Chuan Yuan Li

Summary

Affiliation: University of Colorado Denver
Country: USA

Publications

  1. pmc Caspase 3-mediated stimulation of tumor cell repopulation during cancer radiotherapy
    Qian Huang
    Experimental Research Center, First People s Hospital, Shanghai Jiao Tong University, Shanghai, China
    Nat Med 17:860-6. 2011
  2. pmc Novel luciferase-based reporter system to monitor activation of ErbB2/Her2/neu pathway noninvasively during radiotherapy
    Frank Wolf
    Department of Radiation Oncology, University of Colorado Denver School of Medicine, Aurora, CO 80111, USA
    Int J Radiat Oncol Biol Phys 79:233-8. 2011
  3. ncbi request reprint Enhancement of hypoxia-induced tumor cell death in vitro and radiation therapy in vivo by use of small interfering RNA targeted to hypoxia-inducible factor-1alpha
    Xiuwu Zhang
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Cancer Res 64:8139-42. 2004
  4. ncbi request reprint Increased resistance of tumor cells to hyperthermia mediated by integrin-linked kinase
    Xiuwu Zhang
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Clin Cancer Res 9:1155-60. 2003
  5. pmc Quantitative, noninvasive imaging of radiation-induced DNA double-strand breaks in vivo
    Wenrong Li
    Department of Radiation Oncology, University of Colorado School of Medicine, Aurora, Colorado 80045, USA
    Cancer Res 71:4130-7. 2011
  6. ncbi request reprint Tumor necrosis factor-alpha is a potent endogenous mutagen that promotes cellular transformation
    Bin Yan
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, USA
    Cancer Res 66:11565-70. 2006
  7. pmc Intravital fluorescence facilitates measurement of multiple physiologic functions and gene expression in tumors of live animals
    Mark W Dewhirst
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Dis Markers 18:293-311. 2002
  8. ncbi request reprint Systemic overexpression of angiopoietin-2 promotes tumor microvessel regression and inhibits angiogenesis and tumor growth
    Yiting Cao
    Department of Radiation Oncology, Duke University Medical Center, Research Drive, DUMC 3455, Durham, NC 27710, USA
    Cancer Res 67:3835-44. 2007
  9. ncbi request reprint Cytokine and immuno-gene therapy for solid tumors
    Chuan Yuan Li
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Cell Mol Immunol 2:81-91. 2005
  10. ncbi request reprint A novel conditionally replicative adenovirus vector targeting telomerase-positive tumor cells
    Qian Huang
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Clin Cancer Res 10:1439-45. 2004

