David G Levitt

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. pmc Quantitation of small intestinal permeability during normal human drug absorption
    David G Levitt
    Department of Integrative Biology and Physiology, University of Minnesota, 6 125 Jackson Hall, 321 Church St S E, Minneapolis, MN 55455, USA
    BMC Pharmacol Toxicol 14:34. 2013
  2. pmc Quantitative modeling of the physiology of ascites in portal hypertension
    David G Levitt
    Department of Integrative Biology and Physiology, University of Minnesota, 6 125 Jackson Hall, 321 Church St, S, E, Minneapolis, MN 55455, USA
    BMC Gastroenterol 12:26. 2012
  3. pmc Careers of an elite cohort of U.S. basic life science postdoctoral fellows and the influence of their mentor's citation record
    David G Levitt
    Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, 55455, USA
    BMC Med Educ 10:80. 2010
  4. pmc Quantitative relationship between the octanol/water partition coefficient and the diffusion limitation of the exchange between adipose and blood
    David G Levitt
    Department of Integrative Biology and Physiology, University of Minnesota, 6 125 Jackson Hall, 321 Church St S E, Minneapolis, MN 55455, USA
    BMC Clin Pharmacol 10:1. 2010
  5. pmc PKQuest_Java: free, interactive physiologically based pharmacokinetic software package and tutorial
    David G Levitt
    Department of Integrative Biology and Physiology, University of Minnesota, 6 125 Jackson Hall, 321 Church St, Minneapolis, MN 55455, USA
    BMC Res Notes 2:158. 2009
  6. pmc Physiological models of body composition and human obesity
    David G Levitt
    Department of Integrative Biology and Physiology, University of Minnesota, 321 Church Street SE, Minneapolis, MN 55455, USA
    Nutr Metab (Lond) 6:7. 2009
  7. pmc Physiological models of body composition and human obesity
    David G Levitt
    Department of Integrative Biology and Physiology, University of Minnesota, 321 Church St, S, E, Minneapolis, MN 55455, USA
    Nutr Metab (Lond) 4:19. 2007
  8. pmc Heterogeneity of human adipose blood flow
    David G Levitt
    Department of Integrative Biology and Physiology, University of Minnesota, 6 125 Jackson Hall, Minneapolis, MN 55455, USA
    BMC Clin Pharmacol 7:1. 2007
  9. pmc Human physiologically based pharmacokinetic model for ACE inhibitors: ramipril and ramiprilat
    David G Levitt
    Department of Physiology, University of Minnesota, Minneapolis, MN 55455, USA
    BMC Clin Pharmacol 6:1. 2006
  10. pmc The use of a physiologically based pharmacokinetic model to evaluate deconvolution measurements of systemic absorption
    David G Levitt
    Department of Physiology University of Minnesota, Minneapolis, MN 55455, USA
    BMC Clin Pharmacol 3:1. 2003

