M D Li

Summary

Affiliation: University of Texas Health Science Center
Country: USA

Publications

  1. pmc Mapping susceptibility loci for alcohol consumption using number of grams of alcohol consumed per day as a phenotype measure
    Jennie Z Ma
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    BMC Genet 4:S104. 2003
  2. ncbi request reprint Time-dependent changes in transcriptional profiles within five rat brain regions in response to nicotine treatment
    Ming D Li
    Program in Genomics and Bioinformatics on Drug Abuse, Department of Psychiatry, The University of Texas Health Science Center, MSC 7792, 7703 Floyd Curl Drive, San Antonio, TX 78229, United States
    Brain Res Mol Brain Res 132:168-80. 2004
  3. ncbi request reprint Progress in searching for susceptibility loci and genes for smoking-related behaviour
    M D Li
    Program in Genomics and Bioinformatics on Drug Addiction, Department of Psychiatry, The University of Texas Health Science Center, Floyd Curl Drive, San Antonio 78229, USA
    Clin Genet 66:382-92. 2004
  4. pmc A genome-wide scan to identify loci for smoking rate in the Framingham Heart Study population
    Ming D Li
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    BMC Genet 4:S103. 2003
  5. ncbi request reprint The genetics of smoking related behavior: a brief review
    Ming D Li
    Department of Psychiatry, The University of Texas Health Science Center, San Antonio, Texas 78229, USA
    Am J Med Sci 326:168-73. 2003
  6. ncbi request reprint Nicotine, body weight and potential implications in the treatment of obesity
    Ming D Li
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Curr Top Med Chem 3:899-919. 2003
  7. ncbi request reprint A meta-analysis of estimated genetic and environmental effects on smoking behavior in male and female adult twins
    Ming D Li
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    Addiction 98:23-31. 2003
  8. ncbi request reprint Regulation of Homer and group I metabotropic glutamate receptors by nicotine
    J K Kane
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Eur J Neurosci 21:1145-54. 2005
  9. pmc Convergent evidence that choline acetyltransferase gene variation is associated with prospective smoking cessation and nicotine dependence
    Riju Ray
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
    Neuropsychopharmacology 35:1374-82. 2010
  10. ncbi request reprint Application of a customized pathway-focused microarray for gene expression profiling of cellular homeostasis upon exposure to nicotine in PC12 cells
    Ozlen Konu
    Program in Genomics and Bioinformatics on Drug Addiction, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, Mail Code 7792, San Antonio, TX 78229 3900, USA
    Brain Res Mol Brain Res 121:102-13. 2004

Collaborators

Detail Information

Publications47

  1. pmc Mapping susceptibility loci for alcohol consumption using number of grams of alcohol consumed per day as a phenotype measure
    Jennie Z Ma
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    BMC Genet 4:S104. 2003
    ....
  2. ncbi request reprint Time-dependent changes in transcriptional profiles within five rat brain regions in response to nicotine treatment
    Ming D Li
    Program in Genomics and Bioinformatics on Drug Abuse, Department of Psychiatry, The University of Texas Health Science Center, MSC 7792, 7703 Floyd Curl Drive, San Antonio, TX 78229, United States
    Brain Res Mol Brain Res 132:168-80. 2004
    ..Using a systematic approach to compare the different regional responses to nicotine administration will eventually provide a better understanding of how the different brain regions responding to this drug...
  3. ncbi request reprint Progress in searching for susceptibility loci and genes for smoking-related behaviour
    M D Li
    Program in Genomics and Bioinformatics on Drug Addiction, Department of Psychiatry, The University of Texas Health Science Center, Floyd Curl Drive, San Antonio 78229, USA
    Clin Genet 66:382-92. 2004
    ..More studies are necessary to determine whether these genes play a significant role in smoking behaviour...
  4. pmc A genome-wide scan to identify loci for smoking rate in the Framingham Heart Study population
    Ming D Li
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    BMC Genet 4:S103. 2003
    ..To identify susceptibility loci for nicotine dependence, 313 extended pedigrees selected from the Framingham Heart Study population were analyzed by both the GENEHUNTER and S.A.G.E. programs...
