Research Topics
Species | James D LewisSummaryAffiliation: University of Pennsylvania Country: USA Publications
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Publications
Risk of bladder cancer among diabetic patients treated with pioglitazone: interim report of a longitudinal cohort studyJames D Lewis
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Diabetes Care 34:916-22. 2011..This is an interim report of an ongoing cohort study examining the association between pioglitazone therapy and the risk of bladder cancer in patients with diabetes...- Sampling and pyrosequencing methods for characterizing bacterial communities in the human gut using 16S sequence tagsGary D Wu
Division of Gastroenterology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6076 USA
BMC Microbiol 10:206. 2010.... - Rosiglitazone for active ulcerative colitis: a randomized placebo-controlled trialJames D Lewis
Division of Gastroenterology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Gastroenterology 134:688-95. 2008..Thiazolidinedione ligands for the gamma subtype of peroxisome proliferator-activated receptors (PPARgamma), widely used to treat type 2 diabetes mellitus, have been proposed as novel therapies for ulcerative colitis (UC)... 
Medical therapy for diabetes is associated with increased use of lower endoscopyJames D Lewis
Department of Medicine, Division of Gastroenterology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, USA
Pharmacoepidemiol Drug Saf 16:1195-202. 2007..This study examined the association between diabetes therapies and use of lower endoscopy...
The utility of biomarkers in the diagnosis and therapy of inflammatory bowel diseaseJames D Lewis
Center for Clinical Epidemiology and Biostatistics, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Gastroenterology 140:1817-1826.e2. 2011..This review addresses the potential for biomarker assays to improve treatment strategies and challenges to their use and development...- Thiazolidinedione therapy is not associated with increased colonic neoplasia risk in patients with diabetes mellitusJames D Lewis
Department of Medicine, Division of Gastroenterology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Gastroenterology 135:1914-23, 1923.e1. 2008..This study examined the association between PPARgamma-targeted therapies and the risk of colonic neoplasia in patients with diabetes... - Timing of myelosuppression during thiopurine therapy for inflammatory bowel disease: implications for monitoring recommendationsJames D Lewis
Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6021, USA
Clin Gastroenterol Hepatol 7:1195-201; quiz 1141-2. 2009..Thiopurines (azathioprine and 6-mercaptopurine) can induce life-threatening myelosuppression. This study determined the frequency, timing, and outcomes of mild and severe myelosuppression after initiation of thiopurine therapy... - Validation studies of the health improvement network (THIN) database for pharmacoepidemiology researchJames D Lewis
Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
Pharmacoepidemiol Drug Saf 16:393-401. 2007..We sought to replicate in THIN well-established associations from the medical literature and to compare results from the GPRD practices to the non-GPRD practices within THIN... - Moderate and high affinity serotonin reuptake inhibitors increase the risk of upper gastrointestinal toxicityJames D Lewis
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Pharmacoepidemiol Drug Saf 17:328-35. 2008..This study examined the effect of medications that inhibit serotonin uptake on upper gastrointestinal toxicity... - Immunosuppressant medications and mortality in inflammatory bowel diseaseJames D Lewis
Division of Gastroenterology, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Am J Gastroenterol 103:1428-35; quiz 1436. 2008..This study examined whether treatment of Crohn's disease (CD) and ulcerative colitis (UC) with immunosuppressant medications was associated with an increased risk of death in the era prior to antitumor necrosis factor (TNF) therapies... - Selective serotonin re-uptake inhibitors and the risk of bleedingRobert M Weinrieb
University of Pennsylvania, Department of Psychiatry, 3440 Market Street, Suite 370, Philadelphia, PA 19104, USA
Expert Opin Drug Saf 4:337-44. 2005..Clinicians should caution patients about combining SSRIs with aspirin or NSAIDs. Pharmacotherapy to reduce the risk of GI bleeding should be considered in high risk patients... - Association between longer therapy with thiazolidinediones and risk of bladder cancer: a cohort studyRonac Mamtani
Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
J Natl Cancer Inst 104:1411-21. 2012..In this study, we assessed the risk of bladder cancer associated with the use of TZDs and between pioglitazone and rosiglitazone, an alternative TZD... - Chronic proton pump inhibitor therapy and the risk of colorectal cancerYu Xiao Yang
Division of Gastroenterology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6021, USA
Gastroenterology 133:748-54. 2007.... - Risk for active tuberculosis in inflammatory bowel disease patientsFaten N Aberra
Division of Gastroenterology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Clin Gastroenterol Hepatol 5:1070-5. 2007..The primary aim of this study was to determine the incidence of active tuberculosis in an inflammatory bowel disease population compared with the general population before the availability of infliximab... - Type 2 diabetes mellitus and the risk of colorectal cancerYu Xiao Yang
Division of Gastroenterology, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Clin Gastroenterol Hepatol 3:587-94. 2005..However, epidemiologic evidence for this association is inconclusive. We conducted a population-based study to clarify this association... - Predictors of recall of over-the-counter and prescription non-steroidal anti-inflammatory drug exposureJames D Lewis
Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Pharmacoepidemiol Drug Saf 15:39-45. 2006..Because of the difficulty in establishing a gold standard, data on accuracy of recall of over-the-counter (OTC) medication use are sparse... - Risk of serious upper gastrointestinal toxicity with over-the-counter nonaspirin nonsteroidal anti-inflammatory drugsJames D Lewis
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Gastroenterology 129:1865-74. 2005..Less is known about over-the-counter (OTC) NANSAIDs, which are typically used at lower doses and for shorter durations. This study assessed the risk of toxicity with OTC NANSAIDs... - Linking long-term dietary patterns with gut microbial enterotypesGary D Wu
Division of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Science 334:105-8. 2011..Thus, alternative enterotype states are associated with long-term diet... - Prevalence of colorectal cancer surveillance for ulcerative colitis in an integrated health care delivery systemFernando S Velayos
Division of Gastroenterology, Department of Internal Medicine, University of California, San Francisco 94115, USA
Gastroenterology 139:1511-8. 2010..Limited data are available on rates of colonoscopy surveillance and factors associated with surveillance... - Seasonal variation in flares of inflammatory bowel diseaseJames D Lewis
Center for Clinical Epidemiology and Biostatistics and Department of Medicine, University of Pennsylvania Centers for Education and Research on Therapeutics, Philadelphia, 19104 6021, USA
Gastroenterology 126:665-73. 2004..The purpose of this study was to determine whether relapse of inflammatory bowel disease follows a seasonal pattern either across a cohort of patients or within individual patients... - Cancer incidence in The Health Improvement NetworkKevin Haynes
Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
Pharmacoepidemiol Drug Saf 18:730-6. 2009..This study assessed whether the recorded incidence of cancer among patients in The Health Improvement Network (THIN) database is comparable to that expected in the UK based on national cancer registry data... - Use of the noninvasive components of the Mayo score to assess clinical response in ulcerative colitisJames D Lewis
Division of Gastroenterology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
Inflamm Bowel Dis 14:1660-6. 2008..We sought to assess what constitutes a clinically meaningful change in these indices using data from a recently completed placebo-controlled clinical trial... - No increased risk of myocardial infarction among patients with ulcerative colitis or Crohn's diseaseMark T Osterman
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Clin Gastroenterol Hepatol 9:875-80. 2011..We aimed to determine the risk of first-time acute MI in patients with ulcerative colitis (UC) or Crohn's disease (CD) compared with patients from general practice... - Insulin therapy and colorectal cancer risk among type 2 diabetes mellitus patientsYu Xiao Yang
Division of Gastroenterology, University of Pennsylvania School of Medicine, Philadelphia 19104 6021, USA
