cyclophosphamide in scleroderma interstitial lung disease: findings from the Scleroderma Lung Study
    Arthur C Theodore
    Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Boston University School of Medicine, Boston, MA, USA
    Chest 142:614-21. 2012
  7. doi request reprint Dispersal state of multiwalled carbon nanotubes elicits profibrogenic cellular responses that correlate with fibrogenesis biomarkers and fibrosis in the murine lung
    Xiang Wang
    Division of NanoMedicine, Department of Medicine, University of California, Los Angeles, California 90095, United States
    ACS Nano 5:9772-87. 2011
  8. ncbi request reprint Use of proteomics to demonstrate a hierarchical oxidative stress response to diesel exhaust particle chemicals in a macrophage cell line
    Gary Guishan Xiao
    Keck Functional Proteomics Center, Department of Biochemistry and Biological Chemistry, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA
    J Biol Chem 278:50781-90. 2003
  9. doi request reprint Predicting treatment outcomes and responder subsets in scleroderma-related interstitial lung disease
    Michael D Roth
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1690, USA
    Arthritis Rheum 63:2797-808. 2011
  10. doi request reprint Electrophilic and redox properties of diesel exhaust particles
    Masaru Shinyashiki
    Center for Occupational and Environmental Health, School of Public Health, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Environ Res 109:239-44. 2009

Collaborators

Detail Information

Publications46

  1. pmc Feasibility of biomarker studies for engineered nanoparticles: what can be learned from air pollution research
    Ning Li
    Division of NanoMedicine, Department of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    J Occup Environ Med 53:S74-9. 2011
    ..Occupational exposure to engineered nanoparticles (NP) may pose health risks to the workers. This article is to discuss the feasibility of identifying biomarkers that are associated with NP exposure...
  2. doi request reprint Adjuvant effects of ambient particulate matter monitored by proteomics of bronchoalveolar lavage fluid
    Xuedong Kang
    Department of Biological Chemistry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    Proteomics 10:520-31. 2010
    ..These proteins may be the important specific elements targeted by PM in air pollution through the ability to generate ROS in the immune system, and may be involved in allergen sensitization and asthma pathogenesis...
  3. pmc Ambient ultrafine particles provide a strong adjuvant effect in the secondary immune response: implication for traffic-related asthma flares
    Ning Li
    Division of NanoMedicine, Department of Medicine, University of California, Los Angeles, California 90095, USA
    Am J Physiol Lung Cell Mol Physiol 299:L374-83. 2010
    ....
  4. pmc Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage
    Ning Li
    Department of Medicine, University of California, Los Angeles, California 90095, USA
    Environ Health Perspect 111:455-60. 2003
    ..This may contribute to oxidative stress. Our studies demonstrate that the increased biological potency of UFPs is related to the content of redox cycling organic chemicals and their ability to damage mitochondria...
  5. pmc The role of oxidative stress in ambient particulate matter-induced lung diseases and its implications in the toxicity of engineered nanoparticles
    Ning Li
    Division of NanoMedicine, Department of Medicine, University of California, Los Angeles, CA 90095, USA
    Free Radic Biol Med 44:1689-99. 2008
    ..The importance of cellular antioxidant and detoxification pathways in protecting against particle-induced lung damage will also be discussed...
  6. pmc Correlation of cough with disease activity and treatment with cyclophosphamide in scleroderma interstitial lung disease: findings from the Scleroderma Lung Study
    Arthur C Theodore
    Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Boston University School of Medicine, Boston, MA, USA
    Chest 142:614-21. 2012
    ....
  7. doi request reprint Dispersal state of multiwalled carbon nanotubes elicits profibrogenic cellular responses that correlate with fibrogenesis biomarkers and fibrosis in the murine lung
    Xiang Wang
    Division of NanoMedicine, Department of Medicine, University of California, Los Angeles, California 90095, United States
    ACS Nano 5:9772-87. 2011
    ..Taken together, these results indicate that the dispersal state of MWCNTs affects profibrogenic cellular responses that correlate with the extent of pulmonary fibrosis and are of potential use to predict pulmonary toxicity...
