Research Topics
Species | Douglas F LevinsonSummaryAffiliation: University of Pennsylvania Country: USA Publications
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Publications
Multicenter linkage study of schizophrenia candidate regions on chromosomes 5q, 6q, 10p, and 13q: schizophrenia linkage collaborative group IIID F Levinson
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, 19104, USA
Am J Hum Genet 67:652-63. 2000..0038). More-modest support for linkage was observed for chromosome 10p, with logistic-regression analysis of linkage producing an empirical P=. 045 and with significant evidence for intersample heterogeneity (empirical P=.0096)...
The genetics of depression: a reviewDouglas F Levinson
Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 3309, USA
Biol Psychiatry 60:84-92. 2006....- Genome scan meta-analysis of schizophrenia and bipolar disorder, part I: Methods and power analysisDouglas F Levinson
Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, 3535 Market Street, Room 4006, Philadelphia, PA 19104 3309, USA
Am J Hum Genet 73:17-33. 2003..The results suggest that GSMA can detect linkage across multiple genome scans... - The effect of linkage disequilibrium on linkage analysis of incomplete pedigreesDouglas F Levinson
Department of Psychiatry, University of Pennsylvania School of Medicine, 353 Market Street, Philadelphia, PA, USA
BMC Genet 6:S6. 2005..Simulation studies on the observed pedigree structures and map can also be used to determine the effect of LD on a particular study... - The Lifetime Dimensions of Psychosis Scale (LDPS): description and interrater reliabilityDouglas F Levinson
Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia 19104 3309, USA
Schizophr Bull 28:683-95. 2002..Dimensional scores and multidimensional patterns might prove useful in studying the relationship of clinical phenotype to genotypes, treatment response, and other variables. They may also be useful in clinical practice... - Genetics of recurrent early-onset depression (GenRED): design and preliminary clinical characteristics of a repository sample for genetic linkage studiesDouglas F Levinson
Department of Psychiatry and Center for Neurobiology and Behavior, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 3309, USA
Am J Med Genet B Neuropsychiatr Genet 119:118-30. 2003..This suggests comparability of our cases to those in earlier large family studies. This dataset should prove useful for genetic studies of a highly familial form of major depressive disorder... - No major schizophrenia locus detected on chromosome 1q in a large multicenter sampleDouglas F Levinson
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Science 296:739-41. 2002..If schizophrenia susceptibility genes are present on chromosome 1q, their population-wide genetic effects are likely to be small... - Simulation studies of detection of a complex disease in a partially isolated populationD F Levinson
Department of Psychiatry, University of Pennsylvania, Philadelphia 19104 2648, USA
Am J Med Genet 105:65-70. 2001..LD and linkage mapping provide independent information, and strategies that combine these two methods could be useful in studies of small isolated populations... - Meta-analysis in psychiatric geneticsDouglas F Levinson
Department of Psychiatry, University of Pennsylvania School of Medicine, 3535 Market Street, Room 4006, Philadelphia, PA 19104, USA
Curr Psychiatry Rep 7:143-51. 2005.... - Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sampleKenneth S Kendler
Virginia Institute of Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University School of Medicine, Richmond, 23298, USA
Alcohol Clin Exp Res 35:963-75. 2011..While genetic influences on alcohol dependence (AD) are substantial, progress in the identification of individual genetic variants that impact on risk has been difficult... - Is perinatal depression familial?Kathleen Murphy-Eberenz
Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 3309, USA
J Affect Disord 90:49-55. 2006.... - Smoking and genetic risk variation across populations of European, Asian, and African American ancestry--a meta-analysis of chromosome 15q25Li Shiun Chen
Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
Genet Epidemiol 36:340-51. 2012..Using the cross-population study paradigm provides valuable insights to narrow regions of interest and inform future biological experiments... - Lithium and valproic acid treatments reduce PKC activation and receptor-G protein coupling in platelets of bipolar manic patientsChang-Gyu Hahn
