Ling Li

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. pmc Toll-like receptor 4-dependent upregulation of cytokines in a transgenic mouse model of Alzheimer's disease
    Jing Ji Jin
    Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, Box 1649, Peoria, IL 61656, USA
    J Neuroinflammation 5:23. 2008
  2. ncbi request reprint Double belt structure of discoidal high density lipoproteins: molecular basis for size heterogeneity
    Ling Li
    Department of Medicine, UAB Medical Center, Birmingham, AL 35294, USA
    J Mol Biol 343:1293-311. 2004
  3. pmc Association of aortic atherosclerosis with cerebral beta-amyloidosis and learning deficits in a mouse model of Alzheimer's disease
    Ling Li
    Departments of Medicine, Pharmacology, and Genetics, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Am J Pathol 163:2155-64. 2003
  4. pmc Plasma carboxyl ester lipase activity modulates apolipoprotein B-containing lipoprotein metabolism in a transgenic mouse model
    Ling Li
    Laboratory of Lipoprotein Research, Cardiovascular Institute, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Metabolism 57:1361-8. 2008
  5. pmc Cognitive performance and plasma levels of homocysteine, vitamin B12, folate and lipids in patients with Alzheimer disease
    Ling Li
    Division of Gerontology, Geriatrics, and Palliative Care, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Dement Geriatr Cogn Disord 26:384-90. 2008
  6. ncbi request reprint Simvastatin enhances learning and memory independent of amyloid load in mice
    Ling Li
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA
    Ann Neurol 60:729-39. 2006
  7. doi request reprint Oral apolipoprotein A-I mimetic peptide improves cognitive function and reduces amyloid burden in a mouse model of Alzheimer's disease
    Shaila P Handattu
    Atherosclerosis Research Unit and Department of Medicine, University of Alabama at Birmingham Medical Center, Birmingham, AL 35294, USA
    Neurobiol Dis 34:525-34. 2009
  8. pmc Structures of discoidal high density lipoproteins: a combined computational-experimental approach
    Feifei Gu
    Department of Medicine and Atherosclerosis Research Unit, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Biol Chem 285:4652-65. 2010
  9. ncbi request reprint Lack of LDL receptor aggravates learning deficits and amyloid deposits in Alzheimer transgenic mice
    Dongfeng Cao
    Atherosclerosis Research Unit, Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Alabama at Birmingham, 1530 3rd Avenue South, BDB 658, Birmingham, AL 35294, USA
    Neurobiol Aging 27:1632-43. 2006
  10. pmc Thermal stability of apolipoprotein A-I in high-density lipoproteins by molecular dynamics
    Martin K Jones
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Biophys J 96:354-71. 2009

Collaborators

Detail Information

Publications67

  1. pmc Toll-like receptor 4-dependent upregulation of cytokines in a transgenic mouse model of Alzheimer's disease
    Jing Ji Jin
    Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, Box 1649, Peoria, IL 61656, USA
    J Neuroinflammation 5:23. 2008
    ..Here, we investigated the roles of TLR4 in Abeta-induced upregulation of cytokines and chemokines, Abeta-induced activation of microglia and astrocytes and Abeta-induced immigration of leukocytes...
  2. ncbi request reprint Double belt structure of discoidal high density lipoproteins: molecular basis for size heterogeneity
    Ling Li
    Department of Medicine, UAB Medical Center, Birmingham, AL 35294, USA
    J Mol Biol 343:1293-311. 2004
    ..Although we consider these results to favor the double belt model, the topographically very similar hairpin-belt model cannot be ruled out entirely...
  3. pmc Association of aortic atherosclerosis with cerebral beta-amyloidosis and learning deficits in a mouse model of Alzheimer's disease
    Ling Li
    Departments of Medicine, Pharmacology, and Genetics, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Am J Pathol 163:2155-64. 2003
    ..Our results suggest that synergistic mechanisms may be involved in the pathogenesis of atherosclerosis and AD. These findings may have important implications in the prevention and treatment of cardiovascular diseases as well as AD...