  5. ncbi request reprint The genetics of smoking related behavior: a brief review
    Ming D Li
    Department of Psychiatry, The University of Texas Health Science Center, San Antonio, Texas 78229, USA
    Am J Med Sci 326:168-73. 2003
    ....
  6. ncbi request reprint Nicotine, body weight and potential implications in the treatment of obesity
    Ming D Li
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Curr Top Med Chem 3:899-919. 2003
    ....
  7. ncbi request reprint A meta-analysis of estimated genetic and environmental effects on smoking behavior in male and female adult twins
    Ming D Li
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    Addiction 98:23-31. 2003
    ....
  8. ncbi request reprint Regulation of Homer and group I metabotropic glutamate receptors by nicotine
    J K Kane
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Eur J Neurosci 21:1145-54. 2005
    ..These data provide further evidence for the involvement of nicotine in the glutamatergic neuronal synaptic activity in vivo, suggesting a role for the newly identified Homer proteins in this paradigm...
  9. pmc Convergent evidence that choline acetyltransferase gene variation is associated with prospective smoking cessation and nicotine dependence
    Riju Ray
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
    Neuropsychopharmacology 35:1374-82. 2010
    ..Additional sequencing and characterization of ChAT may reveal functional variants that contribute to nicotine dependence and smoking cessation...
  10. ncbi request reprint Application of a customized pathway-focused microarray for gene expression profiling of cellular homeostasis upon exposure to nicotine in PC12 cells
    Ozlen Konu
    Program in Genomics and Bioinformatics on Drug Addiction, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, Mail Code 7792, San Antonio, TX 78229 3900, USA
    Brain Res Mol Brain Res 121:102-13. 2004
    ....
  11. ncbi request reprint Mapping and verification of susceptibility loci for smoking quantity using permutation linkage analysis
    D Wang
    Program in Genomics and Bioinformatics on Drug Addiction, Department of Psychiatry, The University of Texas Health Science Center, San Antonio, TX 78229, USA
    Pharmacogenomics J 5:166-72. 2005
    ..Further analysis of these positive regions by fine mapping and/or association analysis is warranted. To our knowledge, this study presents the most convincing linkage evidence for nicotine dependence in the field...
  12. ncbi request reprint Significant association of catechol-O-methyltransferase (COMT) haplotypes with nicotine dependence in male and female smokers of two ethnic populations
    Joke Beuten
    Program in Genomics and Bioinformatics on Drug Addiction, Department of Psychiatry, The University of Texas Health Science Center, San Antonio, TX, USA
    Neuropsychopharmacology 31:675-84. 2006
    ..In summary, our results provide evidence for a role of COMT in the susceptibility to ND and further confirm that its effect is ethnic and gender specific...
  13. ncbi request reprint Nicotine coregulates multiple pathways involved in protein modification/degradation in rat brain
    Justin K Kane
    Program in Genomics and Bioinformatics on Drug Addiction, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, United States
    Brain Res Mol Brain Res 132:181-91. 2004
    ....
  14. pmc Single- and multilocus allelic variants within the GABA(B) receptor subunit 2 (GABAB2) gene are significantly associated with nicotine dependence
    Joke Beuten
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    Am J Hum Genet 76:859-64. 2005
    ..In summary, our findings provide evidence of a significant association of GABAB2 variants with ND, implying that this gene plays an important role in the etiology of this drug addiction...
  15. ncbi request reprint Significant association of BDNF haplotypes in European-American male smokers but not in European-American female or African-American smokers
    Joke Beuten
    Program in Genomics and Bioinformatics on Drug Addiction, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, Texas
    Am J Med Genet B Neuropsychiatr Genet 139:73-80. 2005
    ..The significant association of BDNF variants with ND implies that this gene plays a role in the etiology of ND in EAs and that its involvement is gender specific. BDNF may warrant further investigation in ND...
  16. ncbi request reprint Haplotype analysis indicates an association between the DOPA decarboxylase (DDC) gene and nicotine dependence
    Jennie Z Ma
    Program in Genomics and Bioinformatics on Drug Addiction, Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    Hum Mol Genet 14:1691-8. 2005
    ..73, P=0.005 for FTND). In summary, our findings provide the first evidence for the involvement of DDC in the susceptibility to ND and, further, reveal the racial specificity of its impact...
