Brian C Lewis
Affiliation: University of Massachusetts Medical School
Sano M, Driscoll D, De Jesus Monge W, Klimstra D, Lewis B. Activated wnt signaling in stroma contributes to development of pancreatic mucinous cystic neoplasms. Gastroenterology. 2014;146:257-67 pubmed publisher
..Based on studies of mice and pancreatic MCN samples from patients, the canonical Wnt signaling pathway becomes activated and promotes development of the ovarian-like stroma to contribute to formation of MCNs. ..
Lewis B, Klimstra D, Socci N, Xu S, Koutcher J, Varmus H. The absence of p53 promotes metastasis in a novel somatic mouse model for hepatocellular carcinoma. Mol Cell Biol. 2005;25:1228-37 pubmed
..Tumors induced in p53 null, TVA transgenic mice by PyMT mutants with changes in specific tyrosine residues fail to form metastases, indicating that metastasis is dependent on both the oncogene and the absence of p53. ..
Lewis B, Klimstra D, Varmus H. The c-myc and PyMT oncogenes induce different tumor types in a somatic mouse model for pancreatic cancer. Genes Dev. 2003;17:3127-38 pubmed
..Our model appears to be useful for elucidating the genetic alterations, target cells, and signaling pathways that are important in the genesis of different types of pancreatic cancer...
Morton J, Klimstra D, Mongeau M, Lewis B. Trp53 deletion stimulates the formation of metastatic pancreatic tumors. Am J Pathol. 2008;172:1081-7 pubmed publisher
Sano M, Driscoll D, DeJesus Monge W, Quattrochi B, Appleman V, Ou J, et al
. Activation of WNT/?-Catenin Signaling Enhances Pancreatic Cancer Development and the Malignant Potential Via Up-regulation of Cyr61. Neoplasia. 2016;18:785-794 pubmed publisher
..Together, these data suggest that the WNT/?-catenin signaling pathway enhances pancreatic cancer development and malignancy in part via up-regulation of CYR61. ..