Gastroenterology 127:1044-50. 2004..We aimed to determine whether insulin therapy might increase the risk of colorectal cancer among type 2 diabetes mellitus patients... - Serial glycosylated hemoglobin levels and risk of colorectal neoplasia among patients with type 2 diabetes mellitusYu Xiao Yang
Department of Medicine, Division of Gastroenterology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 722 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104, USA
Cancer Epidemiol Biomarkers Prev 19:3027-36. 2010..We sought to determine whether glycemic control measured by serial hemoglobin A1c (HbA1c) was associated with the risk of colorectal adenoma... - Antibiotic use and the risk of flare of inflammatory bowel diseaseFaten N Aberra
Division of Gastroenterolgy, University of Pennsylvania School of Medicine, Philadephia, 19104, USA
Clin Gastroenterol Hepatol 3:459-65. 2005..Intestinal microbial flora participate in the pathogenesis of inflammatory bowel disease. Because antibiotic therapy alters intestinal microbial flora, we hypothesized that use of antibiotics might decrease the risk of flare... - Potential limitations of electronic database studies of prescription non-aspirin non-steroidal anti-inflammatory drugs (NANSAIDs) and risk of myocardial infarction (MI)Leonard Ilkhanoff
Department of Medicine, Cardiovascular Division, Hospital of the University of Pennsylvania, Philadelphia, PA, USA
Pharmacoepidemiol Drug Saf 14:513-22. 2005..Further studies-preferably randomized trials-are needed to address the risk-benefit ratio of NANSAID use... - Women with a prior diagnosis of breast cancer are not at an increased risk for subsequent colorectal cancerRadhika Srinivasan
Division of Gastroenterology, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6021, USA
Am J Gastroenterol 100:2759-64. 2005..08) and 1.81 (95% CI 0.85-3.85), respectively. CONCLUSION: Women with a prior diagnosis of breast cancer are not at an increased risk of colorectal cancer; these women can follow average risk screening guidelines for colorectal cancer... - The effect of selective serotonin re-uptake inhibitors on the risk of myocardial infarction in a cohort of patients with depressionStephen E Kimmel
Center for Clinical Epidemiology and Biostatistics and Cardiovascular Division at the Department of Medicine, University of Pennsylvania School of Medicine, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
Br J Clin Pharmacol 72:514-7. 2011..To evaluate whether selective serotonin re-uptake inhibitor (SSRI) exposure influences the risk of myocardial infarction (MI) in patients with depression... - Tumor necrosis factor α inhibitor therapy and cancer risk in chronic immune-mediated diseasesKevin Haynes
University of Pennsylvania, Philadelphia
Arthritis Rheum 65:48-58. 2013..To compare the incidence of cancer following tumor necrosis factor α (TNFα) inhibitor therapy to that with commonly used alternative therapies across multiple immune-mediated diseases... - Chronic statin therapy and the risk of colorectal cancerYu Xiao Yang
Division of Gastroenterology, University of Pennsylvania, Philadelphia, PA 19104 6021, USA
Pharmacoepidemiol Drug Saf 17:869-76. 2008..We sought to clarify whether long-term statin therapy has a chemopreventive effect on the risk of colorectal cancer (CRC) in a large, population-representative cohort... - Incidence and prevalence of abnormal liver associated enzymes in patients with atrial fibrillation in a routine clinical care populationGeorge A Makar
Division of Gastroenterology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Pharmacoepidemiol Drug Saf 17:43-51. 2008..The aim of this study was to estimate the prevalence and incidence of alanine aminotransferase (ALT) elevations in a cohort with AF... - Risk of colorectal cancer in women with a prior diagnosis of gynecologic malignancyRadhika Srinivasan
Department of Medicine, Division of Gastroenterology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
J Clin Gastroenterol 41:291-6. 2007..Earlier studies regarding the risk of colorectal cancer (CRC) in women with a prior diagnosis of gynecologic malignancies have revealed conflicting results. We sought to further clarify this association... - A meta-analysis of the placebo rates of remission and response in clinical trials of active ulcerative colitisChinyu Su
Division of Gastroenterology, Department of Medicine, Hospital of the University of Pennsylvania and University of Pennsylvania Presbyterian Medical Center, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
