Changgong Li

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. pmc Ror2 modulates the canonical Wnt signaling in lung epithelial cells through cooperation with Fzd2
    Changgong Li
    Department of Pediatrics, Division of Neonatology, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    BMC Mol Biol 9:11. 2008
  2. pmc Stabilized beta-catenin in lung epithelial cells changes cell fate and leads to tracheal and bronchial polyposis
    Changgong Li
    Department of Pediatrics, Women s and Children s Hospital, USC Keck School of Medicine, Los Angeles, CA 90033, USA
    Dev Biol 334:97-108. 2009
  3. ncbi Wnt5a regulates Shh and Fgf10 signaling during lung development
    Changgong Li
    Department of Pediatrics, Women s and Children s Hospital, USC Keck School of Medicine, Los Angeles, CA 90033, USA
    Dev Biol 287:86-97. 2005
  4. pmc Apc deficiency alters pulmonary epithelial cell fate and inhibits Nkx2.1 via triggering TGF-beta signaling
    Changgong Li
    Department of Pediatrics, USC Keck School of Medicine and Childrens Hospital Los Angeles, Los Angeles, CA 90033, USA
    Dev Biol 378:13-24. 2013
  5. pmc Signaling via Alk5 controls the ontogeny of lung Clara cells
    Yiming Xing
    Department of Pediatrics, Division of Neonatology, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA
    Development 137:825-33. 2010
  6. pmc Mesodermal deletion of transforming growth factor-beta receptor II disrupts lung epithelial morphogenesis: cross-talk between TGF-beta and Sonic hedgehog pathways
    Min Li
    Division of Neonatology, Department of Pediatrics, Will Rogers Institute Pulmonary Research Center, University of Southern California School of Medicine, Los Angeles, CA 90093, USA
    J Biol Chem 283:36257-64. 2008
  7. pmc Deletion of Pten expands lung epithelial progenitor pools and confers resistance to airway injury
    Caterina Tiozzo
    Department of Pediatrics, Division of Neonatology, Women s and Children s Hospital, USC Keck School of Medicine
    Am J Respir Crit Care Med 180:701-12. 2009
  8. pmc Physical and functional interactions between homeodomain NKX2.1 and winged helix/forkhead FOXA1 in lung epithelial cells
    Parviz Minoo
    Department of Pediatrics, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    Mol Cell Biol 27:2155-65. 2007
  9. pmc NOTCH1 is required for regeneration of Clara cells during repair of airway injury
    Yiming Xing
    Department of Pediatrics, Division of Neonatology, Will Rogers Institute Pulmonary Research Center, University of Southern California, Keck School of Medicine, Los Angeles, California, USA
    Stem Cells 30:946-55. 2012
  10. pmc Mechanisms of TGFbeta inhibition of LUNG endodermal morphogenesis: the role of TbetaRII, Smads, Nkx2.1 and Pten
    Yiming Xing
    Department of Pediatrics, Division of Neonatology, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA
    Dev Biol 320:340-50. 2008

Research Grants

  1. Fetal Lung Development:Role of Wnt5a Signaling
    Changgong Li; Fiscal Year: 2004
  2. Fetal Lung Development:Role of Wnt5a Signaling
    Changgong Li; Fiscal Year: 2005
  3. Fetal Lung Development:Role of Wnt5a Signaling
    Changgong Li; Fiscal Year: 2006
  4. Fetal Lung Development:Role of Wnt5a Signaling
    Changgong Li; Fiscal Year: 2007

