H Li

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Multivariate survival models induced by genetic frailties, with application to linkage analysis
    Hongzhe Li
    Rowe Program in Human Genetics, School of Medicine, University of California, Davis, CA 95616, USA
    Biostatistics 3:57-75. 2002
  2. ncbi Statistical methods for analysis of time course gene expression data
    Hongzhe Li
    Rowe Program in Human Genetics, Department of Medicine, University of California, Davis, CA 95616, USA
    Front Biosci 7:a90-8. 2002
  3. pmc Cluster-Rasch models for microarray gene expression data
    H Li
    Rowe Program in Human Genetics, Departments of Medicine and Statistics, University of California, Davis, CA 95616, USA
    Genome Biol 2:RESEARCH0031. 2001
  4. ncbi Semiparametric linkage analysis using pseudolikelihoods on neighbouring sets
    H Li
    Rowe Program in Human Genetics, School of Medicine, University of California, Davis 95616 8500, USA
    Ann Hum Genet 62:323-36. 1998
  5. ncbi A general test of association for complex diseases with variable age of onset
    H Li
    Department of Medicine, University of California, Davis 95616, USA
    Genet Epidemiol 19:S43-9. 2000
  6. ncbi Vancomycin-resistant enterococci among chronic hemodialysis patients: a prospective study of acquisition
    E M D'Agata
    Department of Medicine, Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, TN 37232 2605, USA
    Clin Infect Dis 32:23-9. 2001
  7. ncbi NO news is good news
    T L Poulos
    Department of Molecular Biology and Biochemistry, University of California, Irvine 92697 3900, USA
    Structure 6:255-8. 1998
  8. ncbi Heat shock and heat shock protein 70i enhance the oncolytic effect of replicative adenovirus
    Y S Haviv
    Division of Human Gene Therapy, Department of Medicine, University of Alabama at Birmingham, 35294, USA
    Cancer Res 61:8361-5. 2001
  9. pmc An Epstein-Barr virus that expresses only the first 231 LMP1 amino acids efficiently initiates primary B-lymphocyte growth transformation
    K M Kaye
    Department of Medicine, Harvard Medical School, Channing Laboratory, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Virol 73:10525-30. 1999
  10. ncbi The additive genetic gamma frailty model for linkage analysis of age-of-onset variation
    H Li
    Department of Medicine, University of California, Davis School of Medicine, 95616 8500, USA
    Ann Hum Genet 63:455-68. 1999

Collaborators

Detail Information

Publications91

  1. ncbi Multivariate survival models induced by genetic frailties, with application to linkage analysis
    Hongzhe Li
    Rowe Program in Human Genetics, School of Medicine, University of California, Davis, CA 95616, USA
    Biostatistics 3:57-75. 2002
    ..Both simulated and real data sets also indicate that the method is relatively robust to the misspecification to the baseline hazard function...
  2. ncbi Statistical methods for analysis of time course gene expression data
    Hongzhe Li
    Rowe Program in Human Genetics, Department of Medicine, University of California, Davis, CA 95616, USA
    Front Biosci 7:a90-8. 2002
    ..We used the yeast cell cycle gene expression data sets to illustrate these methods and obtained the biologically meaningful conclusions from these analyses...
  3. pmc Cluster-Rasch models for microarray gene expression data
    H Li
    Rowe Program in Human Genetics, Departments of Medicine and Statistics, University of California, Davis, CA 95616, USA
    Genome Biol 2:RESEARCH0031. 2001
    ..The other formulation provides an alternative way of identifying genes that are over- or underexpressed from their expression levels in tissue or cell samples of a given tissue or cell type...
  4. ncbi Semiparametric linkage analysis using pseudolikelihoods on neighbouring sets
    H Li
    Rowe Program in Human Genetics, School of Medicine, University of California, Davis 95616 8500, USA
    Ann Hum Genet 62:323-36. 1998
    ..A pseudolikelihood ratio test is proposed for testing linkage. Simulated and real data sets are used to illustrate these new statistical methods...
  5. ncbi A general test of association for complex diseases with variable age of onset
    H Li
    Department of Medicine, University of California, Davis 95616, USA
    Genet Epidemiol 19:S43-9. 2000
    ..This approach offers a solution to the problem of testing for marker associations when there is a variable age of onset...
  6. ncbi Vancomycin-resistant enterococci among chronic hemodialysis patients: a prospective study of acquisition
    E M D'Agata
    Department of Medicine, Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, TN 37232 2605, USA
    Clin Infect Dis 32:23-9. 2001
    ..Hospital acquisition of VRE contributes substantially to the increasing prevalence of VRE in the chronic hemodialysis patient population...
  7. ncbi NO news is good news
    T L Poulos
    Department of Molecular Biology and Biochemistry, University of California, Irvine 92697 3900, USA
    Structure 6:255-8. 1998
    ..The crystal structure of the NOS heme domain reveals a very different architecture to that observed in P450s and offers significant insight into the production of nitric oxide, one of nature's most important regulatory molecules...
