D Y Li

Summary

Affiliation: University of Utah
Country: USA

Publications

  1. pmc Netrins promote developmental and therapeutic angiogenesis
    Brent D Wilson
    Program in Human Molecular Biology and Genetics, University of Utah, Salt Lake City, UT 84112, USA
    Science 313:640-4. 2006
  2. ncbi Defective angiogenesis in mice lacking endoglin
    D Y Li
    Program in Human Molecular Biology and Genetics, Department of Human Genetics, Howard Hughes Medical Institute, University of Utah, Salt Lake City, UT 84112 5330, USA
    Science 284:1534-7. 1999
  3. ncbi Arteriovenous malformations in mice lacking activin receptor-like kinase-1
    L D Urness
    Program in Human Molecular Biology and Genetics, University of Utah, Salt Lake City, Utah, USA
    Nat Genet 26:328-31. 2000
  4. ncbi Impaired distal airway development in mice lacking elastin
    D P Wendel
    Program in Human and Molecular Biology and Genetics, Department of Human Genetics, Howard Hughes Medical Institute, University of Utah, Salt Lake City, Utah, USA
    Am J Respir Cell Mol Biol 23:320-6. 2000
  5. pmc Novel arterial pathology in mice and humans hemizygous for elastin
    D Y Li
    Cardiology Division and Program in Human Molecular Biology and Genetics, University of Utah Health Sciences Center, Salt Lake City, Utah 84112 5330, USA
    J Clin Invest 102:1783-7. 1998
  6. doi Emerging mechanisms of vascular stabilization
    N R London
    Department of Oncological Sciences, University of Utah, Salt Lake City, UT 84112, USA
    J Thromb Haemost 7:57-60. 2009
  7. pmc The axonal attractant Netrin-1 is an angiogenic factor
    Kye Won Park
    Program in Human Molecular Biology and Genetics, Department of Medicine, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Proc Natl Acad Sci U S A 101:16210-5. 2004
  8. pmc The netrin receptor UNC5B promotes angiogenesis in specific vascular beds
    Sutip Navankasattusas
    Program in Human Molecular Biology and Genetics, University of Utah, Salt Lake City, UT 84112, USA
    Development 135:659-67. 2008
  9. pmc roundabout4 is essential for angiogenesis in vivo
    Victoria M Bedell
    Laboratory of Pathology, National Cancer Institute, National Institutes of Health, 9610 Medical Center Drive, Suite 320, Rockville, MD 20850, USA
    Proc Natl Acad Sci U S A 102:6373-8. 2005
  10. ncbi Loss of distinct arterial and venous boundaries in mice lacking endoglin, a vascular-specific TGFbeta coreceptor
    Lise K Sorensen
    Department of Medicine, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
    Dev Biol 261:235-50. 2003

