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Genomes and GenesSpecies | David LewisSummaryAffiliation: University of Pittsburgh Country: USA Publications
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Publications
Cortical circuit dysfunction and cognitive deficits in schizophrenia--implications for preemptive interventionsDavid A Lewis
Translational Neuroscience Program, Department of Psychiatry, University of Pittsburgh, 3811 O Hara Street, Biomedical Science Tower W1654, Pittsburgh, PA 15213, USA
Eur J Neurosci 35:1871-8. 2012..The implications of these findings for the development and implementation of safe, preemptive, disease-modifying interventions in individuals at high risk for a clinical diagnosis of schizophrenia are considered...- Altered cortical GABA neurotransmission in schizophrenia: insights into novel therapeutic strategiesAna D Stan
Department of Psychiatry, University of Pittsburgh, 3811 O Hara Street, W1651 BST, Pittsburgh, PA 15213, USA
Curr Pharm Biotechnol 13:1557-62. 2012.... - Cortical basket cell dysfunction in schizophreniaAllison A Curley
Translational Neuroscience Program, Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
J Physiol 590:715-24. 2012.... - Perisomatic inhibition and cortical circuit dysfunction in schizophreniaDavid A Lewis
Translational Neuroscience Program, Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, United States
Curr Opin Neurobiol 21:866-72. 2011..These alterations may contribute to the neural substrate for impaired gamma oscillations in schizophrenia... - Cortical parvalbumin interneurons and cognitive dysfunction in schizophreniaDavid A Lewis
Translational Neuroscience Program, Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
Trends Neurosci 35:57-67. 2012..This compensation is thought to rebalance cortical excitation and inhibition, but at a level insufficient to generate the gamma oscillation power required for high levels of cognitive control... - A human-mouse conserved sex bias in amygdala gene expression related to circadian clock and energy metabolismLi Chun Lin
Translational Neuroscience Program, Department of Psychiatry, and Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA 15213, USA
Mol Brain 4:18. 2011..We hypothesized that sex differences in molecular structure may contribute to differential mood regulation and disease vulnerability... - Cell and receptor type-specific alterations in markers of GABA neurotransmission in the prefrontal cortex of subjects with schizophreniaDavid A Lewis
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
Neurotox Res 14:237-48. 2008..In concert with previous findings, these data suggest that working memory dysfunction in schizophrenia may be attributable to altered GABA neurotransmission in specific DLPFC microcircuits... 
Selective alterations in prefrontal cortical GABA neurotransmission in schizophrenia: a novel target for the treatment of working memory dysfunctionDavid A Lewis
Department of Psychiatry, University of Pittsburgh, 3811 O Hara Street, W1651 BST, Pittsburgh, PA 15213, USA
Psychopharmacology (Berl) 174:143-50. 2004....- Subunit-selective modulation of GABA type A receptor neurotransmission and cognition in schizophreniaDavid A Lewis
Department of Psychiatry, W1651 Biomedical Science Tower, 3511 O Hara St, Pittsburgh, PA 15213, USA
Am J Psychiatry 165:1585-93. 2008.... - Schizophrenia from a neural circuitry perspective: advancing toward rational pharmacological therapiesDavid A Lewis
University of Pittsburgh, Department of Psychiatry, W1651 Biomedical Science Tower, 3811 O Hara Street, Pittsburgh, Pennsylvania 15213, USA
J Clin Invest 119:706-16. 2009..The identification of molecular alterations in these circuits is providing critical insights for the rational development of new therapeutic interventions... - Neuroplasticity of excitatory and inhibitory cortical circuits in schizophreniaDavid A Lewis
Department of Psychiatry, University of Pittsburgh, PA 15213, USA
Dialogues Clin Neurosci 11:269-80. 2009..This article reviews disturbances in excitatory and inhibitory components of DLPFC circuitry from the perspective of developmental neuroplasticity and discusses their implications for the identification of novel therapeutic targets... - Cortical inhibitory neurons and schizophreniaDavid A Lewis
Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Nat Rev Neurosci 6:312-24. 2005..These findings reveal specific targets for therapeutic interventions to improve cognitive function in individuals with schizophrenia... - Postnatal development of prefrontal inhibitory circuits and the pathophysiology of cognitive dysfunction in schizophreniaDavid A Lewis