  8. ncbi request reprint Use of proteomics to demonstrate a hierarchical oxidative stress response to diesel exhaust particle chemicals in a macrophage cell line
    Gary Guishan Xiao
    Keck Functional Proteomics Center, Department of Biochemistry and Biological Chemistry, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA
    J Biol Chem 278:50781-90. 2003
    ..These data suggest that DEP induce a hierarchical oxidative stress response in which some of these proteins may serve as markers for oxidative stress during PM exposures...
  9. doi request reprint Predicting treatment outcomes and responder subsets in scleroderma-related interstitial lung disease
    Michael D Roth
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1690, USA
    Arthritis Rheum 63:2797-808. 2011
    ..To identify baseline characteristics of patients with scleroderma-related interstitial lung disease (SSc-ILD) that could serve as predictors of the most favorable response to 12-month treatment with oral cyclophosphamide (CYC)...
  10. doi request reprint Electrophilic and redox properties of diesel exhaust particles
    Masaru Shinyashiki
    Center for Occupational and Environmental Health, School of Public Health, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Environ Res 109:239-44. 2009
    ..The partition properties of the reactive species are important in exposure assessment since the toxicokinetics of particles and solutes are quite distinct...
  11. doi request reprint Joint analysis of bivariate longitudinal ordinal outcomes and competing risks survival times with nonparametric distributions for random effects
    Ning Li
    Biostatistics and Bioinformatics Division, Samuel Oschin Comprehensive Cancer Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Stat Med 31:1707-21. 2012
    ..We show via simulations that robust parameter estimates are obtained from the proposed method under various scenarios. We illustrate the approach using cough severity and frequency data from a scleroderma lung study...
  12. pmc Oxidative stress and asthma: proteome analysis of chitinase-like proteins and FIZZ1 in lung tissue and bronchoalveolar lavage fluid
    Lifeng Zhang
    Division of NanoMedicine, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095, USA
    J Proteome Res 8:1631-8. 2009
    ..The oxidative stress proteins, Ym1/Ym2, FIZZ1, and SP-D, could play an important role in the pathogenesis of asthma and may be useful oxidative stress markers...
  13. ncbi request reprint Use of a fluorescent phosphoprotein dye to characterize oxidative stress-induced signaling pathway components in macrophage and epithelial cultures exposed to diesel exhaust particle chemicals
    Meiying Wang
    Department of Medicine, Division of Clinical Immunology and Allergy, and David Geffen School of Medicine, University of California Los Angeles, CA 90095, USA
    Electrophoresis 26:2092-108. 2005
    ....
  14. pmc The adjuvant effect of ambient particulate matter is closely reflected by the particulate oxidant potential
    Ning Li
    Division of NanoMedicine, Department of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA
    Environ Health Perspect 117:1116-23. 2009
    ....
  15. pmc Quinones and aromatic chemical compounds in particulate matter induce mitochondrial dysfunction: implications for ultrafine particle toxicity
    Tian Xia
    Division of Clinical Immunology and Allergy, Department of Medicine, UCLA School of Medicine, University of California Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095 1680, USA
    Environ Health Perspect 112:1347-58. 2004
    ..In contrast, commercial polystyrene nanoparticles failed to exert mitochondrial effects. These results suggest that DEP and UFP effects on the PTP and Delta-Psi m are mediated by adsorbed chemicals rather than the particles themselves...
  16. ncbi request reprint Cobalamin (vitamin B12) binding, phylogeny, and synteny of human transcobalamin
    Seema Kalra
    Division of Gastroenterology and Hepatology, Department of Medicine, Medical College of Wisconsin and Clement Zablocki VA Medical Center, Milwaukee, WI 53295, USA
    Arch Biochem Biophys 431:189-96. 2004
    ....
  17. ncbi request reprint Toxic potential of materials at the nanolevel
    Andre Nel
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Science 311:622-7. 2006
    ..The establishment of principles and test procedures to ensure safe manufacture and use of nanomaterials in the marketplace is urgently required and achievable...