  4. pmc Plasma carboxyl ester lipase activity modulates apolipoprotein B-containing lipoprotein metabolism in a transgenic mouse model
    Ling Li
    Laboratory of Lipoprotein Research, Cardiovascular Institute, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Metabolism 57:1361-8. 2008
    ..In summary, our results demonstrate that plasma CEL modulates apo B-Lp metabolism in vivo, resulting in reduced VLDL clearance and elevated plasma cholesterol levels...
  5. pmc Cognitive performance and plasma levels of homocysteine, vitamin B12, folate and lipids in patients with Alzheimer disease
    Ling Li
    Division of Gerontology, Geriatrics, and Palliative Care, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Dement Geriatr Cogn Disord 26:384-90. 2008
    ..The objective of this study was to determine the relationship between cognitive performance and plasma levels of tHcy and its biological determinants folate and vitamin B(12), and lipids in clinically diagnosed AD patients...
  6. ncbi request reprint Simvastatin enhances learning and memory independent of amyloid load in mice
    Ling Li
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA
    Ann Neurol 60:729-39. 2006
    ..Our objective was to determine whether administering a statin drug (simvastatin) would protect against the development of behavioral deficits in an established mouse model of Alzheimer's disease...
  7. doi request reprint Oral apolipoprotein A-I mimetic peptide improves cognitive function and reduces amyloid burden in a mouse model of Alzheimer's disease
    Shaila P Handattu
    Atherosclerosis Research Unit and Department of Medicine, University of Alabama at Birmingham Medical Center, Birmingham, AL 35294, USA
    Neurobiol Dis 34:525-34. 2009
    ..These results suggest that the apo A-I mimetic peptide inhibits amyloid beta deposition and improves cognitive function via exerting anti-inflammatory properties in the brain...
  8. pmc Structures of discoidal high density lipoproteins: a combined computational-experimental approach
    Feifei Gu
    Department of Medicine and Atherosclerosis Research Unit, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Biol Chem 285:4652-65. 2010
    ..We propose that apoA-I incorporates increasing PL in the form of minimal surface bilayers through the incremental unwinding of an initially twisted saddle-shaped apoA-I double belt structure...
  9. ncbi request reprint Lack of LDL receptor aggravates learning deficits and amyloid deposits in Alzheimer transgenic mice
    Dongfeng Cao
    Atherosclerosis Research Unit, Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Alabama at Birmingham, 1530 3rd Avenue South, BDB 658, Birmingham, AL 35294, USA
    Neurobiol Aging 27:1632-43. 2006
    ..Our results suggest that the LDLR plays a role in the development of Alzheimer-type learning impairment and amyloidosis and can be a novel therapeutic target for AD...
  10. pmc Thermal stability of apolipoprotein A-I in high-density lipoproteins by molecular dynamics
    Martin K Jones
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Biophys J 96:354-71. 2009
    ..Since HDL remodeling is necessary for cholesterol transport, our model for remodeling has substantial biomedical implications...
  11. pmc Structure of spheroidal HDL particles revealed by combined atomistic and coarse-grained simulations
    Andrea Catte
    Department of Medicine and Center for Computational and Structural Biology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Biophys J 94:2306-19. 2008
    ..We propose that the interaction of annular cholesteryl oleate molecules contributes to apoA-I rigidity stabilizing and regulating the structure and function of the ms-HDL particle...
  12. pmc Dynamics of activation of lecithin:cholesterol acyltransferase by apolipoprotein A-I
    Martin K Jones
    Department of Medicine and Atherosclerosis Research Unit, University ofAlabama, Birmingham, Alabama 35294, USA
    Biochemistry 48:11196-210. 2009
    ..This hypothesis is currently being tested by site-directed mutagenesis...
