G P Lewis

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Müller cell outgrowth after retinal detachment: association with cone photoreceptors
    G P Lewis
    Neuroscience Research Institute, University of California, Santa Barbara 93106, USA
    Invest Ophthalmol Vis Sci 41:1542-5. 2000
  2. doi request reprint Muller cell reactivity and photoreceptor cell death are reduced after experimental retinal detachment using an inhibitor of the Akt/mTOR pathway
    Geoffrey P Lewis
    Neuroscience Research Institute, University of California, Santa Barbara, California 93106 5060, USA
    Invest Ophthalmol Vis Sci 50:4429-35. 2009
  3. pmc Identification of ganglion cell neurites in human subretinal and epiretinal membranes
    Geoffrey P Lewis
    Neuroscience Research Institute, University of California, Santa Barbara, CA 93106, USA
    Br J Ophthalmol 91:1234-8. 2007
  4. ncbi request reprint Microglial cell activation following retinal detachment: a comparison between species
    Geoffrey P Lewis
    Neuroscience Research Institute, University of California Santa Barbara, Santa Barbara, CA 93106, USA
    Mol Vis 11:491-500. 2005
  5. ncbi request reprint The efficacy of delayed oxygen therapy in the treatment of experimental retinal detachment
    Geoffrey P Lewis
    Neuroscience Research Institute, University of California, Santa Barbara, 93106, USA
    Am J Ophthalmol 137:1085-95. 2004
  6. ncbi request reprint Experimental retinal reattachment: a new perspective
    Geoffrey P Lewis
    Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, CA 93106, USA
    Mol Neurobiol 28:159-75. 2003
  7. ncbi request reprint The ability of rapid retinal reattachment to stop or reverse the cellular and molecular events initiated by detachment
    Geoffrey P Lewis
    Neuroscience Research Institute, University of California Santa Barbara, Santa Barbara, CA 93106, USA
    Invest Ophthalmol Vis Sci 43:2412-20. 2002
  8. pmc The fate of Müller's glia following experimental retinal detachment: nuclear migration, cell division, and subretinal glial scar formation
    Geoffrey P Lewis
    Neuroscience Research Institute, University of California, Santa Barbara, CA 93106, USA
    Mol Vis 16:1361-72. 2010
  9. ncbi request reprint Cone photoreceptor recovery after experimental detachment and reattachment: an immunocytochemical, morphological, and electrophysiological study
    Tsutomu Sakai
    Neuroscience Research Institute, University of California Santa Barbara, Santa Barbara, CA 93106 5060, USA
    Invest Ophthalmol Vis Sci 44:416-25. 2003
  10. pmc The effects of transient retinal detachment on cavity size and glial and neural remodeling in a mouse model of X-linked retinoschisis
    Gabriel Luna
    Neuroscience Research Institute, University of California Santa Barbara, Santa Barbara, CA 93106 5060, USA
    Invest Ophthalmol Vis Sci 50:3977-84. 2009

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Müller cell outgrowth after retinal detachment: association with cone photoreceptors
    G P Lewis
    Neuroscience Research Institute, University of California, Santa Barbara 93106, USA
    Invest Ophthalmol Vis Sci 41:1542-5. 2000
    ....
  2. doi request reprint Muller cell reactivity and photoreceptor cell death are reduced after experimental retinal detachment using an inhibitor of the Akt/mTOR pathway
    Geoffrey P Lewis
    Neuroscience Research Institute, University of California, Santa Barbara, California 93106 5060, USA
    Invest Ophthalmol Vis Sci 50:4429-35. 2009
    ..To test the effect of Palomid 529, an inhibitor of the Akt/mTOR pathway, on Müller cell proliferation, subretinal glial scar formation, and photoreceptor survival after experimental retinal detachment (RD)...