  18. ncbi request reprint Particulate air pollutants and asthma. A paradigm for the role of oxidative stress in PM-induced adverse health effects
    Ning Li
    Department of Medicine Division of Clinical Immunology and Allergy, University of California, Los Angeles, CA 90095, USA
    Clin Immunol 109:250-65. 2003
    ..We review the biology of oxidative stress, including protective and injurious effects that explain the impact of particulate matter-induced oxidative stress in asthma...
  19. ncbi request reprint Comparison of the pro-oxidative and proinflammatory effects of organic diesel exhaust particle chemicals in bronchial epithelial cells and macrophages
    Ning Li
    Division of Clinical Immunology and Allergy, Department of Medicine, University of California Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
    J Immunol 169:4531-41. 2002
    ..Moreover, epithelial cells are not able to convert N-acetylcysteine to cytoprotective glutathione...
  20. pmc Comparison of the variability of the annual rates of change in FEV₁ determined from serial measurements of the pre- versus post-bronchodilator FEV₁ over 5 years in mild to moderate COPD: results of the lung health study
    Donald P Tashkin
    Departments of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Respir Res 13:70. 2012
    ..We therefore compared the yearly slope and the variability of the slope of the pre- versus the post-bronchodilator FEV₁ in men and women with mild to moderate COPD who participated in the 5-year Lung Health Study (LHS)...
  21. doi request reprint Potential health impact of nanoparticles
    Tian Xia
    Division of NanoMedicine, Department of Medicine, University of California, Los Angeles, California 90095, USA
    Annu Rev Public Health 30:137-50. 2009
    ..This review discusses the toxicological potential of NMs by comparing the possible injury mechanisms and adverse health effects of engineered and ambient ultrafine particles...
  22. ncbi request reprint Nrf2 is a key transcription factor that regulates antioxidant defense in macrophages and epithelial cells: protecting against the proinflammatory and oxidizing effects of diesel exhaust chemicals
    Ning Li
    Division of Clinical Immunology and Allergy, Department of Medicine, University of California, Los Angeles 90095, USA
    J Immunol 173:3467-81. 2004
    ..We propose that Nrf2-mediated phase II enzyme expression protects against the proinflammatory effects of particulate pollutants in the setting of allergic inflammation and asthma...
  23. pmc Air-pollutant chemicals and oxidized lipids exhibit genome-wide synergistic effects on endothelial cells
    Ke Wei Gong
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Genome Biol 8:R149. 2007
    ..We hypothesize that these pro-oxidative chemicals could synergize with oxidized lipid components generated in low-density lipoprotein particles to enhance vascular inflammation and atherosclerosis...
  24. doi request reprint Decreased dissolution of ZnO by iron doping yields nanoparticles with reduced toxicity in the rodent lung and zebrafish embryos
    Tian Xia
    Division of NanoMedicine, Department of Medicine, University of California, Los Angeles, California 90095, USA
    ACS Nano 5:1223-35. 2011
    ..All considered, the above data show that Fe doping is a possible safe design strategy for preventing ZnO toxicity in animals and the environment...
  25. ncbi request reprint Pro-oxidative diesel exhaust particle chemicals inhibit LPS-induced dendritic cell responses involved in T-helper differentiation
    Ray Chun Fai Chan
    Division of Clinical Immunology and Allergy, Department of Medicine, University of California Los Angeles, CA 90095, USA
    J Allergy Clin Immunol 118:455-65. 2006
    ..Diesel exhaust particles (DEPs), a model pollutant, act as an adjuvant for allergic sensitization. Increasing evidence shows that this effect could be mediated by an effect on dendritic cells (DCs)...
  26. ncbi request reprint Role of the Nrf2-mediated signaling pathway as a negative regulator of inflammation: implications for the impact of particulate pollutants on asthma
    Ning Li
    Division of Clinical Immunology and Allergy, Department of Medicine, University of California, Los Angeles, California 90095, USA
    Antioxid Redox Signal 8:88-98. 2006
    ..Moreover, chemopreventive Nrf2 inducers may be used for treating PM-exacerbated asthma...