  13. pmc Overexpression of human apolipoprotein A-I preserves cognitive function and attenuates neuroinflammation and cerebral amyloid angiopathy in a mouse model of Alzheimer disease
    Terry L Lewis
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Biol Chem 285:36958-68. 2010
    ..These findings suggest that elevating plasma apoA-I/HDL levels may be an effective approach to preserve cognitive function in patients with AD...
  14. pmc "Sticky" and "promiscuous", the yin and yang of apolipoprotein A-I termini in discoidal high-density lipoproteins: a combined computational-experimental approach
    Martin K Jones
    Department of Medicine and Atherosclerosis Research Unit, University of Alabama at Birmingham, Birmingham, Alabama 35294, United States
    Biochemistry 50:2249-63. 2011
    ....
  15. ncbi request reprint Intake of sucrose-sweetened water induces insulin resistance and exacerbates memory deficits and amyloidosis in a transgenic mouse model of Alzheimer disease
    Dongfeng Cao
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Biol Chem 282:36275-82. 2007
    ..These data underscore the potential role of dietary sugar in the pathogenesis of AD and suggest that controlling the consumption of sugar-sweetened beverages may be an effective way to curtail the risk of developing AD...
  16. ncbi request reprint Lipoprotein-like particles and cholesteryl esters in human Bruch's membrane: initial characterization
    Chuan ming Li
    Department of Ophthalmology, University of Alabama School of Medicine, Birmingham, AL 35294 009, USA
    Invest Ophthalmol Vis Sci 46:2576-86. 2005
    ..To isolate and characterize cholesteryl ester-containing, lipoprotein-like particles (LLPs) from normal aged human Bruch's membrane (BrM)/choroid (Ch)...
  17. pmc Rotational and hinge dynamics of discoidal high density lipoproteins probed by interchain disulfide bond formation
    Ling Li
    Department of Medicine and Atherosclerosis Research Unit, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Biochim Biophys Acta 1821:481-9. 2012
    ..g., in smaller particles or perhaps following binding of the enzyme LCAT. This article is part of a Special Issue entitled Advances in High Density Lipoprotein Formation and Metabolism: A Tribute to John F. Oram (1945-2010)...
  18. pmc Assessment of the validity of the double superhelix model for reconstituted high density lipoproteins: a combined computational-experimental approach
    Martin K Jones
    Department of Medicine and Atherosclerosis Research Unit, University of Alabama, Birmingham, Alabama 35294, USA
    J Biol Chem 285:41161-71. 2010
    ..Rather, we conclude that all evidence supports the likelihood that reconstituted apoA-I/HDL particles, in general, are discoidal in shape...
  19. pmc Novel changes in discoidal high density lipoprotein morphology: a molecular dynamics study
    Andrea Catte
    Department of Medicine, and Center for Computational and Structural Biology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Biophys J 90:4345-60. 2006
    ..The lipids of the 100:2 particle family form minimal surfaces at their monolayer-monolayer interface, whereas the 50:2 particle family displays a lipid pocket capable of binding a dynamic range of phospholipid molecules...
  20. pmc Therapeutic potential and anti-amyloidosis mechanisms of tert-butylhydroquinone for Alzheimer's disease
    Hasina Akhter
    Department of Environmental Health Sciences, School of Public Health, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Alzheimers Dis 26:767-78. 2011
    ..Collectively, our data suggest that TBHQ may have therapeutic potential for AD by increasing brain antioxidant capacity/reducing oxidative stress level and by stimulating Aβ degradation/clearance pathways...
  21. pmc Role of toll-like receptor signalling in Abeta uptake and clearance
    Kazuki Tahara
    Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, Peoria, IL 61656, USA
    Brain 129:3006-19. 2006
    ..These results suggest that TLR signalling pathway(s) may be involved in clearance of Abeta-deposits in the brain and that TLRs can be a therapeutic target for Alzheimer's disease...
