David Lewis

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc Inhibitory neurons in human cortical circuits: substrate for cognitive dysfunction in schizophrenia
    David A Lewis
    Translational Neuroscience Program, Department of Psychiatry, University of Pittsburgh, United States Electronic address
    Curr Opin Neurobiol 26:22-6. 2014
  2. pmc Cortical circuit dysfunction and cognitive deficits in schizophrenia--implications for preemptive interventions
    David A Lewis
    Translational Neuroscience Program, Department of Psychiatry, University of Pittsburgh, 3811 O Hara Street, Biomedical Science Tower W1654, Pittsburgh, PA 15213, USA
    Eur J Neurosci 35:1871-8. 2012
  3. pmc Altered cortical GABA neurotransmission in schizophrenia: insights into novel therapeutic strategies
    Ana D Stan
    Department of Psychiatry, University of Pittsburgh, 3811 O Hara Street, W1651 BST, Pittsburgh, PA 15213, USA
    Curr Pharm Biotechnol 13:1557-62. 2012
  4. pmc Cortical basket cell dysfunction in schizophrenia
    Allison A Curley
    Translational Neuroscience Program, Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Physiol 590:715-24. 2012
  5. pmc Perisomatic inhibition and cortical circuit dysfunction in schizophrenia
    David A Lewis
    Translational Neuroscience Program, Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, United States
    Curr Opin Neurobiol 21:866-72. 2011
  6. pmc Cortical parvalbumin interneurons and cognitive dysfunction in schizophrenia
    David A Lewis
    Translational Neuroscience Program, Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Trends Neurosci 35:57-67. 2012
  7. pmc A human-mouse conserved sex bias in amygdala gene expression related to circadian clock and energy metabolism
    Li Chun Lin
    Translational Neuroscience Program, Department of Psychiatry, and Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Mol Brain 4:18. 2011
  8. ncbi request reprint Selective alterations in prefrontal cortical GABA neurotransmission in schizophrenia: a novel target for the treatment of working memory dysfunction
    David A Lewis
    Department of Psychiatry, University of Pittsburgh, 3811 O Hara Street, W1651 BST, Pittsburgh, PA 15213, USA
    Psychopharmacology (Berl) 174:143-50. 2004
  9. ncbi request reprint Neuroplasticity of neocortical circuits in schizophrenia
    David A Lewis
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Neuropsychopharmacology 33:141-65. 2008
  10. pmc Cell and receptor type-specific alterations in markers of GABA neurotransmission in the prefrontal cortex of subjects with schizophrenia
    David A Lewis
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Neurotox Res 14:237-48. 2008

Detail Information

Publications94

  1. pmc Inhibitory neurons in human cortical circuits: substrate for cognitive dysfunction in schizophrenia
    David A Lewis
    Translational Neuroscience Program, Department of Psychiatry, University of Pittsburgh, United States Electronic address
    Curr Opin Neurobiol 26:22-6. 2014
    ..Other recent studies in model systems provide insight into how these alterations may arise in the course of cortical circuitry development. ..
  2. pmc Cortical circuit dysfunction and cognitive deficits in schizophrenia--implications for preemptive interventions
    David A Lewis
    Translational Neuroscience Program, Department of Psychiatry, University of Pittsburgh, 3811 O Hara Street, Biomedical Science Tower W1654, Pittsburgh, PA 15213, USA
    Eur J Neurosci 35:1871-8. 2012
    ..The implications of these findings for the development and implementation of safe, preemptive, disease-modifying interventions in individuals at high risk for a clinical diagnosis of schizophrenia are considered...
  3. pmc Altered cortical GABA neurotransmission in schizophrenia: insights into novel therapeutic strategies
    Ana D Stan
    Department of Psychiatry, University of Pittsburgh, 3811 O Hara Street, W1651 BST, Pittsburgh, PA 15213, USA
    Curr Pharm Biotechnol 13:1557-62. 2012
    ....
  4. pmc Cortical basket cell dysfunction in schizophrenia
    Allison A Curley
    Translational Neuroscience Program, Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Physiol 590:715-24. 2012
    ....
  5. pmc Perisomatic inhibition and cortical circuit dysfunction in schizophrenia
    David A Lewis
    Translational Neuroscience Program, Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, United States
    Curr Opin Neurobiol 21:866-72. 2011
    ..These alterations may contribute to the neural substrate for impaired gamma oscillations in schizophrenia...
  6. pmc Cortical parvalbumin interneurons and cognitive dysfunction in schizophrenia
    David A Lewis
    Translational Neuroscience Program, Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Trends Neurosci 35:57-67. 2012
    ..This compensation is thought to rebalance cortical excitation and inhibition, but at a level insufficient to generate the gamma oscillation power required for high levels of cognitive control...
