J D Lewis

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint Barriers to office-based screening sigmoidoscopy: does reimbursement cover costs?
    J D Lewis
    Center for Clinical Epidemiology and Biostatistics, Philadelphia Veterans Affairs Medical Center and the University of Pennsylvania, 19104 6021, USA
    Ann Intern Med 130:525-30. 1999
  2. ncbi request reprint Detection of proximal adenomatous polyps with screening sigmoidoscopy: a systematic review and meta-analysis of screening colonoscopy
    James D Lewis
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 423 Guardian Dr, Seventh Floor Blockley Hall, Philadelphia, PA 19104 6021, USA
    Arch Intern Med 163:413-20. 2003
  3. pmc Use of the noninvasive components of the Mayo score to assess clinical response in ulcerative colitis
    James D Lewis
    Division of Gastroenterology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
    Inflamm Bowel Dis 14:1660-6. 2008
  4. ncbi request reprint Seasonal variation in flares of inflammatory bowel disease
    James D Lewis
    Center for Clinical Epidemiology and Biostatistics and Department of Medicine, University of Pennsylvania Centers for Education and Research on Therapeutics, Philadelphia, 19104 6021, USA
    Gastroenterology 126:665-73. 2004
  5. ncbi request reprint An evidence-based approach to studies of the natural history of gastrointestinal diseases: recurrence of symptomatic Crohn's disease after surgery
    James D Lewis
    Department of Medicine, and Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
    Clin Gastroenterol Hepatol 1:229-36. 2003
  6. ncbi request reprint Agreement between GPRD smoking data: a survey of general practitioners and a population-based survey
    James D Lewis
    Center for Clinical Epidemiology and Biostatistics, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6021, USA
    Pharmacoepidemiol Drug Saf 13:437-41. 2004
  7. doi request reprint Moderate and high affinity serotonin reuptake inhibitors increase the risk of upper gastrointestinal toxicity
    James D Lewis
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Pharmacoepidemiol Drug Saf 17:328-35. 2008
  8. ncbi request reprint Risk of serious upper gastrointestinal toxicity with over-the-counter nonaspirin nonsteroidal anti-inflammatory drugs
    James D Lewis
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Gastroenterology 129:1865-74. 2005
  9. ncbi request reprint Inflammatory bowel disease is not associated with an increased risk of lymphoma
    J D Lewis
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
    Gastroenterology 121:1080-7. 2001
  10. ncbi request reprint The relationship between time since registration and measured incidence rates in the General Practice Research Database
    James D Lewis
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Pharmacoepidemiol Drug Saf 14:443-51. 2005

Detail Information

Publications93

  1. ncbi request reprint Barriers to office-based screening sigmoidoscopy: does reimbursement cover costs?
    J D Lewis
    Center for Clinical Epidemiology and Biostatistics, Philadelphia Veterans Affairs Medical Center and the University of Pennsylvania, 19104 6021, USA
    Ann Intern Med 130:525-30. 1999
    ..Thus, low reimbursement may limit the adoption of screening flexible sigmoidoscopy with or without biopsy in primary care practices...
  2. ncbi request reprint Detection of proximal adenomatous polyps with screening sigmoidoscopy: a systematic review and meta-analysis of screening colonoscopy
    James D Lewis
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 423 Guardian Dr, Seventh Floor Blockley Hall, Philadelphia, PA 19104 6021, USA
    Arch Intern Med 163:413-20. 2003
    ..To address this, we performed a systematic review and meta-analysis of screening colonoscopy studies...
  3. pmc Use of the noninvasive components of the Mayo score to assess clinical response in ulcerative colitis
    James D Lewis
    Division of Gastroenterology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
    Inflamm Bowel Dis 14:1660-6. 2008
    ..We sought to assess what constitutes a clinically meaningful change in these indices using data from a recently completed placebo-controlled clinical trial...
  4. ncbi request reprint Seasonal variation in flares of inflammatory bowel disease
    James D Lewis
    Center for Clinical Epidemiology and Biostatistics and Department of Medicine, University of Pennsylvania Centers for Education and Research on Therapeutics, Philadelphia, 19104 6021, USA
    Gastroenterology 126:665-73. 2004
    ..The purpose of this study was to determine whether relapse of inflammatory bowel disease follows a seasonal pattern either across a cohort of patients or within individual patients...
  5. ncbi request reprint An evidence-based approach to studies of the natural history of gastrointestinal diseases: recurrence of symptomatic Crohn's disease after surgery
    James D Lewis
    Department of Medicine, and Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
    Clin Gastroenterol Hepatol 1:229-36. 2003
  6. ncbi request reprint Agreement between GPRD smoking data: a survey of general practitioners and a population-based survey
    James D Lewis
    Center for Clinical Epidemiology and Biostatistics, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6021, USA
    Pharmacoepidemiol Drug Saf 13:437-41. 2004
    ..In this study, we compare data recorded in the GPRD with the smoking history obtained from direct query of general practitioners (GPs) and from a population-based survey...