  3. pmc Identification of ganglion cell neurites in human subretinal and epiretinal membranes
    Geoffrey P Lewis
    Neuroscience Research Institute, University of California, Santa Barbara, CA 93106, USA
    Br J Ophthalmol 91:1234-8. 2007
    ..To determine whether neural elements are present in subretinal and epiretinal proliferative vitreoretinopathy (PVR) membranes as well as in diabetic, fibrovascular membranes removed from patients during vitrectomy surgery...
  4. ncbi request reprint Microglial cell activation following retinal detachment: a comparison between species
    Geoffrey P Lewis
    Neuroscience Research Institute, University of California Santa Barbara, Santa Barbara, CA 93106, USA
    Mol Vis 11:491-500. 2005
    ..To compare the activation of microglia in response to retinal detachment in four species...
  5. ncbi request reprint The efficacy of delayed oxygen therapy in the treatment of experimental retinal detachment
    Geoffrey P Lewis
    Neuroscience Research Institute, University of California, Santa Barbara, 93106, USA
    Am J Ophthalmol 137:1085-95. 2004
    ..To evaluate the ability of delayed hyperoxia to slow or prevent degenerative and gliotic changes initiated by retinal detachment...
  6. ncbi request reprint Experimental retinal reattachment: a new perspective
    Geoffrey P Lewis
    Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, CA 93106, USA
    Mol Neurobiol 28:159-75. 2003
    ..The implications of these events for the return of vision are unknown, but they do indicate that simply reattaching the retina does not return the retina to its pre-detachment state within 28 d...
  7. ncbi request reprint The ability of rapid retinal reattachment to stop or reverse the cellular and molecular events initiated by detachment
    Geoffrey P Lewis
    Neuroscience Research Institute, University of California Santa Barbara, Santa Barbara, CA 93106, USA
    Invest Ophthalmol Vis Sci 43:2412-20. 2002
    ..To determine the effects of reattachment on the molecular and cellular events initiated by a retinal detachment lasting 1 hour or 1 day...
  8. pmc The fate of Müller's glia following experimental retinal detachment: nuclear migration, cell division, and subretinal glial scar formation
    Geoffrey P Lewis
    Neuroscience Research Institute, University of California, Santa Barbara, CA 93106, USA
    Mol Vis 16:1361-72. 2010
    ....
  9. ncbi request reprint Cone photoreceptor recovery after experimental detachment and reattachment: an immunocytochemical, morphological, and electrophysiological study
    Tsutomu Sakai
    Neuroscience Research Institute, University of California Santa Barbara, Santa Barbara, CA 93106 5060, USA
    Invest Ophthalmol Vis Sci 44:416-25. 2003
    ..To compare the morphologic and functional recovery of the retina after detachment and reattachment in an animal with a cone-dominant retina, the ground squirrel...
  10. pmc The effects of transient retinal detachment on cavity size and glial and neural remodeling in a mouse model of X-linked retinoschisis
    Gabriel Luna
    Neuroscience Research Institute, University of California Santa Barbara, Santa Barbara, CA 93106 5060, USA
    Invest Ophthalmol Vis Sci 50:3977-84. 2009
    ..To determine the cellular consequences of retinal detachment in retinoschisin knockout (Rs1-KO) mice, a model for retinoschisin in humans...
  11. ncbi request reprint Distribution of S- and M-cones in normal and experimentally detached cat retina
    K A Linberg
    Neuroscience Research Institute, University of California-Santa Barbara, Santa Barbara, CA 93106-5060, USA
    J Comp Neurol 430:343-56. 2001
    ..The implications of these results for visual recovery after retinal reattachment are discussed...
  12. pmc Abnormal reactivity of muller cells after retinal detachment in mice deficient in GFAP and vimentin
    Mark R Verardo
    Neuroscience Research Institute, University of California, Santa Barbara, California 93106, USA
    Invest Ophthalmol Vis Sci 49:3659-65. 2008
    ..To determine the roles of glial fibrillary acidic protein (GFAP) and vimentin in Müller cell reactivity...