  22. ncbi request reprint Renal and bone marrow cells fuse after renal ischemic injury
    Ling Li
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9063, USA
    J Am Soc Nephrol 18:3067-77. 2007
  23. ncbi request reprint A global double-fluorescent Cre reporter mouse
    Mandar Deepak Muzumdar
    Howard Hughes Medical Institute, Stanford University, Stanford, California 94305, USA
    Genesis 45:593-605. 2007
    ..In addition to serving as a global Cre reporter, the mT/mG mouse may also be used as a tool for lineage tracing, transplantation studies, and analysis of cell morphology in vivo...
  24. ncbi request reprint Brain-derived neurotrophic factor rescues neurons from bacterial meningitis
    Ling Li
    Department of Pediatrics, First Affiliated Hospital of Kunming Medical College, Kunming, China
    Pediatr Neurol 36:324-9. 2007
    ..The administration of exogenous BDNF may be a new and effective way to decrease mortality and improve sequelae following bacterial meningitis...
  25. ncbi request reprint Age-associated loss in adiponectin-activation by caloric restriction: lack of compensation by enhanced inducibility of adiponectin paralogs CTRP2 and CTRP7
    Susanne Rohrbach
    The Institute of Pathophysiology of Martin Luther University Halle Wittenberg, Ernst Grube Strasse 40, 06097 Halle, Germany
    Mol Cell Endocrinol 277:26-34. 2007
    ..Thus, the improvement in insulin sensitivity appears to be independent of adiponectin induction by caloric restriction in this model...
  26. ncbi request reprint Effect of S-diclofenac, a novel hydrogen sulfide releasing derivative, on carrageenan-induced hindpaw oedema formation in the rat
    Jenab Sidhapuriwala
    Department of Pharmacology, Cardiovascular Biology Research Group, Yong Loo Lin School of Medicine, National University of Singapore, 18 Medical Drive, Singapore, 117597, Singapore
    Eur J Pharmacol 569:149-54. 2007
    ..It is proposed that the enhanced anti-inflammatory effect of S-diclofenac relates to its ability to release H(2)S at the inflamed site. These data provide evidence for an anti-inflammatory effect of H(2)S...
  27. ncbi request reprint Surgical treatment of epilepsy with chronic cerebral granuloma caused by Schistosoma japonicum
    Ting Lei
    Department of Neurosurgery, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, People s Republic of China
    Epilepsia 49:73-9. 2008
    ..To study the surgical treatment of epilepsy with cerebral granuloma caused by Schistosoma japonicum...
  28. doi request reprint Inactivation of microbial arginine deiminases by L-canavanine
    Ling Li
    Department of Chemistry and Chemical Biology, University of New Mexico, Albuquerque, New Mexico 87131, USA
    J Am Chem Soc 130:1918-31. 2008
    ..cereus ADI from the time controlled inhibition observed with the P. aeruginosa, E. coli, B. mallei, and G. intestinalis ADIs...
  29. pmc Acute kidney injury and aberrant planar cell polarity induce cyst formation in mice lacking renal cilia
    Vishal Patel
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Hum Mol Genet 17:1578-90. 2008
    ..We conclude that primary cilia are required for the maintenance of planar cell polarity in the mammalian kidney and that acute kidney injury exacerbates cystic disease...
  30. ncbi request reprint Drosophila's insulin/PI3-kinase pathway coordinates cellular metabolism with nutritional conditions
    Jessica S Britton
    Molecular and Cellular Biology Program, Seattle, WA 98109, USA
    Dev Cell 2:239-49. 2002
    ..Hence we surmise that an essential function of insulin/PI3K signaling in Drosophila is to coordinate cellular metabolism with nutritional conditions...
  31. doi request reprint Evaluation of renal ischemia-reperfusion injury in rabbits using microbubbles targeted to activated neutrophils
    Xiang xiang Jing
    Department of Ultrasonography, Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, PR China
    Clin Imaging 32:178-82. 2008
    ....
  32. doi request reprint Hydrolysis and soil sorption of insecticide pyraclofos
    Huayun Yang
    Research Center of Environmental Science, Zhejiang University of Technology, Hangzhou, People s Republic of China
    J Environ Sci Health B 43:219-23. 2008
    ..4, 6.7, 5.3, and 7.1, respectively. These results suggest that the sorption of pyraclofos on the tested soils was relatively weak...