  7. pmc A human-mouse conserved sex bias in amygdala gene expression related to circadian clock and energy metabolism
    Li Chun Lin
    Translational Neuroscience Program, Department of Psychiatry, and Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Mol Brain 4:18. 2011
    ..We hypothesized that sex differences in molecular structure may contribute to differential mood regulation and disease vulnerability...
  8. ncbi request reprint Selective alterations in prefrontal cortical GABA neurotransmission in schizophrenia: a novel target for the treatment of working memory dysfunction
    David A Lewis
    Department of Psychiatry, University of Pittsburgh, 3811 O Hara Street, W1651 BST, Pittsburgh, PA 15213, USA
    Psychopharmacology (Berl) 174:143-50. 2004
    ....
  9. ncbi request reprint Neuroplasticity of neocortical circuits in schizophrenia
    David A Lewis
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Neuropsychopharmacology 33:141-65. 2008
    ....
  10. pmc Cell and receptor type-specific alterations in markers of GABA neurotransmission in the prefrontal cortex of subjects with schizophrenia
    David A Lewis
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Neurotox Res 14:237-48. 2008
    ..In concert with previous findings, these data suggest that working memory dysfunction in schizophrenia may be attributable to altered GABA neurotransmission in specific DLPFC microcircuits...
  11. pmc The chandelier neuron in schizophrenia
    David A Lewis
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Dev Neurobiol 71:118-27. 2011
    ..Recent findings that inputs from neocortical chandelier neurons are excitatory provide new ideas about the role of this circuitry in the pathophysiology of cortical dysfunction in schizophrenia...
  12. ncbi request reprint Postnatal development of prefrontal inhibitory circuits and the pathophysiology of cognitive dysfunction in schizophrenia
    David A Lewis
    Department of Psychiatry, University of Pittsburgh, 3811 O Hara Street, W1651 BST, Pittsburgh, PA 15213, USA
    Ann N Y Acad Sci 1021:64-76. 2004
    ..The implications of these findings for treatment and prevention strategies are discussed...
  13. pmc Subunit-selective modulation of GABA type A receptor neurotransmission and cognition in schizophrenia
    David A Lewis
    Department of Psychiatry, W1651 Biomedical Science Tower, 3511 O Hara St, Pittsburgh, PA 15213, USA
    Am J Psychiatry 165:1585-93. 2008
    ....
  14. ncbi request reprint Transcriptome alterations in schizophrenia: disturbing the functional architecture of the dorsolateral prefrontal cortex
    David A Lewis
    Department of Psychiatry, and Department of Neuroscience, University of Pittsburgh, 3811 O Hara Street, W1652 BST, Pittsburgh, PA 15213 2593, USA
    Prog Brain Res 158:141-52. 2006
    ....
  15. pmc Schizophrenia from a neural circuitry perspective: advancing toward rational pharmacological therapies
    David A Lewis
    University of Pittsburgh, Department of Psychiatry, W1651 Biomedical Science Tower, 3811 O Hara Street, Pittsburgh, Pennsylvania 15213, USA
    J Clin Invest 119:706-16. 2009
    ..The identification of molecular alterations in these circuits is providing critical insights for the rational development of new therapeutic interventions...
  16. pmc Neuroplasticity of excitatory and inhibitory cortical circuits in schizophrenia
    David A Lewis
    Department of Psychiatry, University of Pittsburgh, PA 15213, USA
    Dialogues Clin Neurosci 11:269-80. 2009
    ..This article reviews disturbances in excitatory and inhibitory components of DLPFC circuitry from the perspective of developmental neuroplasticity and discusses their implications for the identification of novel therapeutic targets...
  17. ncbi request reprint Pathophysiologically based treatment interventions in schizophrenia
    David A Lewis
    Department of Psychiatry, University of Pittsburgh, 3811 O Hara Street, Pittsburgh, Pennsylvania 15213, USA
    Nat Med 12:1016-22. 2006
    ....
  18. ncbi request reprint Cortical inhibitory neurons and schizophrenia
    David A Lewis
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Nat Rev Neurosci 6:312-24. 2005
    ..These findings reveal specific targets for therapeutic interventions to improve cognitive function in individuals with schizophrenia...
  19. ncbi request reprint Gene expression deficits in a subclass of GABA neurons in the prefrontal cortex of subjects with schizophrenia
    Takanori Hashimoto
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Neurosci 23:6315-26. 2003
    ....
  20. pmc Altered cortical CDC42 signaling pathways in schizophrenia: implications for dendritic spine deficits
    Masayuki Ide
    Department of Psychiatry, University of Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 68:25-32. 2010
    ..Therefore, alterations in CDC42EP3 could contribute to the lamina-specific spine deficits in schizophrenia...
