Douglas F Levinson

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Multicenter linkage study of schizophrenia candidate regions on chromosomes 5q, 6q, 10p, and 13q: schizophrenia linkage collaborative group III
    D F Levinson
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, 19104, USA
    Am J Hum Genet 67:652-63. 2000
  2. ncbi request reprint The genetics of depression: a review
    Douglas F Levinson
    Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 3309, USA
    Biol Psychiatry 60:84-92. 2006
  3. pmc Genome scan meta-analysis of schizophrenia and bipolar disorder, part I: Methods and power analysis
    Douglas F Levinson
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, 3535 Market Street, Room 4006, Philadelphia, PA 19104 3309, USA
    Am J Hum Genet 73:17-33. 2003
  4. pmc The effect of linkage disequilibrium on linkage analysis of incomplete pedigrees
    Douglas F Levinson
    Department of Psychiatry, University of Pennsylvania School of Medicine, 353 Market Street, Philadelphia, PA, USA
    BMC Genet 6:S6. 2005
  5. ncbi request reprint The Lifetime Dimensions of Psychosis Scale (LDPS): description and interrater reliability
    Douglas F Levinson
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia 19104 3309, USA
    Schizophr Bull 28:683-95. 2002
  6. ncbi request reprint Genetics of recurrent early-onset depression (GenRED): design and preliminary clinical characteristics of a repository sample for genetic linkage studies
    Douglas F Levinson
    Department of Psychiatry and Center for Neurobiology and Behavior, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 3309, USA
    Am J Med Genet B Neuropsychiatr Genet 119:118-30. 2003
  7. ncbi request reprint No major schizophrenia locus detected on chromosome 1q in a large multicenter sample
    Douglas F Levinson
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 296:739-41. 2002
  8. ncbi request reprint Simulation studies of detection of a complex disease in a partially isolated population
    D F Levinson
    Department of Psychiatry, University of Pennsylvania, Philadelphia 19104 2648, USA
    Am J Med Genet 105:65-70. 2001
  9. ncbi request reprint Meta-analysis in psychiatric genetics
    Douglas F Levinson
    Department of Psychiatry, University of Pennsylvania School of Medicine, 3535 Market Street, Room 4006, Philadelphia, PA 19104, USA
    Curr Psychiatry Rep 7:143-51. 2005
  10. pmc Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample
    Kenneth S Kendler
    Virginia Institute of Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University School of Medicine, Richmond, 23298, USA
    Alcohol Clin Exp Res 35:963-75. 2011

Detail Information

Publications35

  1. pmc Multicenter linkage study of schizophrenia candidate regions on chromosomes 5q, 6q, 10p, and 13q: schizophrenia linkage collaborative group III
    D F Levinson
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, 19104, USA
    Am J Hum Genet 67:652-63. 2000
    ..0038). More-modest support for linkage was observed for chromosome 10p, with logistic-regression analysis of linkage producing an empirical P=. 045 and with significant evidence for intersample heterogeneity (empirical P=.0096)...
  2. ncbi request reprint The genetics of depression: a review
    Douglas F Levinson
    Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 3309, USA
    Biol Psychiatry 60:84-92. 2006
    ....
  3. pmc Genome scan meta-analysis of schizophrenia and bipolar disorder, part I: Methods and power analysis
    Douglas F Levinson
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, 3535 Market Street, Room 4006, Philadelphia, PA 19104 3309, USA
    Am J Hum Genet 73:17-33. 2003
    ..The results suggest that GSMA can detect linkage across multiple genome scans...
  4. pmc The effect of linkage disequilibrium on linkage analysis of incomplete pedigrees
    Douglas F Levinson
    Department of Psychiatry, University of Pennsylvania School of Medicine, 353 Market Street, Philadelphia, PA, USA
    BMC Genet 6:S6. 2005
    ..Simulation studies on the observed pedigree structures and map can also be used to determine the effect of LD on a particular study...