  33. doi request reprint The electrostatic driving force for nucleophilic catalysis in L-arginine deiminase: a combined experimental and theoretical study
    Ling Li
    Department of Chemistry and Chemical Biology, University of New Mexico, Albuquerque, NM 87131, USA
    Biochemistry 47:4721-32. 2008
    ....
  34. doi request reprint Postmortem confirmation of Lyme carditis with polymerase chain reaction
    Fabio Tavora
    Department of Pulmonary and Mediastinal Pathology, Armed Forces Institute of Pathology, Washington, DC, USA
    Cardiovasc Pathol 17:103-7. 2008
    ..Cardiac involvement in Lyme disease is uncommon and typically manifests clinically by conduction disturbances. Postmortem identification of Borrelia burgdorferi has never been reported in a case of Lyme carditis...
  35. doi request reprint Divergence of function in the hot dog fold enzyme superfamily: the bacterial thioesterase YciA
    Zhihao Zhuang
    Department of Chemistry, University of New Mexico, Albuquerque, New Mexico 81713, USA
    Biochemistry 47:2789-96. 2008
    ..We conclude that YciA is responsible for the efficient, "seemingly" indiscriminant, CoA-regulated hydrolysis of cellular acyl-CoA thioesters in a wide range of bacteria and hypothesize that this activity may support membrane biogenesis...
  36. ncbi request reprint Diabetic vasculopathy and the lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1)
    Geneviève Renie
    CHUM Research Centre, Vascular Immunology Laboratory, Notre Dame Hospital, Department of Medicine, University of Montreal, Montreal, Quebec, Canada
    Curr Diabetes Rev 3:103-10. 2007
    ....
  37. pmc ABCA1 polymorphisms and Alzheimer's disease
    Fabienne Wavrant-De Vrieze
    Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, 35 Convent Drive, Room 1A1015 MSC 3707, Bethesda, MD 20892 3707, USA
    Neurosci Lett 416:180-3. 2007
    ..We show an apparent weak association of rs2230806 (p-value=0.01) with the disease in a sibpair series of Alzheimer's disease that had shown previously evidence for linkage to the chromosome 9 locus where ABCA1 maps...
  38. pmc The Trithorax group protein Lid is a trimethyl histone H3K4 demethylase required for dMyc-induced cell growth
    Julie Secombe
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Genes Dev 21:537-51. 2007
    ..Because Myc binding is associated with high levels of trimethylated H3K4, we propose that the Lid-dMyc complex facilitates Myc binding to, or maintenance of, this chromatin context...
  39. pmc Recombinant chimeric antibody hCAb as a novel anti-human colorectal carcinoma agent
    Hua Xiong
    Cell Engineering Research Center, State Key Laboratory of Cancer Biology, Department of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, Xi an City, 710032, China
    Mol Med 12:229-36. 2006
    ..The chimeric antibody hCAb may be a promising candidate in the treatment of human colorectal cancer. This study can provide a reference for the potential application of hCAb in clinical trial...
  40. ncbi request reprint C-reactive protein enhances LOX-1 expression in human aortic endothelial cells: relevance of LOX-1 to C-reactive protein-induced endothelial dysfunction
    Ling Li
    Department of Biomedical Sciences, University of Montreal, Centre Hospitalier de l Université de Montréal Research Centre, Notre Dame Hospital, Montreal, Quebec, Canada
    Circ Res 95:877-83. 2004
    ..We conclude that CRP enhances endothelial LOX-1 expression and propose a new mechanism by which CRP may promote endothelial dysfunction, that of inducing LOX-1...
  41. ncbi request reprint Effect of hepatic glucose production on acute insulin resistance induced by lipid-infusion in awake rats
    Ling Li
    Department of Endocrinology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, China
    World J Gastroenterol 10:3208-11. 2004
    ..To explore the influence of hepatic glucose production on acute insulin resistance induced by a lipid infusion in awake rats...
