Ming D Li

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. pmc CD-1 mice Show Individual Differences in Nicotine Preference in a Modified Two-Bottle Oral Self-Administration Model
    Junran Cao
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia Charlottesville, VA, USA
    Front Psychiatry 3:28. 2012
  2. pmc Detection of genetic association and a functional polymorphism of dynamin 1 gene with nicotine dependence in European and African Americans
    Qing Xu
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA 22911, USA
    Neuropsychopharmacology 34:1351-9. 2009
  3. pmc Determination of Methylated CpG Sites in the Promoter Region of Catechol-O-Methyltransferase (COMT) and their Involvement in the Etiology of Tobacco Smoking
    Qing Xu
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia Charlottesville, VA, USA
    Front Psychiatry 1:16. 2010
  4. pmc Susceptibility locus in neurokinin-1 receptor gene associated with alcohol dependence
    Chamindi Seneviratne
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, Virginia 22911, USA
    Neuropsychopharmacology 34:2442-9. 2009
  5. pmc Genome-wide expression analysis reveals diverse effects of acute nicotine exposure on neuronal function-related genes and pathways
    Ju Wang
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia Charlottesville, VA, USA
    Front Psychiatry 2:5. 2011
  6. pmc Gestational nicotine exposure modifies myelin gene expression in the brains of adolescent rats with sex differences
    J Cao
    Section of Neurobiology, Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA 22911, USA
    Transl Psychiatry 3:e247. 2013
  7. doi request reprint MicroRNAs in addiction: adaptation's middlemen?
    M D Li
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA 22911, USA
    Mol Psychiatry 16:1159-68. 2011
  8. doi request reprint Identifying susceptibility loci for nicotine dependence: 2008 update based on recent genome-wide linkage analyses
    Ming D Li
    Department of Psychiatry and Neurobehavioral Sciences, Section of Neurobiology, University of Virginia, 1670 Discovery Drive, Suite 110, Charlottesville, VA 22911, USA
    Hum Genet 123:119-31. 2008
  9. pmc Association and interaction analyses of GABBR1 and GABBR2 with nicotine dependence in European- and African-American populations
    Ming D Li
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, Virginia, USA
    PLoS ONE 4:e7055. 2009
  10. pmc Association and interaction analysis of variants in CHRNA5/CHRNA3/CHRNB4 gene cluster with nicotine dependence in African and European Americans
    Ming D Li
    Department of Psychiatry and Neurobehavioral Sciences, Section of Neurobiology, University of Virginia, 1670 Discovery Drive, Suite 110, Charlottesville, VA 22911, USA
    Am J Med Genet B Neuropsychiatr Genet 153:745-56. 2010

Collaborators

Detail Information

Publications88

  1. pmc CD-1 mice Show Individual Differences in Nicotine Preference in a Modified Two-Bottle Oral Self-Administration Model
    Junran Cao
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia Charlottesville, VA, USA
    Front Psychiatry 3:28. 2012
    ..Considering the nature and heterogeneity of CD-1 mice, the striking individual differences imply that genetics plays an important role in nicotine preference observed in these animals...
  2. pmc Detection of genetic association and a functional polymorphism of dynamin 1 gene with nicotine dependence in European and African Americans
    Qing Xu
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA 22911, USA
    Neuropsychopharmacology 34:1351-9. 2009
    ..Taken together, our findings indicate that DNM1 is likely involved in the etiology of ND and represents a plausible candidate for further investigation in independent samples...
  3. pmc Determination of Methylated CpG Sites in the Promoter Region of Catechol-O-Methyltransferase (COMT) and their Involvement in the Etiology of Tobacco Smoking
    Qing Xu
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia Charlottesville, VA, USA
    Front Psychiatry 1:16. 2010
    ..Together, our findings provide the first molecular explanation at the epigenetic level for the association of ND with methylation of the COMT promoter, implying that methylation plays a role in smoking dependence...
  4. pmc Susceptibility locus in neurokinin-1 receptor gene associated with alcohol dependence
    Chamindi Seneviratne
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, Virginia 22911, USA
    Neuropsychopharmacology 34:2442-9. 2009
    ..Additional studies are needed to replicate these results in other samples and to elucidate the mechanism(s) by which these polymorphisms affect NK1R function in the brain...
  5. pmc Genome-wide expression analysis reveals diverse effects of acute nicotine exposure on neuronal function-related genes and pathways
    Ju Wang
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia Charlottesville, VA, USA
    Front Psychiatry 2:5. 2011
    ..Together, our results not only provide insights into the mechanism underlying the acute response of neuronal cells to nicotine but also provide clues to how acute nicotine exposure exerts long-term effects on the nervous system...
