W C Levy

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi The Seattle Heart Failure Model: prediction of survival in heart failure
    Wayne C Levy
    University of Washington, Seattle, WA 98177, USA
    Circulation 113:1424-33. 2006
  2. ncbi Early patency of the infarct-related artery after myocardial infarction preserves diastolic filling
    W C Levy
    University of Washington, Seattle, USA
    Am J Cardiol 87:955-8; A3. 2001
  3. ncbi Maximizing survival benefit with primary prevention implantable cardioverter-defibrillator therapy in a heart failure population
    Wayne C Levy
    Division of Cardiology, University of Washington, Box 356422, 1959 NE Pacific St, Seattle, WA 98195, USA
    Circulation 120:835-42. 2009
  4. ncbi Can the Seattle heart failure model be used to risk-stratify heart failure patients for potential left ventricular assist device therapy?
    Wayne C Levy
    University of Washington, Seattle, 98177, USA
    J Heart Lung Transplant 28:231-6. 2009
  5. ncbi Years-needed-to-treat to add 1 year of life: a new metric to estimate treatment effects in randomized trials
    Wayne C Levy
    Division of Cardiology, University of Washington, Box 356422, 1959 NE Pacific Street, Seattle, WA 98177, USA
    Eur J Heart Fail 11:256-63. 2009
  6. ncbi Prediction of mortality in patients with heart failure and systolic dysfunction
    Wayne C Levy
    University of Washington, Division of Cardiology, Box 356422, 1959 NE Pacific Street, Seattle, WA 98195, USA
    Curr Cardiol Rep 10:198-205. 2008
  7. ncbi Usefulness of relative lymphocyte count as an independent predictor of death/urgent transplant in heart failure
    Kier V Huehnergarth
    Department of Internal Medicine, University of Washington, Seattle, Washington 98195, USA
    Am J Cardiol 95:1492-5. 2005
  8. ncbi Summary health status measures in advanced heart failure: relationship to clinical variables and outcome
    Mark D Sullivan
    Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98195, USA
    J Card Fail 13:560-8. 2007
  9. ncbi Anemia predicts mortality in severe heart failure: the prospective randomized amlodipine survival evaluation (PRAISE)
    Dariush Mozaffarian
    Veterans Affairs Puget Sound Health Care System, 1660 South Columbian Way, MS 152, Seattle, WA 98108, USA
    J Am Coll Cardiol 41:1933-9. 2003
  10. ncbi Evaluating the ROC performance of markers for future events
    Margaret S Pepe
    Biostatistics and Biomathematics, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, M2 B500, Seattle, WA 98109, USA
    Lifetime Data Anal 14:86-113. 2008

Detail Information

Publications38

  1. ncbi The Seattle Heart Failure Model: prediction of survival in heart failure
    Wayne C Levy
    University of Washington, Seattle, WA 98177, USA
    Circulation 113:1424-33. 2006
    ....
  2. ncbi Early patency of the infarct-related artery after myocardial infarction preserves diastolic filling
    W C Levy
    University of Washington, Seattle, USA
    Am J Cardiol 87:955-8; A3. 2001
    ..Improved diastolic function may in part explain part of the long-term benefits of a patent IRA after thrombolytic therapy when there is no documented improvement in the ejection fraction...
  3. ncbi Maximizing survival benefit with primary prevention implantable cardioverter-defibrillator therapy in a heart failure population
    Wayne C Levy
    Division of Cardiology, University of Washington, Box 356422, 1959 NE Pacific St, Seattle, WA 98195, USA
    Circulation 120:835-42. 2009
    ..Although implantable cardioverter-defibrillator (ICD) therapy reduces mortality in moderately symptomatic heart failure patients with an ejection fraction <or=35%, many such patients do not require ICD shocks over long-term follow-up...
  4. ncbi Can the Seattle heart failure model be used to risk-stratify heart failure patients for potential left ventricular assist device therapy?
    Wayne C Levy
    University of Washington, Seattle, 98177, USA
    J Heart Lung Transplant 28:231-6. 2009
    ..The purpose of this analysis was to determine whether the Seattle Heart Failure Model (SHFM) can be used to risk-stratify heart failure patients for potential LVAD therapy...