Collaborators

Detail Information

Publications20

  1. pmc Caspase 3-mediated stimulation of tumor cell repopulation during cancer radiotherapy
    Qian Huang
    Experimental Research Center, First People s Hospital, Shanghai Jiao Tong University, Shanghai, China
    Nat Med 17:860-6. 2011
    ..We propose the existence of a cell death-induced tumor repopulation pathway in which caspase 3 has a major role...
  2. pmc Novel luciferase-based reporter system to monitor activation of ErbB2/Her2/neu pathway noninvasively during radiotherapy
    Frank Wolf
    Department of Radiation Oncology, University of Colorado Denver School of Medicine, Aurora, CO 80111, USA
    Int J Radiat Oncol Biol Phys 79:233-8. 2011
    ..To develop a split-luciferase-based reporter system that allows for noninvasive monitoring of activation of the Her2/neu pathway in vivo in a quantitative and sensitive manner...
  3. ncbi request reprint Enhancement of hypoxia-induced tumor cell death in vitro and radiation therapy in vivo by use of small interfering RNA targeted to hypoxia-inducible factor-1alpha
    Xiuwu Zhang
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Cancer Res 64:8139-42. 2004
    ..They also suggest that an adenovirus-based small interfering RNA gene transfer approach may be a potentially effective adjuvant strategy for cancer treatment...
  4. ncbi request reprint Increased resistance of tumor cells to hyperthermia mediated by integrin-linked kinase
    Xiuwu Zhang
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Clin Cancer Res 9:1155-60. 2003
    ..In this study, we examined the effects of ILK expression on tumor cellular response to hyperthermia...
  5. pmc Quantitative, noninvasive imaging of radiation-induced DNA double-strand breaks in vivo
    Wenrong Li
    Department of Radiation Oncology, University of Colorado School of Medicine, Aurora, Colorado 80045, USA
    Cancer Res 71:4130-7. 2011
    ....
  6. ncbi request reprint Tumor necrosis factor-alpha is a potent endogenous mutagen that promotes cellular transformation
    Bin Yan
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, USA
    Cancer Res 66:11565-70. 2006
    ....
  7. pmc Intravital fluorescence facilitates measurement of multiple physiologic functions and gene expression in tumors of live animals
    Mark W Dewhirst
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Dis Markers 18:293-311. 2002
    ..Examples of some of these differences are provided in this review as a means to illustrate how they can be used...
  8. ncbi request reprint Systemic overexpression of angiopoietin-2 promotes tumor microvessel regression and inhibits angiogenesis and tumor growth
    Yiting Cao
    Department of Radiation Oncology, Duke University Medical Center, Research Drive, DUMC 3455, Durham, NC 27710, USA
    Cancer Res 67:3835-44. 2007
    ..It also reveals that elevated Ang-2 levels have profound pleiotropic effects on tumor vessel structure, perfusion, oxygenation, and apoptosis...
  9. ncbi request reprint Cytokine and immuno-gene therapy for solid tumors
    Chuan Yuan Li
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Cell Mol Immunol 2:81-91. 2005
    ..In this review, we will attempt to provide an overview of the field and discuss some of the problems associated with cytokine-based immuno-gene therapy and potential solutions...
  10. ncbi request reprint A novel conditionally replicative adenovirus vector targeting telomerase-positive tumor cells
    Qian Huang
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Clin Cancer Res 10:1439-45. 2004
    ..To develop a novel conditionally replicative adenovirus vector that targets telomerase-positive cancer cells...
  11. ncbi request reprint Enhancement of cancer radiation therapy by use of adenovirus-mediated secretable glucose-regulated protein 94/gp96 expression
    Shanling Liu
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Cancer Res 65:9126-31. 2005
    ..Our results indicate that combined AdsGRP94-based immunotherapy and radiation therapy may be a potentially effective strategy for cancer treatment...
  12. pmc Direct reprogramming of human fibroblasts into dopaminergic neuron-like cells
    Xinjian Liu
    Department of Radiation Oncology, University of Colorado School of Medicine, Aurora, CO 80045, USA
    Cell Res 22:321-32. 2012
    ..Finally, they provided symptomatic relief in a rat PD model. Therefore, our directly reprogrammed DA neuron-like cells are a promising source of cell-replacement therapy for PD...
  13. pmc Apoptotic caspases regulate induction of iPSCs from human fibroblasts
    Fang Li
    Department of Radiation Oncology, University of Colorado School of Medicine, Aurora, CO 80045, USA
    Cell Stem Cell 7:508-20. 2010
    ..Furthermore, retinoblastoma susceptibility (Rb) protein appears to be one of the factors that act downstream of the caspases. We propose that caspases are key facilitators of nuclear reprogramming in iPSC induction...
  14. pmc Apoptotic cells activate the "phoenix rising" pathway to promote wound healing and tissue regeneration
    Fang Li
    Department of Radiation Oncology, University of Colorado School of Medicine, Aurora, CO 80045, USA
    Sci Signal 3:ra13. 2010
    ..We propose to call the pathway by which executioner caspases in apoptotic cells promote wound healing and tissue regeneration in multicellular organisms the "phoenix rising" pathway...
  15. ncbi request reprint GW112, a novel antiapoptotic protein that promotes tumor growth
    Xiuwu Zhang
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Cancer Res 64:2474-81. 2004
    ..Taken together, our data suggest that GW112 is an important regulator of cell death that plays important roles in tumor cell survival and tumor growth...
  16. pmc Diphtheria toxin-epidermal growth factor fusion protein DAB389EGF for the treatment of bladder cancer
    Xiaoping Yang
    Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
    Clin Cancer Res 19:148-57. 2013
    ..We tested DAB(389)EGF for antitumor activity in both in vitro and in vivo urinary bladder cancer models...
  17. doi request reprint Noninvasive imaging and quantification of epidermal growth factor receptor kinase activation in vivo
    Wenrong Li
    Department of Radiation Oncology, University of Colorado Health Sciences Center, Aurora, Colorado 80010, USA
    Cancer Res 68:4990-7. 2008
    ..This approach should be generally applicable to study biological regulation of RTK, as well as to develop and evaluate novel RTK-targeted therapeutics...
  18. doi request reprint Non-invasive, quantitative monitoring of hyperthermia-induced EGFR activation in xenograft tumours
    Frank Wolf
    Department of Radiation Oncology, University of Colorado School of Medicine, Aurorao, CO 80010, USA
    Int J Hyperthermia 27:427-34. 2011
    ..To examine the molecular mechanism of cellular EGFR activation during hyperthermia treatment...
  19. doi request reprint Distinctive gene transduction efficiencies of commonly used viral vectors in the retina
    Sheng Hai Zhang
    Experimental Research Center, No 1 People s Hospital, Shanghai Jiaotong University, Shanghai, China
    Curr Eye Res 33:81-90. 2008
    ..These results provided important insights into the selection of appropriate vectors when specific retinal diseases are considered for gene therapy...
  20. pmc Regulation of HIF-1alpha stability through S-nitrosylation
    Fang Li
    Department of Radiation Oncology, University of Colorado Health Sciences Center, Aurora, CO 80045, USA
    Mol Cell 26:63-74. 2007
    ..This interaction between NO and HIF-1 sheds new light on their involvement in tumor response to treatment as well as mammalian inflammation process in general...

