Affiliation: University of California
Oktaba K, Zhang W, Lotz T, Jun D, Lemke S, Ng S, et al
. ELAV links paused Pol II to alternative polyadenylation in the Drosophila nervous system. Mol Cell. 2015;57:341-8 pubmed publisher
..ChIP-seq assays identify ELAV in the promoter regions of extended genes. Our study provides evidence for a regulatory link between promoter-proximal pausing and APA. ..
Gainous T, Wagner E, Levine M. Diverse ETS transcription factors mediate FGF signaling in the Ciona anterior neural plate. Dev Biol. 2015;399:218-25 pubmed publisher
..Our results extend recent findings on FGF-dependent patterning of anterior-posterior compartments in the Ciona central nervous system. ..
Levine M. Transcriptional enhancers in animal development and evolution. Curr Biol. 2010;20:R754-63 pubmed publisher
..Finally, there is a discussion of how enhancer evolution can produce novelty in animal morphology and of the prospects for reconstructing transitions in animal evolution by introducing derived enhancers in basal ancestors. ..
Levine M, Cattoglio C, Tjian R. Looping back to leap forward: transcription enters a new era. Cell. 2014;157:13-25 pubmed publisher
..We review progress in unraveling one of the outstanding mysteries of modern biology: the dynamic communication of remote enhancers with target promoters in the specification of cellular identity. ..
Wagner E, Stolfi A, Gi Choi Y, Levine M. Islet is a key determinant of ascidian palp morphogenesis. Development. 2014;141:3084-92 pubmed publisher
..We conclude that Islet is a key regulatory factor governing morphogenesis of the palps. It is conceivable that Islet is also essential for the cellular morphogenesis of placode-derived sensory neurons in vertebrates. ..