  6. pmc Gestational nicotine exposure modifies myelin gene expression in the brains of adolescent rats with sex differences
    J Cao
    Section of Neurobiology, Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA 22911, USA
    Transl Psychiatry 3:e247. 2013
    ..Together, our findings suggest that abnormal brain myelination underlies various psychiatric disorders and drug abuse associated with prenatal exposure to cigarette smoke...
  7. doi request reprint MicroRNAs in addiction: adaptation's middlemen?
    M D Li
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA 22911, USA
    Mol Psychiatry 16:1159-68. 2011
    ..We conclude that miRNA-mediated gene regulation is a conserved means of converting environmental signals into neuronal response, which holds significant implications for addiction and other psychiatric illnesses...
  8. doi request reprint Identifying susceptibility loci for nicotine dependence: 2008 update based on recent genome-wide linkage analyses
    Ming D Li
    Department of Psychiatry and Neurobehavioral Sciences, Section of Neurobiology, University of Virginia, 1670 Discovery Drive, Suite 110, Charlottesville, VA 22911, USA
    Hum Genet 123:119-31. 2008
    ..Among them, the regions on chromosomes 9 (91.9-136.5 cM), 10, 11, and 17 have received the strongest support. A summary of eight regions that have been nominated for "significant" linkage to ND is provided...
  9. pmc Association and interaction analyses of GABBR1 and GABBR2 with nicotine dependence in European- and African-American populations
    Ming D Li
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, Virginia, USA
    PLoS ONE 4:e7055. 2009
    ..Future studies are needed with more dense SNP coverage of GABBR1 and GABBR2 to verify the epistatic effects of the two subunit genes...
  10. pmc Association and interaction analysis of variants in CHRNA5/CHRNA3/CHRNB4 gene cluster with nicotine dependence in African and European Americans
    Ming D Li
    Department of Psychiatry and Neurobehavioral Sciences, Section of Neurobiology, University of Virginia, 1670 Discovery Drive, Suite 110, Charlottesville, VA 22911, USA
    Am J Med Genet B Neuropsychiatr Genet 153:745-56. 2010
    ....
  11. pmc Associations of variants in CHRNA5/A3/B4 gene cluster with smoking behaviors in a Korean population
    Ming D Li
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, Virginia, United States of America
    PLoS ONE 5:e12183. 2010
    ....
  12. pmc New insights into the genetics of addiction
    Ming D Li
    Department of Psychiatry and Neurobehavioural Sciences, University of Virginia, Charlottesville, Virginia 22911, USA
    Nat Rev Genet 10:225-31. 2009
    ..Current efforts aim not only to replicate these findings in independent samples but also to determine the functional mechanisms of these genes and variants...
  13. pmc Gene-gene interactions among CHRNA4, CHRNB2, BDNF, and NTRK2 in nicotine dependence
    Ming D Li
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, Virginia 22911, USA
    Biol Psychiatry 64:951-7. 2008
    ....
  14. pmc A generalized combinatorial approach for detecting gene-by-gene and gene-by-environment interactions with application to nicotine dependence
    Xiang Yang Lou
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA 22911, USA
    Am J Hum Genet 80:1125-37. 2007
    ..In summary, GMDR serves the purpose of identifying contributors to population variation better than do the other existing methods...
  15. doi request reprint Significant association of ANKK1 and detection of a functional polymorphism with nicotine dependence in an African-American sample
    Weihua Huang
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA 22911, USA
    Neuropsychopharmacology 34:319-30. 2009
    ..We conclude that ANKK1 is associated with ND and polymorphism rs2734849 in ANKK1 represents a functional causative variant for ND in African-American smokers...
  16. pmc A combinatorial approach to detecting gene-gene and gene-environment interactions in family studies
    Xiang Yang Lou
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA 22911, USA
    Am J Hum Genet 83:457-67. 2008
    ..Finally, we applied our proposed approach to a genetic data set on tobacco dependence and found a significant interaction between two taste receptor genes (i.e., TAS2R16 and TAS2R38) in affecting nicotine dependence...
  17. ncbi request reprint Significant association of DRD1 with nicotine dependence
    Weihua Huang
    Department of Psychiatry and Neurobehavioral Sciences, Section of Neurobiology, University of Virginia, 1670 Discovery Drive, Suite 125, Charlottesville, VA 22911, USA
    Hum Genet 123:133-40. 2008
    ..Furthermore, in a luciferase reporter assay, rs686, located in the 3' untranslated region, caused differential luciferase activities, indicating that rs686 is a functional polymorphism affecting expression of DRD1...
