D A Lewis

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint GABAergic local circuit neurons and prefrontal cortical dysfunction in schizophrenia
    D A Lewis
    University of Pittsburgh, Departments of Psychiatry and Neuroscience, W1650 BST, 3811 O Hara Street, Pittsburgh, PA, USA
    Brain Res Brain Res Rev 31:270-6. 2000
  2. pmc Parvalbumin-positive basket interneurons in monkey and rat prefrontal cortex
    N V Povysheva
    University of Pittsburgh School of Arts and Sciences, Department of Psychiatry, Langley A210, Pittsburgh, PA 15260, USA
    J Neurophysiol 100:2348-60. 2008
  3. ncbi request reprint Synaptic targets of the intrinsic axon collaterals of supragranular pyramidal neurons in monkey prefrontal cortex
    D S Melchitzky
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Comp Neurol 430:209-21. 2001
  4. ncbi request reprint Dopamine transporter immunoreactivity in monkey cerebral cortex: regional, laminar, and ultrastructural localization
    D A Lewis
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Comp Neurol 432:119-36. 2001
  5. ncbi request reprint Lamina-specific deficits in parvalbumin-immunoreactive varicosities in the prefrontal cortex of subjects with schizophrenia: evidence for fewer projections from the thalamus
    D A Lewis
    Department of Psychiatry, University of Pittsburgh, PA 15213, USA
    Am J Psychiatry 158:1411-22. 2001
  6. ncbi request reprint P/Q-type, but not N-type, calcium channels mediate GABA release from fast-spiking interneurons to pyramidal cells in rat prefrontal cortex
    A V Zaitsev
    Dept of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213 2593, USA
    J Neurophysiol 97:3567-73. 2007
  7. ncbi request reprint Electrophysiological differences between neurogliaform cells from monkey and rat prefrontal cortex
    N V Povysheva
    Department of Psychiatry, University of Pittsburgh School of Medicine, Rm W1651 Biomedical Science Tower, 3811 O Hara Street, Pittsburgh, PA 15213 2593, USA
    J Neurophysiol 97:1030-9. 2007
  8. ncbi request reprint Properties of excitatory synaptic responses in fast-spiking interneurons and pyramidal cells from monkey and rat prefrontal cortex
    N V Povysheva
    Department of Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, PA 15213 2593, USA
    Cereb Cortex 16:541-52. 2006
  9. ncbi request reprint Dopamine innervation of the monkey mediodorsal thalamus: Location of projection neurons and ultrastructural characteristics of axon terminals
    D S Melchitzky
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Neuroscience 143:1021-30. 2006
  10. ncbi request reprint Ultrastructural associations between dopamine terminals and local circuit neurons in the monkey prefrontal cortex: a study of calretinin-immunoreactive cells
    S R Sesack
    Department of Neuroscience, University of Pittsburgh, PA 15260, USA
    Neurosci Lett 200:9-12. 1995

Collaborators

Detail Information

Publications38

  1. ncbi request reprint GABAergic local circuit neurons and prefrontal cortical dysfunction in schizophrenia
    D A Lewis
    University of Pittsburgh, Departments of Psychiatry and Neuroscience, W1650 BST, 3811 O Hara Street, Pittsburgh, PA, USA
    Brain Res Brain Res Rev 31:270-6. 2000
    ..These findings suggest that disturbed GABA neurotransmission in the PFC of schizophrenic subjects may be due to a selective alteration of GAT-1 protein in the axon terminals of chandelier neurons...
  2. pmc Parvalbumin-positive basket interneurons in monkey and rat prefrontal cortex
    N V Povysheva
    University of Pittsburgh School of Arts and Sciences, Department of Psychiatry, Langley A210, Pittsburgh, PA 15260, USA
    J Neurophysiol 100:2348-60. 2008
    ....
  3. ncbi request reprint Synaptic targets of the intrinsic axon collaterals of supragranular pyramidal neurons in monkey prefrontal cortex
    D S Melchitzky
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Comp Neurol 430:209-21. 2001
    ....