Department of Psychiatry, University of Pittsburgh, 3811 O Hara Street, W1651 BST, Pittsburgh, PA 15213, USA
Ann N Y Acad Sci 1021:64-76. 2004..The implications of these findings for treatment and prevention strategies are discussed... - The chandelier neuron in schizophreniaDavid A Lewis
Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Dev Neurobiol 71:118-27. 2011..Recent findings that inputs from neocortical chandelier neurons are excitatory provide new ideas about the role of this circuitry in the pathophysiology of cortical dysfunction in schizophrenia... - Neuroplasticity of neocortical circuits in schizophreniaDavid A Lewis
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
Neuropsychopharmacology 33:141-65. 2008.... - Transcriptome alterations in schizophrenia: disturbing the functional architecture of the dorsolateral prefrontal cortexDavid A Lewis
Department of Psychiatry, and Department of Neuroscience, University of Pittsburgh, 3811 O Hara Street, W1652 BST, Pittsburgh, PA 15213 2593, USA
Prog Brain Res 158:141-52. 2006.... - Pathophysiologically based treatment interventions in schizophreniaDavid A Lewis
Department of Psychiatry, University of Pittsburgh, 3811 O Hara Street, Pittsburgh, Pennsylvania 15213, USA
Nat Med 12:1016-22. 2006.... - Gene expression deficits in a subclass of GABA neurons in the prefrontal cortex of subjects with schizophreniaTakanori Hashimoto
Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
J Neurosci 23:6315-26. 2003.... - Altered cortical CDC42 signaling pathways in schizophrenia: implications for dendritic spine deficitsMasayuki Ide
Department of Psychiatry, University of Pittsburgh, Pennsylvania 15213, USA
Biol Psychiatry 68:25-32. 2010..Therefore, alterations in CDC42EP3 could contribute to the lamina-specific spine deficits in schizophrenia... - Conserved regional patterns of GABA-related transcript expression in the neocortex of subjects with schizophreniaTakanori Hashimoto
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
Am J Psychiatry 165:479-89. 2008.... - Heat shock protein 12A shows reduced expression in the prefrontal cortex of subjects with schizophreniaJulie L Pongrac
Department of Psychiatry, E1655 BST, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
Biol Psychiatry 56:943-50. 2004..001; mean log2 signal difference = -.58) in transcript expression for a gene clone KIAA0417. This database entry has been recently annotated as two highly homologous members of a heat-shock protein family (HSPA12A and HSPA12B)... - Molecular evidence for increased expression of genes related to immune and chaperone function in the prefrontal cortex in schizophreniaDominique Arion
Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Biol Psychiatry 62:711-21. 2007..Schizophrenia is characterized by complex gene expression changes. The transcriptome alterations in the prefrontal cortex have been the subject of several recent postmortem studies that yielded both convergent and divergent findings... - Altered markers of tonic inhibition in the dorsolateral prefrontal cortex of subjects with schizophreniaJaime G Maldonado-Aviles
Department of Psychiatry, University of Pittsburgh, 3811 O Hara St, W1651 BST, Pittsburgh, PA 15213, USA
Am J Psychiatry 166:450-9. 2009..The authors assessed the expression of GABA(A) receptor alpha4 and delta subunits, which coassemble to form receptors mediating tonic inhibition, in schizophrenia... - Postnatal development of parvalbumin- and GABA transporter-immunoreactive axon terminals in monkey prefrontal cortexSusan L Erickson
Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
J Comp Neurol 448:186-202. 2002..These findings suggest that morphologically specialized classes of inhibitory interneurons assume prominence within the prefrontal cortical network at different stages of postnatal development... - Deciphering the disease process of schizophrenia: the contribution of cortical GABA neuronsDavid A Lewis
Department of Psychiatry, University of Pittsburgh, Pennsylvania 15213, USA
Int Rev Neurobiol 78:109-31. 2007.... - Relationship of brain-derived neurotrophic factor and its receptor TrkB to altered inhibitory prefrontal circuitry in schizophreniaTakanori Hashimoto
Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
J Neurosci 25:372-83. 2005..Decreased TrkB signaling appears to underlie the dysfunction of inhibitory neurons in the PFC of subjects with schizophrenia... - Cognitive dysfunction in schizophrenia: convergence of gamma-aminobutyric acid and glutamate alterationsDavid A Lewis
Departments of Psychiatry and Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA
Arch Neurol 63:1372-6. 2006..These findings suggest specific targets for therapeutic interventions to improve cognitive function in individuals with schizophrenia... - Pyramidal neuron local axon terminals in monkey prefrontal cortex: differential targeting of subclasses of GABA neuronsDarlene S Melchitzky
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
Cereb Cortex 13:452-60. 2003..These connections may provide the anatomical substrate for the coordinated activity of pyramidal neurons and fast-spiking GABA neurons during working memory... - Infragranular gene expression disturbances in the prefrontal cortex in schizophrenia: signature of altered neural development?Dominique Arion
Department of Psychiatry, U of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
Neurobiol Dis 37:738-46. 2010.... - Impaired prefrontal inhibition in schizophrenia: relevance for cognitive dysfunctionDavid W Volk
Department of Neuroscience, University of Pittsburgh, 15260, Pittsburgh, PA, USA
Physiol Behav 77:501-5. 2002..Selective disruptions in inhibitory neurotransmission are likely to distort aspects of pyramidal neuron function important for working memory tasks, and thus may contribute to cognitive dysfunction in schizophrenia... - Reciprocal alterations in pre- and postsynaptic inhibitory markers at chandelier cell inputs to pyramidal neurons in schizophreniaDavid W Volk
Department of Neuroscience, University of Pittsburgh, PA 15260, USA
Cereb Cortex 12:1063-70. 2002..Thus, disturbances in inhibition at the chandelier neuron-pyramidal neuron synapse may be a critical component of prefrontal cortical dysfunction in schizophrenia... - Selective alterations in postsynaptic markers of chandelier cell inputs to cortical pyramidal neurons in subjects with schizophreniaDianne A Cruz
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
Neuropsychopharmacology 34:2112-24. 2009.... - GABA neurons in the human prefrontal cortexCarol Tamminga
UT Southwestern Medical Center, Department of Psychiatry, 5323 Harry Hines Blvd, NC5.914, Dallas, TX 75390-9070, USA
Am J Psychiatry 161:1764. 2004 - Gene expression profiling reveals alterations of specific metabolic pathways in schizophreniaFrank A Middleton
Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
J Neurosci 22:2718-29. 2002.... - Effects of a mediodorsal thalamus lesion on prefrontal inhibitory circuitry: implications for schizophreniaDavid W Volk
Department of Neuroscience, University of Pittsburgh, Pennsylvania 15213, USA
Biol Psychiatry 53:385-9. 2003..These results do not support the hypothesis that decreased PFC GAD(67) mRNA expression in schizophrenia is attributable to a reduction in MDTN neuron number... - Postnatal development of pre- and postsynaptic GABA markers at chandelier cell connections with pyramidal neurons in monkey prefrontal cortexDianne A Cruz
Department of Psychiatry, University of Pittsburgh, 3811 O'Hara Street, Pittsburgh, PA 15213, USA
J Comp Neurol 465:385-400. 2003.... - Dopamine increases inhibition in the monkey dorsolateral prefrontal cortex through cell type-specific modulation of interneuronsSven Kroner
Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA
Cereb Cortex 17:1020-32. 2007..Thus, DA and D1 receptor activation affect local recurrent circuits by selectively modulating FS interneurons that control the firing of PCs through perisomatic innervation... - Pyramidal neuron number in layer 3 of primary auditory cortex of subjects with schizophreniaKarl Anton Dorph-Petersen
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
Brain Res 1285:42-57. 2009..Our approach represents a powerful new method for stereologic estimation of features of interest within individual layers of cerebral cortex, with applications beyond the current study... - BDNF Val66Met polymorphism and GAD67 mRNA expression in the prefrontal cortex of subjects with schizophreniaTakanori Hashimoto
Department of Psychiatry, University of Pittsburgh, PA 15213, USA
Am J Psychiatry 163:534-7. 2006..The authors examined in subjects with schizophrenia the effect in the human BDNF gene of a single nucleotide polymorphism (Val66Met), which reduces the trafficking and secretion of BDNF protein, on the expression of GAD(67) mRNA... - GABA transporter GAT1 prevents spillover at proximal and distal GABA synapses onto primate prefrontal cortex neuronsGuillermo Gonzalez-Burgos
Translational Neuroscience Program, Department of Psychiatry, University of Pittsburgh School of Medicine, W1651 Biomedical Science Tower, 200 Lothrop St, Pittsburgh, PA 15261, USA
