Chunhao Li

Summary

Affiliation: University at Buffalo
Country: USA

Publications

  1. doi request reprint Inactivation of a putative flagellar motor switch protein FliG1 prevents Borrelia burgdorferi from swimming in highly viscous media and blocks its infectivity
    Chunhao Li
    Department of Oral Biology, State University of New York, Buffalo, NY 14214, USA
    Mol Microbiol 75:1563-76. 2010
  2. pmc Differential regulation of the multiple flagellins in spirochetes
    Chunhao Li
    Department of Oral Biology, The State University of New York at Buffalo, Buffalo, New York 14214 8031, USA
    J Bacteriol 192:2596-603. 2010
  3. pmc Two CheW coupling proteins are essential in a chemosensory pathway of Borrelia burgdorferi
    Kai Zhang
    Department of Oral Biology, The State University of New York at Buffalo, Buffalo, NY 14214, USA
    Mol Microbiol 85:782-94. 2012
  4. pmc Carbon storage regulator A (CsrA(Bb)) is a repressor of Borrelia burgdorferi flagellin protein FlaB
    Ching Wooen Sze
    Department of Oral Biology, The State University of New York at Buffalo, New York 14214, USA
    Mol Microbiol 82:851-64. 2011
  5. pmc A surface-exposed neuraminidase affects complement resistance and virulence of the oral spirochaete Treponema denticola
    Kurni Kurniyati
    Department of Oral Biology, The State University of New York at Buffalo, New York, 14214, USA
    Mol Microbiol 89:842-56. 2013
  6. pmc Inactivation of cyclic Di-GMP binding protein TDE0214 affects the motility, biofilm formation, and virulence of Treponema denticola
    Jiang Bian
    Department of Oral Biology, State University of New York at Buffalo, Buffalo, New York, USA
    J Bacteriol 195:3897-905. 2013
  7. pmc Study of the response regulator Rrp1 reveals its regulatory role in chitobiose utilization and virulence of Borrelia burgdorferi
    Ching Wooen Sze
    Department of Oral Biology, The State University of New York at Buffalo, Buffalo, New York, USA
    Infect Immun 81:1775-87. 2013
  8. pmc Genetic analysis of spirochete flagellin proteins and their involvement in motility, filament assembly, and flagellar morphology
    Chunhao Li
    Department of Oral Biology, State University of New York at Buffalo, Buffalo, New York 14214, USA
    J Bacteriol 190:5607-15. 2008
  9. pmc Abrogation of neuraminidase reduces biofilm formation, capsule biosynthesis, and virulence of Porphyromonas gingivalis
    Chen Li
    Department of Oral Biology, The State University of New York at Buffalo, New York, USA
    Infect Immun 80:3-13. 2012
  10. pmc Borrelia burgdorferi needs chemotaxis to establish infection in mammals and to accomplish its enzootic cycle
    Ching Wooen Sze
    Department of Oral Biology, The State University of New York at Buffalo, Buffalo, New York, USA
    Infect Immun 80:2485-92. 2012

