Research Topics
| G P LewisSummaryAffiliation: University of California Country: USA Publications
| Collaborators
|
Detail Information
Publications
Müller cell outgrowth after retinal detachment: association with cone photoreceptorsG P Lewis
Neuroscience Research Institute, University of California, Santa Barbara 93106, USA
Invest Ophthalmol Vis Sci 41:1542-5. 2000....
Muller cell reactivity and photoreceptor cell death are reduced after experimental retinal detachment using an inhibitor of the Akt/mTOR pathwayGeoffrey P Lewis
Neuroscience Research Institute, University of California, Santa Barbara, California 93106 5060, USA
Invest Ophthalmol Vis Sci 50:4429-35. 2009..To test the effect of Palomid 529, an inhibitor of the Akt/mTOR pathway, on Müller cell proliferation, subretinal glial scar formation, and photoreceptor survival after experimental retinal detachment (RD)...
Identification of ganglion cell neurites in human subretinal and epiretinal membranesGeoffrey P Lewis
Neuroscience Research Institute, University of California, Santa Barbara, CA 93106, USA
Br J Ophthalmol 91:1234-8. 2007..To determine whether neural elements are present in subretinal and epiretinal proliferative vitreoretinopathy (PVR) membranes as well as in diabetic, fibrovascular membranes removed from patients during vitrectomy surgery...- Microglial cell activation following retinal detachment: a comparison between speciesGeoffrey P Lewis
Neuroscience Research Institute, University of California Santa Barbara, Santa Barbara, CA 93106, USA
Mol Vis 11:491-500. 2005..To compare the activation of microglia in response to retinal detachment in four species... - The efficacy of delayed oxygen therapy in the treatment of experimental retinal detachmentGeoffrey P Lewis
Neuroscience Research Institute, University of California, Santa Barbara, 93106, USA
Am J Ophthalmol 137:1085-95. 2004..To evaluate the ability of delayed hyperoxia to slow or prevent degenerative and gliotic changes initiated by retinal detachment... - Experimental retinal reattachment: a new perspectiveGeoffrey P Lewis
Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, CA 93106, USA
Mol Neurobiol 28:159-75. 2003..The implications of these events for the return of vision are unknown, but they do indicate that simply reattaching the retina does not return the retina to its pre-detachment state within 28 d... - The ability of rapid retinal reattachment to stop or reverse the cellular and molecular events initiated by detachmentGeoffrey P Lewis
Neuroscience Research Institute, University of California Santa Barbara, Santa Barbara, CA 93106, USA
Invest Ophthalmol Vis Sci 43:2412-20. 2002..To determine the effects of reattachment on the molecular and cellular events initiated by a retinal detachment lasting 1 hour or 1 day... - The fate of Müller's glia following experimental retinal detachment: nuclear migration, cell division, and subretinal glial scar formationGeoffrey P Lewis
Neuroscience Research Institute, University of California, Santa Barbara, CA 93106, USA
Mol Vis 16:1361-72. 2010.... - Cone photoreceptor recovery after experimental detachment and reattachment: an immunocytochemical, morphological, and electrophysiological studyTsutomu Sakai
Neuroscience Research Institute, University of California-Santa Barbara, Santa Barbara, CA 93106-5060, USA
Invest Ophthalmol Vis Sci 44:416-25. 2003..No differences were noted in the indices of recovery of M and S cones. CONCLUSIONS: The ERG can be used to follow specifically the changes in the retina that occur after retinal detachment and reattachment... - The effects of transient retinal detachment on cavity size and glial and neural remodeling in a mouse model of X-linked retinoschisisGabriel Luna
Neuroscience Research Institute, University of California Santa Barbara, Santa Barbara, CA 93106 5060, USA
Invest Ophthalmol Vis Sci 50:3977-84. 2009..To determine the cellular consequences of retinal detachment in retinoschisin knockout (Rs1-KO) mice, a model for retinoschisin in humans... - Distribution of S- and M-cones in normal and experimentally detached cat retinaK A Linberg
Neuroscience Research Institute, University of California-Santa Barbara, Santa Barbara, CA 93106-5060, USA