  4. ncbi request reprint Dopamine transporter immunoreactivity in monkey cerebral cortex: regional, laminar, and ultrastructural localization
    D A Lewis
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Comp Neurol 432:119-36. 2001
    ..Moreover, this distribution of DAT suggests that cortical DA fibers may permit greater neurotransmitter diffusion than subcortical DA axons...
  5. ncbi request reprint Lamina-specific deficits in parvalbumin-immunoreactive varicosities in the prefrontal cortex of subjects with schizophrenia: evidence for fewer projections from the thalamus
    D A Lewis
    Department of Psychiatry, University of Pittsburgh, PA 15213, USA
    Am J Psychiatry 158:1411-22. 2001
    ..The authors tested the hypothesis that schizophrenia is associated with a selective deficit in a marker of thalamic axon terminals in the middle layers of the prefrontal cortex, the primary zone of termination of thalamic axons...
  6. ncbi request reprint P/Q-type, but not N-type, calcium channels mediate GABA release from fast-spiking interneurons to pyramidal cells in rat prefrontal cortex
    A V Zaitsev
    Dept of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213 2593, USA
    J Neurophysiol 97:3567-73. 2007
    ..5 microM) completely and irreversibly blocked neurotransmission. These results indicate that P/Q-type VGCCs mediate the GABA release from parvalbumin-positive FS interneurons to PCs in the rat neocortex...
  7. ncbi request reprint Electrophysiological differences between neurogliaform cells from monkey and rat prefrontal cortex
    N V Povysheva
    Department of Psychiatry, University of Pittsburgh School of Medicine, Rm W1651 Biomedical Science Tower, 3811 O Hara Street, Pittsburgh, PA 15213 2593, USA
    J Neurophysiol 97:1030-9. 2007
    ..Finally, NGF cells in monkey showed a more prominent spike-frequency adaptation as compared with rat. Our findings indicate that the canonical cortical circuit differs in at least some aspects of its constituent elements across species...
  8. ncbi request reprint Properties of excitatory synaptic responses in fast-spiking interneurons and pyramidal cells from monkey and rat prefrontal cortex
    N V Povysheva
    Department of Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, PA 15213 2593, USA
    Cereb Cortex 16:541-52. 2006
    ..Similar results were obtained in monkey and rat PFC, suggesting a stable role of FS interneurons in this circuitry across species...
  9. ncbi request reprint Dopamine innervation of the monkey mediodorsal thalamus: Location of projection neurons and ultrastructural characteristics of axon terminals
    D S Melchitzky
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Neuroscience 143:1021-30. 2006
    ....
  10. ncbi request reprint Ultrastructural associations between dopamine terminals and local circuit neurons in the monkey prefrontal cortex: a study of calretinin-immunoreactive cells
    S R Sesack
    Department of Neuroscience, University of Pittsburgh, PA 15260, USA
    Neurosci Lett 200:9-12. 1995
    ..These findings suggest that dopamine afferents to the monkey PFC target the subclasses of GABA interneurons that do not contain CalR...
  11. ncbi request reprint Disease-specific changes in regulator of G-protein signaling 4 (RGS4) expression in schizophrenia
    K Mirnics
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Mol Psychiatry 6:293-301. 2001
    ....
  12. ncbi request reprint Dopaminergic modulation of short-term synaptic plasticity in fast-spiking interneurons of primate dorsolateral prefrontal cortex
    G Gonzalez-Burgos
    Department of Psychiatry, University of Pittsburgh, PA 15213, USA
    J Neurophysiol 94:4168-77. 2005
    ..EPSP bursts displaying short-term depression may transmit spike-timing-dependent temporal codes contained in presynaptic spike trains. Thus DA neuromodulation may increase the signal-to-noise ratio at fast-spiking cell inputs...
  13. ncbi request reprint Dopamine innervation of a subclass of local circuit neurons in monkey prefrontal cortex: ultrastructural analysis of tyrosine hydroxylase and parvalbumin immunoreactive structures
    S R Sesack
    Department of Neuroscience, University of Pittsburgh, PA 15260, USA
    Cereb Cortex 8:614-22. 1998
    ....