  42. pmc Model-based fitting of single-channel dwell-time distributions
    Feng Qin
    Department of Physiology and Biophysical Sciences, State University of New York, Buffalo, New York 14214, USA
    Biophys J 87:1657-71. 2004
    ..Numerical examples are presented to illustrate the performance of the algorithm, and comparisons with the full maximum likelihood fitting are discussed...
  43. ncbi request reprint Glucose enhances human macrophage LOX-1 expression: role for LOX-1 in glucose-induced macrophage foam cell formation
    Ling Li
    Department of Biomedical Sciences, of Montreal, Centre Hospitalier de l Université de Montréal Research Centre, Notre Dame Hospital, Montreal, Quebec, Canada
    Circ Res 94:892-901. 2004
    ..Pilot data showing that MDMs of patients with type 2 diabetes overexpress LOX-1 support the relevance of this work to human diabetic atherosclerosis...
  44. ncbi request reprint Enhanced lipoprotein lipase secretion and foam cell formation by macrophages of patients with growth hormone deficiency: possible contribution to increased risk of atherogenesis?
    Omar Serri
    Centre Hospitalier de l Université de Montréal Research Centre, Notre Dame Hospital, and Department of Nutrition, University of Montreal, Montreal, Canada H2L 4M1
    J Clin Endocrinol Metab 89:979-85. 2004
    ..These alterations may contribute to the increased cardiovascular risk in patients with GH deficiency...
  45. ncbi request reprint MicroRNAs modulate hematopoietic lineage differentiation
    Chang Zheng Chen
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA
    Science 303:83-6. 2004
    ..Our results indicate that microRNAs are components of the molecular circuitry that controls mouse hematopoiesis and suggest that other microRNAs have similar regulatory roles during other facets of vertebrate development...
  46. ncbi request reprint The chemistry and biochemistry of Spiraea japonica complex
    Xiaojiang Hao
    The State Key Laboratory of Phytochemistry and Plant Resources in West China, Kuming Institute of Botany, Chinese Academy of Sciences, Heilongtan, Kunming, Yunnan 650204, China
    Curr Med Chem 10:2253-63. 2003
    ..The studies on the anti-inflammation, anti-platelet aggregation and neuroprotective bioactivities of the alkaloids from S. japonica var. acuta were reviewed as well...
  47. ncbi request reprint Glucose enhances endothelial LOX-1 expression: role for LOX-1 in glucose-induced human monocyte adhesion to endothelium
    Ling Li
    Department of Biomedical Sciences, University of Montreal, Centre Hospitalier de l Université de Montréal CHUM Research Centre, Notre Dame Hospital, Montreal, Quebec, Canada
    Diabetes 52:1843-50. 2003
    ..The study also suggests a role for LOX-1 as mediator of the stimulatory effect of high glucose on monocyte adhesion...
  48. ncbi request reprint Possible association between genetic variability at the apolipoprotein(a) locus and Alzheimer's disease in apolipoprotein E2 carriers
    Danielle Compton
    Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA
    Neurosci Lett 331:60-2. 2002
    ..005). We suggest that this polymorphism and others at the Apo(a) locus be further studied in relation to Alzheimer's disease...
  49. ncbi request reprint Importance of FADD signaling in serum deprivation- and hypoxia-induced cardiomyocyte apoptosis
    Wei Chao
    Program in Cardiovascular Gene Therapy, Cardiovascular Research Center, the Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Biol Chem 277:31639-45. 2002
    ..These data suggest a primary role for FADD/caspase-8 signaling that is necessary and sufficient for apoptosis of CMs subjected to hypoxia/SD...
  50. ncbi request reprint [A novel model for visualization of tumor cell-induced angiogenesis in vivo]
    Ling Li
    Central Experimental Laboratory, First People s Hospital of Shanghai, Shanghai 200080, China
    Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 34:21-7. 2002
    ..Furthermore, there was active VEGF paracrine and autocrine expression in tumor and high level VEGF secretion by tumor cells plays an important role in initiating angiogenesis and supporting micrometastases...
