Li Li

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. pmc Dendritic cells tolerized with adenosine A₂AR agonist attenuate acute kidney injury
    Li Li
    Department of Medicine, University of Virginia, Charlottesville, Virginia, USA
    J Clin Invest 122:3931-42. 2012
  2. pmc IL-17 produced by neutrophils regulates IFN-gamma-mediated neutrophil migration in mouse kidney ischemia-reperfusion injury
    Li Li
    Department of Medicine, Center for Immunity, Inflammation, and Regenerative Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
    J Clin Invest 120:331-42. 2010
  3. pmc The chemokine receptors CCR2 and CX3CR1 mediate monocyte/macrophage trafficking in kidney ischemia-reperfusion injury
    Li Li
    Division of Nephrology, Department of Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
    Kidney Int 74:1526-37. 2008
  4. ncbi request reprint NKT cell activation mediates neutrophil IFN-gamma production and renal ischemia-reperfusion injury
    Li Li
    Department of Medicine, Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA
    J Immunol 178:5899-911. 2007
  5. pmc Dendritic cell sphingosine 1-phosphate receptor-3 regulates Th1-Th2 polarity in kidney ischemia-reperfusion injury
    Amandeep Bajwa
    Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA
    J Immunol 189:2584-96. 2012
  6. pmc Regulatory T cells contribute to the protective effect of ischemic preconditioning in the kidney
    Gilbert R Kinsey
    Division of Nephrology and Center for Immunity, Inflammation and Regenerative Medicine, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Kidney Int 77:771-80. 2010
  7. ncbi request reprint Activation of adenosine 2A receptors attenuates allograft rejection and alloantigen recognition
    Charles P Sevigny
    Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA
    J Immunol 178:4240-9. 2007
  8. pmc Periods of highly synchronous, non-reentrant endocardial activation cycles occur during long-duration ventricular fibrillation
    Robert P Robichaux
    Department of Medicine, Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, USA
    J Cardiovasc Electrophysiol 21:1266-73. 2010
  9. pmc Regulatory T cells suppress innate immunity in kidney ischemia-reperfusion injury
    Gilbert R Kinsey
    Division of Nephrology, University of Virginia Health System, Charlottesville, VA 22908, USA
    J Am Soc Nephrol 20:1744-53. 2009
  10. doi request reprint Progressive histological damage in renal allografts is associated with expression of innate and adaptive immunity genes
    Maarten Naesens
    Division of Nephrology, Department of Pediatrics, Stanford University School of Medicine, Stanford, California, USA
    Kidney Int 80:1364-76. 2011