  18. ncbi request reprint Association of specific haplotypes of neurotrophic tyrosine kinase receptor 2 gene (NTRK2) with vulnerability to nicotine dependence in African-Americans and European-Americans
    Joke Beuten
    Department of Psychiatric Medicine, University of Virginia, Charlottesville, Virginia 22911, USA
    Biol Psychiatry 61:48-55. 2007
    ..However, no association of NTRK2 with ND has been identified...
  19. ncbi request reprint Fine mapping of a linkage region on chromosome 17p13 reveals that GABARAP and DLG4 are associated with vulnerability to nicotine dependence in European-Americans
    Xiang Yang Lou
    Department of Psychiatry and Neurobehavioral Sciencesm, University of Virginia, Charlottesville, VA, USA
    Hum Mol Genet 16:142-53. 2007
    ..Further investigation of neurobiological mechanisms of the two genes in the etiology of ND is thus warranted...
  20. ncbi request reprint Replication and extension of association of choline acetyltransferase with nicotine dependence in European and African American smokers
    Jinxue Wei
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, 1670 Discovery Drive, Suite 110, Charlottesville, VA 22911, USA
    Hum Genet 127:691-8. 2010
    ..Together, our findings, in conjunction with the previous report of the association, warrant further investigation of ChAT in ND...
  21. ncbi request reprint Association analysis of the protein phosphatase 1 regulatory subunit 1B (PPP1R1B) gene with nicotine dependence in European- and African-American smokers
    Joke Beuten
    Department of Psychiatric Medicine, The University of Virginia, Charlottesville, Virginia 22911, USA
    Am J Med Genet B Neuropsychiatr Genet 144:285-90. 2007
    ..No significant associations with haplotypes were found in the AA sample. In summary, our findings provide the first evidence for the potential involvement of PPP1R1B in the etiology of ND and further investigation is thus warranted...
  22. ncbi request reprint Gene-based analysis suggests association of the nicotinic acetylcholine receptor beta1 subunit (CHRNB1) and M1 muscarinic acetylcholine receptor (CHRM1) with vulnerability for nicotine dependence
    Xiang Yang Lou
    Department of Psychiatric Medicine, University of Virginia, 1670 Discovery Drive, Suite 101, Charlottesville, VA 22911, USA
    Hum Genet 120:381-9. 2006
    ..The significant associations, together with their location of linked region to ND, suggest that the CHRNB1 and CHRM1 are likely candidates for further investigation...
  23. doi request reprint Modulation of cell adhesion systems by prenatal nicotine exposure in limbic brain regions of adolescent female rats
    Junran Cao
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA, USA
    Int J Neuropsychopharmacol 14:157-74. 2011
    ..Further, our study underscores that low doses of nicotine produce substantial and long-lasting changes in the brain, implying that nicotine replacement therapy during pregnancy may carry many of the same risks to the offspring as MS...
  24. pmc A genomewide search finds major susceptibility loci for nicotine dependence on chromosome 10 in African Americans
    Ming D Li
    Department of Psychiatric Medicine, University of Virginia, Charlottesville, VA 22911, USA
    Am J Hum Genet 79:745-51. 2006
    ..Further analysis of these positive regions by fine mapping and/or association analysis is thus warranted. To our knowledge, this study represents the first genomewide linkage scan of ND in an AA sample...
  25. pmc Significant association of the neurexin-1 gene (NRXN1) with nicotine dependence in European- and African-American smokers
    Justin Nussbaum
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA, USA
    Hum Mol Genet 17:1569-77. 2008
    ....
  26. pmc Characterization of a functional polymorphism in the 3' UTR of SLC6A4 and its association with drinking intensity
    Chamindi Seneviratne
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, 1670 Discovery Drive, Charlottesville, VA 22911, USA
    Alcohol Clin Exp Res 33:332-9. 2009
    ....
  27. ncbi request reprint Regulation by nicotine of Gpr51 and Ntrk2 expression in various rat brain regions
    Dongxiao Sun
    Section of Neurobiology, Department of Psychiatric Medicine, University of Virginia, Charlottesville, VA 22911, USA
    Neuropsychopharmacology 32:110-6. 2007
    ....