  51. ncbi request reprint Transcriptional effects of chronic Akt activation in the heart
    Stuart A Cook
    Program in Cardiovascular Gene Therapy, Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA
    J Biol Chem 277:22528-33. 2002
    ..Thus, microarray analysis reveals previously unappreciated Akt regulation of genes that could contribute to the effects of Akt on cardiomyocyte survival, metabolism, and growth...
  52. ncbi request reprint Neuroprotective effects of brain-derived neurotrophic factor (BDNF) on hearing in experimental pneumococcal meningitis
    Ling Li
    Department of Pediatric Neurology, the First People s Hospital of Yunnan Province, Kunming, Affiliated Children s Hospital, School of Medicine, Zhejiang University, Hangzhou, China
    J Child Neurol 20:51-6. 2005
    ..05). Our study supports the hypothesis that the administration of exogenous brain-derived neurotrophic factor can be effective in preventing or treating hearing loss following bacterial meningitis...
  53. ncbi request reprint A mass spectrometric determination of the conformation of dimeric apolipoprotein A-I in discoidal high density lipoproteins
    R A Gangani D Silva
    Department of Pathology and Laboratory Medicine, The University of Cincinnati, Cincinnati, Ohio 45237 0507, USA
    Biochemistry 44:8600-7. 2005
    ..A comparison of this work to a previous study is suggestive that a third molecule of apoA-I can form a hairpin in larger particles containing three molecules of apoA-I...
  54. ncbi request reprint Structure and dynamics of the second and third transmembrane domains of human glycine receptor
    Dejian Ma
    Department of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Biochemistry 44:8790-800. 2005
    ..Many structural characteristics of the receptor can be inferred from the structural and dynamical features identified in this study...
  55. ncbi request reprint Characterization, kinetics, and crystal structures of fructose-1,6-bisphosphate aldolase from the human parasite, Giardia lamblia
    Andrey Galkin
    Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute, Rockville, Maryland 20850, USA
    J Biol Chem 282:4859-67. 2007
    ..Determinants of catalysis and substrate recognition, derived from comparison of the G. lamblia FBPA structure with Escherichia coli FBPA and with a closely related enzyme, E. coli tagatose-1,6-bisphosphate aldolase (TBPA), are described...
  56. ncbi request reprint Effects of chronic Akt activation on glucose uptake in the heart
    Takashi Matsui
    Program in Cardiovascular Gene Therapy, Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA
    Am J Physiol Endocrinol Metab 290:E789-97. 2006
    ..These data demonstrate that chronic Akt activation increases basal glucose uptake and glycogen deposition while inhibiting the response to insulin...
  57. pmc Myostatin regulates cardiomyocyte growth through modulation of Akt signaling
    Michael R Morissette
    Cardiology Division, Beth Israel Deaconess Medical Center, Boston, Mass 02215, USA
    Circ Res 99:15-24. 2006
    ..Together, these data demonstrate that myostatin is dynamically regulated in the heart and acts more broadly than previously appreciated to regulate growth of multiple types of striated muscle...
  58. ncbi request reprint Purification and characterization of hatching enzyme from shrimp Penaeus chinensis
    Bing Jun Li
    Department of Marine Biology, College of Marine Life Sciences, Ocean University of China, Qingdao 266003, China
    Arch Biochem Biophys 451:188-93. 2006
    ..Combined with the results that the EDTA-pretreated HE activity could be perfectly recovered by Zn2+, it is indicated that shrimp HE is most probably a kind of Zn-metalloprotease...
  59. ncbi request reprint Biohydrogen production in continuous-flow reactor using mixed microbial culture
    Samir Kumar Khanal
    Department of Civil, Construction and Environmental Engineering, Iowa State University, Ames 50011 3232, USA
    Water Environ Res 78:110-7. 2006
    ..This study showed that sustainable biohydrogen production from carbohydrate-rich substrates is possible through heat activation of settled sludge...