Gastroenterology 132:516-26. 2007..The aims of this study were to estimate the placebo rates of remission and response in placebo-controlled, randomized clinical trials for active UC and to identify factors influencing these rates... - A comparison of sodium phosphosoda purgative to polyethylene glycol bowel preparations prior to colonoscopySteven M Brunelli
Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Fam Med 41:39-45. 2009..We undertook this analysis to determine the relative clinical effectiveness of oral sodium phosphosoda versus polyethylene glycol in clinical practice... - Findings on serial surveillance colonoscopy in patients with low-risk polyps on initial colonoscopyJocelyne Miller
Division of Gastroenterology, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA
J Clin Gastroenterol 44:e46-50. 2010..This study describes the prevalence of adenomatous polyps at serial follow-up exams after a colonoscopy finding 1 to 2 small tubular adenomas... - Conservation of gene cassettes among diverse viruses of the human gutSamuel Minot
Department of Microbiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
PLoS ONE 7:e42342. 2012..These findings thus connect contemporary metagenomic analysis with classical studies of bacteriophage genomic cassettes. Software is available at https://sourceforge.net/projects/optitdba/... - Temporal and within practice variability in the health improvement networkKevin Haynes
Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Pharmacoepidemiol Drug Saf 20:948-55. 2011..However, little is known about the consistency within practices across observation years and among practices within a given year, in THIN or other large medical record databases... - The impact of increased body mass index on the clinical course of Crohn's diseaseDavid J Hass
Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-4283, USA
Clin Gastroenterol Hepatol 4:482-8. 2006..5 kg/m2. This suggests that overweight CD patients require earlier surgical intervention and perhaps more aggressive medical therapy... - The risk of mortality in patients with psoriasis: results from a population-based studyJoel M Gelfand
MSCE, Department of Dermatology, University of Pennsylvania School of Medicine, 2 Maloney Bldg, 3600 Spruce St, Philadelphia, PA 19104, USA
Arch Dermatol 143:1493-9. 2007..To determine the risk of mortality in patients with psoriasis... - The relationship between time since registration and measured incidence rates in the General Practice Research DatabaseJames D Lewis
Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Pharmacoepidemiol Drug Saf 14:443-51. 2005.... - Detection of proximal adenomatous polyps with screening sigmoidoscopy: a systematic review and meta-analysis of screening colonoscopyJames D Lewis
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 423 Guardian Dr, Seventh Floor Blockley Hall, Philadelphia, PA 19104 6021, USA
Arch Intern Med 163:413-20. 2003..To address this, we performed a systematic review and meta-analysis of screening colonoscopy studies... - Long-term proton pump inhibitor therapy and risk of hip fractureYu Xiao Yang
Division of Gastroenterology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
JAMA 296:2947-53. 2006..Proton pump inhibitors (PPIs) may interfere with calcium absorption through induction of hypochlorhydria but they also may reduce bone resorption through inhibition of osteoclastic vacuolar proton pumps... - Development of an internet-based cohort of patients with inflammatory bowel diseases (CCFA Partners): methodology and initial resultsMillie D Long
University of North Carolina, Department of Medicine, Division of Gastroenterology and Hepatology, Chapel Hill, North Carolina 27599, USA
Inflamm Bowel Dis 18:2099-106. 2012..The widespread use of the Internet allows for unique research opportunities. We aimed to develop and follow an Internet-based cohort (e-cohort) of patients with self-reported inflammatory bowel diseases (IBD) over time... - Hypervariable loci in the human gut viromeSamuel Minot
Department of Microbiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 109:3962-6. 2012.... - Trends in hospitalization rates for inflammatory bowel disease in the United StatesMeenakshi Bewtra
Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Clin Gastroenterol Hepatol 5:597-601. 2007..This study examined trends in hospitalization and surgery rates for inflammatory bowel disease (IBD) in the United States over a 14-year period... - Bowman-Birk inhibitor concentrate: a novel therapeutic agent for patients with active ulcerative colitisGary R Lichtenstein