  8. ncbi Heat shock and heat shock protein 70i enhance the oncolytic effect of replicative adenovirus
    Y S Haviv
    Division of Human Gene Therapy, Department of Medicine, University of Alabama at Birmingham, 35294, USA
    Cancer Res 61:8361-5. 2001
    ..A potential therapeutic implication would be the use of local hyperthermia to augment oncolysis by increasing the burst of replication-competent Ad. The role of hsp in Ad-mediated oncolysis should be additionally explored...
  9. pmc An Epstein-Barr virus that expresses only the first 231 LMP1 amino acids efficiently initiates primary B-lymphocyte growth transformation
    K M Kaye
    Department of Medicine, Harvard Medical School, Channing Laboratory, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Virol 73:10525-30. 1999
    ..These data indicate that the LMP1 carboxyl-terminal 155 aa are important for growth at lower cell density and appear to reduce dependence on paracrine growth factors...
  10. ncbi The additive genetic gamma frailty model for linkage analysis of age-of-onset variation
    H Li
    Department of Medicine, University of California, Davis School of Medicine, 95616 8500, USA
    Ann Hum Genet 63:455-68. 1999
    ..The EM algorithm is used for estimating the parameters and the maximum likelihood functions. Simulated data sets are used to illustrate these new statistical methods...
  11. ncbi Model-based methods for identifying periodically expressed genes based on time course microarray gene expression data
    Y Luan
    Rowe Program in Human Genetics, School of Medicine, University of California, Davis, CA 95616, USA
    Bioinformatics 20:332-9. 2004
    ..5%, respectively. Our results also indicate that the shape-invariant model fits the data well and provides estimate of the common shape function and the relative phases for these periodically regulated genes...
  12. ncbi Finnish case-control and family studies support PTPN22 R620W polymorphism as a risk factor in rheumatoid arthritis, but suggest only minimal or no effect in juvenile idiopathic arthritis
    M F Seldin
    Rowe Program in Genetics, Departments of Biochemistry and Medicine, University of California Davis, Davis, CA, USA
    Genes Immun 6:720-2. 2005
    ..27-1.70, P=3 x 10(-7)) and in family studies (P<10(-6)). In contrast, no allelic association was seen with JIA (230 probands) and only weak evidence for a genotypic effect of 1858T homozygotes was observed in this population...
  13. ncbi Association of angiotensin-converting enzyme polymorphisms with systemic lupus erythematosus and nephritis: analysis of 644 SLE families
    A Parsa
    Division of Nephrology, Department of Medicine, University of California, San Francisco, CA, USA
    Genes Immun 3:S42-6. 2002
    ..010). Due to the choice of study design and analytic method these results are unlikely to be due to population admixture. Our findings suggest that DNA sequence variation in the ACE gene influences the risk of developing SLE and LN...
  14. ncbi Dissimilar immunogenicities of human papillomavirus E7 and adenovirus E1A proteins influence primary tumor development
    J M Routes
    Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado, 80206, USA
    Virology 277:48-57. 2000
    ..These data suggest differences in the capacities of E1A or E7 oncoproteins to trigger protective anti-tumor immune responses may contribute to the dissimilar oncogenicities of Ad and HPV in humans...
  15. ncbi Effects of age at onset on the power of the affected sib pair and transmission/disequilibrium tests
    H Li
    Department of Medicine, Rowe Program in Human Genetics, University of California, Davis, CA 95616 8500, USA
    Ann Hum Genet 64:239-54. 2000
    ..These results may be used to guide collection and analysis of sib pairs or families for diseases with variable age at onset...
  16. doi Ibex-associated malignant catarrhal fever-like disease in a group of bongo antelope (Tragelaphus eurycerus)
    D Gasper
    Department of Pathology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Vet Pathol 49:492-7. 2012
    ..The sequence closely matched an MCF viral DNA fragment that had been amplified from an ibex and bongo in a previous case report...
  17. pmc Hepatocyte growth factor, but not insulin-like growth factor I, protects podocytes against cyclosporin A-induced apoptosis
    A Fornoni
    Renal Cell Biology Laboratory, Department of Medicine, University of Miami School of Medicine, Miami, Florida 33101, USA
    Am J Pathol 158:275-80. 2001
    ..Decreased apoptosis appeared to be mediated by regulation of Bcl-xL via the PI3'-K pathway. Our data suggest that the effect of CsA on podocytes may contribute to the glomerular damage and that HGF could provide protection...
  18. ncbi Human immunodeficiency virus type 1-mediated syncytium formation is compatible with adenovirus replication and facilitates efficient dispersion of viral gene products and de novo-synthesized virus particles
    H Li
    Division of Human Gene Therapy, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Hum Gene Ther 12:2155-65. 2001
    ..These data demonstrate the utility of FMGs as a dispersion agent and suggest that FMGs can improve the efficacy of CRAd gene therapy...