Collaborators

  • E C Davis
  • R P Mecham
  • G Faury
  • Emmanuelle Tillet
  • Holger Gerhardt
  • Marie Paule Jacob
  • Ramani Ramchandran
  • DOUGLAS A contact MARCHUK
  • Douglas W Losordo
  • Sang Yeob Yeo
  • Kye Won Park
  • Lise K Sorensen
  • Benjamin S Brooke
  • Christopher A Jones
  • Lisa D Urness
  • Satyajit K Karnik
  • Jessica E Wagenseil
  • Joshua D Wythe
  • Chi Bin Chien
  • Kevin J Whitehead
  • N R London
  • Sutip Navankasattusas
  • Mylène Pezet
  • Carley A E Shaut
  • Wonhee Suh
  • Arminda Suli
  • Kirk R Thomas
  • Frederic Larrieu-Lahargue
  • Pankaj Seth
  • Russell H Knutsen
  • Brent D Wilson
  • Jeffrey A Spencer
  • Victoria M Bedell
  • Lise Sorensen
  • L D Urness
  • D P Wendel
  • M C P Smith
  • Rebecca A Stockton
  • Philippe Huber
  • Haoyu Chen
  • Mark H Ginsberg
  • Roger Vranckx
  • Yoh suke Mukouyama
  • Pascale Perret
  • Jia Zhao
  • Nyall R London
  • Dealba Gheduzzi
  • Per Lindblom
  • Kang Zhang
  • Antonio Frias
  • Walter A Boyle
  • Dominique Sauvaget
  • Brigitte Escoubet
  • Barry Starcher
  • Douglas R Keene
  • Amy H Lim
  • Naoyuki Nishiya
  • H Scott Stadler
  • Daniela Quaglino
  • Tina Thorne
  • Marcy Silver
  • Masaaki Ii
  • Jun Asai
  • Gerhardus A H Kock
  • James A Richardson
  • Eric N Olson
  • Shelby L Hacker
  • Robert D Gerard
  • Venkatesha Shivalingappa
  • Ruth J Okamoto
  • Jinhua Zhao
  • Vikas P Sukhatme
  • Jeffrey Chung
  • Nandan L Nerurkar
  • Russ H Knutsen
  • Tomoko Obara
  • Iain A Drummond
  • Hiromi Yanagisawa
  • Calvin J Kuo
  • Nicholas W Plummer
  • Jennifer A Adams
  • Dana Crouse
  • Mark Lee
  • Kelly J Murphy
  • Jane Y Wu
  • Antoni Bayes-Genis
  • Robert S Schwartz
  • Clayton M Morrison
  • Antonio Bayes-Genis
  • Yi Rao