J Comp Neurol 430:343-56. 2001..The implications of these results for visual recovery after retinal reattachment are discussed... - Abnormal reactivity of muller cells after retinal detachment in mice deficient in GFAP and vimentinMark R Verardo
Neuroscience Research Institute, University of California, Santa Barbara, California 93106, USA
Invest Ophthalmol Vis Sci 49:3659-65. 2008..To determine the roles of glial fibrillary acidic protein (GFAP) and vimentin in Müller cell reactivity... - A survey of molecular expression by photoreceptors after experimental retinal detachmentTonia S Rex
Neuroscience Research Institute, University of California, Santa Barbara 93106-5060, USA
Invest Ophthalmol Vis Sci 43:1234-47. 2002..This difference may account for a faster return of rod vision and for the lingering changes in color vision and acuity that are often reported after successful reattachment surgeries... - FGFR1, signaling, and AP-1 expression after retinal detachment: reactive Müller and RPE cellsS F Geller
Neuroscience Research Institute, University of California, Santa Barbara, CA, USA
Invest Ophthalmol Vis Sci 42:1363-9. 2001..The events described here precede changes in gene expression and morphology that can have serious effects on visual outcome in humans treated for retinal detachment or other retinal injuries... - Evidence that ganglion cells react to retinal detachmentFrancie E Coblentz
Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA 93106, USA
Exp Eye Res 76:333-42. 2003..Cellular remodelling of this type in response to detachment may explain the slow recovery of vision that often occurs after reattachment, or those changes that are often assumed to be permanent... - Up-regulation of glial fibrillary acidic protein in response to retinal injury: its potential role in glial remodeling and a comparison to vimentin expressionGeoffrey P Lewis
Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, California 93106, USA
Int Rev Cytol 230:263-90. 2003..The differential expression of these proteins may give insight into their role in the formation of glial scars in the retina and elsewhere in the CNS... - The ability of hyperoxia to limit the effects of experimental detachment in cone-dominated retinaT Sakai
Neuroscience Research Institute, University of California-Santa Barbara, Santa Barbara, CA 93106-5060, USA
Invest Ophthalmol Vis Sci 42:3264-73. 2001..The current results suggest that the rescue of cones is not secondary to that of rods... - Immunocytochemical evidence that rod-connected horizontal cell axon terminals remodel in response to experimental retinal detachment in the catKenneth A Linberg
Neuroscience Research Institute, University of California, Santa Barbara, CA 93106, USA
Mol Vis 12:1674-86. 2006..We have previously described neurite sprouting from HCs in response to experimental retinal detachment. Here we sought to determine whether one or both types elaborate these outgrowths... - Cellular remodeling in mammalian retina: results from studies of experimental retinal detachmentSteven K Fisher
Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, CA 93106, USA
Prog Retin Eye Res 24:395-431. 2005..The mammalian retina clearly has a vast repertoire of cellular responses to injury, understanding these may help us improve upon current therapies or devise new therapies for blinding conditions... - An animal model for studying cone function in retinal detachmentGerald H Jacobs
Department of Psychology, University of California, Santa Barbara 93106, USA
Doc Ophthalmol 104:119-32. 2002..Surgical reattachment produced a progressive recovery of cone-based signals. The ground squirrel seems likely to provide a useful animal model for studying the dynamics of cone function in retinal detachment and subsequent events... - Experimental retinal detachment in the cone-dominant ground squirrel retina: morphology and basic immunocytochemistryKenneth A Linberg
Neuroscience Research Institute, University of California at Santa Barbara, Santa Barbara 93106-5060, USA
Vis Neurosci 19:603-19. 2002..Moreover, the almost total lack of Müller cell and RPE reactivity in the ground squirrel retina is a significant difference from results in other species... - Automated tool for the detection of cell nuclei in digital microscopic images: application to retinal imagesJiyun Byun
