Long Cheng Li

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint MethPrimer: designing primers for methylation PCRs
    Long Cheng Li
    Department of Urology, Veterans Affairs Medical Center, and University of California San Francisco, San Francisco, CA 94121, USA
    Bioinformatics 18:1427-31. 2002
  2. ncbi request reprint Ethnic group-related differences in CpG hypermethylation of the GSTP1 gene promoter among African-American, Caucasian and Asian patients with prostate cancer
    Hideki Enokida
    Department of Urology and Pathology, Veterans Affairs Medical Center and University of California, San Francisco, CA 94121, USA
    Int J Cancer 116:174-81. 2005
  3. ncbi request reprint CpG hypermethylation of MDR1 gene contributes to the pathogenesis and progression of human prostate cancer
    Hideki Enokida
    Department of Urology, University of California, San Francisco, California 94121, USA
    Cancer Res 64:5956-62. 2004
  4. ncbi request reprint Cytochrome P450 1B1 is overexpressed and regulated by hypomethylation in prostate cancer
    Takashi Tokizane
    Department of Urology, Veterans Affairs Medical Center and University of California, San Francisco, California 94121, USA
    Clin Cancer Res 11:5793-801. 2005
  5. ncbi request reprint Increased heparanase expression is caused by promoter hypomethylation and up-regulation of transcriptional factor early growth response-1 in human prostate cancer
    Tatsuya Ogishima
    Department of Urology, University of California San Francisco and Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA
    Clin Cancer Res 11:1028-36. 2005
  6. ncbi request reprint Smoking influences aberrant CpG hypermethylation of multiple genes in human prostate carcinoma
    Hideki Enokida
    Department of Urology, Veterans Affairs Medical Center and University of California, San Francisco, California 94121, USA
    Cancer 106:79-86. 2006
  7. ncbi request reprint CpG methylation at promoter site -140 inactivates TGFbeta2 receptor gene in prostate cancer
    Hong Zhao
    Department of Urology, Veterans Affairs Medical Center and University of California San Francisco, San Francisco, California 94121, USA
    Cancer 104:44-52. 2005
  8. ncbi request reprint Epigenetic changes in prostate cancer: implication for diagnosis and treatment
    Long Cheng Li
    Department of Urology, Veterans Affairs Medical Center, and University of California San Francisco, 94121, USA
    J Natl Cancer Inst 97:103-15. 2005
  9. ncbi request reprint Epigenetic inactivation of the dioxin-responsive cytochrome P4501A1 gene in human prostate cancer
    Steven T Okino
    Department of Urology, San Francisco Veterans Affairs Medical Center 4150 Clement Street, San Francisco, CA 94121, USA
    Cancer Res 66:7420-8. 2006
  10. ncbi request reprint Epigenetic inactivation of Wnt inhibitory factor-1 plays an important role in bladder cancer through aberrant canonical Wnt/beta-catenin signaling pathway
    Shinji Urakami
    Department of Urology 112F, Veterans Affairs Medical Center, and University of California at San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA
    Clin Cancer Res 12:383-91. 2006

Collaborators

Detail Information

Publications40

  1. ncbi request reprint MethPrimer: designing primers for methylation PCRs
    Long Cheng Li
    Department of Urology, Veterans Affairs Medical Center, and University of California San Francisco, San Francisco, CA 94121, USA
    Bioinformatics 18:1427-31. 2002
    ..Therefore, the present study was designed to develop a program for such applications...
  2. ncbi request reprint Ethnic group-related differences in CpG hypermethylation of the GSTP1 gene promoter among African-American, Caucasian and Asian patients with prostate cancer
    Hideki Enokida
    Department of Urology and Pathology, Veterans Affairs Medical Center and University of California, San Francisco, CA 94121, USA
    Int J Cancer 116:174-81. 2005
    ..Ours is the first study investigating GSTP1 methylation differences in PC among African-American, Caucasian and Asian...