  21. pmc Conserved regional patterns of GABA-related transcript expression in the neocortex of subjects with schizophrenia
    Takanori Hashimoto
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Am J Psychiatry 165:479-89. 2008
    ....
  22. ncbi request reprint Heat shock protein 12A shows reduced expression in the prefrontal cortex of subjects with schizophrenia
    Julie L Pongrac
    Department of Psychiatry, E1655 BST, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Biol Psychiatry 56:943-50. 2004
    ..001; mean log2 signal difference = -.58) in transcript expression for a gene clone KIAA0417. This database entry has been recently annotated as two highly homologous members of a heat-shock protein family (HSPA12A and HSPA12B)...
  23. pmc Altered markers of tonic inhibition in the dorsolateral prefrontal cortex of subjects with schizophrenia
    Jaime G Maldonado-Aviles
    Department of Psychiatry, University of Pittsburgh, 3811 O Hara St, W1651 BST, Pittsburgh, PA 15213, USA
    Am J Psychiatry 166:450-9. 2009
    ..The authors assessed the expression of GABA(A) receptor alpha4 and delta subunits, which coassemble to form receptors mediating tonic inhibition, in schizophrenia...
  24. ncbi request reprint Postnatal development of parvalbumin- and GABA transporter-immunoreactive axon terminals in monkey prefrontal cortex
    Susan L Erickson
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Comp Neurol 448:186-202. 2002
    ..These findings suggest that morphologically specialized classes of inhibitory interneurons assume prominence within the prefrontal cortical network at different stages of postnatal development...
  25. pmc Molecular evidence for increased expression of genes related to immune and chaperone function in the prefrontal cortex in schizophrenia
    Dominique Arion
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Biol Psychiatry 62:711-21. 2007
    ..Schizophrenia is characterized by complex gene expression changes. The transcriptome alterations in the prefrontal cortex have been the subject of several recent postmortem studies that yielded both convergent and divergent findings...
  26. ncbi request reprint Cognitive dysfunction in schizophrenia: convergence of gamma-aminobutyric acid and glutamate alterations
    David A Lewis
    Departments of Psychiatry and Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA
    Arch Neurol 63:1372-6. 2006
    ..These findings suggest specific targets for therapeutic interventions to improve cognitive function in individuals with schizophrenia...
  27. ncbi request reprint Relationship of brain-derived neurotrophic factor and its receptor TrkB to altered inhibitory prefrontal circuitry in schizophrenia
    Takanori Hashimoto
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Neurosci 25:372-83. 2005
    ..Decreased TrkB signaling appears to underlie the dysfunction of inhibitory neurons in the PFC of subjects with schizophrenia...
  28. pmc Infragranular gene expression disturbances in the prefrontal cortex in schizophrenia: signature of altered neural development?
    Dominique Arion
    Department of Psychiatry, U of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Neurobiol Dis 37:738-46. 2010
    ....
  29. ncbi request reprint Reciprocal alterations in pre- and postsynaptic inhibitory markers at chandelier cell inputs to pyramidal neurons in schizophrenia
    David W Volk
    Department of Neuroscience, University of Pittsburgh, PA 15260, USA
    Cereb Cortex 12:1063-70. 2002
    ..Thus, disturbances in inhibition at the chandelier neuron-pyramidal neuron synapse may be a critical component of prefrontal cortical dysfunction in schizophrenia...
  30. ncbi request reprint Impaired prefrontal inhibition in schizophrenia: relevance for cognitive dysfunction
    David W Volk
    Department of Neuroscience, University of Pittsburgh, 15260, Pittsburgh, PA, USA
    Physiol Behav 77:501-5. 2002
    ..Selective disruptions in inhibitory neurotransmission are likely to distort aspects of pyramidal neuron function important for working memory tasks, and thus may contribute to cognitive dysfunction in schizophrenia...
  31. pmc Selective alterations in postsynaptic markers of chandelier cell inputs to cortical pyramidal neurons in subjects with schizophrenia
    Dianne A Cruz
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Neuropsychopharmacology 34:2112-24. 2009
    ....
  32. ncbi request reprint Pyramidal neuron local axon terminals in monkey prefrontal cortex: differential targeting of subclasses of GABA neurons
    Darlene S Melchitzky
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Cereb Cortex 13:452-60. 2003
    ..These connections may provide the anatomical substrate for the coordinated activity of pyramidal neurons and fast-spiking GABA neurons during working memory...
  33. ncbi request reprint Deciphering the disease process of schizophrenia: the contribution of cortical GABA neurons
    David A Lewis
    Department of Psychiatry, University of Pittsburgh, Pennsylvania 15213, USA
    Int Rev Neurobiol 78:109-31. 2007
    ....