  5. ncbi request reprint The Lifetime Dimensions of Psychosis Scale (LDPS): description and interrater reliability
    Douglas F Levinson
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia 19104 3309, USA
    Schizophr Bull 28:683-95. 2002
    ..Dimensional scores and multidimensional patterns might prove useful in studying the relationship of clinical phenotype to genotypes, treatment response, and other variables. They may also be useful in clinical practice...
  6. ncbi request reprint Genetics of recurrent early-onset depression (GenRED): design and preliminary clinical characteristics of a repository sample for genetic linkage studies
    Douglas F Levinson
    Department of Psychiatry and Center for Neurobiology and Behavior, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 3309, USA
    Am J Med Genet B Neuropsychiatr Genet 119:118-30. 2003
    ..This suggests comparability of our cases to those in earlier large family studies. This dataset should prove useful for genetic studies of a highly familial form of major depressive disorder...
  7. ncbi request reprint No major schizophrenia locus detected on chromosome 1q in a large multicenter sample
    Douglas F Levinson
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 296:739-41. 2002
    ..If schizophrenia susceptibility genes are present on chromosome 1q, their population-wide genetic effects are likely to be small...
  8. ncbi request reprint Simulation studies of detection of a complex disease in a partially isolated population
    D F Levinson
    Department of Psychiatry, University of Pennsylvania, Philadelphia 19104 2648, USA
    Am J Med Genet 105:65-70. 2001
    ..LD and linkage mapping provide independent information, and strategies that combine these two methods could be useful in studies of small isolated populations...
  9. ncbi request reprint Meta-analysis in psychiatric genetics
    Douglas F Levinson
    Department of Psychiatry, University of Pennsylvania School of Medicine, 3535 Market Street, Room 4006, Philadelphia, PA 19104, USA
    Curr Psychiatry Rep 7:143-51. 2005
    ....
  10. pmc Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample
    Kenneth S Kendler
    Virginia Institute of Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University School of Medicine, Richmond, 23298, USA
    Alcohol Clin Exp Res 35:963-75. 2011
    ..While genetic influences on alcohol dependence (AD) are substantial, progress in the identification of individual genetic variants that impact on risk has been difficult...
  11. ncbi request reprint Is perinatal depression familial?
    Kathleen Murphy-Eberenz
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 3309, USA
    J Affect Disord 90:49-55. 2006
    ....
  12. pmc Smoking and genetic risk variation across populations of European, Asian, and African American ancestry--a meta-analysis of chromosome 15q25
    Li Shiun Chen
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Genet Epidemiol 36:340-51. 2012
    ..Using the cross-population study paradigm provides valuable insights to narrow regions of interest and inform future biological experiments...
  13. ncbi request reprint Lithium and valproic acid treatments reduce PKC activation and receptor-G protein coupling in platelets of bipolar manic patients
    Chang Gyu Hahn
    Medical College of Pennsylvania, Philadelphia, PA, USA
    J Psychiatr Res 39:355-63. 2005
    ..Thus, increased membrane-associated PKC, cytosol to membrane PKC translocation and receptor-G protein coupling in platelets of BD manic patients were alleviated by lithium or valproic acid treatments...
  14. pmc Mood disorder susceptibility gene CACNA1C modifies mood-related behaviors in mice and interacts with sex to influence behavior in mice and diagnosis in humans
    David T Dao
    Department of Psychiatry, University of Maryland School of Medicine, Baltimore, 21201, USA
    Biol Psychiatry 68:801-10. 2010
    ..Recent genome-wide association studies have associated polymorphisms in the gene CACNA1C, which codes for Ca(v)1.2, with a bipolar disorder and depression diagnosis...
  15. pmc Polymorphisms in the trace amine receptor 4 (TRAR4) gene on chromosome 6q23.2 are associated with susceptibility to schizophrenia
    Jubao Duan
    Center for Psychiatric Genetics, Department of Psychiatry and Behavioral Sciences, Evanston Northwestern Healthcare and Feinberg School of Medicine, Northwestern University, Evanston, IL, USA
    Am J Hum Genet 75:624-38. 2004
    ..These data provide strong preliminary evidence that TRAR4 is a candidate gene for schizophrenia; replication is currently being attempted in additional clinical samples...