  5. ncbi Years-needed-to-treat to add 1 year of life: a new metric to estimate treatment effects in randomized trials
    Wayne C Levy
    Division of Cardiology, University of Washington, Box 356422, 1959 NE Pacific Street, Seattle, WA 98177, USA
    Eur J Heart Fail 11:256-63. 2009
    ..However, in-trial survival benefits typically do not reverse until long after trial-end, so that NNT will substantially underestimate lifetime benefits...
  6. ncbi Prediction of mortality in patients with heart failure and systolic dysfunction
    Wayne C Levy
    University of Washington, Division of Cardiology, Box 356422, 1959 NE Pacific Street, Seattle, WA 98195, USA
    Curr Cardiol Rep 10:198-205. 2008
    ..We discuss systolic heart failure risk models to estimate short- (30-day to 1-year) and longer-term (1- to 5-year) mortality in hospitalized and ambulatory heart failure patients...
  7. ncbi Usefulness of relative lymphocyte count as an independent predictor of death/urgent transplant in heart failure
    Kier V Huehnergarth
    Department of Internal Medicine, University of Washington, Seattle, Washington 98195, USA
    Am J Cardiol 95:1492-5. 2005
    ..There was only a borderline inverse association with cortisol levels during evening hours...
  8. ncbi Summary health status measures in advanced heart failure: relationship to clinical variables and outcome
    Mark D Sullivan
    Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98195, USA
    J Card Fail 13:560-8. 2007
    ..Patient-centered health status measures are important because they capture the patient's perspective on their heart failure, but it is unclear which of these have independent prognostic significance...
  9. ncbi Anemia predicts mortality in severe heart failure: the prospective randomized amlodipine survival evaluation (PRAISE)
    Dariush Mozaffarian
    Veterans Affairs Puget Sound Health Care System, 1660 South Columbian Way, MS 152, Seattle, WA 98108, USA
    J Am Coll Cardiol 41:1933-9. 2003
    ..Our aim was to examine the relationships between serum hematocrit (Hct) and risk of all-cause mortality among patients with severe heart failure (HF)...
  10. ncbi Evaluating the ROC performance of markers for future events
    Margaret S Pepe
    Biostatistics and Biomathematics, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, M2 B500, Seattle, WA 98109, USA
    Lifetime Data Anal 14:86-113. 2008
    ..Applications to two datasets are presented...
  11. ncbi Predictive value of the Seattle Heart Failure Model in patients undergoing left ventricular assist device placement
    Eric S Ketchum
    Division of Cardiology, University of Washington, Seattle, Washington 98177, USA
    J Heart Lung Transplant 29:1021-5. 2010
    ..Left ventricular assist devices (LVADs) are increasingly used in advanced heart failure patients. Despite proven efficacy, optimal timing of LVAD implantation is not well defined...
  12. ncbi Lack of depression effect on platelet activation in patients with heart failure
    Jagoda Pasic
    Department of Psychiatry and Behavioral Sciences, University of Washington, Harborview Medical Center, 325 Ninth Avenue, Box 350896, Seattle, WA 98104 2499, USA
    Psychiatry Res 129:289-92. 2004
    ..Our data show no group differences in P-selectin values, which suggests that comorbid depression has no additive effect on platelet activation in CHF patient...
  13. ncbi Usefulness of depression to predict time to combined end point of transplant or death for outpatients with advanced heart failure
    Mark D Sullivan
    Department of Psychiatry and Behavioral Sciences, Kaiser Permanente Medical Care Program, Oakland California, USA
    Am J Cardiol 94:1577-80. 2004
    ..24 to 4.68). Depressed patients also had more heart failure related hospitalizations (1.5 +/- 1.8 vs 0.6 +/- 1.4, p = 0.04) and clinic visits (2.4 +/- 1.7 vs 1.7 +/- 1.8, p = 0.04) over the first year of follow-up...
  14. ncbi Drifting in a shrinking future: living with advanced heart failure
    Cynthia M Dougherty
    Biobehavioral Nursing and Health Systems, University of Washington School of Nursing, Seattle, WA 98195, USA
    J Cardiovasc Nurs 22:480-7. 2007
    ..Patients with advanced heart failure (HF) have an uncertain prognosis and low rates of advance care planning and hospice use. The purpose of this study was to describe how patients view and plan for their future...