Collaborators

Detail Information

Publications36

  1. pmc Ror2 modulates the canonical Wnt signaling in lung epithelial cells through cooperation with Fzd2
    Changgong Li
    Department of Pediatrics, Division of Neonatology, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    BMC Mol Biol 9:11. 2008
    ..Ror2 is a single-span transmembrane receptor-tyrosine kinase (RTK). The functions of Ror2 in mediating the non-canonical Wnt signaling have been well established. The role of Ror2 in canonical Wnt signaling is not fully understood...
  2. pmc Stabilized beta-catenin in lung epithelial cells changes cell fate and leads to tracheal and bronchial polyposis
    Changgong Li
    Department of Pediatrics, Women s and Children s Hospital, USC Keck School of Medicine, Los Angeles, CA 90033, USA
    Dev Biol 334:97-108. 2009
    ..Thus, excess beta-catenin can alter cell fate determination by both direct and paracrine mechanisms...
  3. ncbi Wnt5a regulates Shh and Fgf10 signaling during lung development
    Changgong Li
    Department of Pediatrics, Women s and Children s Hospital, USC Keck School of Medicine, Los Angeles, CA 90033, USA
    Dev Biol 287:86-97. 2005
    ..These suggest that over-expression of Wnt5a disrupts epithelial-response to FGF10. In conclusion, Wnt5a regulates SHH and FGF10 signaling during lung development...
  4. pmc Apc deficiency alters pulmonary epithelial cell fate and inhibits Nkx2.1 via triggering TGF-beta signaling
    Changgong Li
    Department of Pediatrics, USC Keck School of Medicine and Childrens Hospital Los Angeles, Los Angeles, CA 90033, USA
    Dev Biol 378:13-24. 2013
    ..Therefore, our studies revealed an important mechanism involving Apc and TGF-beta signaling in regulating the key transcriptional factor, Nkx2.1, for lung epithelial progenitor cell fate determination...
  5. pmc Signaling via Alk5 controls the ontogeny of lung Clara cells
    Yiming Xing
    Department of Pediatrics, Division of Neonatology, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA
    Development 137:825-33. 2010
    ..Thus, the signaling pathway by which TGFbeta/ALK5 regulates Clara cell differentiation may entail inhibition of Pten expression, which in turn activates ERK and AKT phosphorylation...
  6. pmc Mesodermal deletion of transforming growth factor-beta receptor II disrupts lung epithelial morphogenesis: cross-talk between TGF-beta and Sonic hedgehog pathways
    Min Li
    Division of Neonatology, Department of Pediatrics, Will Rogers Institute Pulmonary Research Center, University of Southern California School of Medicine, Los Angeles, CA 90093, USA
    J Biol Chem 283:36257-64. 2008
    ..To our knowledge, this is the first in vivo evidence for a reciprocal and novel mode of cross-communication between Shh and TGF-beta pathways during embryonic development...
  7. pmc Deletion of Pten expands lung epithelial progenitor pools and confers resistance to airway injury
    Caterina Tiozzo
    Department of Pediatrics, Division of Neonatology, Women s and Children s Hospital, USC Keck School of Medicine
    Am J Respir Crit Care Med 180:701-12. 2009
    ..In mouse, Pten expression is ubiquitous and begins as early as 7 days of gestation. Pten(-/-) mouse embryos die early during gestation indicating a critical role for Pten in embryonic development...
  8. pmc Physical and functional interactions between homeodomain NKX2.1 and winged helix/forkhead FOXA1 in lung epithelial cells
    Parviz Minoo
    Department of Pediatrics, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    Mol Cell Biol 27:2155-65. 2007
    ..These findings suggest a novel mode of selective gene regulation by proximo-distal gradient distribution of and functional interactions between forkhead and homeodomain transcription factors...
  9. pmc NOTCH1 is required for regeneration of Clara cells during repair of airway injury
    Yiming Xing
    Department of Pediatrics, Division of Neonatology, Will Rogers Institute Pulmonary Research Center, University of Southern California, Keck School of Medicine, Los Angeles, California, USA
    Stem Cells 30:946-55. 2012
    ..The signaling pathway by which Notch1 regulates the repair process includes stimulation of Hes5 and Pax6 gene expression...
  10. pmc Mechanisms of TGFbeta inhibition of LUNG endodermal morphogenesis: the role of TbetaRII, Smads, Nkx2.1 and Pten
    Yiming Xing
    Department of Pediatrics, Division of Neonatology, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA
    Dev Biol 320:340-50. 2008
    ..1. Both of the latter are dependent on signaling through TbetaRII...
  11. pmc Cell type-specific expression of adenomatous polyposis coli in lung development, injury, and repair
    Aimin Li
    Department of Pediatrics, Division of Neonatology, Women s and Children s Hospital, USC Keck School of Medicine, Los Angeles, California 90033, USA
    Dev Dyn 239:2288-97. 2010
    ..nonprogenitor cells suggests a functional role in cell-type specification. Subcellular localization changes of Apc in response to naphthalene injury suggest a role in cell shape and cell migration...
  12. pmc Tissue-dependent consequences of Apc inactivation on proliferation and differentiation of ciliated cell progenitors via Wnt and notch signaling
    Aimin Li
    Division of Newborn Medicine, Department of Pediatrics, Los Angeles County University of Southern California Medical Center, Keck School of Medicine of USC, Los Angeles, California, United States of America
    PLoS ONE 8:e62215. 2013
    ..In sum, the present comparative analysis reveals the tissue-dependent consequences of Apc inactivation on proliferation and differentiation of ciliated cell progenitors by coordinating Wnt and Notch signaling...
  13. pmc Conditional deletion of epithelial IKKβ impairs alveolar formation through apoptosis and decreased VEGF expression during early mouse lung morphogenesis
    Vedang A Londhe
    Department of Pediatrics, Division of Neonatology and Developmental Biology, David Geffen School of Medicine at UCLA, 10833 Le Conte Ave, Mailcode 175217, Los Angeles, CA, USA
    Respir Res 12:134. 2011
    ..The purpose of this study was to test our hypothesis that targeted deletion of NF-κB signaling in lung epithelium would impair alveolar formation...
  14. pmc Formation and differentiation of multiple mesenchymal lineages during lung development is regulated by beta-catenin signaling
    Stijn P De Langhe
    Developmental Biology Program, Department of Surgery, Saban Research Institute of Childrens Hospital Los Angeles, Los Angeles, California, USA
    PLoS ONE 3:e1516. 2008
    ..The role of ss-catenin signaling in mesodermal lineage formation and differentiation has been elusive...
  15. ncbi NF-kB induces lung maturation during mouse lung morphogenesis
    Vedang A Londhe
    Department of Pediatrics, Division of Neonatology and Developmental Biology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1752, USA
    Dev Dyn 237:328-38. 2008
    ..These findings are consistent with a model whereby NF-kB may induce maturation of lung development through decreased apoptosis of epithelial cells...
  16. ncbi NKX2.1 regulates transcription of the gene for human bone morphogenetic protein-4 in lung epithelial cells
    Nian Ling Zhu
    Department of Pediatrics, Women s and Children s Hospital, University of Southern California Keck School of Medicine, LAC USC Medical Center, 1801 E Marengo Street, Room 1G1, Los Angeles, CA 90033, USA
    Gene 327:25-36. 2004
    ..1. These findings bear functional implications regarding the regulation of a key signaling molecule by a homeodomain transcriptional regulator of lung epithelial morphogenesis...
  17. ncbi Wnt5a participates in distal lung morphogenesis
    Changgong Li
    Department of Pediatrics, Women s and Children s Hospital, Los Angeles, CA 90033, USA
    Dev Biol 248:68-81. 2002
    ..Absence of WNT5a activity in the mutant lungs leads to increased expression of Fgf-10, Bmp4, Shh, and its receptor Ptc, raising the possibility that WNT5a, FGF-10, BMP4, and SHH signaling pathways are functionally interactive...
  18. pmc TNF-alpha represses transcription of human Bone Morphogenetic Protein-4 in lung epithelial cells
    Nian Ling Zhu
    University of Southern California, Keck School of Medicine, Department of Pediatrics, Division of Neonatal Medicine, Los Angeles, CA 90033, United States
    Gene 393:70-80. 2007
    ..These findings provide a mechanistic paradigm for interactions between mediators of inflammation and morphogenesis with relevant implications for normal lung development and pathogenesis of disease...
  19. pmc SMAD3 prevents binding of NKX2.1 and FOXA1 to the SpB promoter through its MH1 and MH2 domains
    Parviz Minoo
    Department of Pediatrics, Division of Neonatology, Will Rogers Institute Pulmonary Research Center, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
    Nucleic Acids Res 36:179-88. 2008