Collaborators

Detail Information

Publications31

  1. pmc Dendritic cells tolerized with adenosine A₂AR agonist attenuate acute kidney injury
    Li Li
    Department of Medicine, University of Virginia, Charlottesville, Virginia, USA
    J Clin Invest 122:3931-42. 2012
    ..A₂AR agonists had no effect on DC antigen presentation or on Tregs. We conclude that ex vivo A₂AR-induced tolerized DCs suppress NKT cell activation in vivo and provide a unique and potent cell-based strategy to attenuate organ IRI...
  2. pmc IL-17 produced by neutrophils regulates IFN-gamma-mediated neutrophil migration in mouse kidney ischemia-reperfusion injury
    Li Li
    Department of Medicine, Center for Immunity, Inflammation, and Regenerative Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
    J Clin Invest 120:331-42. 2010
    ..These mechanisms might contribute to reperfusion injury in other organs...
  3. pmc The chemokine receptors CCR2 and CX3CR1 mediate monocyte/macrophage trafficking in kidney ischemia-reperfusion injury
    Li Li
    Division of Nephrology, Department of Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
    Kidney Int 74:1526-37. 2008
    ..Our study shows that inflamed monocyte migration, through CCR2- and CX3CR1-dependent mechanisms, plays a critical role in kidney injury following ischemia reperfusion...
  4. ncbi request reprint NKT cell activation mediates neutrophil IFN-gamma production and renal ischemia-reperfusion injury
    Li Li
    Department of Medicine, Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA
    J Immunol 178:5899-911. 2007
    ..The results support the essential role of NKT cells and neutrophils in the innate immune response of renal IRI by mediating neutrophil infiltration and production of IFN-gamma...
  5. pmc Dendritic cell sphingosine 1-phosphate receptor-3 regulates Th1-Th2 polarity in kidney ischemia-reperfusion injury
    Amandeep Bajwa
    Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA
    J Immunol 189:2584-96. 2012
    ....
  6. pmc Regulatory T cells contribute to the protective effect of ischemic preconditioning in the kidney
    Gilbert R Kinsey
    Division of Nephrology and Center for Immunity, Inflammation and Regenerative Medicine, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Kidney Int 77:771-80. 2010
    ..These studies highlight the role of Treg cells in ischemic preconditioning...
  7. ncbi request reprint Activation of adenosine 2A receptors attenuates allograft rejection and alloantigen recognition
    Charles P Sevigny
    Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA
    J Immunol 178:4240-9. 2007
    ..We conclude that A(2A)R agonists may represent a new class of compounds for induction therapy in organ transplantation...
  8. pmc Periods of highly synchronous, non-reentrant endocardial activation cycles occur during long-duration ventricular fibrillation
    Robert P Robichaux
    Department of Medicine, Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, USA
    J Cardiovasc Electrophysiol 21:1266-73. 2010
    ..Periods of Highly Organized Activation During VF...
  9. pmc Regulatory T cells suppress innate immunity in kidney ischemia-reperfusion injury
    Gilbert R Kinsey
    Division of Nephrology, University of Virginia Health System, Charlottesville, VA 22908, USA
    J Am Soc Nephrol 20:1744-53. 2009
    ..Taken together, these results demonstrate that Tregs modulate injury after kidney IRI through IL-10-mediated suppression of the innate immune system...
  10. doi request reprint Progressive histological damage in renal allografts is associated with expression of innate and adaptive immunity genes
    Maarten Naesens
    Division of Nephrology, Department of Pediatrics, Stanford University School of Medicine, Stanford, California, USA
    Kidney Int 80:1364-76. 2011
    ..Thus, measurement of specific immune gene expression in protocol biopsies may be warranted to predict the development of subsequent chronic injury in histologically quiescent grafts and as a means to titrate immunosuppressive therapy...
  11. ncbi request reprint Blocking the immune response in ischemic acute kidney injury: the role of adenosine 2A agonists
    Li Li
    Department of Medicine, Carter Immunology Center, University of Virginia, Charlottesville, VA, USA
    Nat Clin Pract Nephrol 2:432-44. 2006
    ..This study, together with extensively published preclinical data, will facilitate testing of ATL146e in human trials of AKI...
  12. pmc Inflammation in acute kidney injury
    Gilbert R Kinsey
    Division of Nephrology and Center for Immunity, Inflammation and Regenerative Medicine, University of Virginia, Charlottesville, VA 22908, USA
    Nephron Exp Nephrol 109:e102-7. 2008
    ..This review summarizes these recent advances to further our understanding of the immune mechanisms of acute kidney injury...
  13. pmc Activation becomes highly organized during long-duration ventricular fibrillation in canine hearts
    Li Li
    Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA
    Am J Physiol Heart Circ Physiol 298:H2046-53. 2010
    ..PFs appear to play an important role during this stage of VF...
  14. ncbi request reprint Renal ischemia-reperfusion injury and adenosine 2A receptor-mediated tissue protection: the role of CD4+ T cells and IFN-gamma
    Yuan Ji Day
    Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA
    J Immunol 176:3108-14. 2006
    ..These studies demonstrate that CD4+ IFN-gamma contributes to IRI and that A(2A) agonists mediate protection from IRI through action on CD4+ cells...
  15. pmc Macrophages, dendritic cells, and kidney ischemia-reperfusion injury
    Li Li
    Department of Medicine and the Center for Immunity, Inflammation and Regenerative Medicine, University of Virginia, Charlottesville, VA 22908, USA
    Semin Nephrol 30:268-77. 2010
    ..Although dendritic cells and macrophages contribute to both innate and adaptive immunity and to injury and repair, this review focuses on the initial innate response to kidney ischemia-reperfusion injury...
  16. pmc Dendritic cells in acute kidney injury: cues from the microenvironment
    Mark D Okusa
    University of Virginia Health System, Charlottesville, VA 22908, USA
    Trans Am Clin Climatol Assoc 123:54-62; discussion 62-3. 2012