  14. ncbi request reprint Intrinsic excitatory connections in the prefrontal cortex and the pathophysiology of schizophrenia
    D A Lewis
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Brain Res Bull 52:309-17. 2000
    ....
  15. pmc Alterations in GABA-related transcriptome in the dorsolateral prefrontal cortex of subjects with schizophrenia
    T Hashimoto
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Mol Psychiatry 13:147-61. 2008
    ..In concert with previous findings, these data suggest that working memory dysfunction in schizophrenia is mediated by altered GABA neurotransmission in certain DLPFC microcircuits...
  16. ncbi request reprint Dopamine transporter-immunoreactive axons in the mediodorsal thalamic nucleus of the macaque monkey
    D S Melchitzky
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Neuroscience 103:1033-42. 2001
    ..This dopamine innervation of the mediodorsal thalamic nucleus reveals another possible anatomical substrate through which dopamine may influence the cognitive functions mediated by thalamo-prefrontal circuitry...
  17. ncbi request reprint Synaptic targets of calretinin-containing axon terminals in macaque monkey prefrontal cortex
    D S Melchitzky
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Neuroscience 130:185-95. 2005
    ....
  18. ncbi request reprint Decreased somal size of deep layer 3 pyramidal neurons in the prefrontal cortex of subjects with schizophrenia
    J N Pierri
    Department of Psychiatry, University of Pittsburgh, 3811 O'Hara St, W1650 BST, Pittsburgh PA 15213, USA
    Arch Gen Psychiatry 58:466-73. 2001
    ....
  19. pmc Relationship of cannabinoid CB1 receptor and cholecystokinin immunoreactivity in monkey dorsolateral prefrontal cortex
    S M Eggan
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Neuroscience 169:1651-61. 2010
    ..These axons target the perisomatic region of pyramidal neurons, providing a potential anatomical substrate for the impaired function of the DLPFC associated with cannabis use and schizophrenia...
  20. ncbi request reprint DNA pooling: a comprehensive, multi-stage association analysis of ACSL6 and SIRT5 polymorphisms in schizophrenia
    K V Chowdari
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Genes Brain Behav 6:229-39. 2007
    ..This strategy may be particularly useful for research groups lacking access to high throughput genotyping facilities. Our analyses did not yield convincing evidence for associations of schizophrenia with ACSL6 or SIRT5...
  21. ncbi request reprint Localization of calcium-binding proteins in physiologically and morphologically characterized interneurons of monkey dorsolateral prefrontal cortex
    A V Zaitsev
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Cereb Cortex 15:1178-86. 2005
    ..These findings may help to illuminate the functional roles of different groups of interneurons in primate PFC circuitry...
  22. ncbi request reprint Dopamine modulation of neuronal function in the monkey prefrontal cortex
    G Gonzalez-Burgos
    Department of Neuroscience, University of Pittsburgh, 15260, Pittsburgh, PA, USA
    Physiol Behav 77:537-43. 2002
    ....
  23. ncbi request reprint Analysis of complex brain disorders with gene expression microarrays: schizophrenia as a disease of the synapse
    K Mirnics
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Trends Neurosci 24:479-86. 2001
    ....
  24. ncbi request reprint Regional specificity of chandelier neuron axon terminal alterations in schizophrenia
    G T Konopaske
    Department of Psychiatry, University of Pittsburgh, PA 15213, USA
    Neuroscience 138:189-96. 2006
    ..The goal of this study was to determine if reductions in the density of GABA membrane transporter-1-immunoreactive cartridges in schizophrenia are restricted to the prefrontal cortex...
  25. ncbi request reprint Alterations of striatal dopamine receptor binding in Alzheimer disease are associated with Lewy body pathology and antemortem psychosis
    R A Sweet
    University of Pittsburgh, Division of Geriatrics and Neuropsychiatry, Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Arch Neurol 58:466-72. 2001
    ..Lewy bodies (LB) are present in at least 20% to 30% of persons with Alzheimer disease (AD) and contribute to the risk of psychosis and to excess cognitive burden...
  26. pmc Molecular evidence for BDNF- and GABA-related dysfunctions in the amygdala of female subjects with major depression
    J P Guilloux
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15312, USA
    Mol Psychiatry 17:1130-42. 2012
    ....