Collaborators

Detail Information

Publications18

  1. doi request reprint Inactivation of a putative flagellar motor switch protein FliG1 prevents Borrelia burgdorferi from swimming in highly viscous media and blocks its infectivity
    Chunhao Li
    Department of Oral Biology, State University of New York, Buffalo, NY 14214, USA
    Mol Microbiol 75:1563-76. 2010
    ..burgdorferi and probably other pathogenic spirochetes...
  2. pmc Differential regulation of the multiple flagellins in spirochetes
    Chunhao Li
    Department of Oral Biology, The State University of New York at Buffalo, Buffalo, New York 14214 8031, USA
    J Bacteriol 192:2596-603. 2010
    ..The regulatory mechanism identified here should allow spirochetes to change the relative ratio of these flagellin proteins and, concomitantly, vary the stiffness of their flagellar filament...
  3. pmc Two CheW coupling proteins are essential in a chemosensory pathway of Borrelia burgdorferi
    Kai Zhang
    Department of Oral Biology, The State University of New York at Buffalo, Buffalo, NY 14214, USA
    Mol Microbiol 85:782-94. 2012
    ..Although many bacteria have more than one homologue of CheW, to our knowledge, this report provides the first experimental evidence that two CheW proteins coexist in one chemosensory pathway and that both are essential for chemotaxis...
  4. pmc Carbon storage regulator A (CsrA(Bb)) is a repressor of Borrelia burgdorferi flagellin protein FlaB
    Ching Wooen Sze
    Department of Oral Biology, The State University of New York at Buffalo, New York 14214, USA
    Mol Microbiol 82:851-64. 2011
    ..Taken together, our results indicate that CsrA(Bb) specifically regulates the periplasmic flagellar synthesis by inhibiting translation initiation of the flaB transcript...
  5. pmc A surface-exposed neuraminidase affects complement resistance and virulence of the oral spirochaete Treponema denticola
    Kurni Kurniyati
    Department of Oral Biology, The State University of New York at Buffalo, New York, 14214, USA
    Mol Microbiol 89:842-56. 2013
    ..Based on these results, we propose that T.denticola has evolved a strategy to scavenge host sialic acid using its neuraminidase, which allows the spirochaete to acquire nutrients and evade complement killing...
  6. pmc Inactivation of cyclic Di-GMP binding protein TDE0214 affects the motility, biofilm formation, and virulence of Treponema denticola
    Jiang Bian
    Department of Oral Biology, State University of New York at Buffalo, Buffalo, New York, USA
    J Bacteriol 195:3897-905. 2013
    ..This report also paves a way to further unveil the roles of the c-di-GMP signaling network in the biology and pathogenicity of T. denticola. ..
  7. pmc Study of the response regulator Rrp1 reveals its regulatory role in chitobiose utilization and virulence of Borrelia burgdorferi
    Ching Wooen Sze
    Department of Oral Biology, The State University of New York at Buffalo, Buffalo, New York, USA
    Infect Immun 81:1775-87. 2013
    ..The finding reported here provides us with new insight into the regulatory role of Rrp1 in carbohydrate utilization and virulence of B. burgdorferi...
  8. pmc Genetic analysis of spirochete flagellin proteins and their involvement in motility, filament assembly, and flagellar morphology
    Chunhao Li
    Department of Oral Biology, State University of New York at Buffalo, Buffalo, New York 14214, USA
    J Bacteriol 190:5607-15. 2008
    ..Finally, linear elasticity theory indicates that flagellar stiffness directly affects the spirochete's swimming speed...
  9. pmc Abrogation of neuraminidase reduces biofilm formation, capsule biosynthesis, and virulence of Porphyromonas gingivalis
    Chen Li
    Department of Oral Biology, The State University of New York at Buffalo, New York, USA
    Infect Immun 80:3-13. 2012
    ..gingivalis, and it can potentially serve as a new target for developing therapeutic agents against P. gingivalis infection...
  10. pmc Borrelia burgdorferi needs chemotaxis to establish infection in mammals and to accomplish its enzootic cycle
    Ching Wooen Sze
    Department of Oral Biology, The State University of New York at Buffalo, Buffalo, New York, USA
    Infect Immun 80:2485-92. 2012
    ..The altered phenotypes were completely restored when the mutant was complemented. Collectively, these data demonstrate that B. burgdorferi needs chemotaxis to establish mammalian infection and to accomplish its natural enzootic cycle...
