David Wan Cheng Li

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. ncbi request reprint Expression and activity of the signaling molecules for mitogen-activated protein kinase pathways in human, bovine, and rat lenses
    David Wan Cheng Li
    Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA
    Invest Ophthalmol Vis Sci 44:5277-86. 2003
  2. pmc Calcium-activated RAF/MEK/ERK signaling pathway mediates p53-dependent apoptosis and is abrogated by alpha B-crystallin through inhibition of RAS activation
    David Wan Cheng Li
    Hormel Institute, University of Minnesota, Austin, MN 55912, USA
    Mol Biol Cell 16:4437-53. 2005
  3. ncbi request reprint Human alphaA- and alphaB-crystallins prevent UVA-induced apoptosis through regulation of PKCalpha, RAF/MEK/ERK and AKT signaling pathways
    Jin Ping Liu
    The Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin 55912, USA
    Exp Eye Res 79:393-403. 2004
  4. ncbi request reprint hTERT extends proliferative lifespan and prevents oxidative stress-induced apoptosis in human lens epithelial cells
    Xiao Qin Huang
    College of Life Sciences, Hunan Normal University, Changsha, Hunan, China
    Invest Ophthalmol Vis Sci 46:2503-13. 2005
  5. ncbi request reprint Human Bcl-2 activates ERK signaling pathway to regulate activating protein-1, lens epithelium-derived growth factor and downstream genes
    Hao Feng
    College of Life Sciences, Hunan Normal University, Changsha, PR China
    Oncogene 23:7310-21. 2004
  6. ncbi request reprint Human telomerase reverse transcriptase immortalizes bovine lens epithelial cells and suppresses differentiation through regulation of the ERK signaling pathway
    Juan Wang
    College of Life Sciences, Hunan Normal University, Changsha, China
    J Biol Chem 280:22776-87. 2005
  7. doi request reprint Cataract mutation P20S of alphaB-crystallin impairs chaperone activity of alphaA-crystallin and induces apoptosis of human lens epithelial cells
    Hui Li
    Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, P R China
    Biochim Biophys Acta 1782:303-9. 2008
  8. ncbi request reprint Apoptosis in lens development and pathology
    Qin Yan
    College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, China
    Differentiation 74:195-211. 2006
  9. ncbi request reprint Human telomerase accelerates growth of lens epithelial cells through regulation of the genes mediating RB/E2F pathway
    Hua Xiang
    Department of Molecular Biology, University of Medicine and Dentistry of New Jersey School of Osteopathic Medicine, Stratford, New Jersey, NJ 08084, USA
    Oncogene 21:3784-91. 2002
  10. pmc Differential expression of the catalytic subunits for PP-1 and PP-2A and the regulatory subunits for PP-2A in mouse eye
    Wen Bin Liu
    Key Laboratory of Protein Chemistry and Developmental Biology of National Education Ministry of China, College of Life Sciences, Hunan Normal University, Changsha, Hunan, China
    Mol Vis 14:762-73. 2008

Collaborators

  • Zigang Dong
  • Venkat Reddy
  • J C Reed
  • RHODERICK BROWN
  • Jin Ping Liu
  • Hao Feng
  • Juan Wang
  • Wen Bin Liu
  • Qin Yan
  • Yun Liu
  • Xiao Qin Huang
  • Yan Liu
  • Hua Xiang
  • Hui Li
  • Shuming Sun
  • Mi Deng
  • Lili Gong
  • Chen Luo
  • Xuan Jie Zhang
  • Ying Wei Mao
  • Shao Jun Liu
  • Shaoqiong Zeng
  • Jingyu Liu
  • Chang Li
  • He Ge Chen
  • Qing K Wang
  • Yong Li
  • Mugen Liu
  • Zhihong Zhang
  • Qiulun Lu
  • Mingxiong Yuan
  • Lan Zhang
  • Tie Ke
  • Ting Su
  • Xiang Ren
  • Shu Ming Sun
  • Long Liu
  • Wei Ya Ma
  • Ryan Schlosser
  • Xiao qing Huang
  • Mingyao Liu
  • Yingwei Mao