  3. ncbi request reprint CpG hypermethylation of MDR1 gene contributes to the pathogenesis and progression of human prostate cancer
    Hideki Enokida
    Department of Urology, University of California, San Francisco, California 94121, USA
    Cancer Res 64:5956-62. 2004
    ..These findings suggest that CpG hypermethylation of MDR1 promoter is a frequent event in prostate cancer and is related to disease progression via increased cell proliferation in prostate cancer cells...
  4. ncbi request reprint Cytochrome P450 1B1 is overexpressed and regulated by hypomethylation in prostate cancer
    Takashi Tokizane
    Department of Urology, Veterans Affairs Medical Center and University of California, San Francisco, California 94121, USA
    Clin Cancer Res 11:5793-801. 2005
    ..We hypothesized that promoter/enhancer CpG methylation contributes to the regulation of CYP1B1 expression in human prostate tissue...
  5. ncbi request reprint Increased heparanase expression is caused by promoter hypomethylation and up-regulation of transcriptional factor early growth response-1 in human prostate cancer
    Tatsuya Ogishima
    Department of Urology, University of California San Francisco and Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA
    Clin Cancer Res 11:1028-36. 2005
    ..We hypothesize that CpG hypomethylation in the heparanase promoter coupled with up-regulation of EGR1 levels may induce heparanase expression in human prostate cancer...
  6. ncbi request reprint Smoking influences aberrant CpG hypermethylation of multiple genes in human prostate carcinoma
    Hideki Enokida
    Department of Urology, Veterans Affairs Medical Center and University of California, San Francisco, California 94121, USA
    Cancer 106:79-86. 2006
    ..The authors hypothesized that smoking influences both progression and prognosis of PC through CpG hypermethylation of related genes...
  7. ncbi request reprint CpG methylation at promoter site -140 inactivates TGFbeta2 receptor gene in prostate cancer
    Hong Zhao
    Department of Urology, Veterans Affairs Medical Center and University of California San Francisco, San Francisco, California 94121, USA
    Cancer 104:44-52. 2005
    ..The authors of the current study hypothesized that CpG methylation of the TbetaRII promoter at the Sp1 binding site -140 mediates this loss of TbetaRII expression in prostate cancer...
  8. ncbi request reprint Epigenetic changes in prostate cancer: implication for diagnosis and treatment
    Long Cheng Li
    Department of Urology, Veterans Affairs Medical Center, and University of California San Francisco, 94121, USA
    J Natl Cancer Inst 97:103-15. 2005
    ..In this review, we examine the current literature on epigenetic changes in prostate cancer and discuss the clinical potential of cancer epigenetics for the diagnosis and treatment of this disease...
  9. ncbi request reprint Epigenetic inactivation of the dioxin-responsive cytochrome P4501A1 gene in human prostate cancer
    Steven T Okino
    Department of Urology, San Francisco Veterans Affairs Medical Center 4150 Clement Street, San Francisco, CA 94121, USA
    Cancer Res 66:7420-8. 2006
    ..This is the first report that shows that CYP1A1 is aberrantly hypermethylated in human prostate cancer and has an altered, inaccessible chromatin structure that suppresses its dioxin responsiveness...
  10. ncbi request reprint Epigenetic inactivation of Wnt inhibitory factor-1 plays an important role in bladder cancer through aberrant canonical Wnt/beta-catenin signaling pathway
    Shinji Urakami
    Department of Urology 112F, Veterans Affairs Medical Center, and University of California at San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA
    Clin Cancer Res 12:383-91. 2006
    ..Wnt inhibitory factor-1 (Wif-1) was identified as one of the secreted antagonists that can bind Wnt protein. We hypothesize that Wif-1 plays an important role in bladder cancer pathogenesis...
  11. pmc Small dsRNAs induce transcriptional activation in human cells
    Long Cheng Li
    Department of Urology, Veterans Affairs Medical Center and University of California, San Francisco, CA 94121, USA
    Proc Natl Acad Sci U S A 103:17337-42. 2006
    ..These findings reveal a more diverse role for small RNA molecules in the regulation of gene expression than previously recognized and identify a potential therapeutic use for dsRNA in targeted gene activation...
