Chuan Yuan Li

Summary

Affiliation: University of Colorado Denver
Country: USA

Publications

  1. ncbi Novel luciferase-based reporter system to monitor activation of ErbB2/Her2/neu pathway noninvasively during radiotherapy
    Frank Wolf
    Department of Radiation Oncology, University of Colorado Denver School of Medicine, Aurora, CO 80111, USA
    Int J Radiat Oncol Biol Phys 79:233-8. 2011
  2. ncbi Quantitative, noninvasive imaging of radiation-induced DNA double-strand breaks in vivo
    Wenrong Li
    Department of Radiation Oncology, University of Colorado School of Medicine, Aurora, Colorado 80045, USA
    Cancer Res 71:4130-7. 2011
  3. ncbi Intravital fluorescence facilitates measurement of multiple physiologic functions and gene expression in tumors of live animals
    Mark W Dewhirst
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Dis Markers 18:293-311. 2002
  4. ncbi Systemic overexpression of angiopoietin-2 promotes tumor microvessel regression and inhibits angiogenesis and tumor growth
    Yiting Cao
    Department of Radiation Oncology, Duke University Medical Center, Research Drive, DUMC 3455, Durham, NC 27710, USA
    Cancer Res 67:3835-44. 2007
  5. ncbi Direct reprogramming of human fibroblasts into dopaminergic neuron-like cells
    Xinjian Liu
    Department of Radiation Oncology, University of Colorado School of Medicine, Aurora, CO 80045, USA
    Cell Res 22:321-32. 2012
  6. ncbi Apoptotic caspases regulate induction of iPSCs from human fibroblasts
    Fang Li
    Department of Radiation Oncology, University of Colorado School of Medicine, Aurora, CO 80045, USA
    Cell Stem Cell 7:508-20. 2010
  7. ncbi Noninvasive imaging and quantification of epidermal growth factor receptor kinase activation in vivo
    Wenrong Li
    Department of Radiation Oncology, University of Colorado Health Sciences Center, Aurora, Colorado 80010, USA
    Cancer Res 68:4990-7. 2008
  8. ncbi Non-invasive, quantitative monitoring of hyperthermia-induced EGFR activation in xenograft tumours
    Frank Wolf
    Department of Radiation Oncology, University of Colorado School of Medicine, Aurorao, CO 80010, USA
    Int J Hyperthermia 27:427-34. 2011
  9. ncbi Regulation of HIF-1alpha stability through S-nitrosylation
    Fang Li
    Department of Radiation Oncology, University of Colorado Health Sciences Center, Aurora, CO 80045, USA
    Mol Cell 26:63-74. 2007
  10. ncbi Apoptotic cells activate the "phoenix rising" pathway to promote wound healing and tissue regeneration
    Fang Li
    Department of Radiation Oncology, University of Colorado School of Medicine, Aurora, CO 80045, USA
    Sci Signal 3:ra13. 2010

Research Grants

  1. Molecular mechanisms of tumor response to cytotoxic chemotherapy
    Chuan Yuan Li; Fiscal Year: 2010
  2. HIF genes in head and neck cancer radiotherapy
    Chuan Yuan Li; Fiscal Year: 2010
  3. Hyperthermia-mediated gene therapy approach for cancer
    Chuan Yuan Li; Fiscal Year: 2006
  4. HYPERTHERMIA MEDIATED GENE THERAPY APPROACH FOR CANCER
    Chuan Yuan Li; Fiscal Year: 2002