  27. ncbi request reprint Use of a stratified oxidative stress model to study the biological effects of ambient concentrated and diesel exhaust particulate matter
    Ning Li
    Department of Medicine, University of California Los Angeles, 10833 LeConte Avenue, Los Angeles, CA 90095 1680, USA
    Inhal Toxicol 14:459-86. 2002
    ..This work has important implications for the selection of relevant biological endpoints for in vivo studies...
  28. ncbi request reprint Microfilament actin remodeling as a potential target for cancer drug development
    JianYu Rao
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Curr Cancer Drug Targets 4:345-54. 2004
    ..In addition, the concept of using F/G-actin ratio as a surrogate marker for actin-pathway based therapy will also be introduced...
  29. pmc Effects of 1-year treatment with cyclophosphamide on outcomes at 2 years in scleroderma lung disease
    Donald P Tashkin
    Department of Medicine, David Geffen School of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095 1690, USA
    Am J Respir Crit Care Med 176:1026-34. 2007
    ..Although treatment-related benefits in pulmonary function, skin scores, and patient-centered outcomes were demonstrated after 1 year of therapy, the duration of benefit beyond 1 year was unclear...
  30. pmc Robust joint modeling of longitudinal measurements and competing risks failure time data
    Ning Li
    Department of Biomathematics, University of California at Los Angeles, 90095 1766, USA
    Biom J 51:19-30. 2009
    ..The proposed method is evaluated by simulation studies and is applied to a scleroderma lung study...
  31. doi request reprint Annual rates of change in pre- vs. post-bronchodilator FEV1 and FVC over 4 years in moderate to very severe COPD
    Donald P Tashkin
    David Geffen School of Medicine at UCLA, 10833 Le Conte Ave, Los Angeles, CA 90095, USA Electronic address
    Respir Med 107:1904-11. 2013
    ..While the reasons for these differences are not completely clear, they are important to consider when assessing treatment effects on rates of decline in FEV1 and FVC. ..
  32. doi request reprint Adverse events during the Scleroderma Lung Study
    Daniel E Furst
    David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90025, USA
    Am J Med 124:459-67. 2011
    ..We now report an in-depth assessment of the toxicity of cyclophosphamide during the year of therapy and the year after therapy was completed, during which time the investigators were still masked to the treatment assignment...
  33. doi request reprint T-cell effector pathways in allergic diseases: transcriptional mechanisms and therapeutic targets
    Talal A Chatila
    Division of Immunology, Allergy and Rheumatology, Department of Pediatrics, University of California at Los Angeles, Los Angeles, CA, USA
    J Allergy Clin Immunol 121:812-23; quiz 824-5. 2008
    ....
  34. pmc Inflammation, autophagy, and obesity: common features in the pathogenesis of pancreatitis and pancreatic cancer
    Ilya Gukovsky
    Veterans Affairs Greater Los Angeles Healthcare System, California, USA
    Gastroenterology 144:1199-209.e4. 2013
    ..We review the roles of inflammation and autophagy, and their deregulation by obesity, in pancreatic diseases. We discuss the connections among disordered pathways and important areas for future research...
  35. doi request reprint Sexual satisfaction and quality of life in major depressive disorder before and after treatment with citalopram in the STAR*D study
    Waguih William Ishak
    Cedars Sinai Medical Center and UCLA, 8730 Alden Drive, Thalians W 157, Los Angeles, CA 90048, USA
    J Clin Psychiatry 74:256-61. 2013
    ..This study examined the impact of MDD and the SSRI citalopram on sexual satisfaction and QOL in level 1 of the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial (July 2001-September 2006)...
  36. doi request reprint Correlates and predictors of disability in vulnerable US Hispanics with rheumatoid arthritis
    George A Karpouzas
    Los Angeles Biomedical Research Institute, Harbor UCLA Medical Center, Los Angeles, California 90509, USA
    Arthritis Care Res (Hoboken) 64:1274-81. 2012
    ..In the present report, we identified factors associated with disability in a cross-sectional design, and evaluated their individual contributions to disability over time...