    ..Thus, these studies reveal for the first time a mechanism of TGF-beta-induced SpB gene repression that involves interactions between specific SMAD3 domains and the corresponding functional sites on NKX2.1 and FOXA1 transcription factors...
  20. pmc Localized Fgf10 expression is not required for lung branching morphogenesis but prevents differentiation of epithelial progenitors
    Thomas Volckaert
    Department of Pediatrics, Division of Cell Biology, National Jewish Health, Denver, CO 80206, USA
    Development 140:3731-42. 2013
    ..Interestingly, our data presented here show that once epithelial cells are committed to the Sox2-positive airway epithelial cell fate, Fgf10 prevents ciliated cell differentiation and promotes basal cell differentiation. ..
  21. pmc Foxp2 inhibits Nkx2.1-mediated transcription of SP-C via interactions with the Nkx2.1 homeodomain
    Beiyun Zhou
    Will Rogers Institute Pulmonary Research Center, Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Southern California, 2020 Zonal Avenue, Los Angeles, CA 90033, USA
    Am J Respir Cell Mol Biol 38:750-8. 2008
    ..1 inhibits Nkx2.1 DNA-binding and transcriptional activity and suggest a mechanism for down-regulation of SP-C (and probably other AT2 cell genes) during transition of AT2 cells to an AT1 cell phenotype...
  22. pmc Mesodermal Pten inactivation leads to alveolar capillary dysplasia- like phenotype
    Caterina Tiozzo
    Department of Pediatrics, Division of Newborn Medicine, University of Southern California, Children s Hospital, Los Angeles, California, USA
    J Clin Invest 122:3862-72. 2012
    ..Additionally, these mice could serve as a murine model of ACD...
  23. pmc Epithelium-specific deletion of TGF-β receptor type II protects mice from bleomycin-induced pulmonary fibrosis
    Min Li
    Division of Neonatology, Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    J Clin Invest 121:277-87. 2011
    ..To our knowledge, these findings are the first to demonstrate a specific role for TGF-β signaling in the lung epithelium in the pathogenesis of pulmonary fibrosis...
  24. pmc A subset of epithelial cells with CCSP promoter activity participates in alveolar development
    Vedang A Londhe
    Department of Pediatrics, Division of Neonatology and Developmental Biology, Neonatal Research Center, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California 90095 1752, USA
    Am J Respir Cell Mol Biol 44:804-12. 2011
    ..These findings are consistent with a model in which a unique population of cells with CCSP promoter activity that expresses vascular endothelial growth factor participates in alveolar development...
  25. ncbi Timeless in lung morphogenesis
    Jing Xiao
    School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Dev Dyn 228:82-94. 2003
    ..In cultured lung cells, expression of TIM is independent of cell cycle and proliferation. These studies indicate that the function of Timeless is highly conserved in organs whose formation requires branching morphogenesis...
  26. ncbi In vivo characterization of the Nkx2.1 promoter/enhancer elements in transgenic mice
    Qiuping Pan
    Department of Pediatrics, Women s and Children s Hospital, USC School of Medicine, LAC USC Medical Center, 1801 E Marengo Street, Room 1G1, Los Angeles, CA 9003, USA
    Gene 331:73-82. 2004
    ..The same applies to the brain, which provides the most permissive environment for recognition of Nkx2.1 tissue specific cis-active elements...
  27. pmc The p66Shc adapter protein regulates the morphogenesis and epithelial maturation of fetal mouse lungs
    M K Lee
    General Laboratories Bldg, 1201 E Marengo St, Los Angeles, CA 90033
    Am J Physiol Lung Cell Mol Physiol 306:L316-25. 2014
    ..SP-A was not expressed in either control or treated lungs. These data suggest that p66(Shc) attenuates epithelial proliferation while promoting both distal and proximal epithelial maturation. ..
  28. ncbi Transforming growth factor-beta inhibits pulmonary surfactant protein B gene transcription through SMAD3 interactions with NKX2.1 and HNF-3 transcription factors
    Changgong Li
    Department of Pediatrics, Women s and Children s Hospital, University of Southern California School of Medicine, Los Angeles, California 90033, USA
    J Biol Chem 277:38399-408. 2002
    ..1 was not affected. We conclude that SMAD3 interactions with the positive regulators NKX2.1 and HNF-3 underlie the molecular basis for TGF-beta-induced repression of Sp-B gene transcription...