Department of Medicine, Division of Gastroenterology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
Dig Dis Sci 53:175-80. 2008..22). No severe adverse events were observed. This trial suggests a potential benefit over placebo for both achieving clinical response and induction of remission in patients with active ulcerative colitis without apparent toxicity... - Validity of The Health Improvement Network (THIN) for epidemiologic studies of hepatitis C virus infectionVincent Lo Re
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, PA 19104 6021, USA
Pharmacoepidemiol Drug Saf 18:807-14. 2009..We determined the accuracy of HCV diagnostic codes within The Health Improvement Network (THIN), an electronic database containing medical record data from general medical practices in the United Kingdom... - Endoluminal resection for sessile neoplasia in the GI tract is associated with a low recurrence rate and a high 5-year survival rateAndrew Y Wang
Gastroenterology Division, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
Gastrointest Endosc 68:160-9. 2008..We previously reported a complete resection (CR) rate of 89% when using ELR techniques. However, the long-term efficacy of ELR for the eradication of sessile lesions, as well as patient survival after ELR, is not known... - Renal function after orthotopic liver transplantation is predicted by duration of pretransplantation creatinine elevationMical S Campbell
Division of Gastroenterology, University of Pennsylvania Health System, Philadelphia, PA 19104, USA
Liver Transpl 11:1048-55. 2005..01) after transplantation. In conclusion, duration, but not cause, of renal dysfunction predicts renal outcome in OLTa recipients. Prospective studies may use duration of renal dysfunction to help identify CKLT candidates... - The human gut virome: inter-individual variation and dynamic response to dietSamuel Minot
Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Genome Res 21:1616-25. 2011..Thus these data provide an overview of the composition of the human gut virome and associate virome structure with diet... - Validity and completeness of the General Practice Research Database for studies of inflammatory bowel diseaseJames D Lewis
Center for Clinical Epidemiology and Biostatistics, Department of Medicine, University of Pennsylvania School of Medicine, 9th Floor Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
Pharmacoepidemiol Drug Saf 11:211-8. 2002..The objective of this study was to evaluate the validity and completeness of the General Practice Research Database (GPRD) as a tool for research into inflammatory bowel disease epidemiology... - Risk of kidney injury following oral phosphosoda bowel preparationsSteven M Brunelli
Renal-Electrolyte and Hypertension Division, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
J Am Soc Nephrol 18:3199-205. 2007 - Update on the risk of lymphoma following immunosuppressive therapy for inflammatory bowel diseaseMeenakshi Bewtra
Division of Gastroenterology, Hospital of University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
Expert Rev Clin Immunol 6:621-31. 2010..In this article, we will describe the known lymphoma risks of commonly used immunosuppressant medications in inflammatory bowel disease, with an emphasis on non-Hodgkin's lymphoma and hepatosplenic T-cell lymphoma... - Corticosteroids and immunomodulators: postoperative infectious complication risk in inflammatory bowel disease patientsFaten N Aberra
Division of Gastroenterology, Department of Medicine, Hospital of the University of Pennsylvania, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Gastroenterology 125:320-7. 2003..6-Mercaptopurine/azathioprine alone and the addition of 6-mercaptopurine/azathioprine for patients receiving corticosteroids was not found to significantly increase the risk of postoperative infectious complications... - Incidence and risk factors for herpes zoster among patients with inflammatory bowel diseaseGauree Gupta
Center for Clinical Epidemiology and Biostatistics, Department of Internal Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6021, USA
Clin Gastroenterol Hepatol 4:1483-90. 2006..Future studies should clarify the relative risk associated with anti-tumor necrosis factor alpha therapies and determine the use of the new zoster vaccine for patients with IBD... - Structure-constrained sparse canonical correlation analysis with an application to microbiome data analysisJun Chen
Department of Biostatistics and Epidemiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA19104, USA