  16. ncbi request reprint Genetics of recurrent early-onset major depression (GenRED): significant linkage on chromosome 15q25-q26 after fine mapping with single nucleotide polymorphism markers
    Douglas F Levinson
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 701A Welch Rd, Suite 3325, Palo Alto, CA 94304 5797, USA
    Am J Psychiatry 164:259-64. 2007
    ....
  17. ncbi request reprint Investigating the role of p11 (S100A10) sequence variation in susceptibility to major depression
    Ranjana Verma
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Med Genet B Neuropsychiatr Genet 144:1079-82. 2007
    ..2%, P = 0.15). None of the tag SNPs showed any evidence of association. Our results do not support a major role for either common or rare p11 SNPs with MDD. Several limitations of the study are discussed...
  18. pmc QuickSNP: an automated web server for selection of tagSNPs
    Deepak Grover
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
    Nucleic Acids Res 35:W115-20. 2007
    ..The server is freely available and can be accessed at the URL http://bioinformoodics.jhmi.edu/quickSNP.pl...
  19. doi request reprint No significant association of 14 candidate genes with schizophrenia in a large European ancestry sample: implications for psychiatric genetics
    Alan R Sanders
    Department of Psychiatry and Behavioural Sciences, Evanston Northwestern Healthcare Research Institute, Evanston, IL 60201 3137, USA
    Am J Psychiatry 165:497-506. 2008
    ....
  20. doi request reprint Genetics and suicidal ideation during antidepressant treatment
    Douglas F Levinson
    Am J Psychiatry 165:395; author reply 395-6. 2008
  21. pmc Linkage disequilibrium mapping of a chromosome 15q25-26 major depression linkage region and sequencing of NTRK3
    Ranjana Verma
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Biol Psychiatry 63:1185-9. 2008
    ..Here we present initial linkage-disequilibrium (LD) fine mapping of this signal and sequence analysis of NTRK3 (neurotrophic receptor kinase-3), a biologically plausible candidate gene...
  22. ncbi request reprint CAG repeat polymorphisms in KCNN3 (HSKCa3) and PPP2R2B show no association or linkage to schizophrenia
    Claudine Laurent
    LGN CNRS UMR 7091, Batiment CERVI, Hopital de la Pitie Salpetriere, Paris, France
    Am J Med Genet B Neuropsychiatr Genet 116:45-50. 2003
    ..In conclusion, no significant evidence for linkage or association with SZ was observed for either polymorphism in this population...
  23. ncbi request reprint Genetics of recurrent early-onset major depression (GenRED): final genome scan report
    Peter Holmans
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 701A Welch Rd, Suite 3325, Palo Alto, CA 94304 5797, USA
    Am J Psychiatry 164:248-58. 2007
    ....
  24. pmc A comparison of the familiality of chronic depression in recurrent early-onset depression pedigrees using different definitions of chronicity
    Francis M Mondimore
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
    J Affect Disord 100:171-7. 2007
    ..Because familial clustering is one component of diagnostic validity we compared family clustering of chronicity as defined in the DSM-IV to that of chronicity determined by an assessment of lifetime course of depressive illness...
  25. pmc Genomewide linkage scan of 409 European-ancestry and African American families with schizophrenia: suggestive evidence of linkage at 8p23.3-p21.2 and 11p13.1-q14.1 in the combined sample
    Brian K Suarez
    Department of Psychiatry and Genetics, Washington University, St Louis, MO, USA
    Am J Hum Genet 78:315-33. 2006
    ..3-p15.2, 5p15.2-q13.3, 10p15.3-p14, 10q25.3-q26.3, and 11p13-q23.3. The highest increase in Z(lr) scores was observed for 5p14.1-q12.1, where the maximum Z(lr) increased from 2.77 initially to 3.80 after fine mapping in the EA families...
  26. ncbi request reprint Familial aggregation of illness chronicity in recurrent, early-onset major depression pedigrees
    Francis M Mondimore
    Johns Hopkins Hospital, Meyer 3 181, 600 North Wolfe St, Baltimore, MD 21287, USA
    Am J Psychiatry 163:1554-60. 2006
    ..The authors used a large sample collected for genetic studies to determine whether a chronic course of illness defines a familial clinical subtype in major depressive disorder...