  34. ncbi request reprint Postnatal development of pre- and postsynaptic GABA markers at chandelier cell connections with pyramidal neurons in monkey prefrontal cortex
    Dianne A Cruz
    Department of Psychiatry, University of Pittsburgh, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    J Comp Neurol 465:385-400. 2003
    ....
  35. ncbi request reprint Effects of a mediodorsal thalamus lesion on prefrontal inhibitory circuitry: implications for schizophrenia
    David W Volk
    Department of Neuroscience, University of Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 53:385-9. 2003
    ....
  36. ncbi request reprint GABA neurons in the human prefrontal cortex
    Carol Tamminga
    UT Southwestern Medical Center, Department of Psychiatry, 5323 Harry Hines Blvd, NC5 914, Dallas, TX 75390 9070, USA
    Am J Psychiatry 161:1764. 2004
  37. ncbi request reprint Gene expression profiling reveals alterations of specific metabolic pathways in schizophrenia
    Frank A Middleton
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 22:2718-29. 2002
    ....
  38. pmc GABA transporter GAT1 prevents spillover at proximal and distal GABA synapses onto primate prefrontal cortex neurons
    Guillermo Gonzalez-Burgos
    Translational Neuroscience Program, Department of Psychiatry, University of Pittsburgh School of Medicine, W1651 Biomedical Science Tower, 200 Lothrop St, Pittsburgh, PA 15261, USA
    J Neurophysiol 101:533-47. 2009
    ....
  39. ncbi request reprint Dopamine increases inhibition in the monkey dorsolateral prefrontal cortex through cell type-specific modulation of interneurons
    Sven Kroner
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Cereb Cortex 17:1020-32. 2007
    ..Thus, DA and D1 receptor activation affect local recurrent circuits by selectively modulating FS interneurons that control the firing of PCs through perisomatic innervation...
  40. ncbi request reprint BDNF Val66Met polymorphism and GAD67 mRNA expression in the prefrontal cortex of subjects with schizophrenia
    Takanori Hashimoto
    Department of Psychiatry, University of Pittsburgh, PA 15213, USA
    Am J Psychiatry 163:534-7. 2006
    ..The authors examined in subjects with schizophrenia the effect in the human BDNF gene of a single nucleotide polymorphism (Val66Met), which reduces the trafficking and secretion of BDNF protein, on the expression of GAD(67) mRNA...
  41. pmc Pyramidal neuron number in layer 3 of primary auditory cortex of subjects with schizophrenia
    Karl Anton Dorph-Petersen
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
    Brain Res 1285:42-57. 2009
    ..Our approach represents a powerful new method for stereologic estimation of features of interest within individual layers of cerebral cortex, with applications beyond the current study...
  42. ncbi request reprint Immunocytochemical distribution of the cannabinoid CB1 receptor in the primate neocortex: a regional and laminar analysis
    Stephen M Eggan
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Cereb Cortex 17:175-91. 2007
    ....
  43. ncbi request reprint Transcriptome alterations in the prefrontal cortex of subjects with schizophrenia who committed suicide
    Krassimira Garbett
    Department of Psychiatry, Vanderbilt University, Nashville, TN 37232, USA
    Neuropsychopharmacol Hung 10:9-14. 2008
    ..Finally, the presented data also strengthens previous reports of neuroimmune transcriptome disturbances in subjects with schizophrenia...
  44. ncbi request reprint Synaptic efficacy during repetitive activation of excitatory inputs in primate dorsolateral prefrontal cortex
    Guillermo Gonzalez-Burgos
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15213 2593, USA
    Cereb Cortex 14:530-42. 2004
    ....
  45. ncbi request reprint Functional maturation of excitatory synapses in layer 3 pyramidal neurons during postnatal development of the primate prefrontal cortex
    Guillermo Gonzalez-Burgos
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA15261, USA
    Cereb Cortex 18:626-37. 2008
    ..Thus, remodeling of excitatory connectivity in the DLPFC during adolescence may occur in the absence of widespread maturational changes in synaptic strength...
  46. ncbi request reprint Effect of chronic exposure to antipsychotic medication on cell numbers in the parietal cortex of macaque monkeys
    Glenn T Konopaske
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Neuropsychopharmacology 32:1216-23. 2007
    ....
  47. pmc Dopamine D1 receptor activation regulates sodium channel-dependent EPSP amplification in rat prefrontal cortex pyramidal neurons
    Diana C Rotaru
    Translational Neuroscience Program, Department of Psychiatry, University of Pittsburgh School of Medicine, W1651 Biomedical Science Tower, 200 Lothrop Street, Pittsburgh, PA 15261, USA
    J Physiol 581:981-1000. 2007
    ..Therefore, the effects of D1R activation on Na+ channel-dependent EPSP amplification may regulate the impact of coincidence detection versus temporal integration mechanisms in PFC pyramidal neurons...