  60. pmc ICP27 interacts with the C-terminal domain of RNA polymerase II and facilitates its recruitment to herpes simplex virus 1 transcription sites, where it undergoes proteasomal degradation during infection
    Jenny Q Dai-Ju
    Department of Microbiology and Molecular Genetics, School of Medicine, University of California at Irvine, Irvine, CA 92697 4025, USA
    J Virol 80:3567-81. 2006
    ..Thus, we propose that at later times of infection when robust transcription and DNA replication are occurring, elongating complexes may collide and proteasomal degradation may be required for resolution...
  61. ncbi request reprint Hydrogen sulphide--a novel mediator of inflammation?
    Ling Li
    Cardiovascular Biology Research Group, Department of Pharmacology, Yong Loo Lin School of Medicine, Block MD2, 18 Medical Drive, National University of Singapore, Singapore 117597
    Curr Opin Pharmacol 6:125-9. 2006
    ..In each case, pharmacological inhibition of H2S biosynthesis is anti-inflammatory...
  62. ncbi request reprint Kinetic analysis of Pseudomonas aeruginosa arginine deiminase mutants and alternate substrates provides insight into structural determinants of function
    Xuefeng Lu
    Department of Chemistry, University of New Mexico, Albuquerque, New Mexico 87131, USA
    Biochemistry 45:1162-72. 2006
    ....
  63. ncbi request reprint [Pathologic observation of spleen dendritic cells in mouse multiple organ failure model]
    Jiang yang Lu
    Zhonghua Bing Li Xue Za Zhi 34:427-8. 2005
  64. ncbi request reprint An in vivo model to study osteogenic gene regulation: targeting an avian retroviral receptor (TVA) to bone with the bone sialoprotein (BSP) promoter
    Ling Li
    Division of Oral Biology, Tufts School of Dental Medicine, Boston, Massachusetts 02111, USA
    J Bone Miner Res 20:1403-13. 2005
    ..The model was validated by showing suppressed BSP expression and delayed bone and tooth formation after infection with a virus expressing a mutated Cbfa1/Runx2 gene...
  65. pmc PI3K rescues the detrimental effects of chronic Akt activation in the heart during ischemia/reperfusion injury
    Tomohisa Nagoshi
    Program in Cardiovascular Gene Therapy, Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 115:2128-38. 2005
    ..These data demonstrate that PI3K-dependent but Akt-independent effectors are required for full cardioprotection and suggest a mechanism by which chronic Akt activation can become maladaptive...
  66. ncbi request reprint High selective determination iron(II) by its enhancement effect on the fluorescence of pyrene-tetramethylpiperidinyl (TEMPO) as a spin fluorescence probe
    Jin Long Chen
    College of Chemistry and Materials Science, Anhui Normal University, Wuhu 241000, PR China
    Spectrochim Acta A Mol Biomol Spectrosc 63:438-43. 2006
    ..Results determined by the proposed method agree favorably with those determined UV-vis spectrometry method with 1,10-phenanthroline...
  67. ncbi request reprint Phenotypic spectrum caused by transgenic overexpression of activated Akt in the heart
    Takashi Matsui
    Program in Cardiovascular Gene Therapy, CVRC, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA
    J Biol Chem 277:22896-901. 2002
    ..001). Thus, chronic Akt activation is sufficient to cause a spectrum of phenotypes from moderate cardiac hypertrophy with preserved systolic function and cardioprotection to massive cardiac dilatation and sudden death...

Research Grants3

  1. Effects of Statins on AD beyond Cholesterol and Amyloid
    Ling Li; Fiscal Year: 2006
    ..abstract_text> ..
  2. Protective Mechanisms of Statins in Alzheimer?s Disease
    Ling Li; Fiscal Year: 2009
    ..Results from this project may lead to novel therapies to combat AD. ..