Research Topics
| LONG CHENG contact LISummaryAffiliation: University of California Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
The multifaceted small RNAsLong Cheng Li
Department of Urology, University of California San Francisco, San Francisco, California 94143, USA
RNA Biol 5:61-4. 2008..These two opposing activities of gene silencing and activation together constitute an integrated gene regulatory mechanism...- MethPrimer: designing primers for methylation PCRsLong Cheng Li
Department of Urology, Veterans Affairs Medical Center, and University of California San Francisco, San Francisco, CA 94121, USA
Bioinformatics 18:1427-31. 2002..Primers are then picked around the predicted CpG islands or around regions specified by users. MethPrimer can design primers for BSP and MSP. Results of primer selection are delivered through a web browser in text and in graphic view... - Designing PCR primer for DNA methylation mappingLong Cheng Li
Department of Urology, Veterans Affairs Medical Center and University of California, San Francisco, USA
Methods Mol Biol 402:371-84. 2007..Results of primer selection are delivered through a Web browser in text and graphic views. This chapter discusses the process of using MethPrimer to design BSP and MSP primers... - Epigenetics of prostate cancerLong Cheng Li
Department of Urology, University of California San Francisco and Veterans Affairs Medical Center San Francisco, San Francisco, CA 94121, USA
Front Biosci 12:3377-97. 2007..In this chapter, we examined the current literature regarding epigenetic changes in prostate cancer and discuss the clinical potential of cancer epigenetics for the diagnosis and treatment of this disease... 
Small dsRNAs induce transcriptional activation in human cellsLong Cheng Li
Department of Urology, Veterans Affairs Medical Center and University of California, San Francisco, CA 94121, USA
Proc Natl Acad Sci U S A 103:17337-42. 2006..These findings reveal a more diverse role for small RNA molecules in the regulation of gene expression than previously recognized and identify a potential therapeutic use for dsRNA in targeted gene activation...- Epigenetic changes in prostate cancer: implication for diagnosis and treatmentLong-Cheng Li
Department of Urology, Veterans Affairs Medical Center, and University of California San Francisco, 94121, USA
J Natl Cancer Inst 97:103-15. 2005..In this review, we examine the current literature on epigenetic changes in prostate cancer and discuss the clinical potential of cancer epigenetics for the diagnosis and treatment of this disease... - CpG hypermethylation of promoter region and inactivation of E-cadherin gene in human bladder cancerLeopoldo Alves Ribeiro-Filho
Department of Urology, San Francisco Veterans Affairs Medical Center and University of California, 94121, USA
Mol Carcinog 34:187-98. 2002..These findings may provide a better strategy for the diagnosis and management of bladder cancer... - Increased heparanase expression is caused by promoter hypomethylation and up-regulation of transcriptional factor early growth response-1 in human prostate cancerTatsuya Ogishima
Department of Urology, University of California San Francisco and Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA
Clin Cancer Res 11:1028-36. 2005..We hypothesize that CpG hypomethylation in the heparanase promoter coupled with up-regulation of EGR1 levels may induce heparanase expression in human prostate cancer... - DNA methylation in prostate cancerLong-Cheng Li
Department of Urology, Veterans Affairs Medical Center, and University of California San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA
Biochim Biophys Acta 1704:87-102. 2004..We will also discuss the potential involvement of DNA methylation in age-related, race-related and hereditary prostate cancer, and the potential use of hypermethylated genes as biomarkers to detect prostate cancer and assess its risk... - CpG hypermethylation of MDR1 gene contributes to the pathogenesis and progression of human prostate cancerHideki Enokida
Department of Urology, University of California, San Francisco, California 94121, USA
Cancer Res 64:5956-62. 2004..These findings suggest that CpG hypermethylation of MDR1 promoter is a frequent event in prostate cancer and is related to disease progression via increased cell proliferation in prostate cancer cells... - Smoking influences aberrant CpG hypermethylation of multiple genes in human prostate carcinomaHideki Enokida
Department of Urology, Veterans Affairs Medical Center and University of California, San Francisco, California 94121, USA
Cancer 106:79-86. 2006..Smoking status may influence both progression and prognosis of PC through CpG hypermethylation of related genes... - Multigene methylation analysis for detection and staging of prostate cancerHideki Enokida
Department of Urology, Veterans Affairs Medical Center, University of California, San Francisco, CA 94121, USA
Clin Cancer Res 11:6582-8. 2005..010). CONCLUSIONS: This is the first report demonstrating that M score is a new method for multigene methylation analysis that can serve as a good diagnostic and staging biomarker for prostate cancer... - Age-dependent methylation of ESR1 gene in prostate cancerLong Cheng Li
Department of Urology, Veterans Affairs Medical Center, University of California San Francisco, San Francisco, CA 94121, USA
Biochem Biophys Res Commun 321:455-61. 2004..45; P, 0.018; 95% CI, 1.04-4.26). These findings suggest that methylation of ESR1 is both age-dependent and tumor differentiation-dependent and age-dependent methylation of ESR1 may represent a mechanism linking aging and prostate cancer... - CpG methylation at promoter site -140 inactivates TGFbeta2 receptor gene in prostate cancerHong Zhao