  19. ncbi The t(5;17) acute promyelocytic leukemia fusion protein NPM-RAR interacts with co-repressor and co-activator proteins and exhibits both positive and negative transcriptional properties
    R L Redner
    Division of Hematology Oncology, Department of Medicine, University of Pittsburgh Medical Center, PA 15213, USA
    Blood 95:2683-90. 2000
    ..Blood. 2000;95:2683-2690)..
  20. ncbi Transcriptional profiling suggests that Barrett's metaplasia is an early intermediate stage in esophageal adenocarcinogenesis
    S Wang
    Division of Gastroenterology, Department of Medicine, University of Maryland School of Medicine, Baltimore, USA
    Oncogene 25:3346-56. 2006
    ..These findings suggest that changes modulated at the molecular biologic level supervene earlier than histologic changes, and that BE is an early intermediate stage in the process of EAC...
  21. pmc EMX2 is epigenetically silenced and suppresses growth in human lung cancer
    J Okamoto
    Department of Surgery, University of California, San Francisco, CA 94115, USA
    Oncogene 29:5969-75. 2010
    ..Taken together, our study suggests that EMX2 may have important roles as a novel suppressor in human lung cancer...
  22. ncbi Construction of a high-resolution physical map of the chromosome 10q22-q23 dilated cardiomyopathy locus and analysis of candidate genes
    K R Bowles
    Department of Molecular and Human Genetics, Department of Pediatrics Cardiology, Department of Medicine, Department of Cardiovascular Sciences, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Genomics 67:109-27. 2000
    ..Mutational analysis of ANX11, DLG5, and PPIF revealed no disease-associated mutations. Multiple ESTs have also been mapped to the critical region...
  23. doi 17β-Estradiol up-regulates Nrf2 via PI3K/AKT and estrogen receptor signaling pathways to suppress light-induced degeneration in rat retina
    C Zhu
    Department of Genetics and Molecular Biology, School of Medicine, Xi an Jiaotong University, Xi an 710061, China Department of Periodontology for Stomatology, Stomatological Hospital, School of Medicine, Xi an Jiaotong University, Xi an 710004, China
    Neuroscience 304:328-39. 2015
    ..Our data provide evidence that βE2 is a potentially effective in the treatment of retinal degeneration diseases. ..
  24. ncbi Clinical and molecular characterization of vancomycin-resistant Enterococcus faecium strains during establishment of endemicity
    E M D'Agata
    Department of Medicine, Division of Infectious Diseases, Vanderbilt University School of Medicine, Medical Center North A 3310, 21st Ave and Garland St, Nashville, TN 37232, USA
    Clin Infect Dis 33:511-6. 2001
    ..Establishment of VREF endemicity was initially characterized by clonal spread of type O strains. Subsequently, polyclonal dissemination may have been due to microevolutionary changes among type O strains...
  25. ncbi A permutation procedure for the haplotype method for identification of disease-predisposing variants
    H Li
    Departments of Medicine and Statistics, University of California, Davis CA 95616, USA
    Ann Hum Genet 65:189-96. 2001
    ..Application to both simulated data and real data sets on type 1 diabetes and alcoholism indicates that the proposed procedure works well in testing the important null hypothesis of whether all the predisposing sites are identified...
  26. ncbi Primary biliary cirrhosis and autoimmunity: evaluating the genetic risk
    M E Gershwin
    Division of Rheumatology, Allergy and Clinical Immunology, School of Medicine, University of California at Davis, Davis, CA, USA
    Isr Med Assoc J 2:7-10. 2000
    ..In this review we place these concepts in perspective and highlight in particular the genetic associations in primary biliary cirrhosis...
  27. ncbi Nitric oxide attenuates signal transduction: possible role in dissociating caveolin-1 scaffold
    H Li
    Department of Medicine, State University of New York, Stony Brook, NY11794-8152, USA
    Circ Res 88:229-36. 2001
    ..NO-induced attenuation of signaling involves reversible dissociation of caveolin scaffold, thus providing both spatial and temporal modulation of signal transduction...
  28. doi NRP/B mutations impair Nrf2-dependent NQO1 induction in human primary brain tumors
    S Seng
    Division of Experimental Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Oncogene 28:378-89. 2009
    ..This study provides insights into the mechanism by which the NRP/B modulates Nrf2-dependent NQO1 induction in cellular protection against ROS in brain tumors...
  29. ncbi Effects of dutasteride on prostate growth in the large probasin-large T antigen mouse model of prostate cancer
    T C Shao
    Department of Medicine, Michael E DeBakey Veterans Affairs Medical Center, Houston, Texas 77030, USA
    J Urol 178:1521-7. 2007
    ..We evaluated the effects of dutasteride for preventing or delaying prostate growth and neoplastic changes in a transgenic model of prostate cancer...
  30. ncbi Heme-mediated oxygen activation in biology: cytochrome c oxidase and nitric oxide synthase
    T L Poulos
    Department of Molecular Biology and Biochemistry, University of California, Irvine 92697 3900, USA
    Curr Opin Chem Biol 3:131-7. 1999
    ..Recent advances have also been made for nitric oxide synthase, owing to the crystal structure determination of the heme domain for two of three nitric oxide synthase isoforms...