  7. doi request reprint Moderate and high affinity serotonin reuptake inhibitors increase the risk of upper gastrointestinal toxicity
    James D Lewis
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Pharmacoepidemiol Drug Saf 17:328-35. 2008
    ..This study examined the effect of medications that inhibit serotonin uptake on upper gastrointestinal toxicity...
  8. ncbi request reprint Risk of serious upper gastrointestinal toxicity with over-the-counter nonaspirin nonsteroidal anti-inflammatory drugs
    James D Lewis
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Gastroenterology 129:1865-74. 2005
    ..Less is known about over-the-counter (OTC) NANSAIDs, which are typically used at lower doses and for shorter durations. This study assessed the risk of toxicity with OTC NANSAIDs...
  9. ncbi request reprint Inflammatory bowel disease is not associated with an increased risk of lymphoma
    J D Lewis
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
    Gastroenterology 121:1080-7. 2001
    ..Previous studies of the risk of lymphoma in inflammatory bowel disease patients have provided conflicting results. This study examines the risk of Hodgkin's and non-Hodgkin's lymphoma among patients with inflammatory bowel disease...
  10. ncbi request reprint The relationship between time since registration and measured incidence rates in the General Practice Research Database
    James D Lewis
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Pharmacoepidemiol Drug Saf 14:443-51. 2005
    ....
  11. ncbi request reprint Predictors of recall of over-the-counter and prescription non-steroidal anti-inflammatory drug exposure
    James D Lewis
    Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Pharmacoepidemiol Drug Saf 15:39-45. 2006
    ..Because of the difficulty in establishing a gold standard, data on accuracy of recall of over-the-counter (OTC) medication use are sparse...
  12. ncbi request reprint Azathioprine for maintenance of remission in Crohn's disease: benefits outweigh the risk of lymphoma
    J D Lewis
    Division of Gastroenterology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Gastroenterology 118:1018-24. 2000
    ..The objective of this analysis was to determine the impact of azathioprine therapy on survival and quality-adjusted life expectancy after accounting for both the benefits of therapy and potential increased risk of lymphoma...
  13. ncbi request reprint Validation studies of the health improvement network (THIN) database for pharmacoepidemiology research
    James D Lewis
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Pharmacoepidemiol Drug Saf 16:393-401. 2007
    ..We sought to replicate in THIN well-established associations from the medical literature and to compare results from the GPRD practices to the non-GPRD practices within THIN...
  14. ncbi request reprint Validity and completeness of the General Practice Research Database for studies of inflammatory bowel disease
    James D Lewis
    Center for Clinical Epidemiology and Biostatistics, Department of Medicine, University of Pennsylvania School of Medicine, 9th Floor Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
    Pharmacoepidemiol Drug Saf 11:211-8. 2002
    ..The objective of this study was to evaluate the validity and completeness of the General Practice Research Database (GPRD) as a tool for research into inflammatory bowel disease epidemiology...
  15. ncbi request reprint Flexible sigmoidoscopy training and its impact on colorectal cancer screening by primary care physicians
    J D Lewis
    Division of Gastroenterology, University of Pennsylvania, Philadelphia 19104, USA
    Arch Fam Med 9:420-5. 2000
    ..Colorectal cancer is an ideal disease for prevention with screening programs. Efforts to increase compliance with screening recommendations have included training primary care physicians to perform flexible sigmoidoscopy...
  16. ncbi request reprint Women with a prior diagnosis of breast cancer are not at an increased risk for subsequent colorectal cancer
    Radhika Srinivasan
    Division of Gastroenterology, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Am J Gastroenterol 100:2759-64. 2005
    ..Earlier studies regarding the risk of colorectal cancer in women with a prior diagnosis of breast cancer yielded conflicting results...
  17. pmc Primary care physicians' decisions to perform flexible sigmoidoscopy
    J D Lewis
    Division of Gastroenterology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia 19104, USA
    J Gen Intern Med 14:297-302. 1999
    ..Self-perceived inefficiency in performing office-based flexible sigmoidoscopy deterred many of these physicians from providing this service for their patients...
  18. doi request reprint Immunosuppressant medications and mortality in inflammatory bowel disease
    James D Lewis
    Division of Gastroenterology, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Am J Gastroenterol 103:1428-35; quiz 1436. 2008
    ..This study examined whether treatment of Crohn's disease (CD) and ulcerative colitis (UC) with immunosuppressant medications was associated with an increased risk of death in the era prior to antitumor necrosis factor (TNF) therapies...