Biostatistics 14:244-58. 2013..Both simulations and real data applications show that ssCCA performs better than the standard sparse CCA in identifying meaningful variables when there are structures in the data... - Food and the gut microbiota in inflammatory bowel diseases: a critical connectionLindsey G Albenberg
Division of Gastroenterology, Hepatology, and Nutrition, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
Curr Opin Gastroenterol 28:314-20. 2012..In this review, we describe the current evidence regarding the impact of diet on the gut microbiome and how this may be relevant to the pathogenesis of IBD... - Hospitalization and mortality rates from peptic ulcer disease and GI bleeding in the 1990s: relationship to sales of nonsteroidal anti-inflammatory drugs and acid suppression medicationsJames D Lewis
Center for Clinical Epidemiology and Biostatistics, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104-6021, USA
Am J Gastroenterol 97:2540-9. 2002..Changing rates of peptic ulcer disease morbidity and mortality were temporally related to increasing sales of antiulcerants but not to change in sales of NSAIDs... - A meta-analysis of the placebo rates of remission and response in clinical trials of active Crohn's diseaseChinyu Su
Division of Gastroenterology, Department of Medicine, University of Pennsylvania School of Medicine, UPenn Medical Center Presbyterian, 218 Wright Saunders Building, 39th and Market Streets, Philadelphia, PA 19104, USA
Gastroenterology 126:1257-69. 2004..The aims of this study were to estimate rates of remission and response in patients with active CD receiving placebo and to identify factors influencing these rates... - Efficacy of methotrexate in ulcerative colitis: failure or promiseHans H Herfarth
Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA
Inflamm Bowel Dis 16:1421-30. 2010.... - Potential association between the oral tetracycline class of antimicrobials used to treat acne and inflammatory bowel diseaseDavid J Margolis
Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Am J Gastroenterol 105:2610-6. 2010..The majority of patients prescribed isotretinoin for their acne are previously on an extended course of antibiotics. Therefore, it is important to consider antibiotic use as a confounding variable for the development of IBD... - Colonic dysplasia and cancer in inflammatory bowel diseaseThomas A Judge
Division of Gastroenterology, Department of Medicine, University of Pennsylvania School of Medicine, Hospital of the University of Pennsylvania, 3400 Spruce Street, 3rd Floor Ravdin Building, Philadelphia, PA 19104-4283, USA
Gastrointest Endosc Clin N Am 12:495-523. 2002..Efforts to develop chemopreventative agents and improved surveillance methods remain areas of active investigation... - Prevention and treatment of stress ulcers in critically ill patientsYu Xiao Yang
Gastroenterology Division, Department of Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA, USA
Semin Gastrointest Dis 14:11-9. 2003..More potent acid suppression by proton pump inhibitors may offer additional benefit in the prevention of stress ulcer bleeding... - The association between hepatitis C infection and survival after orthotopic liver transplantationLisa M Forman
Center for Clinical Epidemiology and Biostatistics and the Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Gastroenterology 122:889-96. 2002..Hepatitis C recurrence after transplant is inevitable, but studies to date have not found a survival difference between recipients with and without HCV... - Enhancement of medication recall using medication pictures and lists in telephone interviewsStephen E Kimmel
Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics, University of Pennsylvania School of Medicine, 717 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
Pharmacoepidemiol Drug Saf 12:1-8. 2003..To determine the effect of reading medication lists and providing medication pictures on recall of non-aspirin non-steroidal anti-inflammatory drugs (NANSAIDs) during telephone interviews in a case-control study... - Secular trends in small-bowel obstruction and adhesiolysis in the United States: 1988-2007Frank I Scott
Division of Gastroenterology, Department of Medicine, University of Pennsylvania, Perelman School of Medicine, 3400 Spruce St, Ravdin 3, Philadelphia, PA 19104, USA