J Neurophysiol 101:533-47. 2009.... - Dopamine D1 receptor activation regulates sodium channel-dependent EPSP amplification in rat prefrontal cortex pyramidal neuronsDiana C Rotaru
Translational Neuroscience Program, Department of Psychiatry, University of Pittsburgh School of Medicine, W1651 Biomedical Science Tower, 200 Lothrop Street, Pittsburgh, PA 15261, USA
J Physiol 581:981-1000. 2007..Therefore, the effects of D1R activation on Na+ channel-dependent EPSP amplification may regulate the impact of coincidence detection versus temporal integration mechanisms in PFC pyramidal neurons... - Functional maturation of excitatory synapses in layer 3 pyramidal neurons during postnatal development of the primate prefrontal cortexGuillermo Gonzalez-Burgos
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA15261, USA
Cereb Cortex 18:626-37. 2008..Thus, remodeling of excitatory connectivity in the DLPFC during adolescence may occur in the absence of widespread maturational changes in synaptic strength... - Postnatal development of synaptic structure proteins in pyramidal neuron axon initial segments in monkey prefrontal cortexDianne A Cruz
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
J Comp Neurol 514:353-67. 2009.... - GABA neurons and the mechanisms of network oscillations: implications for understanding cortical dysfunction in schizophreniaGuillermo Gonzalez-Burgos
Translational Neuroscience Program, Department of Psychiatry, Pittsburgh, PA 15213, USA
Schizophr Bull 34:944-61. 2008.... - Transcriptome alterations in the prefrontal cortex of subjects with schizophrenia who committed suicideKrassimira Garbett
Department of Psychiatry, Vanderbilt University, Nashville, TN 37232, USA
Neuropsychopharmacol Hung 10:9-14. 2008..Finally, the presented data also strengthens previous reports of neuroimmune transcriptome disturbances in subjects with schizophrenia... - Effect of chronic exposure to antipsychotic medication on cell numbers in the parietal cortex of macaque monkeysGlenn T Konopaske
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
Neuropsychopharmacology 32:1216-23. 2007.... - Immunocytochemical distribution of the cannabinoid CB1 receptor in the primate neocortex: a regional and laminar analysisStephen M Eggan
Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15213, USA
Cereb Cortex 17:175-91. 2007.... - Synaptic efficacy during repetitive activation of excitatory inputs in primate dorsolateral prefrontal cortexGuillermo Gonzalez-Burgos
Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15213 2593, USA
Cereb Cortex 14:530-42. 2004.... - Functional properties of fast spiking interneurons and their synaptic connections with pyramidal cells in primate dorsolateral prefrontal cortexGuillermo Gonzalez-Burgos
Translational Neuroscience Program, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213 2593, USA
J Neurophysiol 93:942-53. 2005.... - Altered expression of 14-3-3 genes in the prefrontal cortex of subjects with schizophreniaFrank A Middleton
Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Neuropsychopharmacology 30:974-83. 2005.... - Lamina-specific reductions in dendritic spine density in the prefrontal cortex of subjects with schizophreniaNutan Kolluri
Department of Psychiatry, University of Pittsburgh, PA 15213, USA
Am J Psychiatry 162:1200-2. 2005..CONCLUSIONS: These findings are consistent with the idea that prefrontal pyramidal neurons involved in corticocortical and/or thalamocortical connections are preferentially affected in schizophrenia... - Stereological analysis of the mediodorsal thalamic nucleus in schizophrenia: volume, neuron number, and cell typesKarl-Anton Dorph-Petersen
Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
J Comp Neurol 472:449-62. 2004.... - Alterations of cortical GABA neurons and network oscillations in schizophreniaGuillermo Gonzalez-Burgos
Department of Psychiatry, Translational Neuroscience Program, University of Pittsburgh School of Medicine, Biomedical Science Tower, 200 Lothrop Street, Pittsburgh, PA 15261, USA
Curr Psychiatry Rep 12:335-44. 2010.... - Development of cannabinoid 1 receptor protein and messenger RNA in monkey dorsolateral prefrontal cortexStephen M Eggan
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
Cereb Cortex 20:1164-74. 2010..These findings provide a potential substrate for discrete, age-dependent effects of cannabis exposure on the maturation of primate DLPFC circuitry... - Prefrontal cortical circuits in schizophreniaDavid W Volk
Department of Psychiatry, University of Pittsburgh, 3811 O Hara Street, BST W1653, Pittsburgh, PA 15213, USA