  15. ncbi Confirmation of Chagas' cardiomyopathy following heart transplantation
    Binh An P Phan
    Division of Cardiology, Department of Medicine, University of Washington, 1914 N 34th Street, Suite 105, Seattle, WA 98103, USA
    Heart Vessels 21:325-7. 2006
    ..We review the epidemiology, cardiac pathology, and evaluation of patients with Chagas' cardiac disease. We discuss the clinical features of Chagas' cardiomyopathy and available treatments including cardiac transplantation...
  16. ncbi Evidence for pre- to postsynaptic mismatch of the cardiac sympathetic nervous system in ischemic congestive heart failure
    James H Caldwell
    Division of Cardiology, Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    J Nucl Med 49:234-41. 2008
    ..Pre- and postsynaptic cardiac sympathetic function is altered in ischemic congestive heart failure (CHF). Whether there is a presynaptic-to-postsynaptic mismatch or whether mismatch is related to adverse cardiac events is unknown...
  17. ncbi Effects of aging on cardiovascular responses to parasympathetic withdrawal
    John R Stratton
    Division of Cardiology, University of Washington, Seattle, WA 98108, USA
    J Am Coll Cardiol 41:2077-83. 2003
    ..The study was done to determine whether the effects of parasympathetic withdrawal on heart rate, blood pressure (BP), and systolic and diastolic function are altered with normal aging...
  18. ncbi Cytokines in depression and heart failure
    Jagoda Pasic
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, USA
    Psychosom Med 65:181-93. 2003
    ..Currently there are no proposed neurobiological or neuroimmune mechanisms for the comorbidity of heart failure and depression...
  19. ncbi In patients with heart failure elevated soluble TNF-receptor 1 is associated with higher risk of depression
    Alec J Moorman
    Department of Internal Medicine, Division of Cardiology, University of Washington, Seattle, Washington, USA
    J Card Fail 13:738-43. 2007
    ..In this cross-sectional study, we investigated whether systemic inflammation, as assessed by circulating levels of inflammatory cytokines, was associated with comorbid depression in patients with heart failure...
  20. ncbi Biomechanical efficiency is decreased in heart failure during low-level steady state and maximal ramp exercise
    Wayne C Levy
    University of Washington, Box 356422, 1959 NE Pacific Street, Seattle, WA 98195, USA
    Eur J Heart Fail 6:917-26. 2004
    ....
  21. ncbi The circulatory regulation of TPA and UPA secretion, clearance, and inhibition during exercise and during the infusion of isoproterenol and phenylephrine
    W L Chandler
    Department of Laboratory Medicine, University of Washington, Seattle 98195, USA
    Circulation 92:2984-94. 1995
    ..Exercise to exhaustion and infusions of isoproterenol and phenylephrine were used to study interactions between plasminogen activator regulation and the control of regional blood flow in 10 healthy males...
  22. ncbi Genetic variants of the hemostatic system and development of transplant coronary artery disease
    Jian Qing He
    Puget Sound Blood Center, Seattle, Washington, USA
    J Heart Lung Transplant 21:629-36. 2002
    ..The clinical setting of heart transplantation provides a unique opportunity to examine the relative contribution of circulating (i.e., recipient) vs local vascular (i.e., donor) hemostatic components to the occurrence of CAD...
  23. ncbi The influence of age, gender, and training on exercise efficiency
    J Susie Woo
    Department of Internal Medicine, University of Washington, Seattle, Washington 98195, USA
    J Am Coll Cardiol 47:1049-57. 2006
    ..These age-related changes are reversed with exercise training, which improves efficiency to a greater degree in the elderly than in the young...
  24. ncbi Exercise training and heart rate variability in older adult female subjects
    Kenneth M Madden
    Division of Cardiology, Department of Medicine, Seattle Veterans Affairs Medical Center, Seattle, Washington, USA
    Clin Invest Med 29:20-8. 2006
    ..In a randomized trial, this study sought to prospectively compare the effects of endurance and strength training on HRV in 45 healthy elderly females (average age 69.9 +/- 0.9 years)...
  25. ncbi Oxygen cost of exercise is increased in heart failure after accounting for recovery costs
    Steven H Mitchell
    Division of Cardiology, Department of Medicine, University of Washington School of Medicine, Seattle, 98195, USA
    Chest 124:572-9. 2003
    ..The increase in the work VO(2)/W is probably due to changes in skeletal muscle fiber type that occur in patients with heart failure (type I to type IIb)...