  19. ncbi request reprint An open-label trial of the PPAR-gamma ligand rosiglitazone for active ulcerative colitis
    J D Lewis
    Division of Gastroenterology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia 19104-6021, USA
    Am J Gastroenterol 96:3323-8. 2001
    ..CONCLUSIONS: These data suggest that ligands for the gamma subtype of PPARs may represent a novel therapy for ulcerative colitis. A double blind, placebo-controlled, randomized trial is warranted...
  20. ncbi request reprint Endosonography is superior to angiography in the preoperative assessment of vascular involvement among patients with pancreatic carcinoma
    N A Ahmad
    Department of Medicine, Hospital of the University of Pennsyulvania, University of Pennsylvania School of Medicine, Philadelphia 19104-4283, USA
    J Clin Gastroenterol 32:54-8. 2001
    ..Endoscopic ultrasound is significantly more sensitive than angiography for detecting vascu lar involvement in patients with pancreatic adenocarcinoma and, thus, may improve patient selection for attempted curative resection...
  21. ncbi request reprint Risk for active tuberculosis in inflammatory bowel disease patients
    Faten N Aberra
    Division of Gastroenterology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Clin Gastroenterol Hepatol 5:1070-5. 2007
    ..The primary aim of this study was to determine the incidence of active tuberculosis in an inflammatory bowel disease population compared with the general population before the availability of infliximab...
  22. doi request reprint Meta-analysis: factors predicting post-operative recurrence with placebo therapy in patients with Crohn's disease
    M Pascua
    Division of Gastroenterology, Department of Medicine, University of Pennsylvania School of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA
    Aliment Pharmacol Ther 28:545-56. 2008
    ..The use of placebo in randomized clinical trials (PC-RCTs) is often required to evaluate drug efficacy in maintenance of Crohn's disease (CD)...
  23. ncbi request reprint Endoscopy for hematochezia in patients under 50 years of age
    J D Lewis
    Division of Gastroenterology, and Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine Philadelphia 19104-6021, USA
    Dig Dis Sci 46:2660-5. 2001
    ..4, 95% CI 0.89-60.7). In conclusion, the prevalence of colonic neoplasms in patients 40-50 years old with hematochezia is substantial. Among those persons younger than 40 years, the prevalence of colonic neoplasms is significantly lower...
  24. ncbi request reprint Long term survival after pancreatic resection for pancreatic adenocarcinoma
    N A Ahmad
    Department of Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Cancer Center, Philadelphia, Pennsylvania, USA
    Am J Gastroenterol 96:2609-15. 2001
    ....
  25. ncbi request reprint Potential limitations of electronic database studies of prescription non-aspirin non-steroidal anti-inflammatory drugs (NANSAIDs) and risk of myocardial infarction (MI)
    Leonard Ilkhanoff
    Department of Medicine, Cardiovascular Division, Hospital of the University of Pennsylvania, Philadelphia, PA, USA
    Pharmacoepidemiol Drug Saf 14:513-22. 2005
    ..In the 'Confounding Assessment Analysis #2,' we also adjusted for body mass index (BMI) and physical activity. In the 'Interaction Assessment Analysis,' we stratified on aspirin use and repeated the latter analysis...
  26. ncbi request reprint Accuracy of EUS in the evaluation of Barrett's esophagus and high-grade dysplasia or intramucosal carcinoma
    I A Scotiniotis
    Division of Gastroenterology, Department of Pathology, and Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Gastrointest Endosc 54:689-96. 2001
    ..Patients should be evaluated with EUS when nonoperative therapy is contemplated...
  27. ncbi request reprint Corticosteroids and immunomodulators: postoperative infectious complication risk in inflammatory bowel disease patients
    Faten N Aberra
    Division of Gastroenterology, Department of Medicine, Hospital of the University of Pennsylvania, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Gastroenterology 125:320-7. 2003
    ....
  28. pmc Findings on serial surveillance colonoscopy in patients with low-risk polyps on initial colonoscopy
    Jocelyne Miller
    Division of Gastroenterology, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA
    J Clin Gastroenterol 44:e46-50. 2010
    ..This study describes the prevalence of adenomatous polyps at serial follow-up exams after a colonoscopy finding 1 to 2 small tubular adenomas...
  29. pmc Risk of myocardial infarction associated with chronic hepatitis C virus infection: a population-based cohort study
    K A Forde
    Division of Gastroenterology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
    J Viral Hepat 19:271-7. 2012
    ..16; 95% CI, 0.77-1.74). In conclusion, HCV infection was not associated with an increased risk of incident MI...
  30. ncbi request reprint Medical therapy for diabetes is associated with increased use of lower endoscopy
    James D Lewis
    Department of Medicine, Division of Gastroenterology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, USA
    Pharmacoepidemiol Drug Saf 16:1195-202. 2007
    ..This study examined the association between diabetes therapies and use of lower endoscopy...