  28. pmc Association, interaction, and replication analysis of genes encoding serotonin transporter and 5-HT3 receptor subunits A and B in alcohol dependence
    Chamindi Seneviratne
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, 1670 Discovery Drive, Charlottesville, VA, 22911, USA
    Hum Genet 132:1165-76. 2013
    ..007). These findings reveal significant interactive effects among variants in SLC6A4-HTR3A-HTR3B affecting AD. Further studies are needed to confirm these findings and characterize the molecular mechanisms underlying these effects. ..
  29. doi request reprint A functional polymorphism, rs6280, in DRD3 is significantly associated with nicotine dependence in European-American smokers
    Weihua Huang
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, Virginia 22911, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1109-15. 2008
    ....
  30. doi request reprint Nicotine modulates expression of miR-140*, which targets the 3'-untranslated region of dynamin 1 gene (Dnm1)
    Weihua Huang
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA 22911, USA
    Int J Neuropsychopharmacol 12:537-46. 2009
    ....
  31. pmc RNA deep sequencing analysis reveals that nicotine restores impaired gene expression by viral proteins in the brains of HIV-1 transgenic rats
    Junran Cao
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, Virginia, United States of America
    PLoS ONE 8:e68517. 2013
    ..Together, our findings indicate that cholinergic modulators such as nicotine have beneficial effects on HIV-1-induced neurologic deficits. ..
  32. pmc Significant associations of CHRNA2 and CHRNA6 with nicotine dependence in European American and African American populations
    Shaolin Wang
    Department of Psychiatry and Neurobehavioral Sciences, School of Medicine, University of Virginia, Charlottesville, VA, USA
    Hum Genet 133:575-86. 2014
    ..Together, these findings indicate that both CHRNA2 and CHRNA6 play a significant role in the etiology of ND in AA and EA smokers. Further replication in additional independent samples is warranted. ..
  33. pmc Central myelin gene expression during postnatal development in rats exposed to nicotine gestationally
    Junran Cao
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA 22911, United States
    Neurosci Lett 553:115-20. 2013
    ..The effect on adolescents was quite different from that at other ages, which correlated with the unique symptoms of many psychiatric disorders during adolescence...
  34. doi request reprint Gestational nicotine treatment modulates cell death/survival-related pathways in the brains of adolescent female rats
    Jinxue Wei
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA 22911, USA
    Int J Neuropsychopharmacol 14:91-106. 2011
    ....
  35. ncbi request reprint Comorbid alcohol and nicotine dependence: from the biomolecular basis to clinical consequences
    Nassima Ait-Daoud
    Department of Psychiatric Medicine, University of Virginia, Charlottesville 22908 0623, USA
    Alcohol Clin Exp Res 29:1541-9. 2005
    ..Lesch, MD, PhD; and (5) Pharmacotherapy for Promotion of Abstinence from Nicotine Among Alcohol-Dependent Individuals, by Bankole A. Johnson, DSc, MD, PhD...
  36. ncbi request reprint Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons
    Ju Wang
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, Virginia 22911, USA
    Alcohol Clin Exp Res 31:357-75. 2007
    ..However, these mechanisms are largely unknown. By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both...
  37. doi request reprint Significant association of glutamate receptor, ionotropic N-methyl-D-aspartate 3A (GRIN3A), with nicotine dependence in European- and African-American smokers
    Jennie Z Ma
    Department of Public Health Sciences, University of Virginia, P O Box 800717, Charlottesville, VA 22908, USA
    Hum Genet 127:503-12. 2010
    ..Some of them remained significant after correction for multiple testing. We concluded that GRIN3A represents a strong candidate for involvement in the etiology of ND and warrants further investigation in independent samples...
  38. ncbi request reprint Nicotine modulates expression of amyloid precursor protein and amyloid precursor-like protein 2 in mouse brain and in SH-SY5Y neuroblastoma cells
    Ramana Gutala
    Department of Psychiatric Medicine, Section of Neurobiology, University of Virginia, 1670 Discovery Drive, Suite 110, Charlottesville, VA 22911, USA
    Brain Res 1093:12-9. 2006
    ..These findings suggest that nicotine treatment facilitates the increase in the expression of mRNA and protein of the APP and APLP2 genes in rat brain and SH-SY5Y neuroblastoma cells...
  39. pmc Common and unique biological pathways associated with smoking initiation/progression, nicotine dependence, and smoking cessation
    Ju Wang
    Section of Neurobiology, Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA 22911, USA
    Neuropsychopharmacology 35:702-19. 2010
    ....
  40. pmc Differential allelic expression of dopamine D1 receptor gene (DRD1) is modulated by microRNA miR-504
    Weihua Huang
    Departments of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, Virginia 22911, USA
    Biol Psychiatry 65:702-5. 2009
    ..However, the mechanism underlying the differential expression remains to be determined. We hypothesize that it is caused by miRNA targeting...