  48. ncbi request reprint Stereological analysis of the mediodorsal thalamic nucleus in schizophrenia: volume, neuron number, and cell types
    Karl Anton Dorph-Petersen
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Comp Neurol 472:449-62. 2004
    ....
  49. pmc Alterations of cortical GABA neurons and network oscillations in schizophrenia
    Guillermo Gonzalez-Burgos
    Department of Psychiatry, Translational Neuroscience Program, University of Pittsburgh School of Medicine, Biomedical Science Tower, 200 Lothrop Street, Pittsburgh, PA 15261, USA
    Curr Psychiatry Rep 12:335-44. 2010
    ....
  50. pmc GABA neurons and the mechanisms of network oscillations: implications for understanding cortical dysfunction in schizophrenia
    Guillermo Gonzalez-Burgos
    Translational Neuroscience Program, Department of Psychiatry, Pittsburgh, PA 15213, USA
    Schizophr Bull 34:944-61. 2008
    ....
  51. ncbi request reprint Functional properties of fast spiking interneurons and their synaptic connections with pyramidal cells in primate dorsolateral prefrontal cortex
    Guillermo Gonzalez-Burgos
    Translational Neuroscience Program, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213 2593, USA
    J Neurophysiol 93:942-53. 2005
    ....
  52. pmc Postnatal development of synaptic structure proteins in pyramidal neuron axon initial segments in monkey prefrontal cortex
    Dianne A Cruz
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Comp Neurol 514:353-67. 2009
    ....
  53. ncbi request reprint Altered expression of 14-3-3 genes in the prefrontal cortex of subjects with schizophrenia
    Frank A Middleton
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Neuropsychopharmacology 30:974-83. 2005
    ....
  54. ncbi request reprint Lamina-specific reductions in dendritic spine density in the prefrontal cortex of subjects with schizophrenia
    Nutan Kolluri
    Department of Psychiatry, University of Pittsburgh, PA 15213, USA
    Am J Psychiatry 162:1200-2. 2005
    ..The authors' goal was to determine whether their finding in layer 3 was also present in other cortical layers in the same group of subjects with schizophrenia...
  55. pmc Tiagabine increases [11C]flumazenil binding in cortical brain regions in healthy control subjects
    W Gordon Frankle
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Neuropsychopharmacology 34:624-33. 2009
    ....
  56. ncbi request reprint Prefrontal cortical circuits in schizophrenia
    David W Volk
    Department of Psychiatry, University of Pittsburgh, 3811 O Hara Street, BST W1653, Pittsburgh, PA 15213, USA
    Curr Top Behav Neurosci 4:485-508. 2010
    ..Increasing knowledge of the nature of the molecular alterations in these cortical circuits may lead to the development of new pathophysiologically informed treatment options for cognitive deficits in schizophrenia...
  57. pmc Alterations in metabotropic glutamate receptor 1α and regulator of G protein signaling 4 in the prefrontal cortex in schizophrenia
    David W Volk
    Department of Psychiatry, University of Pittsburgh, PA 15213, USA
    Am J Psychiatry 167:1489-98. 2010
    ..The status of endocannabinoid ligands, such as 2-arachidonoylglycerol, can be inferred in part through measures of diacylglycerol lipase and monoglyceride lipase, which synthesize and degrade 2-arachidonoylglycerol, respectively...
  58. pmc Development of cannabinoid 1 receptor protein and messenger RNA in monkey dorsolateral prefrontal cortex
    Stephen M Eggan
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Cereb Cortex 20:1164-74. 2010
    ..These findings provide a potential substrate for discrete, age-dependent effects of cannabis exposure on the maturation of primate DLPFC circuitry...
  59. ncbi request reprint The human brain revisited: opportunities and challenges in postmortem studies of psychiatric disorders
    David A Lewis
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Neuropsychopharmacology 26:143-54. 2002
    ....
  60. pmc NPY mRNA expression in the prefrontal cortex: Selective reduction in the superficial white matter of subjects with schizoaffective disorder
    Harvey M Morris
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Schizophr Res 115:261-9. 2009
    ..However, whether the alterations in these two transcripts identify the same, particularly vulnerable, subset of GABA neurons has not been examined...
  61. pmc The future of psychiatry as clinical neuroscience
    Charles F Reynolds
    University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Acad Med 84:446-50. 2009
    ....