  31. ncbi request reprint Risk of kidney injury following oral phosphosoda bowel preparations
    Steven M Brunelli
    Renal Electrolyte and Hypertension Division, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Am Soc Nephrol 18:3199-205. 2007
  32. ncbi request reprint A meta-analysis of the placebo rates of remission and response in clinical trials of active ulcerative colitis
    Chinyu Su
    Division of Gastroenterology, Department of Medicine, Hospital of the University of Pennsylvania and University of Pennsylvania Presbyterian Medical Center, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Gastroenterology 132:516-26. 2007
    ..The aims of this study were to estimate the placebo rates of remission and response in placebo-controlled, randomized clinical trials for active UC and to identify factors influencing these rates...
  33. ncbi request reprint Long-term proton pump inhibitor therapy and risk of hip fracture
    Yu Xiao Yang
    Division of Gastroenterology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    JAMA 296:2947-53. 2006
    ..Proton pump inhibitors (PPIs) may interfere with calcium absorption through induction of hypochlorhydria but they also may reduce bone resorption through inhibition of osteoclastic vacuolar proton pumps...
  34. ncbi request reprint Incidence and prevalence of abnormal liver associated enzymes in patients with atrial fibrillation in a routine clinical care population
    George A Makar
    Division of Gastroenterology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Pharmacoepidemiol Drug Saf 17:43-51. 2008
    ..The aim of this study was to estimate the prevalence and incidence of alanine aminotransferase (ALT) elevations in a cohort with AF...
  35. ncbi request reprint The risk of mortality in patients with psoriasis: results from a population-based study
    Joel M Gelfand
    MSCE, Department of Dermatology, University of Pennsylvania School of Medicine, 2 Maloney Bldg, 3600 Spruce St, Philadelphia, PA 19104, USA
    Arch Dermatol 143:1493-9. 2007
    ..To determine the risk of mortality in patients with psoriasis...
  36. doi request reprint Safety profile of IBD: lymphoma risks
    Meenakshi Bewtra
    Division of Gastroenterology, Department of Medicine, University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104, USA
    Gastroenterol Clin North Am 38:669-89. 2009
    ..The potential risks of all therapies must be weighed against the benefits these therapies can offer these patients...
  37. doi request reprint Timing of myelosuppression during thiopurine therapy for inflammatory bowel disease: implications for monitoring recommendations
    James D Lewis
    Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6021, USA
    Clin Gastroenterol Hepatol 7:1195-201; quiz 1141-2. 2009
    ..Thiopurines (azathioprine and 6-mercaptopurine) can induce life-threatening myelosuppression. This study determined the frequency, timing, and outcomes of mild and severe myelosuppression after initiation of thiopurine therapy...
  38. pmc Validity of The Health Improvement Network (THIN) for epidemiologic studies of hepatitis C virus infection
    Vincent Lo Re
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, PA 19104 6021, USA
    Pharmacoepidemiol Drug Saf 18:807-14. 2009
    ..We determined the accuracy of HCV diagnostic codes within The Health Improvement Network (THIN), an electronic database containing medical record data from general medical practices in the United Kingdom...
  39. doi request reprint Prevalence of colorectal cancer surveillance for ulcerative colitis in an integrated health care delivery system
    Fernando S Velayos
    Division of Gastroenterology, Department of Internal Medicine, University of California, San Francisco 94115, USA
    Gastroenterology 139:1511-8. 2010
    ..Limited data are available on rates of colonoscopy surveillance and factors associated with surveillance...
  40. doi request reprint Cancer incidence in The Health Improvement Network
    Kevin Haynes
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Pharmacoepidemiol Drug Saf 18:730-6. 2009
    ..This study assessed whether the recorded incidence of cancer among patients in The Health Improvement Network (THIN) database is comparable to that expected in the UK based on national cancer registry data...
  41. pmc A comparison of sodium phosphosoda purgative to polyethylene glycol bowel preparations prior to colonoscopy
    Steven M Brunelli
    Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Fam Med 41:39-45. 2009
    ..We undertook this analysis to determine the relative clinical effectiveness of oral sodium phosphosoda versus polyethylene glycol in clinical practice...
  42. pmc Thiazolidinedione therapy is not associated with increased colonic neoplasia risk in patients with diabetes mellitus
    James D Lewis
    Department of Medicine, Division of Gastroenterology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Gastroenterology 135:1914-23, 1923.e1. 2008
    ..This study examined the association between PPARgamma-targeted therapies and the risk of colonic neoplasia in patients with diabetes...
  43. pmc Sampling and pyrosequencing methods for characterizing bacterial communities in the human gut using 16S sequence tags
    Gary D Wu
    Division of Gastroenterology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6076 USA
    BMC Microbiol 10:206. 2010
    ....