Medical College of Pennsylvania, Philadelphia, PA, USA
J Psychiatr Res 39:355-63. 2005..Thus, increased membrane-associated PKC, cytosol to membrane PKC translocation and receptor-G protein coupling in platelets of BD manic patients were alleviated by lithium or valproic acid treatments... - Mood disorder susceptibility gene CACNA1C modifies mood-related behaviors in mice and interacts with sex to influence behavior in mice and diagnosis in humansDavid T Dao
Department of Psychiatry, University of Maryland School of Medicine, Baltimore, 21201, USA
Biol Psychiatry 68:801-10. 2010..Recent genome-wide association studies have associated polymorphisms in the gene CACNA1C, which codes for Ca(v)1.2, with a bipolar disorder and depression diagnosis... - Polymorphisms in the trace amine receptor 4 (TRAR4) gene on chromosome 6q23.2 are associated with susceptibility to schizophreniaJubao Duan
Center for Psychiatric Genetics, Department of Psychiatry and Behavioral Sciences, Evanston Northwestern Healthcare and Feinberg School of Medicine, Northwestern University, Evanston, IL, USA
Am J Hum Genet 75:624-38. 2004..These data provide strong preliminary evidence that TRAR4 is a candidate gene for schizophrenia; replication is currently being attempted in additional clinical samples... - Genetics of recurrent early-onset major depression (GenRED): significant linkage on chromosome 15q25-q26 after fine mapping with single nucleotide polymorphism markersDouglas F Levinson
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 701A Welch Rd, Suite 3325, Palo Alto, CA 94304 5797, USA
Am J Psychiatry 164:259-64. 2007.... - Investigating the role of p11 (S100A10) sequence variation in susceptibility to major depressionRanjana Verma
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Am J Med Genet B Neuropsychiatr Genet 144:1079-82. 2007..2%, P = 0.15). None of the tag SNPs showed any evidence of association. Our results do not support a major role for either common or rare p11 SNPs with MDD. Several limitations of the study are discussed... - QuickSNP: an automated web server for selection of tagSNPsDeepak Grover
Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
Nucleic Acids Res 35:W115-20. 2007..The server is freely available and can be accessed at the URL http://bioinformoodics.jhmi.edu/quickSNP.pl... 
No significant association of 14 candidate genes with schizophrenia in a large European ancestry sample: implications for psychiatric geneticsAlan R Sanders
Department of Psychiatry and Behavioural Sciences, Evanston Northwestern Healthcare Research Institute, Evanston, IL 60201 3137, USA
Am J Psychiatry 165:497-506. 2008....- Genetics and suicidal ideation during antidepressant treatmentDouglas F Levinson
Am J Psychiatry 165:395; author reply 395-6. 2008 - Linkage disequilibrium mapping of a chromosome 15q25-26 major depression linkage region and sequencing of NTRK3Ranjana Verma
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Biol Psychiatry 63:1185-9. 2008..Here we present initial linkage-disequilibrium (LD) fine mapping of this signal and sequence analysis of NTRK3 (neurotrophic receptor kinase-3), a biologically plausible candidate gene... - CAG repeat polymorphisms in KCNN3 (HSKCa3) and PPP2R2B show no association or linkage to schizophreniaClaudine Laurent
LGN CNRS UMR 7091, Batiment CERVI, Hopital de la Pitie Salpetriere, Paris, France
Am J Med Genet B Neuropsychiatr Genet 116:45-50. 2003..In conclusion, no significant evidence for linkage or association with SZ was observed for either polymorphism in this population... - Genetics of recurrent early-onset major depression (GenRED): final genome scan reportPeter Holmans
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 701A Welch Rd, Suite 3325, Palo Alto, CA 94304 5797, USA
Am J Psychiatry 164:248-58. 2007.... - A comparison of the familiality of chronic depression in recurrent early-onset depression pedigrees using different definitions of chronicityFrancis M Mondimore
Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
J Affect Disord 100:171-7. 2007..Because familial clustering is one component of diagnostic validity we compared family clustering of chronicity as defined in the DSM-IV to that of chronicity determined by an assessment of lifetime course of depressive illness... - Genomewide linkage scan of 409 European-ancestry and African American families with schizophrenia: suggestive evidence of linkage at 8p23.3-p21.2 and 11p13.1-q14.1 in the combined sampleBrian K Suarez
Department of Psychiatry and Genetics, Washington University, St. Louis, MO, USA