  29. pmc Cross-talk between transforming growth factor-beta and Wingless/Int pathways in lung development and disease
    Parviz Minoo
    Division of Neonatology, Department of Pediatrics, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    Int J Biochem Cell Biol 42:809-12. 2010
    ..Understanding the mechanics and the physiological implications of this cross-talk is necessary for therapeutic or preventive targeting of either TGFbeta or Wnt signaling pathways...
  30. ncbi Developmental pathways and specification of intrapulmonary stem cells
    Zea Borok
    Department of Medicine, Will Rogers Institute Pulmonary Research Center, University of Southern California, Los Angeles, 90033, USA
    Pediatr Res 59:84R-93R. 2006
    ....
  31. pmc Wnt5a knock-out mouse as a new model of anorectal malformation
    Cindy C Tai
    Division of Pediatric Surgery, Childrens Hospital Los Angeles, Los Angeles, California 90027, USA
    J Surg Res 156:278-82. 2009
    ..Mutations in Shh signaling and Fgf10 produce a variety of ARM phenotypes. Wnt signaling has been shown to be crucial during gastrointestinal development. We therefore hypothesized that Wnt5a may play a role in anorectal development...
  32. ncbi Constitutive IL-10 expression by lung inflammatory cells and risk for bronchopulmonary dysplasia
    Arlene Garingo
    Division of Neonatology, Department of Pediatrics, Women s and Children s Hospital, Keck School of Medicine, University of Southern California, Los Angeles, California, 90033, USA
    Pediatr Res 61:197-202. 2007
    ..In contrast, constitutive IL-10 production within d 1-3 of life correlated with, and predicted the incidence of BPD in the highly vulnerable very premature infants...
  33. pmc Regulation of p53-MDMX interaction by casein kinase 1 alpha
    Lihong Chen
    H Lee Moffitt Cancer Center, MRC3057A, 12902 Magnolia Drive, Tampa, FL 33612, USA
    Mol Cell Biol 25:6509-20. 2005
    ..These results suggest that CK1alpha is a functionally relevant MDMX-binding protein and plays an important role in regulating p53 activity in the absence or presence of stress...
  34. ncbi Prediction of radiation sensitivity using a gene expression classifier
    Javier F Torres-Roca
    Department of Interdisciplinary Oncology, University of South Florida College of Medicine and H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
    Cancer Res 65:7169-76. 2005
    ..We establish that radiation sensitivity can be predicted based on gene expression profiles and we introduce a genomic approach to the identification of novel molecular markers of radiation sensitivity...
  35. ncbi Rescue of mutant p53 transcription function by ellipticine
    Yanhua Peng
    Molecular Oncology Program, H Lee Moffitt Comprehensive Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA
    Oncogene 22:4478-87. 2003
    ..These results demonstrate that ellipticine can restore transcription function to mutant p53. This property may contribute to the selectivity of ellipticine-derived compounds against tumor cell lines expressing mutant p53...
  36. pmc DNA damage induces MDMX nuclear translocation by p53-dependent and -independent mechanisms
    Changgong Li
    Molecular Oncology Program, H Lee Moffitt Comprehensive Cancer Center and Research Institute, Tampa, Florida 33612, USA
    Mol Cell Biol 22:7562-71. 2002
    ..These results suggest that MDMX function may be regulated by DNA damage. Furthermore, MDMX may complement MDM2 in regulating p53 during embryonic development due to its ability to inhibit p53 in the presence of ARF...

Research Grants5

  1. Fetal Lung Development:Role of Wnt5a Signaling
    Changgong Li; Fiscal Year: 2004
    ..This information will be of utility in understanding the molecular mechanisms of congenital and induced lung disease. ..
  2. Fetal Lung Development:Role of Wnt5a Signaling
    Changgong Li; Fiscal Year: 2005
    ..This information will be of utility in understanding the molecular mechanisms of congenital and induced lung disease. ..
  3. Fetal Lung Development:Role of Wnt5a Signaling
    Changgong Li; Fiscal Year: 2006
    ..This information will be of utility in understanding the molecular mechanisms of congenital and induced lung disease. ..
  4. Fetal Lung Development:Role of Wnt5a Signaling
    Changgong Li; Fiscal Year: 2007
    ..This information will be of utility in understanding the molecular mechanisms of congenital and induced lung disease. ..