  44. pmc Serial glycosylated hemoglobin levels and risk of colorectal neoplasia among patients with type 2 diabetes mellitus
    Yu Xiao Yang
    Department of Medicine, Division of Gastroenterology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 722 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104, USA
    Cancer Epidemiol Biomarkers Prev 19:3027-36. 2010
    ..We sought to determine whether glycemic control measured by serial hemoglobin A1c (HbA1c) was associated with the risk of colorectal adenoma...
  45. pmc Risk of bladder cancer among diabetic patients treated with pioglitazone: interim report of a longitudinal cohort study
    James D Lewis
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Diabetes Care 34:916-22. 2011
    ..This is an interim report of an ongoing cohort study examining the association between pioglitazone therapy and the risk of bladder cancer in patients with diabetes...
  46. doi request reprint Chronic statin therapy and the risk of colorectal cancer
    Yu Xiao Yang
    Division of Gastroenterology, University of Pennsylvania, Philadelphia, PA 19104 6021, USA
    Pharmacoepidemiol Drug Saf 17:869-76. 2008
    ..We sought to clarify whether long-term statin therapy has a chemopreventive effect on the risk of colorectal cancer (CRC) in a large, population-representative cohort...
  47. pmc Rosiglitazone for active ulcerative colitis: a randomized placebo-controlled trial
    James D Lewis
    Division of Gastroenterology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Gastroenterology 134:688-95. 2008
    ..Thiazolidinedione ligands for the gamma subtype of peroxisome proliferator-activated receptors (PPARgamma), widely used to treat type 2 diabetes mellitus, have been proposed as novel therapies for ulcerative colitis (UC)...
  48. ncbi request reprint Chronic proton pump inhibitor therapy and the risk of colorectal cancer
    Yu Xiao Yang
    Division of Gastroenterology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6021, USA
    Gastroenterology 133:748-54. 2007
    ....
  49. ncbi request reprint A critical review of selective serotonin reuptake inhibitor-associated bleeding: balancing the risk of treating hepatitis C-infected patients
    Robert M Weinrieb
    Department of Psychiatry, University of Pennsylvania, Philadelphia, USA
    J Clin Psychiatry 64:1502-10. 2003
    ..Because there is an increased risk of bleeding in HCV-infected patients who have developed cirrhosis and either portal hypertension or hepatic failure or both, we critically reviewed the literature on SSRI-associated bleeding...
  50. ncbi request reprint A meta-analysis of the placebo rates of remission and response in clinical trials of active Crohn's disease
    Chinyu Su
    Division of Gastroenterology, Department of Medicine, University of Pennsylvania School of Medicine, UPenn Medical Center Presbyterian, 218 Wright Saunders Building, 39th and Market Streets, Philadelphia, PA 19104, USA
    Gastroenterology 126:1257-69. 2004
    ..The aims of this study were to estimate rates of remission and response in patients with active CD receiving placebo and to identify factors influencing these rates...
  51. ncbi request reprint Prevention and treatment of stress ulcers in critically ill patients
    Yu Xiao Yang
    Gastroenterology Division, Department of Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA, USA
    Semin Gastrointest Dis 14:11-9. 2003
    ..More potent acid suppression by proton pump inhibitors may offer additional benefit in the prevention of stress ulcer bleeding...
  52. ncbi request reprint Insulin therapy and colorectal cancer risk among type 2 diabetes mellitus patients
    Yu Xiao Yang
    Division of Gastroenterology, University of Pennsylvania School of Medicine, Philadelphia 19104 6021, USA
    Gastroenterology 127:1044-50. 2004
    ..We aimed to determine whether insulin therapy might increase the risk of colorectal cancer among type 2 diabetes mellitus patients...
  53. ncbi request reprint Selective serotonin re-uptake inhibitors and the risk of bleeding
    Robert M Weinrieb
    University of Pennsylvania, Department of Psychiatry, 3440 Market Street, Suite 370, Philadelphia, PA 19104, USA
    Expert Opin Drug Saf 4:337-44. 2005
    ..Clinicians should caution patients about combining SSRIs with aspirin or NSAIDs. Pharmacotherapy to reduce the risk of GI bleeding should be considered in high risk patients...
  54. ncbi request reprint Type 2 diabetes mellitus and the risk of colorectal cancer
    Yu Xiao Yang
    Division of Gastroenterology, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Clin Gastroenterol Hepatol 3:587-94. 2005
    ..However, epidemiologic evidence for this association is inconclusive. We conducted a population-based study to clarify this association...
  55. ncbi request reprint Hospitalization and mortality rates from peptic ulcer disease and GI bleeding in the 1990s: relationship to sales of nonsteroidal anti-inflammatory drugs and acid suppression medications
    James D Lewis
    Center for Clinical Epidemiology and Biostatistics, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104 6021, USA
    Am J Gastroenterol 97:2540-9. 2002
    ..This study examines trends in hospitalization and mortality rates from GI toxicity during the 1990s...