  62. ncbi request reprint Cluster analysis-based physiological classification and morphological properties of inhibitory neurons in layers 2-3 of monkey dorsolateral prefrontal cortex
    Leonid S Krimer
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Neurophysiol 94:3009-22. 2005
    ..Thus a quantitative approach enabled us to demonstrate that intrinsic electrophysiological properties of neurons in the monkey prefrontal cortex define distinct cell types, which also display distinct morphologies...
  63. ncbi request reprint Somal size of immunolabeled pyramidal cells in the prefrontal cortex of subjects with schizophrenia
    Jaime G Maldonado-Aviles
    Department of Neuroscience, University of Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 60:226-34. 2006
    ..Consequently, we hypothesized that the somal volume of another subset of pyramidal cells immunoreactive for neuronal calcium binding protein-1 (Necab-1) is significantly reduced in schizophrenia...
  64. ncbi request reprint Mapping auditory core, lateral belt, and parabelt cortices in the human superior temporal gyrus
    Robert A Sweet
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Comp Neurol 491:270-89. 2005
    ..Variability of regional volume estimates was readily constrained using a multifaceted approach to reduce potential sources of variability in regional delineation...
  65. ncbi request reprint DNA microarray analysis of postmortem brain tissue
    Karoly Mirnics
    Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Int Rev Neurobiol 60:153-81. 2004
  66. ncbi request reprint Structure of the human prefrontal cortex
    David A Lewis
    UT Southwestern Medical Center, Department of Psychiatry, Dallas, TX 75390 9070, USA
    Am J Psychiatry 161:1366. 2004
  67. ncbi request reprint Somal size of prefrontal cortical pyramidal neurons in schizophrenia: differential effects across neuronal subpopulations
    Joseph N Pierri
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Biol Psychiatry 54:111-20. 2003
    ..We tested the hypotheses that the average size of NNFP-IR neurons is smaller in schizophrenia and that the decrease in size of these neurons is greater than that observed in the general population of deep layer 3 pyramidal neurons...
  68. ncbi request reprint Schizophrenia as a disorder of neurodevelopment
    David A Lewis
    Department of Psychiatry, University of Pittsburgh School of Medicine, University of Pittsburgh, Pennsylvania 15213, USA
    Annu Rev Neurosci 25:409-32. 2002
    ....
  69. pmc An automated segmentation methodology for quantifying immunoreactive puncta number and fluorescence intensity in tissue sections
    Kenneth N Fish
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Brain Res 1240:62-72. 2008
    ..g., average fluorescence intensity of proteins of interest). Importantly, the segmentation method presented can be easily adapted for use with most existing microscopy analysis packages...
  70. ncbi request reprint Altered cortical glutamate neurotransmission in schizophrenia: evidence from morphological studies of pyramidal neurons
    David A Lewis
    Department of Psychiatry, University of Pittsburgh, Pennsylvania 15213, USA
    Ann N Y Acad Sci 1003:102-12. 2003
    ....
  71. pmc Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophrenia
    Hader A Mansour
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Bipolar Disord 11:701-10. 2009
    ..The results are plausible, based on prior studies of circadian abnormalities. As replications have not been attempted uniformly, we evaluated representative, common polymorphisms in all three disorders...
  72. pmc Altered expression of regulators of the cortical chloride transporters NKCC1 and KCC2 in schizophrenia
    Dominique Arion
    Department of Psychiatry, University of Pittsburgh, PA 15213, USA
    Arch Gen Psychiatry 68:21-31. 2011
    ..The activities of these transporters are in turn regulated by a network of serine-threonine kinases that includes OXSR1, STK39, and the WNK kinases WNK1, WNK3, and WNK4...
  73. pmc Postnatal developmental trajectories of neural circuits in the primate prefrontal cortex: identifying sensitive periods for vulnerability to schizophrenia
    Gil D Hoftman
    Medical Scientist Training Program, University of Pittsburgh, Pittsburgh, PA, USA
    Schizophr Bull 37:493-503. 2011
    ....
  74. ncbi request reprint Inhibition and timing in cortical neural circuits
    Guillermo Gonzalez-Burgos
    Am J Psychiatry 164:12. 2007
  75. doi request reprint Dendritic-targeting GABA neurons in monkey prefrontal cortex: comparison of somatostatin- and calretinin-immunoreactive axon terminals
    Darlene S Melchitzky
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Synapse 62:456-65. 2008
    ..19%, respectively). This specialized synaptic circuitry of SST neurons in the primate PFC suggests that the alterations of these neurons in schizophrenia is likely to have distinct functional consequences...
  76. ncbi request reprint Specificity in the functional architecture of primate prefrontal cortex
    David A Lewis
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Neurocytol 31:265-76. 2002
    ....