  31. pmc Energy balance and type 2 diabetes: a report from the Shanghai Women's Health Study
    R Villegas
    Department of Medicine, Vanderbilt Epidemiology Center, 2525 West End Avenue, Suite 600, Nashville, TN 37203, USA
    Nutr Metab Cardiovasc Dis 19:190-7. 2009
    ..The aim of this study was to examine the components of energy balance and the incidence of T2D in a cohort of middle-aged women...
  32. ncbi The Fcgamma receptor IIIA-158F allele is a major risk factor for the development of lupus nephritis among Caucasians but not non-Caucasians
    V A Seligman
    Rosalind Russell Medical Research Center for Arthritis, University of California, San Francisco, USA
    Arthritis Rheum 44:618-25. 2001
    ..To determine whether inheritance of Fcgamma receptor (FcgammaR) alleles conferring lower affinity for IgG binding increases the risk of developing lupus nephritis...
  33. ncbi Anthropometric predictors of coronary heart disease in Chinese women
    X Zhang
    Department of Medicine, Center for Health Services Research, Vanderbilt University, Nashville, TN, USA
    Int J Obes Relat Metab Disord 28:734-40. 2004
    ..To evaluate the associations of body size and fat distribution with incidence of coronary heart disease (CHD) in Chinese women...
  34. pmc The Rop GTPase switch controls multiple developmental processes in Arabidopsis
    H Li
    Department of Botany and Plant Sciences, University of California, Riverside, California 92521, USA
    Plant Physiol 126:670-84. 2001
    ..Based on these observations and previous results, we propose that Rop2 and other members of the Rop family participate in multiple distinct signaling pathways that control plant growth, development, and responses to the environment...
  35. ncbi Relationship between the regulatory region polymorphism of human tissue kallikrein gene and essential hypertension
    H Hua
    1School of Basic Medicine and Forensic, West China Medical Center, Sichuan University, Chengdu, Sichuan, PR China
    J Hum Hypertens 19:715-21. 2005
    ..Differences in both allele frequencies and genotype frequencies between these two groups have provided evidence towards the association of hypertension with the polymorphisms in this studied site...
  36. ncbi African origin of modern humans in East Asia: a tale of 12,000 Y chromosomes
    Y Ke
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, 220 Handan Road, Shanghai, China
    Science 292:1151-3. 2001
    ..Therefore, the data do not support even a minimal in situ hominid contribution in the origin of anatomically modern humans in East Asia...
  37. ncbi Computer prediction of cardiovascular and hematological agents by statistical learning methods
    X Chen
    Bioinformatics and Drug Design Group, Department of Pharmacy, National University of Singapore, Singapore 117543
    Cardiovasc Hematol Agents Med Chem 5:11-9. 2007
    ..It also evaluates algorithms for properly representing and extracting the structural and physicochemical properties of compounds relevant to the prediction of cardiovascular and hematological agents...
  38. ncbi Functional hierarchical models for identifying genes with different time-course expression profiles
    F Hong
    Plant Biology Laboratory, The Salk Institute, La Jolla, California 92037, USA
    Biometrics 62:534-44. 2006
    ..Genes identified from the C. elegans developmental data set show clear patterns of changes between the two experimental conditions...
  39. ncbi Association of TNF-alpha promoter polymorphisms with the outcomes of hepatitis B virus infection in Chinese Han population
    T Du
    National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, China
    J Viral Hepat 13:618-24. 2006
    ..0001, P = 0.0004). In conclusion, TNF-alpha promoter polymorphisms are independently associated with different outcomes of HBV infection...
  40. ncbi Prevention of murine experimental autoimmune encephalomyelitis by in vivo expression of a novel recombinant immunotoxin DT390-RANTES
    Y Jia
    West China School of Preclinical and Forensic Medicine, Sichuan University, Sichuan, People s Republic of China
    Gene Ther 13:1351-9. 2006
    ..This study indicates that recombinant immunotoxin can be expressed in vivo, and targeting CCR5 can attenuate the disease activity of EAE in mice...
  41. ncbi Plasminogen activator inhibitor-1 promoter polymorphism is not associated with the aggressiveness of disease in prostate cancer
    H Li
    Department of Thoracic Surgery, Cancer Hospital Cancer Institute, Fudan University, Shanghai, People s Republic of China
    Clin Oncol (R Coll Radiol) 18:333-7. 2006
    ..This study aims to test whether the promoter polymorphism in the PAI-1 gene is related to the aggressiveness of disease in prostate cancer...
  42. pmc Association of TPH1 with suicidal behaviour and psychiatric disorders in the Chinese population
    X Liu
    J Med Genet 43:e4. 2006
    ..24 and p = 0.018; OR = 1.41; 95% CI 1.05 to 1.91), which suggests an association of TPH1 with suicidal behaviour and indicates that TPH1 may play a significant role in the aetiology of psychiatric disorders in the Han Chinese population...