  56. ncbi request reprint The association between hepatitis C infection and survival after orthotopic liver transplantation
    Lisa M Forman
    Center for Clinical Epidemiology and Biostatistics and the Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Gastroenterology 122:889-96. 2002
    ..Hepatitis C recurrence after transplant is inevitable, but studies to date have not found a survival difference between recipients with and without HCV...
  57. ncbi request reprint Antibiotic use and the risk of flare of inflammatory bowel disease
    Faten N Aberra
    Division of Gastroenterolgy, University of Pennsylvania School of Medicine, Philadephia, 19104, USA
    Clin Gastroenterol Hepatol 3:459-65. 2005
    ..Intestinal microbial flora participate in the pathogenesis of inflammatory bowel disease. Because antibiotic therapy alters intestinal microbial flora, we hypothesized that use of antibiotics might decrease the risk of flare...
  58. ncbi request reprint Enhancement of medication recall using medication pictures and lists in telephone interviews
    Stephen E Kimmel
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics, University of Pennsylvania School of Medicine, 717 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
    Pharmacoepidemiol Drug Saf 12:1-8. 2003
    ..To determine the effect of reading medication lists and providing medication pictures on recall of non-aspirin non-steroidal anti-inflammatory drugs (NANSAIDs) during telephone interviews in a case-control study...
  59. doi request reprint Potential association between the oral tetracycline class of antimicrobials used to treat acne and inflammatory bowel disease
    David J Margolis
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Am J Gastroenterol 105:2610-6. 2010
    ..The majority of patients prescribed isotretinoin for their acne are previously on an extended course of antibiotics. Therefore, it is important to consider antibiotic use as a confounding variable for the development of IBD...
  60. ncbi request reprint Bowman-Birk inhibitor concentrate: a novel therapeutic agent for patients with active ulcerative colitis
    Gary R Lichtenstein
    Department of Medicine, Division of Gastroenterology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    Dig Dis Sci 53:175-80. 2008
    ..22). No severe adverse events were observed. This trial suggests a potential benefit over placebo for both achieving clinical response and induction of remission in patients with active ulcerative colitis without apparent toxicity...
  61. pmc Update on the risk of lymphoma following immunosuppressive therapy for inflammatory bowel disease
    Meenakshi Bewtra
    Division of Gastroenterology, Hospital of University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Expert Rev Clin Immunol 6:621-31. 2010
    ..In this article, we will describe the known lymphoma risks of commonly used immunosuppressant medications in inflammatory bowel disease, with an emphasis on non-Hodgkin's lymphoma and hepatosplenic T-cell lymphoma...
  62. ncbi request reprint Initial evaluation of rectal bleeding in young persons: a cost-effectiveness analysis
    James D Lewis
    Center for Clinical Epidemiology and Biostatistics, Blockley Hall, 9th Floor, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
    Ann Intern Med 136:99-110. 2002
    ..Evaluation of rectal bleeding in young patients is a frequent diagnostic challenge...
  63. ncbi request reprint Incidence and risk factors for herpes zoster among patients with inflammatory bowel disease
    Gauree Gupta
    Center for Clinical Epidemiology and Biostatistics, Department of Internal Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
    Clin Gastroenterol Hepatol 4:1483-90. 2006
    ..An increased risk of herpes zoster in patients with inflammatory bowel disease (IBD) is hypothesized based on altered immune function, especially among patients receiving immunosuppressive medications...
  64. pmc Childhood onset arthritis is associated with an increased risk of fracture: a population based study using the General Practice Research Database
    J M Burnham
    Children s Hospital of Philadelphia, Room 1579 CHOP North, 3535 Market Street, Philadelphia, PA 19104, USA
    Ann Rheum Dis 65:1074-9. 2006
    ..Childhood onset arthritis is associated with low bone mass and strength...
  65. ncbi request reprint Can EUS alone differentiate between malignant and benign cystic lesions of the pancreas?
    N A Ahmad
    Department of Medicine, and Center for Clinical Epidemiology and Biostatistics, Hospital of the University of Pennsylvania, University of Pennsylvania School of Medicine, Philadelphia 19104 4283, USA
    Am J Gastroenterol 96:3295-300. 2001
    ..The aim of this study was to evaluate the ability of endoscopic ultrasound (EUS) alone to predict and differentiate malignant from benign cystic lesions of the pancreas...
  66. doi request reprint Endoluminal resection for sessile neoplasia in the GI tract is associated with a low recurrence rate and a high 5-year survival rate
    Andrew Y Wang
    Gastroenterology Division, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
    Gastrointest Endosc 68:160-9. 2008
    ..We previously reported a complete resection (CR) rate of 89% when using ELR techniques. However, the long-term efficacy of ELR for the eradication of sessile lesions, as well as patient survival after ELR, is not known...