Curr Top Behav Neurosci 4:485-508. 2010..Increasing knowledge of the nature of the molecular alterations in these cortical circuits may lead to the development of new pathophysiologically informed treatment options for cognitive deficits in schizophrenia... - Tiagabine increases [11C]flumazenil binding in cortical brain regions in healthy control subjectsW Gordon Frankle
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
Neuropsychopharmacology 34:624-33. 2009.... - NPY mRNA expression in the prefrontal cortex: Selective reduction in the superficial white matter of subjects with schizoaffective disorderHarvey M Morris
Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15213, USA
Schizophr Res 115:261-9. 2009..However, whether the alterations in these two transcripts identify the same, particularly vulnerable, subset of GABA neurons has not been examined... - DNA microarray analysis of postmortem brain tissueKaroly Mirnics
Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
Int Rev Neurobiol 60:153-81. 2004 - Schizophrenia as a disorder of neurodevelopmentDavid A Lewis
Department of Psychiatry, University of Pittsburgh School of Medicine, University of Pittsburgh, Pennsylvania 15213, USA
Annu Rev Neurosci 25:409-32. 2002.... - Somal size of prefrontal cortical pyramidal neurons in schizophrenia: differential effects across neuronal subpopulationsJoseph N Pierri
Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Biol Psychiatry 54:111-20. 2003..Thus, a subpopulation of dPFC deep layer 3 pyramidal neurons, other than those identified by NNFP-IR, may be selectively vulnerable in schizophrenia... - The human brain revisited: opportunities and challenges in postmortem studies of psychiatric disordersDavid A Lewis
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
Neuropsychopharmacology 26:143-54. 2002.... - The future of psychiatry as clinical neuroscienceCharles F Reynolds
University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
Acad Med 84:446-50. 2009.... - Somal size of immunolabeled pyramidal cells in the prefrontal cortex of subjects with schizophreniaJaime G Maldonado-Aviles
Department of Neuroscience, University of Pittsburgh, Pennsylvania 15213, USA
Biol Psychiatry 60:226-34. 2006..Consequently, we hypothesized that the somal volume of another subset of pyramidal cells immunoreactive for neuronal calcium binding protein-1 (Necab-1) is significantly reduced in schizophrenia... - Cluster analysis-based physiological classification and morphological properties of inhibitory neurons in layers 2-3 of monkey dorsolateral prefrontal cortexLeonid S Krimer
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
J Neurophysiol 94:3009-22. 2005..Thus a quantitative approach enabled us to demonstrate that intrinsic electrophysiological properties of neurons in the monkey prefrontal cortex define distinct cell types, which also display distinct morphologies... - Mapping auditory core, lateral belt, and parabelt cortices in the human superior temporal gyrusRobert A Sweet
Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
J Comp Neurol 491:270-89. 2005..Variability of regional volume estimates was readily constrained using a multifaceted approach to reduce potential sources of variability in regional delineation... - Alterations in metabotropic glutamate receptor 1α and regulator of G protein signaling 4 in the prefrontal cortex in schizophreniaDavid W Volk
Department of Psychiatry, University of Pittsburgh, PA 15213, USA
Am J Psychiatry 167:1489-98. 2010..The status of endocannabinoid ligands, such as 2-arachidonoylglycerol, can be inferred in part through measures of diacylglycerol lipase and monoglyceride lipase, which synthesize and degrade 2-arachidonoylglycerol, respectively... - Structure of the human prefrontal cortexDavid A Lewis
UT Southwestern Medical Center, Department of Psychiatry, Dallas, TX 75390-9070, USA
Am J Psychiatry 161:1366. 2004 - An automated segmentation methodology for quantifying immunoreactive puncta number and fluorescence intensity in tissue sectionsKenneth N Fish
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
Brain Res 1240:62-72. 2008..g., average fluorescence intensity of proteins of interest). Importantly, the segmentation method presented can be easily adapted for use with most existing microscopy analysis packages... - Altered cortical glutamate neurotransmission in schizophrenia: evidence from morphological studies of pyramidal neuronsDavid A Lewis
Department of Psychiatry, University of Pittsburgh, Pennsylvania 15213, USA
Ann N Y Acad Sci 1003:102-12. 2003.... - Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophreniaHader A Mansour
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