Research Grants12

  1. Molecular mechanisms of tumor response to cytotoxic chemotherapy
    Chuan Yuan Li; Fiscal Year: 2010
    ..It may provide new insights that allow for the development of new therapeutics that can enhance current treatments for cancer. ..
  2. HYPERTHERMIA MEDIATED GENE THERAPY APPROACH FOR CANCER
    Chuan Yuan Li; Fiscal Year: 1999
    ..abstract_text> ..
  3. HIF genes in head and neck cancer radiotherapy
    Chuan Yuan Li; Fiscal Year: 2010
    ..It may provide new insights that allow for the development of new therapeutics that can enhance current head and neck cancer therapy. ..
  4. Molecular mechanisms of tumor response to cytotoxic chemotherapy
    Chuan Yuan Li; Fiscal Year: 2009
    ..It may provide new insights that allow for the development of new therapeutics that can enhance current treatments for cancer. ..
  5. HIF genes in head and neck cancer radiotherapy
    Chuan Yuan Li; Fiscal Year: 2009
    ..It may provide new insights that allow for the development of new therapeutics that can enhance current head and neck cancer therapy. ..
  6. Hyperthermia-mediated gene therapy approach for cancer
    Chuan Yuan Li; Fiscal Year: 2006
    ..At the end of the new funding cycle, we hope to make significant advancement in both the delivery and the regulation of the hyperthermia-mediated gene therapy approach, thereby making it even closer to clinical human cancer treatment. ..
  7. Hyperthermia-mediated gene therapy approach for cancer
    Chuan Yuan Li; Fiscal Year: 2005
    ..At the end of the new funding cycle, we hope to make significant advancement in both the delivery and the regulation of the hyperthermia-mediated gene therapy approach, thereby making it even closer to clinical human cancer treatment. ..
  8. Hyperthermia-mediated gene therapy approach for cancer
    Chuan Yuan Li; Fiscal Year: 2004
    ..At the end of the new funding cycle, we hope to make significant advancement in both the delivery and the regulation of the hyperthermia-mediated gene therapy approach, thereby making it even closer to clinical human cancer treatment. ..
  9. Hyperthermia-mediated gene therapy approach for cancer
    Chuan Yuan Li; Fiscal Year: 2003
    ..At the end of the new funding cycle, we hope to make significant advancement in both the delivery and the regulation of the hyperthermia-mediated gene therapy approach, thereby making it even closer to clinical human cancer treatment. ..
  10. HYPERTHERMIA MEDIATED GENE THERAPY APPROACH FOR CANCER
    Chuan Yuan Li; Fiscal Year: 2002
    ..abstract_text> ..
  11. HYPERTHERMIA MEDIATED GENE THERAPY APPROACH FOR CANCER
    Chuan Yuan Li; Fiscal Year: 2001
    ..abstract_text> ..
  12. HYPERTHERMIA MEDIATED GENE THERAPY APPROACH FOR CANCER
    Chuan Yuan Li; Fiscal Year: 2000
    ..abstract_text> ..