    ..Understanding the function of DCs and macrophages as well as the microenvironment that governs their phenotype will shed light on the pathogenesis of kidney disease and offer novel drug targets...
  17. doi request reprint Expression of soluble HLA-G identifies favorable outcomes in liver transplant recipients
    Valeriya Zarkhin
    Division of Nephrology, Department of Pediatrics, Stanford University, Palo Alto, CA 94304, USA
    Transplantation 90:1000-5. 2010
    ..However, the clinical relevance of soluble serum HLA-G molecules in tolerant pediatric and young adult liver transplant patients remains to be studied...
  18. doi request reprint The dual role of epithelial-to-mesenchymal transition in chronic allograft injury in pediatric renal transplantation
    Matthew J Vitalone
    Division of Nephrology, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA
    Transplantation 92:787-95. 2011
    ..This has yet to be studied in late TID or in pediatric renal transplantation; both questions were investigated...
  19. ncbi request reprint Selective sphingosine 1-phosphate 1 receptor activation reduces ischemia-reperfusion injury in mouse kidney
    Alaa S Awad
    Department of Medicine, Univ of Virginia, Charlottesville, VA, USA
    Am J Physiol Renal Physiol 290:F1516-24. 2006
    ..The mechanism of protection is not known but may be related to peripheral lymphocyte depletion or direct effects on kidney cells expressing S1P1 receptor...
  20. pmc Neointimal hyperplasia associated with synthetic hemodialysis grafts
    Li Li
    Department of Medicine, University of Utah, Salt Lake City, Utah, USA
    Kidney Int 74:1247-61. 2008
    ..Successful prevention of graft stenosis would provide a superior alternative to the native fistula as hemodialysis vascular access...
  21. pmc Natural killer T cell-derived IL-17 mediates lung ischemia-reperfusion injury
    Ashish K Sharma
    Department of Surgery, University of Virginia Health System, Charlottesville, VA 22908, USA
    Am J Respir Crit Care Med 183:1539-49. 2011
    ..However, identification of the specific subset of CD4(+) T cells and their mechanistic role in IR injury remains unknown...
  22. doi request reprint A novel high-throughput screening assay for discovery of molecules that increase cellular tetrahydrobiopterin
    Li Li
    The Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
    J Biomol Screen 16:836-44. 2011
    ..Thus, this TR-FRET assay could be applied in future uHTS of additional libraries to search for molecules that increase GTPCH-1 activity and BH(4) levels...
  23. doi request reprint Protein microarrays identify antibodies to protein kinase Czeta that are associated with a greater risk of allograft loss in pediatric renal transplant recipients
    Scott M Sutherland
    Division of Nephrology, Department of Pediatrics, Stanford University Medical Center, Stanford, CA 94305, USA
    Kidney Int 76:1277-83. 2009
    ..Prospective assessment of serum anti-PKCzeta levels at allograft rejection will be needed to confirm these results...
  24. pmc Tetrahydrobiopterin deficiency and nitric oxide synthase uncoupling contribute to atherosclerosis induced by disturbed flow
    Li Li
    Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA
    Arterioscler Thromb Vasc Biol 31:1547-54. 2011
    ..We therefore aimed to determine whether atherosclerosis induced by disturbed flow is due to BH(4) deficiency and NOS uncoupling and whether increasing BH(4) would prevent endothelial dysfunction, plaque inflammation, and atherosclerosis...
  25. pmc Binding and uptake of H-ferritin are mediated by human transferrin receptor-1
    Li Li
    Department of Medicine, Veterans Administration Medical Center, San Francisco, CA 94121, USA
    Proc Natl Acad Sci U S A 107:3505-10. 2010
    ..The demonstration that TfR1 can bind HFt as well as Tf raises the possibility that this dual receptor function may coordinate the processing and use of iron by these iron-binding molecules...
  26. pmc Role of interleukin 23 signaling in Clostridium difficile colitis
    Erica L Buonomo
    Department of Microbiology, Immunology, and Cancer, University of Virginia, Charlottesville, USA
    J Infect Dis 208:917-20. 2013
    ..7%-50% [12 mice]). These data suggest a new potential drug target for human C. difficile treatment and indicate the first link between IL-23 and disease severity during murine infection. ..
  27. pmc Cysteinyl leukotriene 2 receptor on dendritic cells negatively regulates ligand-dependent allergic pulmonary inflammation
    Nora A Barrett
    Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 189:4556-65. 2012
    ..Furthermore, these studies highlight how the biologic activity of cys-LTs can be tightly regulated by competition between these endogenously expressed receptors...
  28. pmc Dampening enthusiasm for circulating microRNA in breast cancer
    Rom S Leidner
    Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA
    PLoS ONE 8:e57841. 2013
    ..This finding, along with widespread inconsistencies across prior studies, highlight the need for better understanding of factors influencing circulating miRNA levels as prerequisites to progress in this area of translational research...
  29. pmc Purkinje activation precedes myocardial activation following defibrillation after long-duration ventricular fibrillation
    Derek J Dosdall
    Department of Medicine, Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Heart Rhythm 7:405-12. 2010
    ....
  30. pmc Longitudinal assessment of hyperplasia using magnetic resonance imaging without contrast in a porcine arteriovenous graft model
    Christi M Terry
    Department of Medicine, Division of Nephrology and Hypertension, University of Utah, Salt Lake City, UT 84112, USA
    Acad Radiol 16:96-107. 2009
    ..The authors report the use of magnetic resonance (MR) imaging (MRI) without contrast agent to monitor tissue hyperplasia formation as well as luminal area in a porcine model of AV graft stenosis...
  31. pmc STAT5 signaling is required for the efficient induction and maintenance of CML in mice
    Dan Ye
    Department of Medicine, University of Texas Southwestern Medical Center, Dallas, USA
    Blood 107:4917-25. 2006
    ..A greater understanding of the STAT5 target genes involved in CML induction may lead to new therapeutic targets that influence CML progenitor cell biology...