Detail Information

Publications25

  1. pmc Netrins promote developmental and therapeutic angiogenesis
    Brent D Wilson
    Program in Human Molecular Biology and Genetics, University of Utah, Salt Lake City, UT 84112, USA
    Science 313:640-4. 2006
    ..We propose that the attractive vascular and neural guidance functions of netrins offer a unique therapeutic potential...
  2. ncbi Defective angiogenesis in mice lacking endoglin
    D Y Li
    Program in Human Molecular Biology and Genetics, Department of Human Genetics, Howard Hughes Medical Institute, University of Utah, Salt Lake City, UT 84112 5330, USA
    Science 284:1534-7. 1999
    ..Loss of endoglin caused poor vascular smooth muscle development and arrested endothelial remodeling. These results demonstrate that endoglin is essential for angiogenesis and suggest a pathogenic mechanism for HHT1...
  3. ncbi Arteriovenous malformations in mice lacking activin receptor-like kinase-1
    L D Urness
    Program in Human Molecular Biology and Genetics, University of Utah, Salt Lake City, Utah, USA
    Nat Genet 26:328-31. 2000
    ..The early loss of anatomical, molecular and functional distinctions between arteries and veins indicates that Acvrl1 is required for developing distinct arterial and venous vascular beds...
  4. ncbi Impaired distal airway development in mice lacking elastin
    D P Wendel
    Program in Human and Molecular Biology and Genetics, Department of Human Genetics, Howard Hughes Medical Institute, University of Utah, Salt Lake City, Utah, USA
    Am J Respir Cell Mol Biol 23:320-6. 2000
    ..Thus, in addition to its role in the structure and function of the mature lung, elastin is essential for pulmonary development and is important for terminal airway branching...
  5. pmc Novel arterial pathology in mice and humans hemizygous for elastin
    D Y Li
    Cardiology Division and Program in Human Molecular Biology and Genetics, University of Utah Health Sciences Center, Salt Lake City, Utah 84112 5330, USA
    J Clin Invest 102:1783-7. 1998
    ..Humans are exquisitely sensitive to reduced ELN expression, developing profound arterial thickening and markedly increased risk of obstructive vascular disease...
  6. doi Emerging mechanisms of vascular stabilization
    N R London
    Department of Oncological Sciences, University of Utah, Salt Lake City, UT 84112, USA
    J Thromb Haemost 7:57-60. 2009
    ..Thus, neurobiology and neurology are providing insights into the concepts of vascular stability...
  7. pmc The axonal attractant Netrin-1 is an angiogenic factor
    Kye Won Park
    Program in Human Molecular Biology and Genetics, Department of Medicine, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Proc Natl Acad Sci U S A 101:16210-5. 2004
    ..Thus, we demonstrate that Netrin-1 is a secreted neural guidance cue with the unique ability to attract both blood vessels and axons, and suggest that other cues may also function as vascular endothelial growth factors...
  8. pmc The netrin receptor UNC5B promotes angiogenesis in specific vascular beds
    Sutip Navankasattusas
    Program in Human Molecular Biology and Genetics, University of Utah, Salt Lake City, UT 84112, USA
    Development 135:659-67. 2008
    ....
  9. pmc roundabout4 is essential for angiogenesis in vivo
    Victoria M Bedell
    Laboratory of Pathology, National Cancer Institute, National Institutes of Health, 9610 Medical Center Drive, Suite 320, Rockville, MD 20850, USA
    Proc Natl Acad Sci U S A 102:6373-8. 2005
    ..Also, human robo4 gene functionally compensates for loss of robo4 gene function, suggesting evolutionary conservation. This article reports an endothelial-specific function for a robo gene in vertebrates in vivo...
  10. ncbi Loss of distinct arterial and venous boundaries in mice lacking endoglin, a vascular-specific TGFbeta coreceptor
    Lise K Sorensen
    Department of Medicine, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
    Dev Biol 261:235-50. 2003
    ..We propose that endoglin and Alk1 are necessary for the maintenance of distinct arterial-venous vascular beds and that attenuation of the Alk1 signaling pathway is the precipitating event in the etiology of HHT...
  11. pmc HOXA13 Is essential for placental vascular patterning and labyrinth endothelial specification
    Carley A E Shaut
    Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, Oregon, United States of America
    PLoS Genet 4:e1000073. 2008
    ....
  12. pmc Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability
    Christopher A Jones
    Department of Oncological Sciences, University of Utah, 15 North 2030 East, Salt Lake City, Utah 84112, USA
    Nat Med 14:448-53. 2008
    ....
  13. ncbi New insights into elastin and vascular disease
    Benjamin S Brooke
    Program in Human Molecular Biology and Genetics, Department of Medicine, University of Utah, Salt Lake City, UT 84112 5330, USA
    Trends Cardiovasc Med 13:176-81. 2003
    ..This review examines the complexity of elastin-smooth muscle cell interactions, and how new insights may impact understanding of the pathogenesis and treatment of vascular disease...
  14. pmc Elastin haploinsufficiency induces alternative aging processes in the aorta