  27. ncbi request reprint Molecular mechanisms contributing to dendritic spine alterations in the prefrontal cortex of subjects with schizophrenia
    J J Hill
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Mol Psychiatry 11:557-66. 2006
    ..In conclusion, reduced expression of Cdc42 and Duo mRNAs may represent molecular mechanisms that contribute to the decreased density of dendritic spines in the DLPFC of subjects with schizophrenia...
  28. ncbi request reprint Subcortical afferents to the lateral mediodorsal thalamus in cynomolgus monkeys
    S L Erickson
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Neuroscience 129:675-90. 2004
    ....
  29. ncbi request reprint Genetic polymorphisms of the RGS4 and dorsolateral prefrontal cortex morphometry among first episode schizophrenia patients
    K M R Prasad
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Mol Psychiatry 10:213-9. 2005
    ..The findings suggest that RGS4 polymorphisms may contribute to structural alterations in the DLPFC...
  30. pmc Altered parvalbumin basket cell inputs in the dorsolateral prefrontal cortex of schizophrenia subjects
    J R Glausier
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Mol Psychiatry 19:30-6. 2014
    ..In concert with prior reports, these findings indicate that PVBC dysfunction in schizophrenia reflects molecular and not structural alterations in these cells and their axon terminals. ..
  31. pmc Acquisition and baseline performance of working memory tasks by adolescent rhesus monkeys
    C D Verrico
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Brain Res 1378:91-104. 2011
    ..As such, this approach should be useful for assessing the influence of environmental risk factors on the protracted maturation of working memory in adolescent macaques...
  32. ncbi request reprint Dendritic morphology of callosal and ipsilateral projection neurons in monkey prefrontal cortex
    A S Soloway
    Department of Psychiatry, University of Pittsburgh, PA 15213, USA
    Neuroscience 109:461-71. 2002
    ....
  33. ncbi request reprint Localized decrease in serotonin transporter-immunoreactive axons in the prefrontal cortex of depressed subjects committing suicide
    M C Austin
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, W1645 Biomedical Science Tower, Pittsburgh, PA 15213, USA
    Neuroscience 114:807-15. 2002
    ....
  34. ncbi request reprint Molecular characterization of schizophrenia viewed by microarray analysis of gene expression in prefrontal cortex
    K Mirnics
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pennsylvania 15261, USA
    Neuron 28:53-67. 2000
    ..The combined data suggest that subjects with schizophrenia share a common abnormality in presynaptic function. We set forth a predictive, testable model...
  35. ncbi request reprint DNA microarray profiling of developing PS1-deficient mouse brain reveals complex and coregulated expression changes
    Z K Mirnics
    Department of Pediatrics and Neurology, University of Pittsburgh, School of Medicine, Children s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA
    Mol Psychiatry 8:863-78. 2003
    ....
  36. ncbi request reprint Specificity and timing of neocortical transcriptome changes in response to BDNF gene ablation during embryogenesis or adulthood
    C Glorioso
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15261, USA
    Mol Psychiatry 11:633-48. 2006
    ..These BDNF-dependent gene expression changes may illuminate the biological basis for transcriptome changes observed in certain human brain disorders...
  37. ncbi request reprint Prevention of ventilator-induced lung injury with partial liquid ventilation
    D A Lewis
    Department of Surgery and Pathology at the University of Michigan Medical Center, Ann Arbor, MI, USA
    J Pediatr Surg 36:1333-6. 2001
    ..024) and VT versus VT-PLV (P =.014). CONCLUSION: (125)I-BSA leak produced during high-pressure or high-volume mechanical ventilation is reduced by partial liquid ventilation...
  38. pmc Identification of the znuA-encoded periplasmic zinc transport protein of Haemophilus ducreyi
    D A Lewis
    Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9048, USA
    Infect Immun 67:5060-8. 1999
    ..0001) when tested in the temperature-dependent rabbit model for experimental chancroid. This decreased virulence was not observed when the znuA mutant was complemented with the wild-type H. ducreyi znuA gene provided in trans...