Collaborators

Detail Information

Publications19

  1. pmc Quantitation of small intestinal permeability during normal human drug absorption
    David G Levitt
    Department of Integrative Biology and Physiology, University of Minnesota, 6 125 Jackson Hall, 321 Church St S E, Minneapolis, MN 55455, USA
    BMC Pharmacol Toxicol 14:34. 2013
    ..Because of limited experimental human small intestinal permeability data, approximate surrogates such as the fraction absorbed or Caco-2 permeability are used, both of which have limitations...
  2. pmc Quantitative modeling of the physiology of ascites in portal hypertension
    David G Levitt
    Department of Integrative Biology and Physiology, University of Minnesota, 6 125 Jackson Hall, 321 Church St, S, E, Minneapolis, MN 55455, USA
    BMC Gastroenterol 12:26. 2012
    ..The model's predictions accurately mimic clinical observations in ascites, including the magnitude and time course of changes observed following paracentesis or diuretic therapy...
  3. pmc Careers of an elite cohort of U.S. basic life science postdoctoral fellows and the influence of their mentor's citation record
    David G Levitt
    Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, 55455, USA
    BMC Med Educ 10:80. 2010
    ..The latter view requires that students have objective information about what careers options will be available for them...
  4. pmc Quantitative relationship between the octanol/water partition coefficient and the diffusion limitation of the exchange between adipose and blood
    David G Levitt
    Department of Integrative Biology and Physiology, University of Minnesota, 6 125 Jackson Hall, 321 Church St S E, Minneapolis, MN 55455, USA
    BMC Clin Pharmacol 10:1. 2010
    ..This paper describes the physical basis of this adipose diffusion limitation and its quantitative dependence on the blood/water (Kbld-wat) and octanol/water (Kow) partition coefficient...
  5. pmc PKQuest_Java: free, interactive physiologically based pharmacokinetic software package and tutorial
    David G Levitt
    Department of Integrative Biology and Physiology, University of Minnesota, 6 125 Jackson Hall, 321 Church St, Minneapolis, MN 55455, USA
    BMC Res Notes 2:158. 2009
    ..PKQuest_Java, along with the included tutorial, could be used as the basis of an interactive, on-line, pharmacokinetic course...
  6. pmc Physiological models of body composition and human obesity
    David G Levitt
    Department of Integrative Biology and Physiology, University of Minnesota, 321 Church Street SE, Minneapolis, MN 55455, USA
    Nutr Metab (Lond) 6:7. 2009
    ..ABSTRACT: Correction to Levitt DG, Heymsfield SB, Pierson Jr RN, Shapses SA, Kral JG: Physiological models of body composition and human obesity. Nutrition & Metabolism 2007, 4:19...
  7. pmc Physiological models of body composition and human obesity
    David G Levitt
    Department of Integrative Biology and Physiology, University of Minnesota, 321 Church St, S, E, Minneapolis, MN 55455, USA
    Nutr Metab (Lond) 4:19. 2007
    ..We attempt to develop regression relations that are based on realistic models of body composition changes in obesity. These models, if valid, can then be extrapolated to the high fat fraction of the morbidly obese...
  8. pmc Heterogeneity of human adipose blood flow
    David G Levitt
    Department of Integrative Biology and Physiology, University of Minnesota, 6 125 Jackson Hall, Minneapolis, MN 55455, USA
    BMC Clin Pharmacol 7:1. 2007
    ..The purpose of this paper is to quantitate human adipose blood flow heterogeneity and determine its importance for human pharmacokinetics...
  9. pmc Human physiologically based pharmacokinetic model for ACE inhibitors: ramipril and ramiprilat
    David G Levitt
    Department of Physiology, University of Minnesota, Minneapolis, MN 55455, USA
    BMC Clin Pharmacol 6:1. 2006
    ..Most inhibitors are given orally in a prodrug form that is systemically converted to the active form. This paper describes the first human physiologically based pharmacokinetic (PBPK) model of this drug class...
  10. pmc The use of a physiologically based pharmacokinetic model to evaluate deconvolution measurements of systemic absorption
    David G Levitt
    Department of Physiology University of Minnesota, Minneapolis, MN 55455, USA
    BMC Clin Pharmacol 3:1. 2003
    ..The quantitative relation between the duration of the input and the accuracy of r is unknown. Although a large number of deconvolution procedures have been described, these routines are not available in a convenient software package...
  11. pmc The pharmacokinetics of the interstitial space in humans
    David G Levitt
    Department of Physiology University of Minnesota
    BMC Clin Pharmacol 3:3. 2003
    ..This information can be used to develop a general physiologically based pharmacokinetic (PBPK) model applicable to most extracellular solutes...
  12. pmc Physiologically based pharmacokinetic modeling of arterial - antecubital vein concentration difference
    David G Levitt
    Department of Physiology, University of Minnesota, Minneapolis, U S A
    BMC Clin Pharmacol 4:2. 2004
    ..In most cases, experimental measurements are only available for a peripheral vein (usually antecubital) whose concentration may differ significantly from both arterial and central vein concentration...
  13. pmc PKQuest: measurement of intestinal absorption and first pass metabolism - application to human ethanol pharmacokinetics
    David G Levitt
    Department of Physiology, Minneapolis, MN 55455, USA
    BMC Clin Pharmacol 2:4. 2002
    ..This input function equals the peripheral availability (PA) and the FPM is defined by: FPM = Total oral dose - PA. PKQuest also provides a quantitative measurement of the time course of intestinal absorption...
  14. pmc PKQuest: capillary permeability limitation and plasma protein binding - application to human inulin, dicloxacillin and ceftriaxone pharmacokinetics
    David G Levitt
    Department of Physiology, University of Minnesota, Minneapolis, MN 55455, USA
    BMC Clin Pharmacol 2:7. 2002
    ..PKQuest, a new generic physiologically based pharmacokinetic software routine (PBPK), provides a novel approach to modeling capillary permeability in which the only adjustable parameter is the PS of muscle...
  15. pmc Modeling free energies of solvation in olive oil
    Adam C Chamberlin
    Department of Chemistry, University of Minnesota, 207 Pleasant Street SE, Minneapolis, Minnesota 55455, USA
    Mol Pharm 5:1064-79. 2008
    ..We also describe the database of experimental partition coefficients used to parametrize the model; this database includes 371 entries for 304 compounds spanning the 291-310 K temperature range...
  16. ncbi request reprint Identification and characterization of the ATP-binding site in human pancreatic glucokinase
    Diane E Marotta
    Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA
    Arch Biochem Biophys 436:23-31. 2005
    ..5) for ATP and glucose. Results suggest a role for Asp78, Thr82, Gly227, Thr228, and Ser336 in ATP binding and indicate these residues are essential for glucose phosphorylation by human pancreatic glucokinase...
  17. pmc Comparison of DXA and water measurements of body fat following gastric bypass surgery and a physiological model of body water, fat, and muscle composition
    David G Levitt
    Department of Integrative Biology and Physiology, University of Minnesota Twin Cities, 225 Food Science and Nutrition, 1334 Eckles Ave, St Paul, MN 55108 6099, USA
    J Appl Physiol (1985) 109:786-95. 2010
    ..This model is also used to predict the muscle mass loss following RYGB...
  18. pmc PKQuest: a general physiologically based pharmacokinetic model. Introduction and application to propranolol
    David G Levitt
    Department of Physiology, Minneapolis, MN 55455, USA
    BMC Clin Pharmacol 2:5. 2002
    ..Previous PBPKs have been designed for specific solutes, required specification of a large number of parameters and have not been designed for general use...