Department of Electrical and Computer Engineering, Center for Bio image Informatics, University of California, Santa Barbara, CA 93106, USA
Mol Vis 12:949-60. 2006..To develop an automated tool that provides reliable, consistent, and accurate results for counting cell nuclei in tissue sections... - Drusen-associated degeneration in the retinaPatrick T Johnson
Neuroscience Research Institute, University of California, Santa Barbara, California 93106, USA
Invest Ophthalmol Vis Sci 44:4481-8. 2003..The purpose of this study was to investigate the impact of drusen on overlying cells of the retina... - Müller cell and neuronal remodeling in retinal detachment and reattachment and their potential consequences for visual recovery: a review and reconsideration of recent dataSteven K Fisher
Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, CA 93106, USA
Vision Res 43:887-97. 2003..Reattachment halts the growth of Müller cell processes into the subretinal space, but induces their growth on the vitreal surface. It also induces the outgrowth of rod axons into the inner retina... - Retraction and remodeling of rod spherules are early events following experimental retinal detachment: an ultrastructural study using serial sectionsKenneth A Linberg
Neuroscience Research Institute, University of California, Santa Barbara, CA 93106 5060, USA
Mol Vis 15:10-25. 2009..To describe changes induced by retinal detachment in the ultrastructure and organization of rod terminals and their connections with B-type horizontal cell (HC) axon terminals and rod bipolar cell (RB) dendrites... - Differential expression of cone opsin mRNA levels following experimental retinal detachment and reattachmentTonia S Rex
Neuroscience Research Institute and Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA
Mol Vis 8:114-8. 2002..To identify changes in S- and M-sensitive cone opsin gene expression following retinal detachment (RD) and reattachment... - The effect of alkylphosphocholines on intraretinal proliferation initiated by experimental retinal detachmentKirsten H Eibl
Department of Ophthalmology, Ludwig Maximilians University, Munich, Germany
Invest Ophthalmol Vis Sci 48:1305-11. 2007..To determine the effect of alkylphosphocholines (APCs) on intraretinal proliferation induced by experimental retinal detachment in the rabbit... - Attenuated glial reactions and photoreceptor degeneration after retinal detachment in mice deficient in glial fibrillary acidic protein and vimentinToru Nakazawa
Angiogenesis Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
Invest Ophthalmol Vis Sci 48:2760-8. 2007.... - The neurons of the ground squirrel retina as revealed by immunostains for calcium binding proteins and neurotransmittersNicolas Cuenca
Department of Biotechnology, University of Alicante, Alicante, Spain
J Neurocytol 31:649-66. 2002..The differences in staining patterns and phenotypes revealed suggest a functional diversity in the populations of amacrine cells according to whether the retinas are rod or cone dominated... - Glial and neural response in short-term human retinal detachmentLouisa Wickham
Vitreoretinal Research, Moorfields Eye Hosital, London, England
Arch Ophthalmol 124:1779-82. 2006 - Electrophysiologic and retinal penetration studies following intravitreal injection of bevacizumab (Avastin)Jonathan Shahar
Department of Ophthalmology, Tel-Aviv Medical Center, Israel
Retina 26:262-9. 2006..Full thickness retinal penetration may explain observed clinical effects of intravitreal bevacizumab. Although it is difficult to directly extrapolate to humans, our study supports the safe use of intravitreal bevacizumab injection... - Glial remodeling and neural plasticity in human retinal detachment with proliferative vitreoretinopathyCharanjit S Sethi
Moorfields Eye Hospital and the Institute of Ophthalmology, University College London, London, United Kingdom
Invest Ophthalmol Vis Sci 46:329-42. 2005..Evidence of remodeling in the first-, second-, and third-order neurons of detached adult human retina may represent an attempt to re-establish synaptic connectivity...