  41. pmc Association and interaction analyses of 5-HT3 receptor and serotonin transporter genes with alcohol, cocaine, and nicotine dependence using the SAGE data
    Jiekun Yang
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, 450 Ray C Hunt Drive, Charlottesville, VA, 22903, USA
    Hum Genet 133:905-18. 2014
    ....
  42. doi request reprint Genes and pathways co-associated with the exposure to multiple drugs of abuse, including alcohol, amphetamine/methamphetamine, cocaine, marijuana, morphine, and/or nicotine: a review of proteomics analyses
    Ju Wang
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA 22911, USA
    Mol Neurobiol 44:269-86. 2011
    ..Furthermore, the proteins and biological processes highlighted here may provide valuable insight into the cellular activities and biological processes in neurons in the development of drug addiction...
  43. pmc Transcriptome sequencing of gene expression in the brain of the HIV-1 transgenic rat
    Ming D Li
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, Virginia, United States of America
    PLoS ONE 8:e59582. 2013
    ....
  44. pmc Improvement of mapping accuracy by unifying linkage and association analysis
    Xiang Yang Lou
    Department of Psychiatric Medicine, University of Virginia, Charlottesville, Virginia 22911, USA
    Genetics 172:647-61. 2006
    ..Finally, we apply our methodology to a genetic study on bone mineral density (BMD) for the vitamin D receptor (VDR) gene and find that VDR is significantly linked to BMD at the one-third region of the wrist...
  45. pmc Identification and characterization of poly(I:C)-induced molecular responses attenuated by nicotine in mouse macrophages
    Wen Yan Cui
    Department of Psychiatry and Neurobehavioral Sciences University of Virginia 1670 Discovery Drive, Suite 110, Charlottesville, VA 22911, USA
    Mol Pharmacol 83:61-72. 2013
    ..7 cells. Collectively, these results indicate that poly(I:C)-induced molecular responses of macrophages could be significantly attenuated by nicotine...
  46. pmc Pharmacogenetic approach at the serotonin transporter gene as a method of reducing the severity of alcohol drinking
    Bankole A Johnson
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA 22908 0623, USA
    Am J Psychiatry 168:265-75. 2011
    ....
  47. pmc Determination of allelic expression of SNP rs1880676 in choline acetyltransferase gene in HeLa cells
    Zhongli Yang
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA, USA Shanxi Key Laboratory of Environmental Veterinary Sciences, Shanxi Agricultural University, Shanxi, China
    Neurosci Lett 555:215-9. 2013
    ..00016). We concluded that rs1880676 is functional and that the allelic variations of this polymorphism are involved in developing ND by altering ChAT expression. ..
  48. pmc Significant modulation of mitochondrial electron transport system by nicotine in various rat brain regions
    Ju Wang
    Department of Psychiatry and Neurobehavioral Sciences, Section of Neurobiology, University of Virginia, 1670 Discovery Drive, Suite 110, Charlottesville, VA 22911, United States
    Mitochondrion 9:186-95. 2009
    ..Finally, the results from the microarray analysis were verified by quantitative RT-PCR for four representative genes. Together, our findings imply that mitochondria are involved in neuronal adaptation to chronic nicotine exposure...
  49. pmc Introduction to deep sequencing and its application to drug addiction research with a focus on rare variants
    Shaolin Wang
    Department of Psychiatry and Neurobiology Science, University of Virginia, 1670 Discovery Drive, Suite 110, Charlottesville, VA, 22911, USA
    Mol Neurobiol 49:601-14. 2014
    ..This review presents an update on recently developed methods for rare-variant identification and association analysis and on studies focused on rare-variant discovery and function related to addictions. ..
  50. pmc Serotonin transporter and receptor genes significantly impact nicotine dependence through genetic interactions in both European American and African American smokers
    Zhongli Yang
    Shanxi Key Laboratory of Environmental Veterinary Science, Shanxi Agricultural University, Shanxi, China
    Drug Alcohol Depend 129:217-25. 2013
    ..Pharmacologic studies implicate a significant role of genes encoding the serotonin transporter (SLC6A4) and the 5-HT3AB subunits HTR3A and HTR3B in nicotine dependence (ND). However, whether they are involved in ND remains largely unknown...
  51. pmc ACSL6 is associated with the number of cigarettes smoked and its expression is altered by chronic nicotine exposure
    Jingchun Chen
    Department of Psychiatry and Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia, United States of America
    PLoS ONE 6:e28790. 2011
    ..The independent associations of this locus with schizophrenia and with numCIG in non-schizophrenic subjects suggest that this locus may be a common liability to both conditions...