  12. ncbi request reprint Age-dependent methylation of ESR1 gene in prostate cancer
    Long Cheng Li
    Department of Urology, Veterans Affairs Medical Center, University of California San Francisco, San Francisco, CA 94121, USA
    Biochem Biophys Res Commun 321:455-61. 2004
    ..45; P, 0.018; 95% CI, 1.04-4.26). These findings suggest that methylation of ESR1 is both age-dependent and tumor differentiation-dependent and age-dependent methylation of ESR1 may represent a mechanism linking aging and prostate cancer...
  13. ncbi request reprint CpG hypermethylation of promoter region and inactivation of E-cadherin gene in human bladder cancer
    Leopoldo Alves Ribeiro-Filho
    Department of Urology, San Francisco Veterans Affairs Medical Center and University of California, 94121, USA
    Mol Carcinog 34:187-98. 2002
    ..These findings may provide a better strategy for the diagnosis and management of bladder cancer...
  14. doi request reprint Targeted induction of endogenous NKX3-1 by small activating RNA inhibits prostate tumor growth
    Shancheng Ren
    Department of Urology and Helen Diller Comprehensive Cancer Center, University of California San Francisco, San Francisco, California, USA
    Prostate 73:1591-601. 2013
    ..We used saRNA as a molecular tool to examine NKX3-1's role as a tumor suppressor and tested in vitro and in vivo antitumor effects of NKX3-1 induction by saRNA...
  15. pmc PGDB: a curated and integrated database of genes related to the prostate
    Long Cheng Li
    Department of Urology, Veterans Affairs Medical Center, and University of California San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA
    Nucleic Acids Res 31:291-3. 2003
    ..Detailed expression data calculated from the UniGene and SAGEmap databases are also presented...
  16. pmc Prognostic value and function of KLF4 in prostate cancer: RNAa and vector-mediated overexpression identify KLF4 as an inhibitor of tumor cell growth and migration
    Ji Wang
    Department of Urology and Helen Diller Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California, USA
    Cancer Res 70:10182-91. 2010
    ..These results suggest that KLF4 functions as an inhibitor of tumor cell growth and migration in prostate cancer and decreased expression has prognostic value for predicting prostate cancer metastasis...
  17. pmc Effects of transplantation of adipose tissue-derived stem cells on prostate tumor
    Guiting Lin
    Knuppe Molecular Urology Laboratory, Department of Urology, School of Medicine, University of California, San Francisco, California 94143 0738, USA
    Prostate 70:1066-73. 2010
    ..Obesity is a risk factor for prostate cancer development, but the underlying mechanism is unknown. The present study tested the hypothesis that stromal cells of the adipose tissue might be recruited by cancer cells to help tumor growth...
  18. ncbi request reprint DNA methylation in prostate cancer
    Long Cheng Li
    Department of Urology, Veterans Affairs Medical Center, and University of California San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA
    Biochim Biophys Acta 1704:87-102. 2004
    ..We will also discuss the potential involvement of DNA methylation in age-related, race-related and hereditary prostate cancer, and the potential use of hypermethylated genes as biomarkers to detect prostate cancer and assess its risk...
  19. pmc Formulation of Small Activating RNA Into Lipidoid Nanoparticles Inhibits Xenograft Prostate Tumor Growth by Inducing p21 Expression
    Robert F Place
    1 Department of Urology and Helen Diller Comprehensive Cancer Center, University of California, San Francisco, California, USA 2 RNA Therapeutics, Inc, San Francisco, California, USA
    Mol Ther Nucleic Acids 1:e15. 2012
    ..Our results provide proof-of-principle that RNAa in conjunction with lipidioids may represent a novel approach for stimulating gene expression in vivo to treat disease...
  20. pmc Upregulation of Cyclin B1 by miRNA and its implications in cancer
    Vera Huang
    Department of Urology and Helen Diller Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94158, USA
    Nucleic Acids Res 40:1695-707. 2012
    ..Such phenotypes were recapitulated by overexpression of Ccnb1. Our findings reveal an endogenous system by which miRNA functions to activate Ccnb1 expression in mouse cells and manipulate in vivo tumor development/growth...