  13. ncbi request reprint A survey of molecular expression by photoreceptors after experimental retinal detachment
    Tonia S Rex
    Neuroscience Research Institute, University of California, Santa Barbara 93106 5060, USA
    Invest Ophthalmol Vis Sci 43:1234-47. 2002
    ..To describe changes in the localization patterns and levels of rod and cone photoreceptor proteins after experimental retinal detachment (RD)...
  14. ncbi request reprint FGFR1, signaling, and AP-1 expression after retinal detachment: reactive Müller and RPE cells
    S F Geller
    Neuroscience Research Institute, University of California, Santa Barbara, CA, USA
    Invest Ophthalmol Vis Sci 42:1363-9. 2001
    ..The events described here precede changes in gene expression and morphology that can have serious effects on visual outcome in humans treated for retinal detachment or other retinal injuries...
  15. ncbi request reprint Evidence that ganglion cells react to retinal detachment
    Francie E Coblentz
    Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA 93106, USA
    Exp Eye Res 76:333-42. 2003
    ..Cellular remodelling of this type in response to detachment may explain the slow recovery of vision that often occurs after reattachment, or those changes that are often assumed to be permanent...
  16. ncbi request reprint Up-regulation of glial fibrillary acidic protein in response to retinal injury: its potential role in glial remodeling and a comparison to vimentin expression
    Geoffrey P Lewis
    Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, California 93106, USA
    Int Rev Cytol 230:263-90. 2003
    ..The differential expression of these proteins may give insight into their role in the formation of glial scars in the retina and elsewhere in the CNS...
  17. ncbi request reprint The ability of hyperoxia to limit the effects of experimental detachment in cone-dominated retina
    T Sakai
    Neuroscience Research Institute, University of California-Santa Barbara, Santa Barbara, CA 93106-5060, USA
    Invest Ophthalmol Vis Sci 42:3264-73. 2001
    ..The current results suggest that the rescue of cones is not secondary to that of rods...
  18. ncbi request reprint Immunocytochemical evidence that rod-connected horizontal cell axon terminals remodel in response to experimental retinal detachment in the cat
    Kenneth A Linberg
    Neuroscience Research Institute, University of California, Santa Barbara, CA 93106, USA
    Mol Vis 12:1674-86. 2006
    ..We have previously described neurite sprouting from HCs in response to experimental retinal detachment. Here we sought to determine whether one or both types elaborate these outgrowths...
  19. ncbi request reprint Cellular remodeling in mammalian retina: results from studies of experimental retinal detachment
    Steven K Fisher
    Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, CA 93106, USA
    Prog Retin Eye Res 24:395-431. 2005
    ..The mammalian retina clearly has a vast repertoire of cellular responses to injury, understanding these may help us improve upon current therapies or devise new therapies for blinding conditions...
  20. ncbi request reprint An animal model for studying cone function in retinal detachment
    Gerald H Jacobs
    Department of Psychology, University of California, Santa Barbara 93106, USA
    Doc Ophthalmol 104:119-32. 2002
    ..Surgical reattachment produced a progressive recovery of cone-based signals. The ground squirrel seems likely to provide a useful animal model for studying the dynamics of cone function in retinal detachment and subsequent events...
  21. ncbi request reprint Experimental retinal detachment in the cone-dominant ground squirrel retina: morphology and basic immunocytochemistry
    Kenneth A Linberg
    Neuroscience Research Institute, University of California at Santa Barbara, Santa Barbara 93106 5060, USA
    Vis Neurosci 19:603-19. 2002
    ..Moreover, the almost total lack of Müller cell and RPE reactivity in the ground squirrel retina is a significant difference from results in other species...
  22. ncbi request reprint Automated tool for the detection of cell nuclei in digital microscopic images: application to retinal images
    Jiyun Byun
    Department of Electrical and Computer Engineering, Center for Bio image Informatics, University of California, Santa Barbara, CA 93106, USA
    Mol Vis 12:949-60. 2006
    ..To develop an automated tool that provides reliable, consistent, and accurate results for counting cell nuclei in tissue sections...