  26. ncbi Cost-consequences of ultrafiltration for acute heart failure: a decision model analysis
    Steven M Bradley
    Health Services Research and Development, VA Puget Sound Health Care System, Seattle, WA 98101, USA
    Circ Cardiovasc Qual Outcomes 2:566-73. 2009
    ..Ultrafiltration for heart failure may reduce costs associated with acute heart failure by decreasing rehospitalization rates compared to intravenous diuretics...
  27. ncbi Discordance between patient-predicted and model-predicted life expectancy among ambulatory patients with heart failure
    Larry A Allen
    Duke Clinical Research Institute and Division of Cardiology, Durham, NC 27705, USA
    JAMA 299:2533-42. 2008
    ..Patients with chronic heart failure have impaired long-term survival, but their own expectations regarding prognosis have not been well studied...
  28. ncbi Statin therapy is associated with lower mortality among patients with severe heart failure
    Dariush Mozaffarian
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Am J Cardiol 93:1124-9. 2004
    ..52, 95% confidence interval 0.30 to 0.89). Although this observational study does not prove causality, further investigation of potential benefits of statins in patients with severe heart failure appears warranted...
  29. ncbi Can B-type natriuretic peptides replace heart failure risk models?
    Wayne C Levy
    Eur J Heart Fail 10:224-5. 2008
  30. ncbi Depression and health status in patients with advanced heart failure: a prospective study in tertiary care
    Mark Sullivan
    Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle 98195, USA
    J Card Fail 10:390-6. 2004
    ..CONCLUSIONS: Depression is prospectively associated with poorer health status in patients with advanced heart failure. Physical and role function, symptom severity, and quality of life are all significantly affected...
  31. ncbi trans fatty acids and systemic inflammation in heart failure
    Dariush Mozaffarian
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Clin Nutr 80:1521-5. 2004
    ..trans fatty acid (TFA) intake increases systemic inflammation in healthy persons. However, the effect in patients with established heart disease is unknown...
  32. ncbi The effects of atorvastatin (10 mg) on systemic inflammation in heart failure
    Dariush Mozaffarian
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Am J Cardiol 96:1699-704. 2005
    ..In conclusion, short-term atorvastatin therapy reduced the levels of several important inflammatory markers in patients with HF...
  33. ncbi Validation of the Seattle Heart Failure Model in a community-based heart failure population and enhancement by adding B-type natriuretic peptide
    Heidi T May
    LDS Hospital, Intermountain Medical Center, Salt Lake City, Utah, USA
    Am J Cardiol 100:697-700. 2007
    ..02). In conclusion, the SHFM predicts survival in patients with HF in a hospital-based population, with areas under the curve similar to those from data on which models were initially fit...
  34. ncbi Prediction of mode of death in heart failure: the Seattle Heart Failure Model
    Dariush Mozaffarian
    Harvard Medical School and Harvard School of Public Health, Boston, Mass, USA
    Circulation 116:392-8. 2007
    ..Prediction of mode of death may facilitate decisions about specific medications or devices...
  35. ncbi The role of norepinephrine in exercise impairment in congestive heart failure
    Kenneth M Leclerc
    Brooke Army Medical Center, 3857 Roger Brooke Drive, San Antonio, TX 78234 6200, USA
    Congest Heart Fail 9:25-8. 2003
    ..Regular exercise has been shown to reduce resting norepinephrine levels in heart failure subjects. This may serve as an additional rationale to recommend chronic exercise for these patients...
  36. ncbi Utility of impedance cardiography for the identification of short-term risk of clinical decompensation in stable patients with chronic heart failure
    Milton Packer
    University of Texas Southwestern Medical Center, Dallas, Texas 75390 8822, USA
    J Am Coll Cardiol 47:2245-52. 2006
    ..This study sought to assess the potential utility of impedance cardiography (ICG) in predicting clinical deterioration in ambulatory patients with heart failure (HF)...
  37. ncbi Normal aging impairs upregulation of the beta-adrenergic but not the alpha-adrenergic response: aging and adrenergic upregulation
    Kenneth M Madden
    Division of Geriatric Medicine, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    J Cardiovasc Pharmacol 48:153-9. 2006
    ..To determine if centrally reducing sympathetic tone with clonidine will reverse the downregulation in the alpha-adrenergic (alphaAR) and beta-adrenergic (betaAR) responses seen with normal aging...
  38. ncbi Successful management of asystole with an isolated left ventricular assist device
    Hiroo Takayama
    J Heart Lung Transplant 25:490-2. 2006