Am J Surg 204:315-20. 2012..The impact that laparoscopy and other surgical advances have had on rates of SBO and adhesiolysis remains controversial. This study examines trends in discharges from US hospitals for SBO and adhesiolysis from 1988 to 2007... - Use of abdominopelvic computed tomography in emergency departments and rates of urgent diagnoses in Crohn's diseaseCaroline Kerner
Division of Gastroenterology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Clin Gastroenterol Hepatol 10:52-7. 2012..We proposed that trends would be similar for patients with Crohn's disease (CD)... - Quality of manufacturer provided information on safety and efficacy claims for dietary supplements for colonic healthDavid J Hass
Department of Medicine, Division of Gastroenterology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA
Pharmacoepidemiol Drug Saf 15:578-86. 2006..CONCLUSIONS: There is a need to increase availability of supplement safety data to physicians and the general public. Consideration should be given to various responses, including legislative actions that address this issue... - Safety profile of IBD: lymphoma risksMeenakshi Bewtra
Division of Gastroenterology, Department of Medicine, University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104, USA
Gastroenterol Clin North Am 38:669-89. 2009..The potential risks of all therapies must be weighed against the benefits these therapies can offer these patients... - Schatzki ring and Barrett's esophagus: do they occur together?Marcia C Mitre
Division of Gastroenterology, Department of Medicine, University of Pennsylvania Health System, Philadelphia, Pennsylvania 19104, USA
Dig Dis Sci 49:770-3. 2004..Long segment Barrett's esophagus was not observed in patients with Schatzki ring. A responsible protective effect or mutually exclusive pathophysiology should be considered... - Increased risk for demyelinating diseases in patients with inflammatory bowel diseaseGauree Gupta
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6021, USA
Gastroenterology 129:819-26. 2005..Future studies should clarify whether treatment with tumor necrosis factor alpha blockers results in further increased incidence of MS/D/ON among IBD patients... - An evidence-based approach to studies of the natural history of gastrointestinal diseases: recurrence of symptomatic Crohn's disease after surgeryJames D Lewis
Department of Medicine, and Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6021, USA
Clin Gastroenterol Hepatol 1:229-36. 2003 - Relationship between 6-mercaptopurine dose and 6-thioguanine nucleotide levels in patients with inflammatory bowel diseaseAhmed Morales
Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6021, USA
Inflamm Bowel Dis 13:380-5. 2007..However, many physicians prescribe AZA/6MP using milligrams per kilogram (mg/kg) dosing regimens without measuring 6-TGN levels. The aim of this study was to examine the association between 6MP dose and 6-TGN levels... - Agreement between GPRD smoking data: a survey of general practitioners and a population-based surveyJames D Lewis
Center for Clinical Epidemiology and Biostatistics, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6021, USA
Pharmacoepidemiol Drug Saf 13:437-41. 2004..In this study, we compare data recorded in the GPRD with the smoking history obtained from direct query of general practitioners (GPs) and from a population-based survey... - A critical review of selective serotonin reuptake inhibitor-associated bleeding: balancing the risk of treating hepatitis C-infected patientsRobert M Weinrieb
Department of Psychiatry, University of Pennsylvania, Philadelphia, USA
J Clin Psychiatry 64:1502-10. 2003..Because there is an increased risk of bleeding in HCV-infected patients who have developed cirrhosis and either portal hypertension or hepatic failure or both, we critically reviewed the literature on SSRI-associated bleeding... - Patterns of complementary and alternative medicine use in a population of pediatric patients with inflammatory bowel diseaseJonathan E Markowitz
Division of Gastroenterology and Nutrition, The Children s Hospital of Philadelphia, Pennsylvania, USA
Inflamm Bowel Dis 10:599-605. 2004.... - Passive smoking and inflammatory bowel disease: a meta-analysisDeborah T Jones
School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6021, USA
Am J Gastroenterol 103:2382-93. 2008..This meta-analysis examined the relationship between prenatal smoke exposure and childhood passive smoke exposure and the development of IBD... - Efficacy of anti-tumor necrosis factor therapy in patients with ulcerative colitisChinyu Su
Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104-4283, USA