  23. ncbi request reprint Drusen-associated degeneration in the retina
    Patrick T Johnson
    Neuroscience Research Institute, University of California, Santa Barbara, California 93106, USA
    Invest Ophthalmol Vis Sci 44:4481-8. 2003
    ..The purpose of this study was to investigate the impact of drusen on overlying cells of the retina...
  24. ncbi request reprint Müller cell and neuronal remodeling in retinal detachment and reattachment and their potential consequences for visual recovery: a review and reconsideration of recent data
    Steven K Fisher
    Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, CA 93106, USA
    Vision Res 43:887-97. 2003
    ..Reattachment halts the growth of Müller cell processes into the subretinal space, but induces their growth on the vitreal surface. It also induces the outgrowth of rod axons into the inner retina...
  25. pmc Retraction and remodeling of rod spherules are early events following experimental retinal detachment: an ultrastructural study using serial sections
    Kenneth A Linberg
    Neuroscience Research Institute, University of California, Santa Barbara, CA 93106 5060, USA
    Mol Vis 15:10-25. 2009
    ..To describe changes induced by retinal detachment in the ultrastructure and organization of rod terminals and their connections with B-type horizontal cell (HC) axon terminals and rod bipolar cell (RB) dendrites...
  26. ncbi request reprint Differential expression of cone opsin mRNA levels following experimental retinal detachment and reattachment
    Tonia S Rex
    Neuroscience Research Institute and Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA
    Mol Vis 8:114-8. 2002
    ..To identify changes in S- and M-sensitive cone opsin gene expression following retinal detachment (RD) and reattachment...
  27. ncbi request reprint The effect of alkylphosphocholines on intraretinal proliferation initiated by experimental retinal detachment
    Kirsten H Eibl
    Department of Ophthalmology, Ludwig Maximilians University, Munich, Germany
    Invest Ophthalmol Vis Sci 48:1305-11. 2007
    ..To determine the effect of alkylphosphocholines (APCs) on intraretinal proliferation induced by experimental retinal detachment in the rabbit...
  28. pmc Attenuated glial reactions and photoreceptor degeneration after retinal detachment in mice deficient in glial fibrillary acidic protein and vimentin
    Toru Nakazawa
    Angiogenesis Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
    Invest Ophthalmol Vis Sci 48:2760-8. 2007
    ....
  29. ncbi request reprint The neurons of the ground squirrel retina as revealed by immunostains for calcium binding proteins and neurotransmitters
    Nicolas Cuenca
    Department of Biotechnology, University of Alicante, Alicante, Spain
    J Neurocytol 31:649-66. 2002
    ..The differences in staining patterns and phenotypes revealed suggest a functional diversity in the populations of amacrine cells according to whether the retinas are rod or cone dominated...
  30. ncbi request reprint Glial and neural response in short-term human retinal detachment
    Louisa Wickham
    Vitreoretinal Research, Moorfields Eye Hosital, London, England
    Arch Ophthalmol 124:1779-82. 2006
  31. ncbi request reprint Electrophysiologic and retinal penetration studies following intravitreal injection of bevacizumab (Avastin)
    Jonathan Shahar
    Department of Ophthalmology, Tel Aviv Medical Center, Israel
    Retina 26:262-9. 2006
    ..Intravitreal bevacizumab (Avastin; Genentech Inc., San Francisco, CA) is a new treatment for age-related macular degeneration. The aim of this study was to evaluate retinal penetration and toxicity of bevacizumab...
  32. ncbi request reprint Glial remodeling and neural plasticity in human retinal detachment with proliferative vitreoretinopathy
    Charanjit S Sethi
    Moorfields Eye Hospital and the Institute of Ophthalmology, University College London, London, United Kingdom
    Invest Ophthalmol Vis Sci 46:329-42. 2005
    ..To investigate glial remodeling and neuronal plasticity in adult human retinal detachment complicated by proliferative vitreoretinopathy (PVR) and to grade pathologic changes with a severity scoring system...