    Mylène Pezet
    Universite Joseph Fourier, UFR de Biologie, Grenoble, France
    Rejuvenation Res 11:97-112. 2008
    ..Our results suggest that early elastin expression and organization modify arterial aging through their impact on both vascular cell physiology and structure and mechanics of blood vessels...
  15. pmc Common cues regulate neural and vascular patterning
    Christopher A Jones
    Department of Oncological Sciences, University of Utah, Salt Lake City, UT 84112, United States
    Curr Opin Genet Dev 17:332-6. 2007
    ..Recent studies of the Dll4-Notch1 signaling pathway have provided valuable insight into how the vasculature accomplishes this crucial task...
  16. ncbi Elastin-insufficient mice show normal cardiovascular remodeling in 2K1C hypertension despite higher baseline pressure and unique cardiovascular architecture
    Jessica E Wagenseil
    Department of Cell Biology and Physiology, Washington University School of Medicine, 660 S Euclid Street, St Louis, MO 63110, USA
    Am J Physiol Heart Circ Physiol 293:H574-82. 2007
    ..Therefore, the cardiovascular properties of ELN(+/-) mice are likely due to developmental remodeling in response to altered hemodynamics and reduced elastin levels...
  17. pmc Developmental adaptation of the mouse cardiovascular system to elastin haploinsufficiency
    Gilles Faury
    Laboratoire de Développement et Vieillissement de l Endothélium, Commisarriat à l Energie Atomique Institut National de la Santé et de la Recherche Médicale Equipq Mixte 0219, Universite Joseph Fourier, Grenoble, France
    J Clin Invest 112:1419-28. 2003
    ..The association of hypertension with elastin haploinsufficiency in humans and mice strongly suggests that elastin and other proteins of the elastic fiber should be considered as causal genes for essential hypertension...
  18. ncbi Effects of elastin haploinsufficiency on the mechanical behavior of mouse arteries
    Jessica E Wagenseil
    Department of Cell Biology and Physiology, CB 8228, Washington University School of Medicine, 660 S Euclid, St Louis, MO 63110, USA
    Am J Physiol Heart Circ Physiol 289:H1209-17. 2005
    ..The mechanical behavior of ELN(+/-) arteries is likely due to the reduced elastin content combined with adaptive remodeling during vascular development...
  19. ncbi Robo4 is a vascular-specific receptor that inhibits endothelial migration
    Kye Won Park
    School of Medicine, University of Utah, Salt Lake City, UT 84112, USA
    Dev Biol 261:251-67. 2003
    ..These data demonstrate that Robo4 is a bona fide member of the Robo family and may provide a repulsive cue to migrating endothelial cells during vascular development...
  20. pmc Altered vascular remodeling in fibulin-5-deficient mice reveals a role of fibulin-5 in smooth muscle cell proliferation and migration
    Jeffrey A Spencer
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA
    Proc Natl Acad Sci U S A 102:2946-51. 2005
    ..These findings demonstrate the importance of the elastic laminae in vascular injury, and reveal an unexpected role of fbln-5 as an inhibitor of vascular smooth muscle cell proliferation and migration...
  21. ncbi Wiring the vascular circuitry: from growth factors to guidance cues
    Lisa D Urness
    Division of Cardiology, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA
    Curr Top Dev Biol 62:87-126. 2004
  22. ncbi A critical role for elastin signaling in vascular morphogenesis and disease
    Satyajit K Karnik
    Program in Human Molecular Biology and Genetics, University of Utah, Salt Lake City, UT, USA
    Development 130:411-23. 2003
    ..Together, this work demonstrates that signaling pathways crucial for arterial morphogenesis can play an important role in the pathogenesis and treatment of vascular disease...
  23. ncbi Ccm1 is required for arterial morphogenesis: implications for the etiology of human cavernous malformations
    Kevin J Whitehead
    Program in Human Molecular Biology and Genetics, University of Utah, Building 533 Room 4220, 15 N 2030 East, Salt Lake City, Utah 84112, USA
    Development 131:1437-48. 2004
    ..Our studies suggest that cavernous malformations result from primary vascular rather than neural defects...
  24. ncbi Elastin induces myofibrillogenesis via a specific domain, VGVAPG
    Satyajit K Karnik
    Program in Human Molecular Biology and Genetics and Department of Oncological Sciences, University of Utah, 15 North 2030 East Rm 4450, Salt Lake City, UT 84112 5330, USA
    Matrix Biol 22:409-25. 2003
    ..Collectively, these data support a model whereby the elastin gene product, signaling through the VGVAPG domain, directly induces VSMC myofibrillogenesis...
  25. ncbi Extracellular matrix in vascular morphogenesis and disease: structure versus signal
    Benjamin S Brooke
    Program in Human Molecular Biology and Genetics, Department of Medicine, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
    Trends Cell Biol 13:51-6. 2003
    ..Here, we examine human genetics, murine gene targeting and cell biology to better understand the relationship between structural and signaling roles for the ECM in vascular morphogenesis and disease...