  17. ncbi request reprint Effect of nicotine on the expression of leptin and forebrain leptin receptors in the rat
    Ming D Li
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, MSC 7792, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Brain Res 991:222-31. 2003
    ..Taken together, our results revealed that nicotine is involved in the regulation of leptin signaling, suggesting that leptin and its receptor play a role in the anorectic effects of nicotine on food intake and body weight in rats...
  18. ncbi request reprint Fine mapping functional sites or regions from case-control data using haplotypes of multiple linked SNPs
    Rong Cheng
    Program in Genomics and Bioinformatics on Drug Addiction, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Ann Hum Genet 69:102-12. 2005
    ..Moreover, the program is very flexible and can be used in either regional or genome-wide scanning for association analysis with SNP markers...
  19. pmc Nonparametric disequilibrium mapping of functional sites using haplotypes of multiple tightly linked single-nucleotide polymorphism markers
    Rong Cheng
    Department of Psychiatry, The University of Texas Health Science Center, San Antonio, Texas 78229, USA
    Genetics 164:1175-87. 2003
    ..The sensitivity of the proposed procedure was examined on the simulated data set from the Genetic Analysis Workshop (GAW) 12. Compared with the conventional and generalized TDT methods, our procedure is more flexible and powerful...
  20. ncbi request reprint Microarray analysis of ethanol-treated cortical neurons reveals disruption of genes related to the ubiquitin-proteasome pathway and protein synthesis
    Ramana Gutala
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229, USA
    Alcohol Clin Exp Res 28:1779-88. 2004
    ..The objective of this research was to identify transcripts that are differentially regulated in ethanol-treated cortical neurons compared with controls by using a pathway-focused complementary DNA microarray...
  21. ncbi request reprint Normalization of cDNA microarray data using wavelet regressions
    Ju Wang
    Program in Genomics and Bioinformatics on Drug Addiction, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Comb Chem High Throughput Screen 7:783-91. 2004
    ..The computing speed represents one of the most important advantages over other algorithms, especially when one is interested in analyzing a large microarray experiment involving hundreds of slides...
  22. ncbi request reprint Fine mapping of a linkage region on chromosome 17p13 reveals that GABARAP and DLG4 are associated with vulnerability to nicotine dependence in European-Americans
    Xiang Yang Lou
    Department of Psychiatry and Neurobehavioral Sciencesm, University of Virginia, Charlottesville, VA, USA
    Hum Mol Genet 16:142-53. 2007
    ..Further investigation of neurobiological mechanisms of the two genes in the etiology of ND is thus warranted...
  23. ncbi request reprint Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons
    Ju Wang
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, Virginia 22911, USA
    Alcohol Clin Exp Res 31:357-75. 2007
    ..However, these mechanisms are largely unknown. By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both...
  24. pmc A generalized combinatorial approach for detecting gene-by-gene and gene-by-environment interactions with application to nicotine dependence
    Xiang Yang Lou
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA 22911, USA
    Am J Hum Genet 80:1125-37. 2007
    ..In summary, GMDR serves the purpose of identifying contributors to population variation better than do the other existing methods...
  25. ncbi request reprint Significant association of DRD1 with nicotine dependence
    Weihua Huang
    Department of Psychiatry and Neurobehavioral Sciences, Section of Neurobiology, University of Virginia, 1670 Discovery Drive, Suite 125, Charlottesville, VA 22911, USA
    Hum Genet 123:133-40. 2008
    ..Furthermore, in a luciferase reporter assay, rs686, located in the 3' untranslated region, caused differential luciferase activities, indicating that rs686 is a functional polymorphism affecting expression of DRD1...
  26. doi request reprint Identifying susceptibility loci for nicotine dependence: 2008 update based on recent genome-wide linkage analyses
    Ming D Li
    Department of Psychiatry and Neurobehavioral Sciences, Section of Neurobiology, University of Virginia, 1670 Discovery Drive, Suite 110, Charlottesville, VA 22911, USA
    Hum Genet 123:119-31. 2008
    ..Among them, the regions on chromosomes 9 (91.9-136.5 cM), 10, 11, and 17 have received the strongest support. A summary of eight regions that have been nominated for "significant" linkage to ND is provided...
  27. doi request reprint A functional polymorphism, rs6280, in DRD3 is significantly associated with nicotine dependence in European-American smokers
    Weihua Huang
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, Virginia 22911, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1109-15. 2008
    ....