  43. ncbi The N terminus of eukaryotic translation elongation factor 3 interacts with 18 S rRNA and 80 S ribosomes
    R R Gontarek
    RNA Research Group, Department of Molecular Recognition, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406, USA
    J Biol Chem 273:10249-52. 1998
    ..These data taken together suggest that at least one of the ribosome-binding sites of EF-3 is located at the N terminus...
  44. ncbi New mutations in the KVLQT1 potassium channel that cause long-QT syndrome
    H Li
    Lillie Frank Abercrombie Section of Cardiology, Department of Pediatrics, Baylor College of Medicine, Houston, Tex 77030, USA
    Circulation 97:1264-9. 1998
    ..5 (LQT1), 7q35-36 (LQT2), 3p21-24 (LQT3), and 4q25-27 (LQT4). Genes responsible for LQT1, LQT2, and LQT3 have been identified as cardiac potassium channel genes (KVLQT1, HERG) and the cardiac sodium channel gene (SCN5A)...
  45. pmc Caspase-dependent activation of cyclin-dependent kinases during Fas-induced apoptosis in Jurkat cells
    B B Zhou
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 95:6785-90. 1998
    ..Our results do not support the idea that apoptosis is simply an aberrant mitosis but, instead, suggest that a subset of mitotic mechanisms plays an important role in apoptosis through elevated cdk activities...
  46. ncbi Hypoglycemia enhances the expression of prion protein and heat-shock protein 70 in a mouse neuroblastoma cell line
    W C Shyu
    Neuro Medical Scientific Center, Tzu Chi Buddhist General Hospital, Hualien, Taiwan
    J Neurosci Res 80:887-94. 2005
    ..We propose that hypoglycemia-increased PrP(C) expression might be due to JNK phosphorylation of a heat-shock transcriptional factor, which then interacts with HSE in the promoter of PrP(C)...
  47. ncbi Determination of gene organization in the human IGHV region on single chromosomes
    N O Chimge
    Department of Molecular Genetics, Microbiology and Immunology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, NJ, USA
    Genes Immun 6:186-93. 2005
    ..Since these three polymorphisms are located within or next to the 3' half of the IGHV region, they may have an important role in the expressed IGHV gene repertoire during immune response...
  48. ncbi Production of pro-inflammatory cytokines correlates with the symptoms of acute sickness behaviour in humans
    U Vollmer-Conna
    Department of Human Behaviour, School of Psychiatry, University of New South Wales, Sydney 2052, Australia
    Psychol Med 34:1289-97. 2004
    ..The aim of this research was to examine human sickness behaviour and its immunological correlates in documented Epstein-Barr virus (EBV), Q fever or Ross River virus (RRV) infections...
  49. ncbi The recent demographic and adaptive history of Drosophila melanogaster
    W Stephan
    Section of Evolutionary Biology, Department of Biology II, University of Munich, Planegg Martinsried, Germany
    Heredity (Edinb) 98:65-8. 2007
    ..Comparable (but not significantly higher) substitution rates are found in derived populations that colonized new habitats outside Africa, such as in a European population that branched off from the African lineage about 16,000 ya...
  50. ncbi Sequencing-based analysis of the HLA-DPB1 polymorphism in Nu ethnic group of south-west China
    W Hu
    Key Laboratory of Bioresources Conservation and Utilization and Human Genetics Center, Yunnan University, Kunming, Yunnan 650091, China
    Int J Immunogenet 33:397-400. 2006
    ..In addition, the results obtained in this study will also provide useful information on organ transplantation, forensic investigations and disease association studies...
  51. ncbi Alleviation of ischemia-reperfusion injury in rat liver transplantation by induction of small interference RNA targeting Fas
    X Li
    Department of Liver Transplantation, The Third Affiliated Hospital of Sun Yat Sen University, 600 Tianhe Road, Guangzhou, Guangdong Province 510630, China
    Langenbecks Arch Surg 392:345-51. 2007
    ..The objective of this study is to investigate the silencing impact of Fas siRNA to alleviate I/R injury in rat liver transplantation...
  52. pmc An E box in the desmin promoter cooperates with the E box and MEF-2 sites of a distal enhancer to direct muscle-specific transcription
    H Li
    Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030
    EMBO J 13:3580-9. 1994
    ..Its inactivation diminishes the transactivation by these factors; MRF4 and Myf5, however, can still partially function, possibly by using the distal E2 box...
  53. pmc Inhibition of desmin expression blocks myoblast fusion and interferes with the myogenic regulators MyoD and myogenin
    H Li
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030
    J Cell Biol 124:827-41. 1994
    ..These data suggested that myogenesis is modulated by at least more than one pathway and desmin, which so far was believed to be merely an architectural protein, seems to play a key role in this process...
  54. ncbi The DExH box protein Suv3p is a component of a yeast mitochondrial 3'-to-5' exoribonuclease that suppresses group I intron toxicity
    S P Margossian
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas 75235, USA
    Cell 84:199-209. 1996
    ..These findings account for group I intron overaccumulation in cells lacking Suv3p and define a novel function for putative RNA helicases in direct RNA degradation...