Department of Urology, Veterans Affairs Medical Center and University of California San Francisco, San Francisco, California 94121, USA
Cancer 104:44-52. 2005..Treatment with 5-aza-2' deoxycytidine can restore gene expression. The current study results report the first association between prostate cancer and loss of the TGF- beta signaling pathway by TbetaRII DNA promoter methylation... - Ethnic group-related differences in CpG hypermethylation of the GSTP1 gene promoter among African-American, Caucasian and Asian patients with prostate cancerHideki Enokida
Department of Urology and Pathology, Veterans Affairs Medical Center and University of California, San Francisco, CA 94121, USA
Int J Cancer 116:174-81. 2005..Ours is the first study investigating GSTP1 methylation differences in PC among African-American, Caucasian and Asian... - MicroRNA-373 induces expression of genes with complementary promoter sequencesRobert F Place
Department of Urology, Veterans Affairs Medical Center and University of California, San Francisco, CA 94121, USA
Proc Natl Acad Sci U S A 105:1608-13. 2008..In conclusion, we have identified a miRNA that targets promoter sequences and induces gene expression. These findings reveal a new mode by which miRNAs may regulate gene expression... - Epigenetic inactivation of the dioxin-responsive cytochrome P4501A1 gene in human prostate cancerSteven T Okino
Department of Urology, San Francisco Veterans Affairs Medical Center 4150 Clement Street, San Francisco, CA 94121, USA
Cancer Res 66:7420-8. 2006..This is the first report that shows that CYP1A1 is aberrantly hypermethylated in human prostate cancer and has an altered, inaccessible chromatin structure that suppresses its dioxin responsiveness... - PGDB: a curated and integrated database of genes related to the prostateLong-Cheng Li
Department of Urology, Veterans Affairs Medical Center, and University of California San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA
Nucleic Acids Res 31:291-3. 2003..Detailed expression data calculated from the UniGene and SAGEmap databases are also presented... - The E-cadherin -160 C/A polymorphism and prostate cancer risk in white and black American menDeepa Pookot
Department of Urology, Veterans Affairs Medical Center and University of California San Francisco, 94121, USA
J Urol 176:793-6. 2006..We hypothesized that allelic variation at this site may be associated with racial differences in the incidence and severity of prostate cancer... - Epigenetic inactivation of Wnt inhibitory factor-1 plays an important role in bladder cancer through aberrant canonical Wnt/beta-catenin signaling pathwayShinji Urakami
Department of Urology 112F, Veterans Affairs Medical Center, and University of California at San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA
Clin Cancer Res 12:383-91. 2006..Wnt inhibitory factor-1 (Wif-1) was identified as one of the secreted antagonists that can bind Wnt protein. We hypothesize that Wif-1 plays an important role in bladder cancer pathogenesis... - Cytochrome P450 1B1 is overexpressed and regulated by hypomethylation in prostate cancerTakashi Tokizane
Department of Urology, Veterans Affairs Medical Center and University of California, San Francisco, California 94121, USA
Clin Cancer Res 11:5793-801. 2005..We hypothesized that promoter/enhancer CpG methylation contributes to the regulation of CYP1B1 expression in human prostate tissue... - Chromatin changes on the GSTP1 promoter associated with its inactivation in prostate cancerSteven T Okino
Department of Urology, San Francisco Veterans Affairs Medical Center and the University of California San Francisco, San Francisco, California 94121, USA
Mol Carcinog 46:839-46. 2007..We conclude that, in the process of prostate carcinogenesis, activating histone modifications on GSTP1 are lost and the DNA becomes methylated and inaccessible resulting in transcriptional silencing... 
Antitumor effect of dsRNA-induced p21(WAF1/CIP1) gene activation in human bladder cancer cellsZhong Chen
Department of Urology, University of California San Francisco, San Francisco, CA 94143, USA
Mol Cancer Ther 7:698-703. 2008..In conclusion, p21 activation by RNAa has antitumor activity in vitro in bladder cancer cells. These results suggest that RNAa could be used for cancer treatment by targeted activation of tumor suppressor genes...- Association between a C/A single nucleotide polymorphism of the E-cadherin gene promoter and transitional cell carcinoma of the bladderXu Zhang
Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People s Republic of China
J Urol 170:1379-82. 2003..We investigated whether a C/A single nucleotide polymorphism at position -160 from the transcription start site of the E-cadherin gene promoter is associated with transitional cell carcinoma of the bladder (TCCB)... - Functional Loss of the gamma-catenin gene through epigenetic and genetic pathways in human prostate cancerHiroaki Shiina
Department of Urology, Shimane University School of Medicine, Izumo, Japan
Cancer Res 65:2130-8. 2005..The gamma-catenin mutation related to Bcl-2 overexpression has a significant effect on the pathogenesis of HRPC. This is the first report to characterize the epigenetic and genetic regulation of gamma-catenin in human prostate cancer...
Research Grants
- Transcriptional Activation by Small RNA: Mechanism and Design RulesLong Cheng Li; Fiscal Year: 2009....
- Transcriptional Activation by Small RNA: Mechanism and Design RulesLONG CHENG contact LI; Fiscal Year: 2010....