  77. ncbi request reprint The human precentral sulcus: chemoarchitecture of a region corresponding to the frontal eye fields
    Caterina Rosano
    Graduate School of Public Health, University of Pittsburgh, 130 Bellefield, 519, Pittsburgh, PA, USA
    Brain Res 972:16-30. 2003
    ..These specific chemoarchitectural features may differentiate the location of the human FEF from rostral cortical regions and support the functions for which it is specialized...
  78. ncbi request reprint Reduced pyramidal cell somal volume in auditory association cortex of subjects with schizophrenia
    Robert A Sweet
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Neuropsychopharmacology 28:599-609. 2003
    ..This reduction may contribute to impairment in auditory function. The correlated reductions of somal volume in BA42 and BA9 suggest that a common factor may affect deep layer 3 pyramidal cells in both regions...
  79. ncbi request reprint Gene expression profiling with DNA microarrays: advancing our understanding of psychiatric disorders
    Julie Pongrac
    Neurochem Res 27:1049-63. 2002
    ..Our goal will be to integrate this expression data within the context of the relevant anatomical, biochemical, molecular, imaging and clinical findings...
  80. ncbi request reprint In pursuit of the pathogenesis and pathophysiology of schizophrenia: where do we stand?
    David A Lewis
    Am J Psychiatry 159:1467-9. 2002
  81. pmc Reduced cortical cannabinoid 1 receptor messenger RNA and protein expression in schizophrenia
    Stephen M Eggan
    Department of Psychiatry, University of Pittsburgh, 3811 O Hara St, W1651 BST, Pittsburgh, PA 15213, USA
    Arch Gen Psychiatry 65:772-84. 2008
    ....
  82. pmc Selective reduction by dopamine of excitatory synaptic inputs to pyramidal neurons in primate prefrontal cortex
    Nathaniel N Urban
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA
    J Physiol 539:707-12. 2002
    ..This input specificity may be a critical aspect of the dopaminergic regulation of recurrent excitatory circuits in the PFC...
  83. ncbi request reprint Anatomical evidence of impaired feedforward auditory processing in schizophrenia
    Robert A Sweet
    Department of Psychiatry, University of Pittsburgh, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 61:854-64. 2007
    ....
  84. ncbi request reprint Serotonin1A receptors at the axon initial segment of prefrontal pyramidal neurons in schizophrenia
    Dianne A Cruz
    Department of Psychiatry, University of Pittsburgh, PA 15213, USA
    Am J Psychiatry 161:739-42. 2004
    ....
  85. ncbi request reprint Mitochondrial dysfunction as a cause of axonal degeneration in multiple sclerosis patients
    Ranjan Dutta
    Department of Neurosciences, Lerner Research Institute, Cleveland Clinic Foundation, OH 44195, USA
    Ann Neurol 59:478-89. 2006
    ..Development of neuroprotective therapies will require elucidation of the molecular mechanisms by which neurons and axons degenerate...
  86. ncbi request reprint Primary visual cortex volume and total neuron number are reduced in schizophrenia
    Karl Anton Dorph-Petersen
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Comp Neurol 501:290-301. 2007
    ..Subjects with schizophrenia therefore have a smaller cortical area allocated to primary visual perception. This finding suggests the existence of a schizophrenia-related change in cortical parcellation...
  87. ncbi request reprint Molecular markers distinguishing supragranular and infragranular layers in the human prefrontal cortex
    Dominique Arion
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Eur J Neurosci 25:1843-54. 2007
    ....
  88. ncbi request reprint Neuropathologic correlates of late-onset major depression
    Robert A Sweet
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Neuropsychopharmacology 29:2242-50. 2004
    ..These preliminary findings suggest that AD is the predominant neuropathologic condition in LLMD subjects with dementia. Further assessment of the role of comorbid cerebrovascular disease and comorbid DLB is needed...
  89. pmc Large-scale estimates of cellular origins of mRNAs: enhancing the yield of transcriptome analyses
    Etienne Sibille
    Department of Psychiatry, University of Pittsburgh, PA 15213, USA
    J Neurosci Methods 167:198-206. 2008
    ..As this approach can be applied post hoc, we provide tables of ratios for analysis of existing mouse and human brain datasets...
  90. pmc Effect of chronic antipsychotic exposure on astrocyte and oligodendrocyte numbers in macaque monkeys
    Glenn T Konopaske
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 63:759-65. 2008
    ..Consequently, in this study we sought to determine whether the lower glial cell number was due to fewer oligodendrocytes as opposed to lower numbers of astrocytes...