  55. ncbi Characterization of the structure and function of the gene for transcription factor BF-1, an essential regulator of forebrain development
    H Li
    Molecular Biology Program, Sloan Kettering Division, Cornell University Graduate School of Medical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Brain Res Mol Brain Res 37:96-104. 1996
    ..Using these cells, we demonstrate that the genomic region between -3.7kb and -79 bp upstream of the P1 promoter contains cell-specific enhancer activity in transient transfection assays...
  56. doi A nonlinear mixed-effect mixture model for functional mapping of dynamic traits
    W Hou
    Department of Statistics, University of Florida, Gainesville, FL 32611, USA
    Heredity (Edinb) 101:321-8. 2008
    ..The new model can be useful for the identification of the ontogenetic patterns of QTL genetic effects during time course...
  57. ncbi Polymorphisms in Toll-like receptors-2 and -4 are not associated with disease manifestations in acute Q fever
    B Everett
    Centre for Infection and Inflammation Research, School of Medical Sciences, University of New South Wales, Sydney, New South Wales, Australia
    Genes Immun 8:699-702. 2007
    ..No correlation was demonstrated between these polymorphisms and susceptibility to Q fever, illness severity or illness course...
  58. ncbi Crystal structure and evolution of a transfer RNA splicing enzyme
    H Li
    Division of Biology, Mail Code 147 75, California Institute of Technology, Pasadena, CA 91125, USA
    Science 280:279-84. 1998
    ..These results suggest an evolutionary pathway for splice site recognition...
  59. ncbi Association of Spot14alpha gene polymorphisms with body weight in the chicken
    Z P Cao
    College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, PR China
    Poult Sci 86:1873-80. 2007
    ..The A213C and 9 bp insertion-deletion of the Spot14alpha gene in the F(2) population was found to be associated with BW, which implied that Spot14alpha gene or a tightly linked gene had an important effect on growth in the chicken...
  60. ncbi Heart-specific inhibition of protooncogene c-myc attenuates cold-induced cardiac hypertrophy
    M Bello Roufai
    Department of Physiology, College of Medicine, University of Oklahoma Health Science Center, Oklahoma City, OK 73190, USA
    Gene Ther 14:1406-16. 2007
    ..The increased c-Myc expression may play a critical role in the pathogenesis of CICH. Thus, heart-specific inhibition of c-Myc expression may be a new and effective approach for the control of CH...
  61. ncbi Resistance to malignant catarrhal fever in American bison (Bison bison) is associated with MHC class IIa polymorphisms
    D L Traul
    Animal Disease Research Unit, USDA Agricultural Research Service, Washington State University, Pullman, WA 99164 6630, USA
    Anim Genet 38:141-6. 2007
    ..0327), while the S/S genotype was associated with clinical MCF (P = 0.0069). This is the first evidence that MHC class IIa polymorphism is associated with resistance or susceptibility to OvHV-2-induced MCF...
  62. ncbi HLA alleles in patients with Guillain-Barre syndrome
    H Li
    Department of Neurology, First Hospital, Beijing Medical University, Beijing 100034, China
    Chin Med J (Engl) 113:429-32. 2000
    ..To determine whether genetic factors may work in concert with autoimmune factors in the pathogenesis of Guillain-Barre syndrome (GBS)...
  63. ncbi The incidence of venous thromboembolism among Factor V Leiden carriers: a community-based cohort study
    J A Heit
    Division of Cardiovascular Diseases and Section of Haematology Research, Department of Internal Medicine, Mayo Clinic, 200 First Street, SW, Rochester, MN 55905, USA
    J Thromb Haemost 3:305-11. 2005
    ..Among all carriers, those > or = 60 years old are at the highest risk for VTE. The incidence of VTE among asymptomatic women carriers during pregnancy is low and insufficient to warrant prophylaxis...
  64. ncbi Differential expression of peroxisome proliferator-activated receptors alpha and gamma gene in various chicken tissues
    H Meng
    School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 201101, PR China
    Domest Anim Endocrinol 28:105-10. 2005
    ..This work will provide some basic data for the PPAR genes expression and lipids metabolism of birds...
  65. ncbi Distributions of allelic frequencies of three new STR loci in a Chinese Han population
    Z J Jia
    School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, Sichuan, PR China
    J Forensic Sci 49:1367. 2004
  66. ncbi [Expression and significance of urokinase-type plasminogen activator, its receptor, and type 2 inhibitor in giant cell tumor of bone]
    H Li
    Department of Pathology, Memorial Hospital, Sun Yat-sen University of Medical Sciences, Guangzhou 510120, China
    Zhonghua Zhong Liu Za Zhi 23:386-8. 2001
    ..Mononuclear cells may be the main tumor cell in giant cell tumor of bone...
  67. ncbi A genetic linkage map of 96 loci on the short arm of human chromosome 3
    K Tory
    Program Resources Inc, Frederick, Maryland 21701
    Genomics 13:275-86. 1992
    ..Seventeen probes were localized by fluorescence in situ hybridization. The loci described in this report will be useful in building an integrated genetic and physical map of this chromosome...