  67. ncbi request reprint Colonic dysplasia and cancer in inflammatory bowel disease
    Thomas A Judge
    Division of Gastroenterology, Department of Medicine, University of Pennsylvania School of Medicine, Hospital of the University of Pennsylvania, 3400 Spruce Street, 3rd Floor Ravdin Building, Philadelphia, PA 19104 4283, USA
    Gastrointest Endosc Clin N Am 12:495-523. 2002
    ..Efforts to develop chemopreventative agents and improved surveillance methods remain areas of active investigation...
  68. ncbi request reprint The impact of increased body mass index on the clinical course of Crohn's disease
    David J Hass
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4283, USA
    Clin Gastroenterol Hepatol 4:482-8. 2006
    ..This study evaluated overweight patients with CD to determine if their clinical course differs from those with a normal or low body mass index (BMI)...
  69. ncbi request reprint Renal function after orthotopic liver transplantation is predicted by duration of pretransplantation creatinine elevation
    Mical S Campbell
    Division of Gastroenterology, University of Pennsylvania Health System, Philadelphia, PA 19104, USA
    Liver Transpl 11:1048-55. 2005
    ..01) after transplantation. In conclusion, duration, but not cause, of renal dysfunction predicts renal outcome in OLTa recipients. Prospective studies may use duration of renal dysfunction to help identify CKLT candidates...
  70. ncbi request reprint Increased risk for demyelinating diseases in patients with inflammatory bowel disease
    Gauree Gupta
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
    Gastroenterology 129:819-26. 2005
    ..However, the underlying relationship between IBD and these neurologic conditions has not been established...
  71. ncbi request reprint Risk of colorectal cancer in women with a prior diagnosis of gynecologic malignancy
    Radhika Srinivasan
    Department of Medicine, Division of Gastroenterology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Clin Gastroenterol 41:291-6. 2007
    ..Earlier studies regarding the risk of colorectal cancer (CRC) in women with a prior diagnosis of gynecologic malignancies have revealed conflicting results. We sought to further clarify this association...
  72. ncbi request reprint Trends in hospitalization rates for inflammatory bowel disease in the United States
    Meenakshi Bewtra
    Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Clin Gastroenterol Hepatol 5:597-601. 2007
    ..This study examined trends in hospitalization and surgery rates for inflammatory bowel disease (IBD) in the United States over a 14-year period...
  73. ncbi request reprint Relationship between 6-mercaptopurine dose and 6-thioguanine nucleotide levels in patients with inflammatory bowel disease
    Ahmed Morales
    Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6021, USA
    Inflamm Bowel Dis 13:380-5. 2007
    ..However, many physicians prescribe AZA/6MP using milligrams per kilogram (mg/kg) dosing regimens without measuring 6-TGN levels. The aim of this study was to examine the association between 6MP dose and 6-TGN levels...
  74. pmc NOD2 mutations and anti-Saccharomyces cerevisiae antibodies are risk factors for Crohn's disease in African Americans
    Themistocles Dassopoulos
    Gastroenterology Division, Department of Medicine, The Harvey M and Lyn P Meyerhoff Inflammatory Bowel Disease Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Am J Gastroenterol 105:378-86. 2010
    ..NOD2 mutations and anti-Saccharomyces cerevisiae antibodies (ASCAs) are established risk factors of Crohn's disease (CD) in whites but have not been assessed in African-American (AA) adults with CD...
  75. ncbi request reprint Schatzki ring and Barrett's esophagus: do they occur together?
    Marcia C Mitre
    Division of Gastroenterology, Department of Medicine, University of Pennsylvania Health System, Philadelphia, Pennsylvania 19104, USA
    Dig Dis Sci 49:770-3. 2004
    ..Long segment Barrett's esophagus was not observed in patients with Schatzki ring. A responsible protective effect or mutually exclusive pathophysiology should be considered...
  76. ncbi request reprint Quality of manufacturer provided information on safety and efficacy claims for dietary supplements for colonic health
    David J Hass
    Department of Medicine, Division of Gastroenterology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA
    Pharmacoepidemiol Drug Saf 15:578-86. 2006
    ..This study was designed to evaluate accessibility and quality of such data from manufacturers of dietary supplements for 'colonic health.'..
  77. ncbi request reprint Patterns of complementary and alternative medicine use in a population of pediatric patients with inflammatory bowel disease
    Jonathan E Markowitz
    Division of Gastroenterology and Nutrition, The Children s Hospital of Philadelphia, Pennsylvania, USA
    Inflamm Bowel Dis 10:599-605. 2004
    ....