  28. pmc A combinatorial approach to detecting gene-gene and gene-environment interactions in family studies
    Xiang Yang Lou
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA 22911, USA
    Am J Hum Genet 83:457-67. 2008
    ..Finally, we applied our proposed approach to a genetic data set on tobacco dependence and found a significant interaction between two taste receptor genes (i.e., TAS2R16 and TAS2R38) in affecting nicotine dependence...
  29. pmc A genomewide search finds major susceptibility loci for nicotine dependence on chromosome 10 in African Americans
    Ming D Li
    Department of Psychiatric Medicine, University of Virginia, Charlottesville, VA 22911, USA
    Am J Hum Genet 79:745-51. 2006
    ..Further analysis of these positive regions by fine mapping and/or association analysis is thus warranted. To our knowledge, this study represents the first genomewide linkage scan of ND in an AA sample...
  30. ncbi request reprint Nicotine modulates expression of amyloid precursor protein and amyloid precursor-like protein 2 in mouse brain and in SH-SY5Y neuroblastoma cells
    Ramana Gutala
    Department of Psychiatric Medicine, Section of Neurobiology, University of Virginia, 1670 Discovery Drive, Suite 110, Charlottesville, VA 22911, USA
    Brain Res 1093:12-9. 2006
    ..These findings suggest that nicotine treatment facilitates the increase in the expression of mRNA and protein of the APP and APLP2 genes in rat brain and SH-SY5Y neuroblastoma cells...
  31. ncbi request reprint Ethnic- and gender-specific association of the nicotinic acetylcholine receptor alpha4 subunit gene (CHRNA4) with nicotine dependence
    Ming D Li
    Hum Mol Genet 14:1211-9. 2005
    ..In summary, our findings provide convincing evidence for the involvement of the nAChR alpha4 subunit, but not of the nAChR beta2 subunit, in nicotine addiction...
  32. ncbi request reprint Comorbid alcohol and nicotine dependence: from the biomolecular basis to clinical consequences
    Nassima Ait-Daoud
    Department of Psychiatric Medicine, University of Virginia, Charlottesville 22908 0623, USA
    Alcohol Clin Exp Res 29:1541-9. 2005
    ..Lesch, MD, PhD; and (5) Pharmacotherapy for Promotion of Abstinence from Nicotine Among Alcohol-Dependent Individuals, by Bankole A. Johnson, DSc, MD, PhD...
  33. ncbi request reprint Microarray technology and its application on nicotine research
    Ming D Li
    Department of Pharmacology, University of Tennessee College of Medicine, Memphis 38163, USA
    Mol Neurobiol 25:265-85. 2002
    ..Lastly, given the early stage of microarray research on nicotine, we elaborate on the need for an efficient analysis of genetic networks to further enhance our understanding of the mechanisms involved in nicotine abuse and addiction...
  34. ncbi request reprint Association of specific haplotypes of neurotrophic tyrosine kinase receptor 2 gene (NTRK2) with vulnerability to nicotine dependence in African-Americans and European-Americans
    Joke Beuten
    Department of Psychiatric Medicine, University of Virginia, Charlottesville, Virginia 22911, USA
    Biol Psychiatry 61:48-55. 2007
    ..However, no association of NTRK2 with ND has been identified...
  35. doi request reprint Association of amyloid precursor protein-binding protein, family B, member 1 with nicotine dependence in African and European American smokers
    Guo Bo Chen
    Institute of Bioinformatics, Zhejiang University, Hangzhou, Zhejiang, People s Republic of China
    Hum Genet 124:393-8. 2008
    ..Based on these findings, we conclude that APBB1 represents an important candidate gene in the genetic study on ND and neurodegenerative diseases and warrants further investigation in future...
  36. ncbi request reprint Setting priorities for genomic research
    Wade Berrettini
    Science 304:1445-7; author reply 1445-7. 2004
  37. pmc Significant association of the neurexin-1 gene (NRXN1) with nicotine dependence in European- and African-American smokers
    Justin Nussbaum
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA, USA
    Hum Mol Genet 17:1569-77. 2008
    ....