  68. ncbi Possible human leukocyte antigen-mediated genetic interaction between type 1 and type 2 Diabetes
    H Li
    Diabetes and Endocrine Research Laboratory, Department of Endocrinology, Lund University, S 20502 Malmo, Sweden
    J Clin Endocrinol Metab 86:574-82. 2001
    ..The findings support a possible genetic interaction between type 1 and type 2 diabetes mediated by the HLA locus...
  69. ncbi [A case-control study of endogenous estrogen and risk of Alzheimer's disease]
    X Hong
    Department of Neurology, Peiking Union Medical College Hospital, Beijing 100730, China
    Zhonghua Liu Xing Bing Xue Za Zhi 22:379-82. 2001
    ..The OR for AD increased parallel to the increase of age at menarche (adjusted OR = 1.160 for each increased year, P = 0.0342). CONCLUSION: The decrease of endogenous level in postmenopausal women might serve an etiological factor for AD...
  70. ncbi Spz1, a novel bHLH-Zip protein, is specifically expressed in testis
    S H Hsu
    Institute of Molecular Biology, Academia Sinica, 11529, Taipei, Taiwan
    Mech Dev 100:177-87. 2001
    ..This nuclear transcription factor may play a crucial role in spermatogenesis by regulating cell proliferation or differentiation through binding to specific DNA sequences like other bHLH-Zip molecules...
  71. pmc Calreticulin and calnexin in the endoplasmic reticulum are important for phagocytosis
    A Müller-Taubenberger
    Max Planck Institut fur Biochemie, D 82152 Martinsried, Germany
    EMBO J 20:6772-82. 2001
    ....
  72. ncbi Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA
    L Deng
    Department of Biochemistry and Molecular Biology, UMDNJ-New Jersey Medical School, Newark, New Jersey 07103, USA
    Virology 289:312-26. 2001
    ..Therefore, transcription of integrated viral DNA in vivo requires the HAT activity of coactivators that are modulated by Tat to derepress the HIV-1 chromatin structure and aid in activated transcription...
  73. ncbi Effect of Cr(VI) exposure on sperm quality: human and animal studies
    H Li
    Department of Occupational Health, College of Public Health, Henan Medical University, Zhengzhou, Henan 450052, People's Republic of China
    Ann Occup Hyg 45:505-11. 2001
    ..The diameters of seminiferous tubules in exposed rats were smaller. These results suggest that occupational exposure to chromium(VI) leads to alteration of semen status and may affect the reproductive success of exposed workers...
  74. ncbi Efficacy and safety of intravenous phytonadione (vitamin K1) in patients on long-term oral anticoagulant therapy
    R C Shields
    Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, Minn 55905, USA
    Mayo Clin Proc 76:260-6. 2001
    ..In small doses, it does not prolong the patient's time to return to therapeutic anticoagulation...
  75. ncbi Can we predict poor outcome at presentation in patients with lobar hemorrhage?
    K D Flemming
    Department of Neurology, Neurological and Neurosurgical Intensive Care Unit, Saint Mary s Hospital, Rochester, Minn, USA
    Cerebrovasc Dis 11:183-9. 2001
    ..We performed a decision tree analysis combining clinical and CT scan features to predict poor and hopeless outcome at initial presentation in patients with lobar hemorrhage...
  76. pmc Characterization and mutational analysis of three allelic lsc genes encoding levansucrase in Pseudomonas syringae
    H Li
    AG Okophysiologie, Max Planck Institut fur terrestrische Mikrobiologie, Karl von Frisch Strasse, 35043 Marburg, Germany
    J Bacteriol 183:3282-92. 2001
    ..PCR screening in various P. syringae strains with primers derived from the three characterized lsc genes demonstrated the presence of multiple Lsc isoenzymes in other P. syringae pathovars...
  77. ncbi The cloning and nucleotide sequence of human ST2L cDNA
    H Li
    Department of Biochemistry, Jichi Medical School, Tochigi, Japan
    Genomics 67:284-90. 2000
    ..We also established stable transfectants of a human glioblastoma cell line, T98G, that express human ST2L constitutively, and we confirmed cell-surface expression of human ST2L protein on the transfectants...
  78. ncbi [Effects of Lewis Y oligosaccharide on secretion and gene expression of EGF and EGF-R in mouse embryos]
    Y Kong
    Department of Biochemistry, Institute of Glycobiology, Dalian Medical University, Dalian 116027, China
    Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 34:373-7. 2002
    ..The results suggest that Lewis Y oligosaccharide on the surface of embryo may be involved in the regulation of embryo development and implantation, by affecting the expression and secretion of EGF in embryo...
  79. ncbi Collagen metabolism and turnover in women with stress urinary incontinence and pelvic prolapse
    B H Chen
    Department of Gynecology and Obstetrics, Stanford University Medical School, California 94305 5317, USA
    Int Urogynecol J Pelvic Floor Dysfunct 13:80-7; discussion 87. 2002
    ..Both these findings are consistent with increased collagen breakdown as a pathologic etiology of incontinence...