  91. ncbi request reprint Pyramidal cell size reduction in schizophrenia: evidence for involvement of auditory feedforward circuits
    Robert A Sweet
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Biol Psychiatry 55:1128-37. 2004
    ..To discriminate between involvement of feedforward and feedback circuit components, we examined pyramidal cell somal volume in layer 3 of primary auditory cortex (feedforward) and layer 5 of auditory association cortex (feedback)...
  92. ncbi request reprint Ultrastructural interactions between terminals expressing the norepinephrine transporter and dopamine neurons in the rat and monkey ventral tegmental area
    Lindsay A Liprando
    Departments of Neuroscience and Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    Synapse 52:233-44. 2004
    ..The latter finding agrees with observations in cortical regions and represents the first report of its type in a subcortical structure...
  93. ncbi request reprint Cortical connections of the lateral mediodorsal thalamus in cynomolgus monkeys
    Susan L Erickson
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Comp Neurol 473:107-27. 2004
    ....
  94. pmc Petilla terminology: nomenclature of features of GABAergic interneurons of the cerebral cortex
    Giorgio A Ascoli
    Molecular Neuroscience Department and Center for Neural Informatics, Structures, and Plasticity, Krasnow Institute for Advanced Study, George Mason University, MS2A1, 4400 University Drive, Fairfax, Virginia 22030, USA
    Nat Rev Neurosci 9:557-68. 2008
    ..Consistent adoption will be important for the success of such an initiative, and we also encourage the active involvement of the broader scientific community in the dynamic evolution of this project...

Research Grants19

  1. GABA Neurons and Cortical Circuitry in Schizophrenia
    David Lewis; Fiscal Year: 2007
    ..Together, these studies will provide a comprehensive molecular-and circuit-based accounting of the contribution of abnormalities in GABA neurotransmission to dPFC dysfunction in schizophrenia. ..
  2. Cannabis and Adolescent Brain Development
    David A Lewis; Fiscal Year: 2010
    ..Thus, these studies will provide an explicit test of the biological events and mechanisms that make the adolescent brain especially vulnerable to the effects of cannabis. ..
  3. Cannabis and Adolescent Brain Development
    David Lewis; Fiscal Year: 2009
    ..Thus, these studies will provide an explicit test of the biological events and mechanisms that make the adolescent brain especially vulnerable to the effects of cannabis. ..
  4. Development of Prefrontal Inhibition and Schizophrenia
    David Lewis; Fiscal Year: 2009
    ..abstract_text> ..
  5. CORTICAL CIRCUITRY AND COGNITION IN SCHIZOPHRENIA
    David Lewis; Fiscal Year: 2007
    ..Our extensive interactions enable us to conduct a translational research program in schizophrenia that effectively transfers information from the clinic to the laboratory and back to the clinic in a truly bidirectional fashion. ..
  6. Development of Prefrontal Inhibition and Schizophrenia
    David Lewis; Fiscal Year: 2007
    ..abstract_text> ..
  7. Development of Prefrontal Inhibition and Schizophrenia
    David Lewis; Fiscal Year: 2006
    ..abstract_text> ..
  8. SCHIZOPHRENIA AND PREFRONTAL CORTICAL CIRCUITRY
    David Lewis; Fiscal Year: 2004
    ....
  9. FUNCTIONAL ARCHITECTURE OF PREFRONTAL CORTEX
    David Lewis; Fiscal Year: 2003
    ..The results of these studies will inform our understanding of the normal functional architecture of the primate DLPFC, and will guide the conduct and interpretation of studies of DLPFC circuitry in schizophrenia. ..
  10. FUNCTIONAL ARCHITECTURE OF PREFRONTAL CORTEX
    David Lewis; Fiscal Year: 2002
    ..The results of these studies will inform our understanding of the normal functional architecture of the primate DLPFC, and will guide the conduct and interpretation of studies of DLPFC circuitry in schizophrenia. ..
  11. FUNCTIONAL ARCHITECTURE OF PREFRONTAL CORTEX
    David Lewis; Fiscal Year: 2001
    ..The results of these studies will inform our understanding of the normal functional architecture of the primate DLPFC, and will guide the conduct and interpretation of studies of DLPFC circuitry in schizophrenia. ..
  12. FUNCTIONAL ARCHITECTURE OF PREFRONTAL CORTEX
    David Lewis; Fiscal Year: 2000
    ..The results of these studies will inform our understanding of the normal functional architecture of the primate DLPFC, and will guide the conduct and interpretation of studies of DLPFC circuitry in schizophrenia. ..
  13. Developmental Trajectories in Prefrontal GABA Circuits
    David A Lewis; Fiscal Year: 2010
    ..These studies will delineate sensitive periods during prefrontal cortical development when pharmacological interventions in individuals vulnerable for schizophrenia might have the greatest reward, or risk, potential. ..