  21. ncbi request reprint Designing PCR primer for DNA methylation mapping
    Long Cheng Li
    Department of Urology, Veterans Affairs Medical Center and University of California, San Francisco, USA
    Methods Mol Biol 402:371-84. 2007
    ..Results of primer selection are delivered through a Web browser in text and graphic views. This chapter discusses the process of using MethPrimer to design BSP and MSP primers...
  22. pmc Induction of NANOG expression by targeting promoter sequence with small activating RNA antagonizes retinoic acid-induced differentiation
    Xiaoling Wang
    Department of Urology, University of California San Francisco, San Francisco, CA 94158, USA
    Biochem J 443:821-8. 2012
    ..Ectopic overexpression of NANOG via lentiviral transduction further recapitulates saRNA results, providing proof-of-concept that RNAa may be utilized to activate development-related genes and manipulate cell fate...
  23. ncbi request reprint Kidney gene database: a curated and integrated database of genes involved in kidney disease
    Hong Zhao
    Department of Urology, Veterans Affairs Medical Center and University of California San Francisco, San Francisco, California 94121, USA
    J Urol 172:2344-6. 2004
    ..We have created a curated and integrated database, the Kidney Gene Database (KGDB) (http://www.urogene.org/kgdb) that contains current information about genes or genomic loci involved in human kidney disease...
  24. ncbi request reprint Transforming growth factor-beta(s) and their receptors in aging rat prostate
    Hong Zhao
    Department of Urology, Veterans Affairs Medical Center, University of California San Francisco, San Francisco, CA 94121, USA
    Biochem Biophys Res Commun 294:464-9. 2002
    ..These findings are important in understanding the mechanisms of UGM mediated prostatic growth...
  25. pmc MicroRNA-373 induces expression of genes with complementary promoter sequences
    Robert F Place
    Department of Urology, Veterans Affairs Medical Center and University of California, San Francisco, CA 94121, USA
    Proc Natl Acad Sci U S A 105:1608-13. 2008
    ..In conclusion, we have identified a miRNA that targets promoter sequences and induces gene expression. These findings reveal a new mode by which miRNAs may regulate gene expression...
  26. ncbi request reprint The E-cadherin -160 C/A polymorphism and prostate cancer risk in white and black American men
    Deepa Pookot
    Department of Urology, Veterans Affairs Medical Center and University of California San Francisco, 94121, USA
    J Urol 176:793-6. 2006
    ..We hypothesized that allelic variation at this site may be associated with racial differences in the incidence and severity of prostate cancer...
  27. pmc RNAa is conserved in mammalian cells
    Vera Huang
    Helen Diller Comprehensive Cancer Center, University of California San Francisco, San Francisco, California, USA
    PLoS ONE 5:e8848. 2010
    ..Thus far, RNAa has only been demonstrated in human cells and is unclear whether it is conserved in other mammals...
  28. ncbi request reprint Chromatin changes on the GSTP1 promoter associated with its inactivation in prostate cancer
    Steven T Okino
    Department of Urology, San Francisco Veterans Affairs Medical Center and the University of California San Francisco, San Francisco, California 94121, USA
    Mol Carcinog 46:839-46. 2007
    ..We conclude that, in the process of prostate carcinogenesis, activating histone modifications on GSTP1 are lost and the DNA becomes methylated and inaccessible resulting in transcriptional silencing...
  29. ncbi request reprint The multifaceted small RNAs
    Long Cheng Li
    Department of Urology, University of California San Francisco, San Francisco, California 94143, USA
    RNA Biol 5:61-4. 2008
    ..These two opposing activities of gene silencing and activation together constitute an integrated gene regulatory mechanism...
  30. pmc Targeted p21WAF1/CIP1 activation by RNAa inhibits hepatocellular carcinoma cells
    Mika Kosaka
    Department of Urology and Helen Diller Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA
    Nucleic Acid Ther 22:335-43. 2012
    ..This study suggests that targeted activation of p21 by RNAa may be explored as a novel therapy for the treatment of HCC...
  31. pmc miRNA goes nuclear
    Vera Huang
    Department of Urology and Helen Diller Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA
    RNA Biol 9:269-73. 2012
    ..In this point-of-view, we will specifically focus on the nuclear functions of miRNAs and discuss examples of miRNA-directed transcriptional gene regulation identified in recent years...