  37. pmc An exploration of fixed and random effects selection for longitudinal binary outcomes in the presence of nonignorable dropout
    Ning Li
    Department of Biomathematics, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Biom J 55:17-37. 2013
    ..Mixture priors with a point mass at zero are used to facilitate variable selection. We illustrate the proposed approach using a clinical trial for acute ischemic stroke...
  38. pmc A joint model for longitudinal measurements and survival data in the presence of multiple failure types
    Robert M Elashoff
    Department of Biostatistics, School of Public Health, University of California at Los Angeles, Los Angeles, California 90095, USA
    Biometrics 64:762-71. 2008
    ..The developed method works well in our simulation studies and is applied to a clinical trial for the scleroderma lung disease...
  39. pmc Cardiac small conductance Ca2+-activated K+ channel subunits form heteromultimers via the coiled-coil domains in the C termini of the channels
    Dipika Tuteja
    Department of Medicine, University of California, Davis, CA 95616, USA
    Circ Res 107:851-9. 2010
    ..SK channels are proposed to be assembled as tetramers similar to other K(+) channels, but the molecular determinants driving their subunit interaction and assembly are not defined in cardiac tissues...
  40. pmc GABRA2 markers moderate the subjective effects of alcohol
    Magdalena Uhart
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Addict Biol 18:357-69. 2013
    ..Our findings provide further evidence that variation within GABRA2 is associated with attenuated negative responses to alcohol, a known risk factor for vulnerability to alcohol use disorders...
  41. ncbi request reprint Function and stability of human transcobalamin II: role of intramolecular disulfide bonds C98-C291 and C147-C187
    Seema Kalra
    Department of Medicine, Medical College of Wisconsin and Veterans Adminstration Medical Center, Milwaukee, WI 53295, USA
    Am J Physiol Cell Physiol 285:C150-60. 2003
    ..These studies suggest that optimal binding of Cbl by human TC II is supported by disulfide bonds C98-C291 and C147-C187 and that their disruption results in loss of Cbl binding and their rapid degradation by the proteasomal machinery...
  42. ncbi request reprint Thiol antioxidants inhibit the adjuvant effects of aerosolized diesel exhaust particles in a murine model for ovalbumin sensitization
    Michael J Whitekus
    Department of Pathology and Laboratory Medicine and Jonsson Comprehensive Cancer Center, University of California School of Medicine, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
    J Immunol 168:2560-7. 2002
    ..Antioxidant treatment strategies may therefore serve to alleviate allergic inflammation and may provide a rational basis for treating the contribution of particulate matter to asthmatic disease...
  43. ncbi request reprint Boron workers in China: exploring work and lifestyle factors related to boron exposure
    Betty L Chang
    School of Nursing, University of California, Los Angeles, CA, USA
    AAOHN J 54:435-43. 2006
    ..Implications for occupational health nurses and recommendations for future research are provided...
  44. doi request reprint Surfactant protein D and KL-6 as serum biomarkers of interstitial lung disease in patients with scleroderma
    Faye N Hant
    Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, 96 Jonathan Lucas Street, Suite 912, Charleston, SC 29425 6370, USA
    J Rheumatol 36:773-80. 2009
    ....
  45. pmc An approach to joint analysis of longitudinal measurements and competing risks failure time data
    Robert M Elashoff
    Department of Biostatistics, School of Public Health, University of California at Los Angeles, Los Angeles, CA, USA
    Stat Med 26:2813-35. 2007
    ..The performance of our method is evaluated and compared with separate analyses using both simulated data and a clinical trial for the scleroderma lung disease...
  46. pmc Alpha-actinin2 cytoskeletal protein is required for the functional membrane localization of a Ca2+-activated K+ channel (SK2 channel)
    Ling Lu
    Division of Cardiovascular Medicine, Department of Medicine, University of California, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 106:18402-7. 2009
    ..The importance of our findings may transcend the area of K(+) channels, given that similar cytoskeletal interaction and anchoring may be critical for the membrane localization of other ion channels in neurons and other excitable cells...