Am J Gastroenterol 97:2577-84. 2002..Individuals who are refractory to corticosteroids, however, may be unlikely to respond to infliximab. A randomized controlled trial is necessary to further investigate the efficacy of infliximab in patients with UC... - Initial evaluation of rectal bleeding in young persons: a cost-effectiveness analysisJames D Lewis
Center for Clinical Epidemiology and Biostatistics, Blockley Hall, 9th Floor, 423 Guardian Drive, Philadelphia, PA 19104-6021, USA
Ann Intern Med 136:99-110. 2002..CONCLUSIONS: Evaluation of the colon of persons 25 to 45 years of age with otherwise asymptomatic rectal bleeding increases the life expectancy at a cost comparable to that of colon cancer screening... - NOD2 mutations and anti-Saccharomyces cerevisiae antibodies are risk factors for Crohn's disease in African AmericansThemistocles Dassopoulos
Gastroenterology Division, Department of Medicine, The Harvey M and Lyn P Meyerhoff Inflammatory Bowel Disease Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
Am J Gastroenterol 105:378-86. 2010..NOD2 mutations and anti-Saccharomyces cerevisiae antibodies (ASCAs) are established risk factors of Crohn's disease (CD) in whites but have not been assessed in African-American (AA) adults with CD... - Design issues and outcomes in IBD clinical trialsBruce E Sands
Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
Inflamm Bowel Dis 11:S22-8. 2005..Careful subject selection, standardization of disease activity indices, and precise outcome measurement are the keys to continued improvement of the inflammatory bowel disease research process... - Risk of proximal and distal colorectal cancer following flexible sigmoidoscopy: a population-based cohort studyLinda Rabeneck
Department of Medicine, Management and Evaluation, University of Toronto, Toronto, Canada
Am J Gastroenterol 103:2075-82. 2008..Our objective was to estimate the annual incidence of CRC within 7 yr following FS and to identify factors associated with incident CRC in those with a negative FS... - Anti-TNF antibodies for Crohn's disease--in pursuit of the perfect clinical trialJames D Lewis
N Engl J Med 357:296-8. 2007 - The many faces of low-grade dysplasiaJames D Lewis
Gastroenterology 125:1531-3. 2003 - In clarificationBrian L Strom
Pharmacoepidemiol Drug Saf 16:1063-4; author reply 1063-4. 2007 - How safe are the safest IBD drugs?James D Lewis
Gastroenterology 124:1986-7; discussion 1987-8. 2003 - Are two tests better than one?James D Lewis
Gastroenterology 122:236-7. 2002 - Incidence and prevalence of inflammatory bowel disease in a Northern California managed care organization, 1996-2002Lisa J Herrinton
Division of Research, Kaiser Permanente Northern California, 2000 Broadway Avenue, Oakland, CA 94612, USA
Am J Gastroenterol 103:1998-2006. 2008..2 million members of Kaiser Permanente, Northern California, for the period 1996-2002... - The genesis of IBD geneticsJames D Lewis
Gastroenterology 123:2148-9. 2002 - C-reactive protein: anti-placebo or predictor of responseJames D Lewis
Gastroenterology 129:1114-6. 2005 - Association of 6-thioguanine nucleotide levels and inflammatory bowel disease activity: a meta-analysisMark T Osterman
Division of Gastroenterology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Gastroenterology 130:1047-53. 2006..Again, excluding the 1 outlier study eliminated this heterogeneity. CONCLUSIONS: Although prior studies yielded inconsistent conclusions, this analysis strongly supports that higher 6-TGN levels are associated with clinical remission... - Site organization and managementDouglas C Wolf
Atlanta Gastroenterology Associates, Atlanta, Georgia, USA
Inflamm Bowel Dis 11:S29-33. 2005..Careful attention to the details of site organization, administrative requirements, and patient recruitment and retention all contribute to the successful performance of clinical research... - State of the art: IBD therapy and clinical trials in IBDKim L Isaacs
University of North Carolina, Chapel Hill, North Carolina, USA
Inflamm Bowel Dis 11:S3-12. 2005..The number of products under development and continued investigations into the pathogenesis of IBD emphasize the need to expand clinical research efforts in IBD... - Will the safest analgesic please stand upJames D Lewis
Bayer Corporation
Gastroenterology 122:1535-6. 2002 - Gastroenterologists' attitudes and self-reported practices regarding inflammatory bowel diseaseAndrea Altschuler
Division of Research, Kaiser Permanente Northern California, Oakland, California 94612, USA
Inflamm Bowel Dis 14:992-9. 2008....