  52. ncbi request reprint The genetics of nicotine dependence
    Ming D Li
    Department of Psychiatric Medicine, University of Virginia, 1670 Discovery Drive, Suite 110, Charlottesville, VA 22911, USA
    Curr Psychiatry Rep 8:158-64. 2006
    ..As genotyping technology is being improved and well-characterized clinical samples on smoking behavior become available, more and more genes and genetic variants responsible for ND will be identified in the near future...
  53. doi request reprint Fine-grain analysis of the treatment effect of topiramate on methamphetamine addiction with latent variable analysis
    Jennie Z Ma
    Department of Public Health Sciences, University of Virginia, PO Box 800717, Charlottesville, VA 22908, USA
    Drug Alcohol Depend 130:45-51. 2013
    ....
  54. doi request reprint Identification and characterization of a long isoform of human IFT80, IFT80-L
    Weihua Huang
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA 22911, USA
    Biochem Biophys Res Commun 373:653-8. 2008
    ..Our findings suggest that IFT80-L, like other IFT proteins, plays an important role in cell proliferation and differentiation...
  55. pmc Evaluation of the brief wisconsin inventory of smoking dependence motives in african-american and European-american heavy smokers
    Jennie Z Ma
    Department of Public Health Sciences, University of Virginia Charlottesville, VA, USA
    Front Psychiatry 3:36. 2012
    ..Together, we provide support for the general validity of the brief form but suggest individual item selections may benefit from further investigation...
  56. pmc Nine generations of selection for high and low nicotine intake in outbred Sprague-Dawley rats
    Tanseli Nesil
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, 1670 Discovery Drive, Charlottesville, VA 22911, USA
    Behav Genet 43:436-44. 2013
    ....
  57. doi request reprint Nicotinic modulation of innate immune pathways via α7 nicotinic acetylcholine receptor
    Wen Yan Cui
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA 22911, USA
    J Neuroimmune Pharmacol 5:479-88. 2010
    ..Understanding the mechanism of the nicotinic anti-inflammatory effect and neuron-protective function may guide the development of novel medicines for infectious and neuron-degenerative diseases...
  58. ncbi request reprint Two rare variations, D478N and D478E, that occur at the same amino acid residue in nicotinic acetylcholine receptor (nAChR) α2 subunit influence nAChR function
    Bhagirathi Dash
    Department of Psychiatry and Neurobehavioral Sciences, School of Medicine, University of Virginia, Charlottesville, VA 22903, USA
    Neuropharmacology 85:471-81. 2014
    ..These effects could be attributed to alteration in cytoplasmic 'portals' and/or ion permeation through it owing to change in amino acid electronegativity (D → N) and side chain length (D → E) in nAChR α2 subunit. ..
  59. pmc A signal peptide missense mutation associated with nicotine dependence alters α2*-nicotinic acetylcholine receptor function
    Bhagirathi Dash
    Department of Psychiatry and Neurobehavioral Sciences, School of Medicine, University of Virginia, Charlottesville, VA 22911, USA
    Neuropharmacology 79:715-25. 2014
    ..To our knowledge this is the first report of a SP mutation having a functional effect in a member of cys-loop family of ligand-gated ion channels. ..
  60. pmc Analysis of rare variations reveals roles of amino acid residues in the N-terminal extracellular domain of nicotinic acetylcholine receptor (nAChR) alpha6 subunit in the functional expression of human alpha6*-nAChRs
    Bhagirathi Dash
    Department of Psychiatry and Neurobehavioral Sciences, School of Medicine, University of Virginia, Charlottesville, VA, USA
    Mol Brain 7:35. 2014
    ....
  61. ncbi request reprint Proteins differentially expressed in response to nicotine in five rat brain regions: identification using a 2-DE/MS-based proteomics approach
    Yoon Y Hwang
    Department of Psychiatric Medicine, University of Virginia, 1670 Discovery Drive, Charlottesville, VA 22911, USA
    Proteomics 6:3138-53. 2006
    ..These data, in combination with microarray analysis of mRNA transcripts, have the potential to identify the CNS gene products that show coordinated changes in expression at both the RNA and protein levels in response to nicotine...
  62. doi request reprint Neuroproteomics and its applications in research on nicotine and other drugs of abuse
    Ming D Li
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA, USA
    Proteomics Clin Appl 1:1406-27. 2007
    ....
