Brian C Lewis

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. pmc The c-myc and PyMT oncogenes induce different tumor types in a somatic mouse model for pancreatic cancer
    Brian C Lewis
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Genes Dev 17:3127-38. 2003
  2. pmc Trp53 deletion stimulates the formation of metastatic pancreatic tumors
    Jennifer P Morton
    University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    Am J Pathol 172:1081-7. 2008
  3. ncbi request reprint Development of the pancreas and pancreatic cancer
    Brian C Lewis
    Program in Gene Function and Expression, University of Massachusetts Medical School, 364 Plantation Street, LRB 521, Worcester, MA 01605 USA
    Endocrinol Metab Clin North Am 35:397-404, xi. 2006
  4. pmc The absence of p53 promotes metastasis in a novel somatic mouse model for hepatocellular carcinoma
    Brian C Lewis
    University of Massachusetts Medical School, 364 Plantation St, LRB 521, Worcester, MA 01605, USA
    Mol Cell Biol 25:1228-37. 2005
  5. pmc TRIB2 acts downstream of Wnt/TCF in liver cancer cells to regulate YAP and C/EBPα function
    Jiayi Wang
    Department of Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Mol Cell 51:211-25. 2013
  6. pmc p19Arf inhibits the invasion of hepatocellular carcinoma cells by binding to C-terminal binding protein
    Ya Wen Chen
    Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Cancer Res 68:476-82. 2008
  7. pmc Differential roles of insulin-like growth factor receptor- and insulin receptor-mediated signaling in the phenotypes of hepatocellular carcinoma cells
    Ya Wen Chen
    Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Neoplasia 11:835-45. 2009
  8. pmc Loss of p53 and Ink4a/Arf cooperate in a cell autonomous fashion to induce metastasis of hepatocellular carcinoma cells
    Ya Wen Chen
    Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Cancer Res 67:7589-96. 2007
  9. pmc Specific requirement of Gli transcription factors in Hedgehog-mediated intestinal development
    He Huang
    Department of Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Biol Chem 288:17589-96. 2013
  10. pmc Assessing tumor progression factors by somatic gene transfer into a mouse model: Bcl-xL promotes islet tumor cell invasion
    Yi Chieh Nancy Du
    Program in Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    PLoS Biol 5:e276. 2007