  80. ncbi A new single nucleotide polymorphism in the chicken pituitary-specific transcription factor (POU1F1) gene associated with growth rate
    R Jiang
    Department of Animal Genetics and Breeding, China Agricultural University, Beijing, China
    Anim Genet 35:344-6. 2004
    ..The results revealed a positive relationship between genotype A/A and body weight at 8 weeks of age, indicating that the SNP in PIT1 gene is a potential molecular marker for early growth rate in chicken...
  81. ncbi Regulation of expression of MSG1 melanocyte-specific nuclear protein in human melanocytes and melanoma cells
    H Li
    MGH Cancer Center, Massachusetts General Hospital East, Charlestown, Massachusetts, 02129, USA
    Exp Cell Res 242:478-86. 1998
    ..These results demonstrate that MSG1 expression is regulated transcriptionally and posttranscriptionally by local growth factors as well as by the cellular status of differentiation...
  82. ncbi Mutation analysis of hereditary multiple exostoses in the Chinese
    L Xu
    National Laboratory of Medical Genetics, Hunan Medical University, Changsha, PR China
    Hum Genet 105:45-50. 1999
    ..Our findings suggest a possibly different genetic spectrum of this disease in different populations...
  83. ncbi Association analysis of bone mineral density and single nucleotide polymorphisms in two candidate genes on chromosome 1p36
    L D Spotila
    Department of Bioscience and Biotechnology, Drexel University, Philadelphia, PA 19104, USA
    Calcif Tissue Int 73:140-6. 2003
    ..04). These findings strengthen the potential importance of chromosome 1p36.2-1p36.3 in contributing to BMD variation, and are consistent with genetic variation in either PLOD1, TNFRSF1B or nearby genes playing a role in the phenotype...
  84. ncbi Inhibition of intimal lipid deposition in human apolipoprotein A1 transgenic mice
    M She
    Department of Pathology, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
    Clin Exp Pharmacol Physiol 26:833-4. 1999
    ..Expression of platelet-derived growth factor-B, c-myc and c-fos proteins was much weaker in smooth muscle cells at the aortic sinus in transgenic mice...
  85. ncbi [Development of a canine adenovirus type 1 vaccine strain E3-deleted based expression vector]
    H Li
    Department of Etiology, Institute of Basic Medical Sciences, CAMS, PUMC, Beijing 100005, China
    Zhongguo Yi Xue Ke Xue Yuan Xue Bao 23:40-4. 2001
    ..CONCLUSIONS: These results indicate that CLL possess powerful potential as recombinant vaccine and gene transfer vector...
  86. ncbi A genetic approach to understanding tumor angiogenesis
    R Benezra
    Department of Cell Biology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cold Spring Harb Symp Quant Biol 67:249-54. 2002
  87. ncbi Genetic markers associated with antibody response kinetics in adult chickens
    H Zhou
    Department of Animal Science, Iowa State University, Ames, Iowa 50011 3150, USA
    Poult Sci 82:699-708. 2003
    ..The variance explained by the QTL ranged from 6.46 to 7.50%. The results suggest that regions on Chromosomes 3, 5, 6, and Z contain QTL that affect antibody kinetics in the hen...
  88. ncbi [Biosynthesis of glutathione: construction of ATP regeneration system between recombinant E. coli and S. cerevisiae]
    Y Li
    Ministry of Education, Lab of Industrial Biotechnology, Wuxi University of Light Industry, Wuxi 214036, China
    Wei Sheng Wu Xue Bao 41:191-7. 2001
    ..By adding magnesium to the coupling system, a final concentration of GSH, 14.3 mmol/L (4.4 g/L), was achieved at 6 h of reaction...
  89. pmc Cloning and characterization of IL-17B and IL-17C, two new members of the IL-17 cytokine family
    H Li
    Department of Molecular Biology, Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    Proc Natl Acad Sci U S A 97:773-8. 2000
    ..These data show that there is a family of IL-17-related cytokines differing in patterns of expression and proinflammatory responses that may be transduced through a cognate set of cell surface receptors...
  90. ncbi Cytokine regulation of syndecan-1 and -2 gene expression in human periodontal fibroblasts and osteoblasts
    W Worapamorn
    School of Dentistry, Department of Physiology and Pharmacology, The University of Queensland, Brisbane, QLD, Australia
    J Periodontal Res 37:273-8. 2002
    ..These findings lend support to the notion that syndecan-1 and syndecan-2 have distinct functions which correlate with their source and functions within the periodontium...
  91. ncbi Lipopolysaccharide-induced switch between retinoid receptor (RXR) alpha and glucocorticoid attenuated response gene (GARG)-16 messenger RNAs in cultured rat microglia
    Y Kitamura
    Department of Neurobiology, Kyoto Pharmaceutical University, Misasagi, Kyoto, Japan
    J Neurosci Res 64:553-63. 2001
    ..The counter regulatory control of GARG16 and RXRalpha mRNA expression is believed to be an example of a fine-tuned cellular mechanism to react to inflammatory stimuli...