Bipolar Disord 11:701-10. 2009..The results are plausible, based on prior studies of circadian abnormalities. As replications have not been attempted uniformly, we evaluated representative, common polymorphisms in all three disorders... - Altered expression of regulators of the cortical chloride transporters NKCC1 and KCC2 in schizophreniaDominique Arion
Department of Psychiatry, University of Pittsburgh, PA 15213, USA
Arch Gen Psychiatry 68:21-31. 2011..The activities of these transporters are in turn regulated by a network of serine-threonine kinases that includes OXSR1, STK39, and the WNK kinases WNK1, WNK3, and WNK4... - Postnatal developmental trajectories of neural circuits in the primate prefrontal cortex: identifying sensitive periods for vulnerability to schizophreniaGil D Hoftman
Medical Scientist Training Program, University of Pittsburgh, Pittsburgh, PA, USA
Schizophr Bull 37:493-503. 2011.... - Cortical connections of the lateral mediodorsal thalamus in cynomolgus monkeysSusan L Erickson
Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
J Comp Neurol 473:107-27. 2004.... - Molecular markers distinguishing supragranular and infragranular layers in the human prefrontal cortexDominique Arion
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15261, USA
Eur J Neurosci 25:1843-54. 2007.... - Primary visual cortex volume and total neuron number are reduced in schizophreniaKarl Anton Dorph Petersen
Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
J Comp Neurol 501:290-301. 2007..Subjects with schizophrenia therefore have a smaller cortical area allocated to primary visual perception. This finding suggests the existence of a schizophrenia-related change in cortical parcellation... - Inhibition and timing in cortical neural circuitsGuillermo Gonzalez-Burgos
Am J Psychiatry 164:12. 2007 - Mitochondrial dysfunction as a cause of axonal degeneration in multiple sclerosis patientsRanjan Dutta
Department of Neurosciences, Lerner Research Institute, Cleveland Clinic Foundation, OH 44195, USA
Ann Neurol 59:478-89. 2006.... - Gene expression profiling with DNA microarrays: advancing our understanding of psychiatric disordersJulie Pongrac
Neurochem Res 27:1049-63. 2002..Our goal will be to integrate this expression data within the context of the relevant anatomical, biochemical, molecular, imaging and clinical findings... - In pursuit of the pathogenesis and pathophysiology of schizophrenia: where do we stand?David A Lewis
Am J Psychiatry 159:1467-9. 2002 - Anatomical evidence of impaired feedforward auditory processing in schizophreniaRobert A Sweet
Department of Psychiatry, University of Pittsburgh, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania 15213, USA
Biol Psychiatry 61:854-64. 2007.... - Selective reduction by dopamine of excitatory synaptic inputs to pyramidal neurons in primate prefrontal cortexNathaniel N Urban
Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA
J Physiol 539:707-12. 2002..This input specificity may be a critical aspect of the dopaminergic regulation of recurrent excitatory circuits in the PFC... - Large-scale estimates of cellular origins of mRNAs: enhancing the yield of transcriptome analysesEtienne Sibille
Department of Psychiatry, University of Pittsburgh, PA 15213, USA
J Neurosci Methods 167:198-206. 2008..As this approach can be applied post hoc, we provide tables of ratios for analysis of existing mouse and human brain datasets... - Effect of chronic antipsychotic exposure on astrocyte and oligodendrocyte numbers in macaque monkeysGlenn T Konopaske
Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Biol Psychiatry 63:759-65. 2008..Consequently, in this study we sought to determine whether the lower glial cell number was due to fewer oligodendrocytes as opposed to lower numbers of astrocytes... - Serotonin1A receptors at the axon initial segment of prefrontal pyramidal neurons in schizophreniaDianne A Cruz
Department of Psychiatry, University of Pittsburgh, PA 15213, USA
Am J Psychiatry 161:739-42. 2004..CONCLUSIONS: The findings do not support a role for altered serotonin transmission by means of the 5-HT(1A) receptor in dysfunction of prefrontal cortex pyramidal neurons in schizophrenia... - Pyramidal cell size reduction in schizophrenia: evidence for involvement of auditory feedforward circuitsRobert A Sweet
Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Biol Psychiatry 55:1128-37. 2004..This pattern of abnormalities is consistent with impairments of auditory feedforward projection neurons... - Ultrastructural interactions between terminals expressing the norepinephrine transporter and dopamine neurons in the rat and monkey ventral tegmental areaLindsay A Liprando