Collaborators

Detail Information

Publications11

  1. ncbi Novel luciferase-based reporter system to monitor activation of ErbB2/Her2/neu pathway noninvasively during radiotherapy
    Frank Wolf
    Department of Radiation Oncology, University of Colorado Denver School of Medicine, Aurora, CO 80111, USA
    Int J Radiat Oncol Biol Phys 79:233-8. 2011
    ..To develop a split-luciferase-based reporter system that allows for noninvasive monitoring of activation of the Her2/neu pathway in vivo in a quantitative and sensitive manner...
  2. ncbi Quantitative, noninvasive imaging of radiation-induced DNA double-strand breaks in vivo
    Wenrong Li
    Department of Radiation Oncology, University of Colorado School of Medicine, Aurora, Colorado 80045, USA
    Cancer Res 71:4130-7. 2011
    ....
  3. ncbi Intravital fluorescence facilitates measurement of multiple physiologic functions and gene expression in tumors of live animals
    Mark W Dewhirst
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Dis Markers 18:293-311. 2002
    ..Examples of some of these differences are provided in this review as a means to illustrate how they can be used...
  4. ncbi Systemic overexpression of angiopoietin-2 promotes tumor microvessel regression and inhibits angiogenesis and tumor growth
    Yiting Cao
    Department of Radiation Oncology, Duke University Medical Center, Research Drive, DUMC 3455, Durham, NC 27710, USA
    Cancer Res 67:3835-44. 2007
    ..It also reveals that elevated Ang-2 levels have profound pleiotropic effects on tumor vessel structure, perfusion, oxygenation, and apoptosis...
  5. ncbi Direct reprogramming of human fibroblasts into dopaminergic neuron-like cells
    Xinjian Liu
    Department of Radiation Oncology, University of Colorado School of Medicine, Aurora, CO 80045, USA
    Cell Res 22:321-32. 2012
    ..Finally, they provided symptomatic relief in a rat PD model. Therefore, our directly reprogrammed DA neuron-like cells are a promising source of cell-replacement therapy for PD...
  6. ncbi Apoptotic caspases regulate induction of iPSCs from human fibroblasts
    Fang Li
    Department of Radiation Oncology, University of Colorado School of Medicine, Aurora, CO 80045, USA
    Cell Stem Cell 7:508-20. 2010
    ..Furthermore, retinoblastoma susceptibility (Rb) protein appears to be one of the factors that act downstream of the caspases. We propose that caspases are key facilitators of nuclear reprogramming in iPSC induction...
  7. ncbi Noninvasive imaging and quantification of epidermal growth factor receptor kinase activation in vivo
    Wenrong Li
    Department of Radiation Oncology, University of Colorado Health Sciences Center, Aurora, Colorado 80010, USA
    Cancer Res 68:4990-7. 2008
    ..This approach should be generally applicable to study biological regulation of RTK, as well as to develop and evaluate novel RTK-targeted therapeutics...
  8. ncbi Non-invasive, quantitative monitoring of hyperthermia-induced EGFR activation in xenograft tumours
    Frank Wolf
    Department of Radiation Oncology, University of Colorado School of Medicine, Aurorao, CO 80010, USA
    Int J Hyperthermia 27:427-34. 2011
    ..To examine the molecular mechanism of cellular EGFR activation during hyperthermia treatment...
  9. ncbi Regulation of HIF-1alpha stability through S-nitrosylation
    Fang Li
    Department of Radiation Oncology, University of Colorado Health Sciences Center, Aurora, CO 80045, USA
    Mol Cell 26:63-74. 2007
    ..This interaction between NO and HIF-1 sheds new light on their involvement in tumor response to treatment as well as mammalian inflammation process in general...
  10. ncbi Apoptotic cells activate the "phoenix rising" pathway to promote wound healing and tissue regeneration
    Fang Li
    Department of Radiation Oncology, University of Colorado School of Medicine, Aurora, CO 80045, USA
    Sci Signal 3:ra13. 2010
    ..We propose to call the pathway by which executioner caspases in apoptotic cells promote wound healing and tissue regeneration in multicellular organisms the "phoenix rising" pathway...
  11. ncbi Diphtheria toxin-epidermal growth factor fusion protein DAB389EGF for the treatment of bladder cancer
    Xiaoping Yang
    Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
    Clin Cancer Res 19:148-57. 2013
    ..We tested DAB(389)EGF for antitumor activity in both in vitro and in vivo urinary bladder cancer models...

Research Grants12

  1. Molecular mechanisms of tumor response to cytotoxic chemotherapy
    Chuan Yuan Li; Fiscal Year: 2010
    ..It may provide new insights that allow for the development of new therapeutics that can enhance current treatments for cancer. ..
  2. HIF genes in head and neck cancer radiotherapy
    Chuan Yuan Li; Fiscal Year: 2010
    ..It may provide new insights that allow for the development of new therapeutics that can enhance current head and neck cancer therapy. ..
  3. Hyperthermia-mediated gene therapy approach for cancer
    Chuan Yuan Li; Fiscal Year: 2006
    ..At the end of the new funding cycle, we hope to make significant advancement in both the delivery and the regulation of the hyperthermia-mediated gene therapy approach, thereby making it even closer to clinical human cancer treatment. ..
  4. HYPERTHERMIA MEDIATED GENE THERAPY APPROACH FOR CANCER
    Chuan Yuan Li; Fiscal Year: 2002
    ..abstract_text> ..