Am J Hum Genet 78:315-33. 2006..3-p15.2, 5p15.2-q13.3, 10p15.3-p14, 10q25.3-q26.3, and 11p13-q23.3. The highest increase in Z(lr) scores was observed for 5p14.1-q12.1, where the maximum Z(lr) increased from 2.77 initially to 3.80 after fine mapping in the EA families... - Familial aggregation of illness chronicity in recurrent, early-onset major depression pedigreesFrancis M Mondimore
Johns Hopkins Hospital, Meyer 3 181, 600 North Wolfe St, Baltimore, MD 21287, USA
Am J Psychiatry 163:1554-60. 2006..The authors used a large sample collected for genetic studies to determine whether a chronic course of illness defines a familial clinical subtype in major depressive disorder... - Association study of the dystrobrevin-binding gene with schizophrenia in Australian and Indian samplesElizabeth G Holliday
Queensland Centre for Mental Health Research, The Park, Centre for Mental Health, Wacol, Queensland, Australia
Twin Res Hum Genet 9:531-9. 2006..More comprehensive studies in multiple samples will be required to determine whether specific DTNBP1 variants function as risk factors for schizophrenia... - Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: Bipolar disorderRicardo Segurado
Neuropsychiatric Genetics Unit, Department of Genetics, Trinity College, Dublin 2, Ireland
Am J Hum Genet 73:49-62. 2003..We note that meta-analysis can sometimes provide support for linkage but cannot disprove linkage in any candidate region... - Genomewide significant linkage to recurrent, early-onset major depressive disorder on chromosome 15qPeter Holmans
Biostatistics and Bioinformatics Unit, University of Wales College of Medicine, Cardiff, United Kingdom
Am J Hum Genet 74:1154-67. 2004..Chromosome 15q25.3-26.2 deserves further study as a candidate region for susceptibility to MDD... - Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: SchizophreniaCathryn M Lewis
Division of Genetics and Development, Guy's, King's and St Thomas' School of Medicine, London, UK
Am J Hum Genet 73:34-48. 2003..There is greater consistency of linkage results across studies than has been previously recognized. The results suggest that some or all of these regions contain loci that increase susceptibility to schizophrenia in diverse populations... - GSMA: software implementation of the genome search meta-analysis methodFabio Pardi
Department of Medical and Molecular Genetics, King's College London, 8th Floor Guy's Tower, Guy's Hospital, London SE1 9RT, United Kingdom
Bioinformatics 21:4430-1. 2005..The genome search meta-analysis (GSMA) method is widely used for this analysis, and a computer program is now available to implement the GSMA... - Tumor necrosis factor haplotype analysis amongst schizophrenia probands from four distinct populations in the Asia-Pacific regionHerlina Y Handoko
Queensland Centre for Schizophrenia Research, The Park, Centre for Mental Health, Wacol, Queensland, Australia
Am J Med Genet B Neuropsychiatr Genet 121:1-6. 2003..Taken together, these data provide no support for the involvement of TNF promoter variants TNF(-308), TNF(-376), and TNF(-238) in schizophrenia susceptibility within four ethnically distinct cohorts... - Reproductive cycle-associated mood symptoms in women with major depression and bipolar disorderJennifer L Payne
Department of Psychiatry, Women s Mood Disorders Center, The Johns Hopkins Hospital, 600 North Wolfe Street Meyer 3 181, Baltimore, MD 21287 7381, United States
J Affect Disord 99:221-9. 2007..We hypothesized that symptoms would correlate with each other across a woman's reproductive life span in both major depression (MDD) and bipolar I disorder (BP)... - Data acquisition for meta-analysis of genome-wide linkage studies using the genome search meta-analysis methodPaola Forabosco
Department of Medical and Molecular Genetics, King s College London School of Medicine at Guy s, King s College and St Thomas Hospitals, London, UK
Hum Hered 64:74-81. 2007..Ranks are then summed across studies, with high summed ranks potentially showing evidence for linkage in the meta-analysis... - Comparison of single-nucleotide polymorphisms and microsatellite markers for linkage analysis in the COGA and simulated data sets for Genetic Analysis Workshop 14: Presentation Groups 1, 2, and 3Marsha A Wilcox
Genetics Program, Division of Graduate Medical Sciences, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
Genet Epidemiol 29:S7-28. 2005..5) Analyses with SNPs were computationally challenging, and identified areas where improvements in analysis tools will be necessary to make analysis practical for widespread use...