  63. pmc Mapping susceptibility loci for alcohol consumption using number of grams of alcohol consumed per day as a phenotype measure
    Jennie Z Ma
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    BMC Genet 4:S104. 2003
    ....
  64. pmc A genome-wide scan to identify loci for smoking rate in the Framingham Heart Study population
    Ming D Li
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    BMC Genet 4:S103. 2003
    ..To identify susceptibility loci for nicotine dependence, 313 extended pedigrees selected from the Framingham Heart Study population were analyzed by both the GENEHUNTER and S.A.G.E. programs...
  65. ncbi request reprint The genetics of smoking related behavior: a brief review
    Ming D Li
    Department of Psychiatry, The University of Texas Health Science Center, San Antonio, Texas 78229, USA
    Am J Med Sci 326:168-73. 2003
    ....
  66. pmc Single- and multilocus allelic variants within the GABA(B) receptor subunit 2 (GABAB2) gene are significantly associated with nicotine dependence
    Joke Beuten
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    Am J Hum Genet 76:859-64. 2005
    ..In summary, our findings provide evidence of a significant association of GABAB2 variants with ND, implying that this gene plays an important role in the etiology of this drug addiction...
  67. ncbi request reprint Ethnic- and gender-specific association of the nicotinic acetylcholine receptor alpha4 subunit gene (CHRNA4) with nicotine dependence
    Ming D Li
    Hum Mol Genet 14:1211-9. 2005
    ..In summary, our findings provide convincing evidence for the involvement of the nAChR alpha4 subunit, but not of the nAChR beta2 subunit, in nicotine addiction...
  68. ncbi request reprint Haplotype analysis indicates an association between the DOPA decarboxylase (DDC) gene and nicotine dependence
    Jennie Z Ma
    Program in Genomics and Bioinformatics on Drug Addiction, Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    Hum Mol Genet 14:1691-8. 2005
    ..73, P=0.005 for FTND). In summary, our findings provide the first evidence for the involvement of DDC in the susceptibility to ND and, further, reveal the racial specificity of its impact...
  69. ncbi request reprint Significant association of BDNF haplotypes in European-American male smokers but not in European-American female or African-American smokers
    Joke Beuten
    Program in Genomics and Bioinformatics on Drug Addiction, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, Texas
    Am J Med Genet B Neuropsychiatr Genet 139:73-80. 2005
    ..The significant association of BDNF variants with ND implies that this gene plays a role in the etiology of ND in EAs and that its involvement is gender specific. BDNF may warrant further investigation in ND...
  70. ncbi request reprint DOPA decarboxylase gene is associated with nicotine dependence
    Heping Zhang
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520 8034, USA
    Pharmacogenomics 7:1159-66. 2006
    ..Although the heritability of nicotine dependence (ND) is well documented and many candidate genetic regions have been identified, few of them were confirmed. This may be, in part, due to analytic methods that sacrifice power...
  71. ncbi request reprint Microarray technology and its application on nicotine research
    Ming D Li
    Department of Pharmacology, University of Tennessee College of Medicine, Memphis 38163, USA
    Mol Neurobiol 25:265-85. 2002
    ..Lastly, given the early stage of microarray research on nicotine, we elaborate on the need for an efficient analysis of genetic networks to further enhance our understanding of the mechanisms involved in nicotine abuse and addiction...
  72. ncbi request reprint Significant association of catechol-O-methyltransferase (COMT) haplotypes with nicotine dependence in male and female smokers of two ethnic populations
    Joke Beuten
    Program in Genomics and Bioinformatics on Drug Addiction, Department of Psychiatry, The University of Texas Health Science Center, San Antonio, TX, USA
    Neuropsychopharmacology 31:675-84. 2006
    ..In summary, our results provide evidence for a role of COMT in the susceptibility to ND and further confirm that its effect is ethnic and gender specific...
  73. ncbi request reprint Nicotine, body weight and potential implications in the treatment of obesity
    Ming D Li
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Curr Top Med Chem 3:899-919. 2003
    ....
  74. pmc Nonparametric disequilibrium mapping of functional sites using haplotypes of multiple tightly linked single-nucleotide polymorphism markers
    Rong Cheng
    Department of Psychiatry, The University of Texas Health Science Center, San Antonio, Texas 78229, USA
    Genetics 164:1175-87. 2003
    ..The sensitivity of the proposed procedure was examined on the simulated data set from the Genetic Analysis Workshop (GAW) 12. Compared with the conventional and generalized TDT methods, our procedure is more flexible and powerful...