Collaborators

Detail Information

Publications18

  1. pmc The c-myc and PyMT oncogenes induce different tumor types in a somatic mouse model for pancreatic cancer
    Brian C Lewis
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Genes Dev 17:3127-38. 2003
    ..Our model appears to be useful for elucidating the genetic alterations, target cells, and signaling pathways that are important in the genesis of different types of pancreatic cancer...
  2. pmc Trp53 deletion stimulates the formation of metastatic pancreatic tumors
    Jennifer P Morton
    University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    Am J Pathol 172:1081-7. 2008
    ....
  3. ncbi request reprint Development of the pancreas and pancreatic cancer
    Brian C Lewis
    Program in Gene Function and Expression, University of Massachusetts Medical School, 364 Plantation Street, LRB 521, Worcester, MA 01605 USA
    Endocrinol Metab Clin North Am 35:397-404, xi. 2006
    ..These findings indicate that developmentally regulated gene expression programs are important in the pathogenesis of pancreatic cancer...
  4. pmc The absence of p53 promotes metastasis in a novel somatic mouse model for hepatocellular carcinoma
    Brian C Lewis
    University of Massachusetts Medical School, 364 Plantation St, LRB 521, Worcester, MA 01605, USA
    Mol Cell Biol 25:1228-37. 2005
    ..Tumors induced in p53 null, TVA transgenic mice by PyMT mutants with changes in specific tyrosine residues fail to form metastases, indicating that metastasis is dependent on both the oncogene and the absence of p53...
  5. pmc TRIB2 acts downstream of Wnt/TCF in liver cancer cells to regulate YAP and C/EBPα function
    Jiayi Wang
    Department of Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Mol Cell 51:211-25. 2013
    ....
  6. pmc p19Arf inhibits the invasion of hepatocellular carcinoma cells by binding to C-terminal binding protein
    Ya Wen Chen
    Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Cancer Res 68:476-82. 2008
    ..Thus, our data indicate a novel role for the Arf tumor suppressor protein in regulating phenotypes associated with tumor progression and metastasis in HCC cells...
  7. pmc Differential roles of insulin-like growth factor receptor- and insulin receptor-mediated signaling in the phenotypes of hepatocellular carcinoma cells
    Ya Wen Chen
    Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Neoplasia 11:835-45. 2009
    ..Finally, we identify matrix metalloproteinase 2 as a mediator of the invasive phenotype downstream of IGF1R-induced signaling. Thus, our studies demonstrate the importance of IGF2-induced signaling in the dissemination of HCC cells...
  8. pmc Loss of p53 and Ink4a/Arf cooperate in a cell autonomous fashion to induce metastasis of hepatocellular carcinoma cells
    Ya Wen Chen
    Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Cancer Res 67:7589-96. 2007
    ..Thus, our data illustrate a new model system amenable for the analysis of HCC metastasis...
  9. pmc Specific requirement of Gli transcription factors in Hedgehog-mediated intestinal development
    He Huang
    Department of Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Biol Chem 288:17589-96. 2013
    ..Taken together, our study reveals, for the first time, the distinct roles of Gli proteins in intestine development and suggests SLRPs as novel regulators of smooth muscle cell differentiation...
  10. pmc Assessing tumor progression factors by somatic gene transfer into a mouse model: Bcl-xL promotes islet tumor cell invasion
    Yi Chieh Nancy Du
    Program in Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    PLoS Biol 5:e276. 2007
    ..In addition, myosin Va was identified as a novel Bcl-xL-interacting protein that might mediate the effects of Bcl-xL on tumor cell migration and invasion...
  11. pmc The activity of Gli transcription factors is essential for Kras-induced pancreatic tumorigenesis
    Mihir Rajurkar
    Department of Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Proc Natl Acad Sci U S A 109:E1038-47. 2012
    ....
  12. pmc Activated wnt signaling in stroma contributes to development of pancreatic mucinous cystic neoplasms
    Makoto Sano
    Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, Massachusetts Division of Pathology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan Electronic address
    Gastroenterology 146:257-67. 2014
    ..We investigated the involvement of Wnt signaling in KRAS-mediated pancreatic tumorigenesis and development of MCN in mice, and Wnt activation in human MCN samples...
  13. ncbi request reprint Shh signaling and pancreatic cancer: implications for therapy?
    Jennifer P Morton
    Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Cell Cycle 6:1553-7. 2007
    ..Here we discuss the significance of these findings and the implications for therapy...
  14. pmc Sonic hedgehog acts at multiple stages during pancreatic tumorigenesis
    Jennifer P Morton
    Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Proc Natl Acad Sci U S A 104:5103-8. 2007
    ..Collectively, our findings demonstrate crucial roles for Shh signaling in multiple stages of pancreatic carcinogenesis...
  15. ncbi request reprint The alternative reading frame tumor suppressor antagonizes hypoxia-induced cancer cell migration via interaction with the COOH-terminal binding protein corepressor
    Seema Paliwal
    Department of Cancer Biology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    Cancer Res 67:9322-9. 2007
    ..Thus, ARF can suppress cell migration by antagonizing CtBP2 and the phosphatidylinositol 3-kinase pathway, and these data may explain the increased aggressiveness of ARF-null tumors in mouse models...
  16. pmc Functional activity of RLIM/Rnf12 is regulated by phosphorylation-dependent nucleocytoplasmic shuttling
    Baowei Jiao
    Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, MA 01605 2324 Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605 2324 Centre for Molecular Neurobiology, University Medical Center Hamburg Eppendorf, 20246 Hamburg, Germany Institute for Tumor Biology, University Medical Center Hamburg Eppendorf, 20246 Hamburg, Germany
    Mol Biol Cell 24:3085-96. 2013
    ..Thus regulated nucleocytoplasmic shuttling of RLIM/Rnf12 coordinates cellular compartments during mammary alveolar cell survival. ..
  17. pmc p16 Stimulates CDC42-dependent migration of hepatocellular carcinoma cells
    Ya Wen Chen
    National Institute of Cancer Research, National Health Research Institutes, Miaoli, Taiwan
    PLoS ONE 8:e69389. 2013
    ..Our results demonstrate for the first time a pro-migratory role for p16, and suggest a potential mechanism for the observed association between cytoplasmic p16 and tumor progression in diverse tumor types. ..
  18. pmc KRAS(G12D)- and BRAF(V600E)-induced transformation of murine pancreatic epithelial cells requires MEK/ERK-stimulated IGF1R signaling
    Victoria A Appleman
    Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Mol Cancer Res 10:1228-39. 2012
    ....

Research Grants12

  1. Molecular mediators of metastasis in hepatocellular carcinoma
    Brian Lewis; Fiscal Year: 2006
    ....
  2. Molecular dissection of pancreatic ductal adenocarcinoma
    Brian Lewis; Fiscal Year: 2009
    ..Such gene expression signatures may potentially be used as diagnostic tools, as well as surrogate markers for response to targeted therapeutic interventions. ..
  3. Molecular dissection of pancreatic ductal adenocarcinoma
    Brian C Lewis; Fiscal Year: 2010
    ..Such gene expression signatures may potentially be used as diagnostic tools, as well as surrogate markers for response to targeted therapeutic interventions. ..
  4. Molecular mediators of metastasis in hepatocellular carcinoma
    Brian C Lewis; Fiscal Year: 2010
    ..abstract_text> ..
  5. Molecular dissection of pancreatic ductal adenocarcinoma
    Brian Lewis; Fiscal Year: 2009
    ..Such gene expression signatures may potentially be used as diagnostic tools, as well as surrogate markers for response to targeted therapeutic interventions. ..
  6. Molecular mediators of metastasis in hepatocellular carcinoma
    Brian Lewis; Fiscal Year: 2009
    ..abstract_text> ..
  7. Molecular dissection of pancreatic ductal adenocarcinoma
    Brian Lewis; Fiscal Year: 2007
    ..Such gene expression signatures may potentially be used as diagnostic tools, as well as surrogate markers for response to targeted therapeutic interventions. ..
  8. A flexible somatic and sporadic mouse model for pancreatic ductal adenocarcinoma
    Brian Lewis; Fiscal Year: 2007
    ..Such an advance would benefit public health by reducing the mortality associated with this disease. ..
  9. Molecular mediators of metastasis in hepatocellular carcinoma
    Brian Lewis; Fiscal Year: 2007
    ....
  10. Molecular dissection of pancreatic ductal adenocarcinoma
    Brian C Lewis; Fiscal Year: 2010
    ..Such gene expression signatures may potentially be used as diagnostic tools, as well as surrogate markers for response to targeted therapeutic interventions. ..