  11. pmc A single-domain FlgJ contributes to flagellar hook and filament formation in the Lyme disease spirochete Borrelia burgdorferi
    Kai Zhang
    Department of Oral Biology, The State University of New York at Buffalo, Buffalo, New York, USA
    J Bacteriol 194:866-74. 2012
    ..burgdorferi. The observed phenotype is different from that of flgJ mutants in the enteric bacteria...
  12. pmc Chemoreceptors and flagellar motors are subterminally located in close proximity at the two cell poles in spirochetes
    Hongbin Xu
    Department of Oral Biology, The State University of New York at Buffalo, NY 14214 3092, USA
    J Bacteriol 193:2652-6. 2011
    ..These arrays are in close proximity to the flagellar motors. This information provides a basis for further understanding motility, chemotaxis, and protein localization in spirochetes...
  13. pmc Inactivation of bb0184, which encodes carbon storage regulator A, represses the infectivity of Borrelia burgdorferi
    Ching Wooen Sze
    Department of Oral Biology, SUNY at Buffalo, 3435 Main St, Buffalo, NY 14214 3092, USA
    Infect Immun 79:1270-9. 2011
    ..Collectively, these results suggest that CsrA(Bb) may influence the infectivity of B. burgdorferi via regulation of acetate metabolism and subsequent activation of the Rrp2-RpoN-RpoS pathway...
  14. pmc Transcription and genetic analyses of a putative N-acetylmuramyl-L-alanine amidase in Borrelia burgdorferi
    Yu Yang
    Department of Oral Biology, State University of New York at Buffalo, NY 14214 3092, USA
    FEMS Microbiol Lett 290:164-73. 2009
    ..coli. Taken together, these results demonstrate that bb0666 is a homolog of MurNac-LAAs that contributes to the cell division of B. burgdorferi...
  15. pmc Development of a modified gentamicin resistance cassette for genetic manipulation of the oral spirochete Treponema denticola
    Jiang Bian
    Department of Oral Biology, State University of New York at Buffalo, Buffalo, New York, USA
    Appl Environ Microbiol 78:2059-62. 2012
    ..This approach minimizes polar effects and spontaneous antibiotic resistance. Therefore, it can serve as a reliable tool for genetic manipulation of T. denticola...
  16. pmc Disruption of a type II endonuclease (TDE0911) enables Treponema denticola ATCC 35405 to accept an unmethylated shuttle vector
    Jiang Bian
    Department of Oral Biology, The State University of New York at Buffalo, Buffalo, New York 14214, USA
    Appl Environ Microbiol 77:4573-8. 2011
    ..The study described here provides us with a new tool and strategy to genetically manipulate T. denticola, in particular ATCC 35405, and other strains that may carry similar endonucleases...
  17. pmc The riboswitch regulates a thiamine pyrophosphate ABC transporter of the oral spirochete Treponema denticola
    Jiang Bian
    Department of Oral Biology, The State University of New York at Buffalo, Buffalo, New York 14214, USA
    J Bacteriol 193:3912-22. 2011
    ....
  18. pmc Development of a transposon mutagenesis system in the oral spirochete Treponema denticola
    Yu Yang
    Department of Oral Biology, State University of New York at Buffalo, Buffalo, New York 14214, 14214 3092, USA
    Appl Environ Microbiol 74:6461-4. 2008
    ..This random mutagenesis system should facilitate research on the biology and pathogenesis of this spirochete, which is associated with human periodontal diseases...

Research Grants5

  1. Developing Inhibitors of LuxS-dependent Quorum Sensing Systems in Oral Bacteria
    Chunhao Li; Fiscal Year: 2010
    ..Growth as biofilms is essential for oral bacteria to adapt and thrive in oral flora and cause the infections. The goal of this application is to develop inhibitors that are able to inhibit the biofilm formation of oral bacteria. ..
  2. Understanding Unique Aspects of Motility and Chemotaxis in Borrelia burgdorferi
    Chunhao Li; Fiscal Year: 2010
    ..The goal of this project is to understand the basic biology of spirochete motility and chemotaxis, and their roles in the pathogenesis of the diseases. The obtained results may lead to new means of disease prevention and treatment. ..
  3. Understanding Unique Aspects of Motility and Chemotaxis in Borrelia burgdorferi
    Chunhao Li; Fiscal Year: 2010
    ..The goal of this project is to understand the basic biology of spirochete motility and chemotaxis, and their roles in the pathogenesis of the diseases. The obtained results may lead to new means of disease prevention and treatment. ..