  27. ncbi request reprint Association study of the dystrobrevin-binding gene with schizophrenia in Australian and Indian samples
    Elizabeth G Holliday
    Queensland Centre for Mental Health Research, The Park, Centre for Mental Health, Wacol, Queensland, Australia
    Twin Res Hum Genet 9:531-9. 2006
    ..More comprehensive studies in multiple samples will be required to determine whether specific DTNBP1 variants function as risk factors for schizophrenia...
  28. pmc Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: Bipolar disorder
    Ricardo Segurado
    Neuropsychiatric Genetics Unit, Department of Genetics, Trinity College, Dublin 2, Ireland
    Am J Hum Genet 73:49-62. 2003
    ..We note that meta-analysis can sometimes provide support for linkage but cannot disprove linkage in any candidate region...
  29. pmc Genomewide significant linkage to recurrent, early-onset major depressive disorder on chromosome 15q
    Peter Holmans
    Biostatistics and Bioinformatics Unit, University of Wales College of Medicine, Cardiff, United Kingdom
    Am J Hum Genet 74:1154-67. 2004
    ..Chromosome 15q25.3-26.2 deserves further study as a candidate region for susceptibility to MDD...
  30. pmc Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Schizophrenia
    Cathryn M Lewis
    Division of Genetics and Development, Guy s, King s and St Thomas School of Medicine, London, UK
    Am J Hum Genet 73:34-48. 2003
    ..There is greater consistency of linkage results across studies than has been previously recognized. The results suggest that some or all of these regions contain loci that increase susceptibility to schizophrenia in diverse populations...
  31. ncbi request reprint GSMA: software implementation of the genome search meta-analysis method
    Fabio Pardi
    Department of Medical and Molecular Genetics, King s College London, 8th Floor Guy s Tower, Guy s Hospital, London SE1 9RT, United Kingdom
    Bioinformatics 21:4430-1. 2005
    ..The genome search meta-analysis (GSMA) method is widely used for this analysis, and a computer program is now available to implement the GSMA...
  32. ncbi request reprint Tumor necrosis factor haplotype analysis amongst schizophrenia probands from four distinct populations in the Asia-Pacific region
    Herlina Y Handoko
    Queensland Centre for Schizophrenia Research, The Park, Centre for Mental Health, Wacol, Queensland, Australia
    Am J Med Genet B Neuropsychiatr Genet 121:1-6. 2003
    ..Taken together, these data provide no support for the involvement of TNF promoter variants TNF(-308), TNF(-376), and TNF(-238) in schizophrenia susceptibility within four ethnically distinct cohorts...
  33. ncbi request reprint Reproductive cycle-associated mood symptoms in women with major depression and bipolar disorder
    Jennifer L Payne
    Department of Psychiatry, Women s Mood Disorders Center, The Johns Hopkins Hospital, 600 North Wolfe Street Meyer 3 181, Baltimore, MD 21287 7381, United States
    J Affect Disord 99:221-9. 2007
    ..We hypothesized that symptoms would correlate with each other across a woman's reproductive life span in both major depression (MDD) and bipolar I disorder (BP)...
  34. ncbi request reprint Data acquisition for meta-analysis of genome-wide linkage studies using the genome search meta-analysis method
    Paola Forabosco
    Department of Medical and Molecular Genetics, King s College London School of Medicine at Guy s, King s College and St Thomas Hospitals, London, UK
    Hum Hered 64:74-81. 2007
    ..Ranks are then summed across studies, with high summed ranks potentially showing evidence for linkage in the meta-analysis...
  35. ncbi request reprint Comparison of single-nucleotide polymorphisms and microsatellite markers for linkage analysis in the COGA and simulated data sets for Genetic Analysis Workshop 14: Presentation Groups 1, 2, and 3
    Marsha A Wilcox
    Genetics Program, Division of Graduate Medical Sciences, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Genet Epidemiol 29:S7-28. 2005
    ..5) Analyses with SNPs were computationally challenging, and identified areas where improvements in analysis tools will be necessary to make analysis practical for widespread use...