Detail Information

Publications10

  1. ncbi request reprint Expression and activity of the signaling molecules for mitogen-activated protein kinase pathways in human, bovine, and rat lenses
    David Wan Cheng Li
    Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA
    Invest Ophthalmol Vis Sci 44:5277-86. 2003
    ....
  2. pmc Calcium-activated RAF/MEK/ERK signaling pathway mediates p53-dependent apoptosis and is abrogated by alpha B-crystallin through inhibition of RAS activation
    David Wan Cheng Li
    Hormel Institute, University of Minnesota, Austin, MN 55912, USA
    Mol Biol Cell 16:4437-53. 2005
    ..Together, our results provide 1) a partial explanation for the lack of spontaneous tumor in the lens, 2) a novel signaling pathway for calcium-induced apoptosis, and 3) a novel antiapoptotic mechanism for alphaB-crystallin...
  3. ncbi request reprint Human alphaA- and alphaB-crystallins prevent UVA-induced apoptosis through regulation of PKCalpha, RAF/MEK/ERK and AKT signaling pathways
    Jin Ping Liu
    The Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin 55912, USA
    Exp Eye Res 79:393-403. 2004
    ..Together, our results for the first time reveal that by regulating multiple signaling pathways the two alpha-crystallins can prevent stress-induced apoptosis through different mechanisms...
  4. ncbi request reprint hTERT extends proliferative lifespan and prevents oxidative stress-induced apoptosis in human lens epithelial cells
    Xiao Qin Huang
    College of Life Sciences, Hunan Normal University, Changsha, Hunan, China
    Invest Ophthalmol Vis Sci 46:2503-13. 2005
    ..In this study, the human telomerase reverse transcriptase (hTERT) catalytic subunit was introduced into HLECs. A stable cell line expressing hTERT was established and the functions of hTERT were studied...
  5. ncbi request reprint Human Bcl-2 activates ERK signaling pathway to regulate activating protein-1, lens epithelium-derived growth factor and downstream genes
    Hao Feng
    College of Life Sciences, Hunan Normal University, Changsha, PR China
    Oncogene 23:7310-21. 2004
    ..Thus, our results provide a mechanism to explain how Bcl-2 may regulate expression of other genes...
  6. ncbi request reprint Human telomerase reverse transcriptase immortalizes bovine lens epithelial cells and suppresses differentiation through regulation of the ERK signaling pathway
    Juan Wang
    College of Life Sciences, Hunan Normal University, Changsha, China
    J Biol Chem 280:22776-87. 2005
    ..Our finding that hTERT can suppress RAS/RAF/MEK/ERK signaling pathway to prevent differentiation provides a novel mechanism to explain how hTERT regulates cell differentiation...
  7. doi request reprint Cataract mutation P20S of alphaB-crystallin impairs chaperone activity of alphaA-crystallin and induces apoptosis of human lens epithelial cells
    Hui Li
    Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, P R China
    Biochim Biophys Acta 1782:303-9. 2008
    ..These results suggest that the changes in the structure and function of the alpha-crystallin complex and cytotoxicity are vital factors in the pathogenesis of congenital cataract linked to the P20S mutation in the alphaB-crystallin...
  8. ncbi request reprint Apoptosis in lens development and pathology
    Qin Yan
    College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, China
    Differentiation 74:195-211. 2006
    ..The present review summarizes the current knowledge on apoptosis in the ocular lens with emphasis on its role in lens development and pathology...
  9. ncbi request reprint Human telomerase accelerates growth of lens epithelial cells through regulation of the genes mediating RB/E2F pathway
    Hua Xiang
    Department of Molecular Biology, University of Medicine and Dentistry of New Jersey School of Osteopathic Medicine, Stratford, New Jersey, NJ 08084, USA
    Oncogene 21:3784-91. 2002
    ..Taken together, our results suggest that hTERT, when overexpressed in human lens epithelial cells, accelerates cell growth rate through regulation of RB/E2F pathway and possibly other genes...
  10. pmc Differential expression of the catalytic subunits for PP-1 and PP-2A and the regulatory subunits for PP-2A in mouse eye
    Wen Bin Liu
    Key Laboratory of Protein Chemistry and Developmental Biology of National Education Ministry of China, College of Life Sciences, Hunan Normal University, Changsha, Hunan, China
    Mol Vis 14:762-73. 2008
    ..In addition, we have also demonstrated the differential protections of PP-1 and PP-2A in mouse lens epithelial cell line, alphaTN4-1, against oxidative stress-induced apoptosis...