Research Topics
Genomes and Genes | Brian C LewisSummaryAffiliation: University of Massachusetts Medical School Country: USA Publications
Research Grants
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Publications
The c-myc and PyMT oncogenes induce different tumor types in a somatic mouse model for pancreatic cancerBrian C Lewis
Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Genes Dev 17:3127-38. 2003..Our model appears to be useful for elucidating the genetic alterations, target cells, and signaling pathways that are important in the genesis of different types of pancreatic cancer...- The absence of p53 promotes metastasis in a novel somatic mouse model for hepatocellular carcinomaBrian C Lewis
University of Massachusetts Medical School, 364 Plantation St, LRB 521, Worcester, MA 01605, USA
Mol Cell Biol 25:1228-37. 2005..Tumors induced in p53 null, TVA transgenic mice by PyMT mutants with changes in specific tyrosine residues fail to form metastases, indicating that metastasis is dependent on both the oncogene and the absence of p53... 
Development of the pancreas and pancreatic cancerBrian C Lewis
Program in Gene Function and Expression, University of Massachusetts Medical School, 364 Plantation Street, LRB 521, Worcester, MA 01605 USA
Endocrinol Metab Clin North Am 35:397-404, xi. 2006..These findings indicate that developmentally regulated gene expression programs are important in the pathogenesis of pancreatic cancer...- Trp53 deletion stimulates the formation of metastatic pancreatic tumorsJennifer P Morton
University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
Am J Pathol 172:1081-7. 2008.... - p19Arf inhibits the invasion of hepatocellular carcinoma cells by binding to C-terminal binding proteinYa Wen Chen
Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Cancer Res 68:476-82. 2008..Thus, our data indicate a novel role for the Arf tumor suppressor protein in regulating phenotypes associated with tumor progression and metastasis in HCC cells... - Differential roles of insulin-like growth factor receptor- and insulin receptor-mediated signaling in the phenotypes of hepatocellular carcinoma cellsYa Wen Chen
Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, MA 01605, USA
Neoplasia 11:835-45. 2009..Finally, we identify matrix metalloproteinase 2 as a mediator of the invasive phenotype downstream of IGF1R-induced signaling. Thus, our studies demonstrate the importance of IGF2-induced signaling in the dissemination of HCC cells... - Loss of p53 and Ink4a/Arf cooperate in a cell autonomous fashion to induce metastasis of hepatocellular carcinoma cellsYa Wen Chen
Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Cancer Res 67:7589-96. 2007..Thus, our data illustrate a new model system amenable for the analysis of HCC metastasis... 
Assessing tumor progression factors by somatic gene transfer into a mouse model: Bcl-xL promotes islet tumor cell invasionYi Chieh Nancy Du
Program in Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, New York, USA
PLoS Biol 5:e276. 2007..In addition, myosin Va was identified as a novel Bcl-xL-interacting protein that might mediate the effects of Bcl-xL on tumor cell migration and invasion...- The activity of Gli transcription factors is essential for Kras-induced pancreatic tumorigenesisMihir Rajurkar
Department of Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA
Proc Natl Acad Sci U S A 109:E1038-47. 2012.... - The alternative reading frame tumor suppressor antagonizes hypoxia-induced cancer cell migration via interaction with the COOH-terminal binding protein corepressorSeema Paliwal
Department of Cancer Biology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
Cancer Res 67:9322-9. 2007..Thus, ARF can suppress cell migration by antagonizing CtBP2 and the phosphatidylinositol 3-kinase pathway, and these data may explain the increased aggressiveness of ARF-null tumors in mouse models... - Shh signaling and pancreatic cancer: implications for therapy?Jennifer P Morton
Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, Massachusetts, USA
Cell Cycle 6:1553-7. 2007..Here we discuss the significance of these findings and the implications for therapy... - Sonic hedgehog acts at multiple stages during pancreatic tumorigenesisJennifer P Morton
Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, MA 01605, USA
Proc Natl Acad Sci U S A 104:5103-8. 2007..Collectively, our findings demonstrate crucial roles for Shh signaling in multiple stages of pancreatic carcinogenesis... - KRAS(G12D)- and BRAF(V600E)-induced transformation of murine pancreatic epithelial cells requires MEK/ERK-stimulated IGF1R signalingVictoria A Appleman
Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, MA 01605, USA
Mol Cancer Res 10:1228-39. 2012....
Research Grants
- Molecular dissection of pancreatic ductal adenocarcinomaBrian Lewis; Fiscal Year: 2009..Such gene expression signatures may potentially be used as diagnostic tools, as well as surrogate markers for response to targeted therapeutic interventions. ..
- Molecular dissection of pancreatic ductal adenocarcinomaBrian C Lewis; Fiscal Year: 2010..Such gene expression signatures may potentially be used as diagnostic tools, as well as surrogate markers for response to targeted therapeutic interventions. ..
- Molecular mediators of metastasis in hepatocellular carcinomaBrian C Lewis; Fiscal Year: 2010..abstract_text> ..
- Molecular dissection of pancreatic ductal adenocarcinomaBrian Lewis; Fiscal Year: 2009..Such gene expression signatures may potentially be used as diagnostic tools, as well as surrogate markers for response to targeted therapeutic interventions. ..
- Molecular mediators of metastasis in hepatocellular carcinomaBrian Lewis; Fiscal Year: 2009..abstract_text> ..
- A flexible somatic and sporadic mouse model for pancreatic ductal adenocarcinomaBrian Lewis; Fiscal Year: 2007..Such an advance would benefit public health by reducing the mortality associated with this disease. ..
- Molecular mediators of metastasis in hepatocellular carcinomaBrian Lewis; Fiscal Year: 2007....
- Molecular dissection of pancreatic ductal adenocarcinomaBrian C Lewis; Fiscal Year: 2010..Such gene expression signatures may potentially be used as diagnostic tools, as well as surrogate markers for response to targeted therapeutic interventions. ..