Gail Li

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi Statin therapy and risk of dementia in the elderly: a community-based prospective cohort study
    G Li
    Department of Psychiatry and Behavioral Science, University of Washington, Seattle, USA
    Neurology 63:1624-8. 2004
  2. ncbi Temporal relationship between depression and dementia: findings from a large community-based 15-year follow-up study
    Ge Li
    Departments of Psychiatry andBehavioral Sciences, University of Washington, Seattle, USA
    Arch Gen Psychiatry 68:970-7. 2011
  3. ncbi Age-varying association between statin use and incident Alzheimer's disease
    Ge Li
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA
    J Am Geriatr Soc 58:1311-7. 2010
  4. ncbi Cerebrospinal fluid concentration of brain-derived neurotrophic factor and cognitive function in non-demented subjects
    Ge Li
    Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington, USA
    PLoS ONE 4:e5424. 2009
  5. ncbi Statin therapy is associated with reduced neuropathologic changes of Alzheimer disease
    G Li
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA
    Neurology 69:878-85. 2007
  6. ncbi Age-varying association between blood pressure and risk of dementia in those aged 65 and older: a community-based prospective cohort study
    Ge Li
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, USA
    J Am Geriatr Soc 55:1161-7. 2007
  7. ncbi Salivary cortisol and memory function in human aging
    Ge Li
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98195, USA
    Neurobiol Aging 27:1705-14. 2006
  8. ncbi Serum cholesterol and risk of Alzheimer disease: a community-based cohort study
    G Li
    Department of Psychiatry and Behavioral Science, University of Washington, Seattle, WA, USA
    Neurology 65:1045-50. 2005
  9. ncbi Tau phosphorylation pathway genes and cerebrospinal fluid tau levels in Alzheimer's disease
    Lynn M Bekris
    Geriatric Research, Education, and Clinical Center GRECC, VA Puget Sound Health Care System, Seattle, Washington 98108, USA
    Am J Med Genet B Neuropsychiatr Genet 159:874-83. 2012
  10. ncbi ADAM10 expression and promoter haplotype in Alzheimer's disease
    Lynn M Bekris
    Geriatric Research, Education, and Clinical Center GRECC, VA Puget Sound Health Care System, Seattle, WA, USA
    Neurobiol Aging 33:2229.e1-2229.e9. 2012

Research Grants

  1. Effects of Simvastatin on CSF AD biomarkers in cognitively normal subjects
    Gail Li; Fiscal Year: 2010
  2. Vascular Risk Factors in Alzheimer's Disease
    Gail Li; Fiscal Year: 2006

Detail Information

Publications12

  1. ncbi Statin therapy and risk of dementia in the elderly: a community-based prospective cohort study
    G Li
    Department of Psychiatry and Behavioral Science, University of Washington, Seattle, USA
    Neurology 63:1624-8. 2004
    ..To assess the association between statin therapy and risk of Alzheimer disease (AD) in a prospective cohort study with documented statin exposure and incident dementia...
  2. ncbi Temporal relationship between depression and dementia: findings from a large community-based 15-year follow-up study
    Ge Li
    Departments of Psychiatry andBehavioral Sciences, University of Washington, Seattle, USA
    Arch Gen Psychiatry 68:970-7. 2011
    ..Late-life depression is associated with increased risk of dementia, but the temporal relationship between depression and development of dementia remains unclear...
  3. ncbi Age-varying association between statin use and incident Alzheimer's disease
    Ge Li
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA
    J Am Geriatr Soc 58:1311-7. 2010
    ..To determine whether risk reduction of statins for Alzheimer's disease (AD) varies by age or presence of apolipoprotein E (APOE) epsilon4 allele...
  4. ncbi Cerebrospinal fluid concentration of brain-derived neurotrophic factor and cognitive function in non-demented subjects
    Ge Li
    Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington, USA
    PLoS ONE 4:e5424. 2009
    ..01). CONCLUSIONS/SIGNIFICANCE: Reduced CSF BDNF was associated with age-related cognitive decline, suggesting a potential mechanism that may contribute in part to cognitive decline in older individuals...
  5. ncbi Statin therapy is associated with reduced neuropathologic changes of Alzheimer disease
    G Li
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA
    Neurology 69:878-85. 2007
    ..We investigated whether antecedent statin exposure is associated with neuritic plaque (NP) or neurofibrillary tangle (NFT) burden in a population-based sample of human subjects...
  6. ncbi Age-varying association between blood pressure and risk of dementia in those aged 65 and older: a community-based prospective cohort study
    Ge Li
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, USA
    J Am Geriatr Soc 55:1161-7. 2007
    ..To assess variation in the association between blood pressure (BP) and risk for dementia across a spectrum of older ages and to examine BP changes before dementia onset...
  7. ncbi Salivary cortisol and memory function in human aging
    Ge Li
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98195, USA
    Neurobiol Aging 27:1705-14. 2006
    ..Previous studies have suggested that elevated glucocorticoid concentrations alter hippocampal neuronal morphology, inhibit neurogenesis, and impair cognition...
  8. ncbi Serum cholesterol and risk of Alzheimer disease: a community-based cohort study
    G Li
    Department of Psychiatry and Behavioral Science, University of Washington, Seattle, WA, USA
    Neurology 65:1045-50. 2005
    ..To examine the association of serum total cholesterol (TC) and high density lipoprotein (HDL) levels and subsequent incidence of dementia and Alzheimer disease (AD) in a population-based cohort study...
  9. ncbi Tau phosphorylation pathway genes and cerebrospinal fluid tau levels in Alzheimer's disease
    Lynn M Bekris
    Geriatric Research, Education, and Clinical Center GRECC, VA Puget Sound Health Care System, Seattle, Washington 98108, USA
    Am J Med Genet B Neuropsychiatr Genet 159:874-83. 2012
    ..These results suggest that rs7768046 and rs913275 both influence CSF tau levels in an AD-associated manner...
  10. ncbi ADAM10 expression and promoter haplotype in Alzheimer's disease
    Lynn M Bekris
    Geriatric Research, Education, and Clinical Center GRECC, VA Puget Sound Health Care System, Seattle, WA, USA
    Neurobiol Aging 33:2229.e1-2229.e9. 2012
    ..Taken together, these findings suggest that ADAM10 expression is modulated according to a promoter haplotype that is influenced in a brain region- and cell type-specific manner...
  11. ncbi Evaluation of selection bias in an incident-based dementia autopsy case series
    Debby Tsuang
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, USA
    Alzheimer Dis Assoc Disord 19:67-73. 2005
    ....
  12. ncbi CSF tau/Abeta42 ratio for increased risk of mild cognitive impairment: a follow-up study
    G Li
    Mental Illness Research, Education, and Clinical Center and Department of Psychiatry, VA Puget Sound Health Care System, University of Washington, Seattle, WA, USA
    Neurology 69:631-9. 2007
    ..While many studies have evaluated CSF tau and Abeta(42) as biomarkers of the dementia or prodromal stages of AD, we are unaware of any study to evaluate these potential CSF biomarkers of latent AD...

Research Grants3

  1. Effects of Simvastatin on CSF AD biomarkers in cognitively normal subjects
    Gail Li; Fiscal Year: 2010
    ..Simvastatin has been widely used for prevention of coronary artery disease. The findings of the proposed study may provide proof of concept in support of large scale primary prevention trials in persons at high risk for AD. ..
  2. Vascular Risk Factors in Alzheimer's Disease
    Gail Li; Fiscal Year: 2006
    ..abstract_text> ..