  38. ncbi request reprint Correlations between mRNA expression levels and GC contents of coding and untranslated regions of genes in rodents
    Ozlen Konu
    Department of Pharmacology and Molecular Resource Center, University of Tennessee College of Medicine, Memphis, TN 38163, USA
    J Mol Evol 54:35-41. 2002
    ..g., >or=threefold the median expression for R. norvegicus), suggesting that conflicting demands posed by different aspects of transcriptional and translational machineries (e.g., efficiency versus fidelity) may set an upper limit for GC3...
  39. pmc Improvement of mapping accuracy by unifying linkage and association analysis
    Xiang Yang Lou
    Department of Psychiatric Medicine, University of Virginia, Charlottesville, Virginia 22911, USA
    Genetics 172:647-61. 2006
    ..Finally, we apply our methodology to a genetic study on bone mineral density (BMD) for the vitamin D receptor (VDR) gene and find that VDR is significantly linked to BMD at the one-third region of the wrist...
  40. ncbi request reprint Genetic research and smoking behavior
    Laura Jean Bierut
    JAMA 297:809; author reply 810. 2007
  41. ncbi request reprint Molecular cloning, mapping and characterization of a novel mouse RING finger gene, Mrf1
    Ruying Chang
    Department of Pharmacology, University of Tennessee College of Medicine, 874 Union Avenue, Memphis, TN 38163, USA
    Gene 291:241-9. 2002
    ..The possible functions of Mrf1 are discussed in the contexts of protein-protein interactions, oncogenesis and ubiquitination...
  42. ncbi request reprint Association analysis of the protein phosphatase 1 regulatory subunit 1B (PPP1R1B) gene with nicotine dependence in European- and African-American smokers
    Joke Beuten
    Department of Psychiatric Medicine, The University of Virginia, Charlottesville, Virginia 22911, USA
    Am J Med Genet B Neuropsychiatr Genet 144:285-90. 2007
    ..No significant associations with haplotypes were found in the AA sample. In summary, our findings provide the first evidence for the potential involvement of PPP1R1B in the etiology of ND and further investigation is thus warranted...
  43. ncbi request reprint The genetics of nicotine dependence
    Ming D Li
    Department of Psychiatric Medicine, University of Virginia, 1670 Discovery Drive, Suite 110, Charlottesville, VA 22911, USA
    Curr Psychiatry Rep 8:158-64. 2006
    ..As genotyping technology is being improved and well-characterized clinical samples on smoking behavior become available, more and more genes and genetic variants responsible for ND will be identified in the near future...
  44. ncbi request reprint Proteins differentially expressed in response to nicotine in five rat brain regions: identification using a 2-DE/MS-based proteomics approach
    Yoon Y Hwang
    Department of Psychiatric Medicine, University of Virginia, 1670 Discovery Drive, Charlottesville, VA 22911, USA
    Proteomics 6:3138-53. 2006
    ..These data, in combination with microarray analysis of mRNA transcripts, have the potential to identify the CNS gene products that show coordinated changes in expression at both the RNA and protein levels in response to nicotine...
  45. ncbi request reprint Gene-based analysis suggests association of the nicotinic acetylcholine receptor beta1 subunit (CHRNB1) and M1 muscarinic acetylcholine receptor (CHRM1) with vulnerability for nicotine dependence
    Xiang Yang Lou
    Department of Psychiatric Medicine, University of Virginia, 1670 Discovery Drive, Suite 101, Charlottesville, VA 22911, USA
    Hum Genet 120:381-9. 2006
    ..The significant associations, together with their location of linked region to ND, suggest that the CHRNB1 and CHRM1 are likely candidates for further investigation...
  46. ncbi request reprint Regulation by nicotine of Gpr51 and Ntrk2 expression in various rat brain regions
    Dongxiao Sun
    Section of Neurobiology, Department of Psychiatric Medicine, University of Virginia, Charlottesville, VA 22911, USA
    Neuropsychopharmacology 32:110-6. 2007
    ....
  47. ncbi request reprint DOPA decarboxylase gene is associated with nicotine dependence
    Heping Zhang
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520 8034, USA
    Pharmacogenomics 7:1159-66. 2006
    ..Although the heritability of nicotine dependence (ND) is well documented and many candidate genetic regions have been identified, few of them were confirmed. This may be, in part, due to analytic methods that sacrifice power...