  32. pmc Defining features and exploring chemical modifications to manipulate RNAa activity
    Robert F Place
    Helen Diller Comprehensive Cancer Center, Department of Urology, University of California, PO Box 589001, San Francisco, CA 94158 9001, USA
    Curr Pharm Biotechnol 11:518-26. 2010
    ..These findings reveal functional features of RNAa that may be utilized to augment saRNA function for mechanistic studies or the development of RNAa-based drugs...
  33. ncbi request reprint Epigenetics of prostate cancer
    Long Cheng Li
    Department of Urology, University of California San Francisco and Veterans Affairs Medical Center San Francisco, San Francisco, CA 94121, USA
    Front Biosci 12:3377-97. 2007
    ..In this chapter, we examined the current literature regarding epigenetic changes in prostate cancer and discuss the clinical potential of cancer epigenetics for the diagnosis and treatment of this disease...
  34. doi request reprint Intravesical delivery of small activating RNA formulated into lipid nanoparticles inhibits orthotopic bladder tumor growth
    Moo Rim Kang
    Department of Urology and Helen Diller Comprehensive Cancer Center, University of California, San Francisco, California, USA
    Cancer Res 72:5069-79. 2012
    ..Our results provide preclinical proof-of-concept for a novel method to treat bladder cancer by intravesical administration of LNP-formulated RNA duplexes...
  35. pmc MicroRNA regulation of neuron-like differentiation of adipose tissue-derived stem cells
    Hongxiu Ning
    Knuppe Molecular Urology Laboratory, Department of Urology, School of Medicine, University of California, San Francisco, CA 94143 0738, USA
    Differentiation 78:253-9. 2009
    ..Thus, IGF-I signaling and miR-133b co-regulate potential neural differentiation of ADSC through a feedback mechanism, in which IGF-I upregulates miR-133b while miR-133b in turn downregulates IGF-IR...
  36. doi request reprint Adaptation and clonal selection models of castration-resistant prostate cancer: current perspective
    Muhammed Ahmed
    Department of Urology and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA
    Int J Urol 20:362-71. 2013
    ..Here we review existing knowledge and current research findings addressing the timing of events in the course of prostate cancer progression to castration-resistant prostate cancer...
  37. ncbi request reprint Multigene methylation analysis for detection and staging of prostate cancer
    Hideki Enokida
    Department of Urology, Veterans Affairs Medical Center, University of California, San Francisco, CA 94121, USA
    Clin Cancer Res 11:6582-8. 2005
    ..We hypothesize that a new method of multigene methylation analysis could be a good diagnostic and staging biomarker for prostate cancer...
  38. doi request reprint Antitumor effect of dsRNA-induced p21(WAF1/CIP1) gene activation in human bladder cancer cells
    Zhong Chen
    Department of Urology, University of California San Francisco, San Francisco, CA 94143, USA
    Mol Cancer Ther 7:698-703. 2008
    ..In conclusion, p21 activation by RNAa has antitumor activity in vitro in bladder cancer cells. These results suggest that RNAa could be used for cancer treatment by targeted activation of tumor suppressor genes...
  39. ncbi request reprint Association between a C/A single nucleotide polymorphism of the E-cadherin gene promoter and transitional cell carcinoma of the bladder
    Xu Zhang
    Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People s Republic of China
    J Urol 170:1379-82. 2003
    ..We investigated whether a C/A single nucleotide polymorphism at position -160 from the transcription start site of the E-cadherin gene promoter is associated with transitional cell carcinoma of the bladder (TCCB)...
  40. ncbi request reprint Functional Loss of the gamma-catenin gene through epigenetic and genetic pathways in human prostate cancer
    Hiroaki Shiina
    Department of Urology, Shimane University School of Medicine, Izumo, Japan
    Cancer Res 65:2130-8. 2005
    ..The gamma-catenin mutation related to Bcl-2 overexpression has a significant effect on the pathogenesis of HRPC. This is the first report to characterize the epigenetic and genetic regulation of gamma-catenin in human prostate cancer...