  78. ncbi request reprint In clarification
    Brian L Strom
    Pharmacoepidemiol Drug Saf 16:1063-4; author reply 1063-4. 2007
  79. ncbi request reprint Design issues and outcomes in IBD clinical trials
    Bruce E Sands
    Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Inflamm Bowel Dis 11:S22-8. 2005
    ..Careful subject selection, standardization of disease activity indices, and precise outcome measurement are the keys to continued improvement of the inflammatory bowel disease research process...
  80. ncbi request reprint Are two tests better than one?
    James D Lewis
    Gastroenterology 122:236-7. 2002
  81. ncbi request reprint How safe are the safest IBD drugs?
    James D Lewis
    Gastroenterology 124:1986-7; discussion 1987-8. 2003
  82. doi request reprint Incidence and prevalence of inflammatory bowel disease in a Northern California managed care organization, 1996-2002
    Lisa J Herrinton
    Division of Research, Kaiser Permanente Northern California, 2000 Broadway Avenue, Oakland, CA 94612, USA
    Am J Gastroenterol 103:1998-2006. 2008
    ..2 million members of Kaiser Permanente, Northern California, for the period 1996-2002...
  83. doi request reprint Risk of proximal and distal colorectal cancer following flexible sigmoidoscopy: a population-based cohort study
    Linda Rabeneck
    Department of Medicine, Management and Evaluation, University of Toronto, Toronto, Canada
    Am J Gastroenterol 103:2075-82. 2008
    ..Our objective was to estimate the annual incidence of CRC within 7 yr following FS and to identify factors associated with incident CRC in those with a negative FS...
  84. ncbi request reprint The many faces of low-grade dysplasia
    James D Lewis
    Gastroenterology 125:1531-3. 2003
  85. ncbi request reprint Anti-TNF antibodies for Crohn's disease--in pursuit of the perfect clinical trial
    James D Lewis
    N Engl J Med 357:296-8. 2007
  86. ncbi request reprint State of the art: IBD therapy and clinical trials in IBD
    Kim L Isaacs
    University of North Carolina, Chapel Hill, North Carolina, USA
    Inflamm Bowel Dis 11:S3-12. 2005
    ..The number of products under development and continued investigations into the pathogenesis of IBD emphasize the need to expand clinical research efforts in IBD...
  87. ncbi request reprint Association of 6-thioguanine nucleotide levels and inflammatory bowel disease activity: a meta-analysis
    Mark T Osterman
    Division of Gastroenterology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Gastroenterology 130:1047-53. 2006
    ..Previous studies, most with small sample sizes, yielded conflicting conclusions. Our aim was to pool the available data to provide a more precise estimate of the association between 6-TGN levels and IBD activity...
  88. ncbi request reprint Site organization and management
    Douglas C Wolf
    Atlanta Gastroenterology Associates, Atlanta, Georgia, USA
    Inflamm Bowel Dis 11:S29-33. 2005
    ..Careful attention to the details of site organization, administrative requirements, and patient recruitment and retention all contribute to the successful performance of clinical research...
  89. ncbi request reprint Will the safest analgesic please stand up
    James D Lewis
    Bayer Corporation
    Gastroenterology 122:1535-6. 2002
  90. ncbi request reprint C-reactive protein: anti-placebo or predictor of response
    James D Lewis
    Gastroenterology 129:1114-6. 2005
  91. ncbi request reprint Efficacy of anti-tumor necrosis factor therapy in patients with ulcerative colitis
    Chinyu Su
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104 4283, USA
    Am J Gastroenterol 97:2577-84. 2002
    ..Preclinical studies suggest the importance of TNF-alpha in treating ulcerative colitis (UC). We report the effectiveness of infliximab for UC and examine factors predictive of response to medication...
  92. doi request reprint Gastroenterologists' attitudes and self-reported practices regarding inflammatory bowel disease
    Andrea Altschuler
    Division of Research, Kaiser Permanente Northern California, Oakland, California 94612, USA
    Inflamm Bowel Dis 14:992-9. 2008
    ....
  93. ncbi request reprint The genesis of IBD genetics
    James D Lewis
    Gastroenterology 123:2148-9. 2002

Research Grants11

  1. Test-Treat strategy to prevent ulcerative colitis relapse
    James Lewis; Fiscal Year: 2007
    ..This K24 award will be essential to allow Dr. Lewis sufficient protected time from clinical activities to continue to develop his research program and mementoring activities. ..
  2. Association of PPAR gamma ligands & colonic neoplasia
    James Lewis; Fiscal Year: 2006
    ..Our results will allow us to translate the existing in vitro and in vivo observations to the intact human colon and could lead to further chemoprevention strategies. ..
  3. Randomized Trial of Rosiglitazone for Ulcerative Colitis
    James Lewis; Fiscal Year: 2005
    ..If our hypothesis is correct, this study will serve to establish that ligands for PPARg possess biological activity necessary to modulate the inflammatory response in the intact human colon. ..