  75. ncbi request reprint Effect of nicotine on the expression of leptin and forebrain leptin receptors in the rat
    Ming D Li
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, MSC 7792, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Brain Res 991:222-31. 2003
    ..Taken together, our results revealed that nicotine is involved in the regulation of leptin signaling, suggesting that leptin and its receptor play a role in the anorectic effects of nicotine on food intake and body weight in rats...
  76. ncbi request reprint Application of a customized pathway-focused microarray for gene expression profiling of cellular homeostasis upon exposure to nicotine in PC12 cells
    Ozlen Konu
    Program in Genomics and Bioinformatics on Drug Addiction, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, Mail Code 7792, San Antonio, TX 78229 3900, USA
    Brain Res Mol Brain Res 121:102-13. 2004
    ....
  77. ncbi request reprint A meta-analysis of estimated genetic and environmental effects on smoking behavior in male and female adult twins
    Ming D Li
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    Addiction 98:23-31. 2003
    ....
  78. doi request reprint Association of amyloid precursor protein-binding protein, family B, member 1 with nicotine dependence in African and European American smokers
    Guo Bo Chen
    Institute of Bioinformatics, Zhejiang University, Hangzhou, Zhejiang, People s Republic of China
    Hum Genet 124:393-8. 2008
    ..Based on these findings, we conclude that APBB1 represents an important candidate gene in the genetic study on ND and neurodegenerative diseases and warrants further investigation in future...
  79. ncbi request reprint Normalization of cDNA microarray data using wavelet regressions
    Ju Wang
    Program in Genomics and Bioinformatics on Drug Addiction, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Comb Chem High Throughput Screen 7:783-91. 2004
    ..The computing speed represents one of the most important advantages over other algorithms, especially when one is interested in analyzing a large microarray experiment involving hundreds of slides...
  80. ncbi request reprint Setting priorities for genomic research
    Wade Berrettini
    Science 304:1445-7; author reply 1445-7. 2004
  81. ncbi request reprint Time-dependent changes in transcriptional profiles within five rat brain regions in response to nicotine treatment
    Ming D Li
    Program in Genomics and Bioinformatics on Drug Abuse, Department of Psychiatry, The University of Texas Health Science Center, MSC 7792, 7703 Floyd Curl Drive, San Antonio, TX 78229, United States
    Brain Res Mol Brain Res 132:168-80. 2004
    ..Using a systematic approach to compare the different regional responses to nicotine administration will eventually provide a better understanding of how the different brain regions responding to this drug...
  82. ncbi request reprint Nicotine coregulates multiple pathways involved in protein modification/degradation in rat brain
    Justin K Kane
    Program in Genomics and Bioinformatics on Drug Addiction, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, United States
    Brain Res Mol Brain Res 132:181-91. 2004
    ....
  83. ncbi request reprint Microarray analysis of ethanol-treated cortical neurons reveals disruption of genes related to the ubiquitin-proteasome pathway and protein synthesis
    Ramana Gutala
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229, USA
    Alcohol Clin Exp Res 28:1779-88. 2004
    ..The objective of this research was to identify transcripts that are differentially regulated in ethanol-treated cortical neurons compared with controls by using a pathway-focused complementary DNA microarray...
  84. ncbi request reprint Fine mapping functional sites or regions from case-control data using haplotypes of multiple linked SNPs
    Rong Cheng
    Program in Genomics and Bioinformatics on Drug Addiction, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Ann Hum Genet 69:102-12. 2005
    ..Moreover, the program is very flexible and can be used in either regional or genome-wide scanning for association analysis with SNP markers...
  85. ncbi request reprint Correlations between mRNA expression levels and GC contents of coding and untranslated regions of genes in rodents
    Ozlen Konu
    Department of Pharmacology and Molecular Resource Center, University of Tennessee College of Medicine, Memphis, TN 38163, USA
    J Mol Evol 54:35-41. 2002
    ..g., >or=threefold the median expression for R. norvegicus), suggesting that conflicting demands posed by different aspects of transcriptional and translational machineries (e.g., efficiency versus fidelity) may set an upper limit for GC3...
  86. ncbi request reprint Genetic research and smoking behavior
    Laura Jean Bierut
    JAMA 297:809; author reply 810. 2007
  87. ncbi request reprint Molecular cloning, mapping and characterization of a novel mouse RING finger gene, Mrf1
    Ruying Chang
    Department of Pharmacology, University of Tennessee College of Medicine, 874 Union Avenue, Memphis, TN 38163, USA
    Gene 291:241-9. 2002
    ..The possible functions of Mrf1 are discussed in the contexts of protein-protein interactions, oncogenesis and ubiquitination...