Departments of Neuroscience and Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
Synapse 52:233-44. 2004..The latter finding agrees with observations in cortical regions and represents the first report of its type in a subcortical structure... - Neuropathologic correlates of late-onset major depressionRobert A Sweet
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Neuropsychopharmacology 29:2242-50. 2004..These preliminary findings suggest that AD is the predominant neuropathologic condition in LLMD subjects with dementia. Further assessment of the role of comorbid cerebrovascular disease and comorbid DLB is needed... - Reduced cortical cannabinoid 1 receptor messenger RNA and protein expression in schizophreniaStephen M Eggan
Department of Psychiatry, University of Pittsburgh, 3811 O Hara St, W1651 BST, Pittsburgh, PA 15213, USA
Arch Gen Psychiatry 65:772-84. 2008.... - Petilla terminology: nomenclature of features of GABAergic interneurons of the cerebral cortexGiorgio A Ascoli
Molecular Neuroscience Department and Center for Neural Informatics, Structures, and Plasticity, Krasnow Institute for Advanced Study, George Mason University, MS2A1, 4400 University Drive, Fairfax, Virginia 22030, USA
Nat Rev Neurosci 9:557-68. 2008..Consistent adoption will be important for the success of such an initiative, and we also encourage the active involvement of the broader scientific community in the dynamic evolution of this project... 
Dendritic-targeting GABA neurons in monkey prefrontal cortex: comparison of somatostatin- and calretinin-immunoreactive axon terminalsDarlene S Melchitzky
Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Synapse 62:456-65. 2008..19%, respectively). This specialized synaptic circuitry of SST neurons in the primate PFC suggests that the alterations of these neurons in schizophrenia is likely to have distinct functional consequences...- Specificity in the functional architecture of primate prefrontal cortexDavid A Lewis
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
J Neurocytol 31:265-76. 2002.... - The human precentral sulcus: chemoarchitecture of a region corresponding to the frontal eye fieldsCaterina Rosano
Graduate School of Public Health, University of Pittsburgh, 130 Bellefield, 519, Pittsburgh, PA, USA
Brain Res 972:16-30. 2003..These specific chemoarchitectural features may differentiate the location of the human FEF from rostral cortical regions and support the functions for which it is specialized... - Reduced pyramidal cell somal volume in auditory association cortex of subjects with schizophreniaRobert A Sweet
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
Neuropsychopharmacology 28:599-609. 2003..This reduction may contribute to impairment in auditory function. The correlated reductions of somal volume in BA42 and BA9 suggest that a common factor may affect deep layer 3 pyramidal cells in both regions...
Research Grants
- GABA Neurons and Cortical Circuitry in SchizophreniaDavid Lewis; Fiscal Year: 2007..Together, these studies will provide a comprehensive molecular-and circuit-based accounting of the contribution of abnormalities in GABA neurotransmission to dPFC dysfunction in schizophrenia. ..
- Cannabis and Adolescent Brain DevelopmentDavid A Lewis; Fiscal Year: 2010..Thus, these studies will provide an explicit test of the biological events and mechanisms that make the adolescent brain especially vulnerable to the effects of cannabis. ..
- Development of Prefrontal Inhibition and SchizophreniaDavid Lewis; Fiscal Year: 2009..abstract_text> ..
- CORTICAL CIRCUITRY AND COGNITION IN SCHIZOPHRENIADavid Lewis; Fiscal Year: 2007..Our extensive interactions enable us to conduct a translational research program in schizophrenia that effectively transfers information from the clinic to the laboratory and back to the clinic in a truly bidirectional fashion. ..
- SCHIZOPHRENIA AND PREFRONTAL CORTICAL CIRCUITRYDavid Lewis; Fiscal Year: 2004....
- FUNCTIONAL ARCHITECTURE OF PREFRONTAL CORTEXDavid Lewis; Fiscal Year: 2003..The results of these studies will inform our understanding of the normal functional architecture of the primate DLPFC, and will guide the conduct and interpretation of studies of DLPFC circuitry in schizophrenia. ..
- Developmental Trajectories in Prefrontal GABA CircuitsDavid A Lewis; Fiscal Year: 2010..These studies will delineate sensitive periods during prefrontal cortical development when pharmacological interventions in individuals vulnerable for schizophrenia might have the greatest reward, or risk, potential. ..