J Levine

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint High serum and cerebrospinal fluid Ca/Mg ratio in recently hospitalized acutely depressed patients
    J Levine
    Beersheva Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beersheva, Israel
    Neuropsychobiology 39:63-70. 1999
  2. ncbi request reprint Low CSF soluble interleukin 2 receptor levels in acute depression. Short communication
    J Levine
    Beersheva Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Israel
    J Neural Transm 106:1011-5. 1999
  3. ncbi request reprint Stability of CSF metabolites measured by proton NMR
    J Levine
    Department of Psychiatry, School of Medicine, University of Pittsburgh, Pennsylvania 15213, USA
    J Neural Transm 107:843-8. 2000
  4. ncbi request reprint Psychotropic drug prescription patterns among patients with bipolar I disorder
    J Levine
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA, USA
    Bipolar Disord 2:120-30. 2000
  5. ncbi request reprint Topiramate as add-on treatment for patients with bipolar mania
    K N Chengappa
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, PA 15215 2593, USA
    Bipolar Disord 1:42-53. 1999
  6. ncbi request reprint Clozapine reduces severe self-mutilation and aggression in psychotic patients with borderline personality disorder
    K N Chengappa
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, PA 15213 2593, USA
    J Clin Psychiatry 60:477-84. 1999
  7. ncbi request reprint Illness characteristics and their association with prescription patterns for bipolar I disorder
    J Levine
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA 15213-2593, USA
    Bipolar Disord 3:41-9. 2001
  8. doi request reprint Global leukocyte DNA methylation is not altered in euthymic bipolar patients
    A Bromberg
    Psychiatry Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev and Mental Health Center, PO Box 4600 Beer Sheva 84170, Israel
    J Affect Disord 118:234-9. 2009
  9. ncbi request reprint Effects of chronic lithium administration on rat brain phosphatidylinositol cycle constituents, membrane phospholipids and amino acids
    J W Pettegrew
    Neurophysics Laboratory, Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Bipolar Disord 3:189-201. 2001
  10. ncbi request reprint Chronic myo-inositol increases rat brain phosphatidylethanolamine plasmalogen
    J W Pettegrew
    Neurophysics Laboratory, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 49:444-53. 2001

Detail Information

Publications31

  1. ncbi request reprint High serum and cerebrospinal fluid Ca/Mg ratio in recently hospitalized acutely depressed patients
    J Levine
    Beersheva Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beersheva, Israel
    Neuropsychobiology 39:63-70. 1999
    ..A retrospective analysis of previous trials assessing serum/plasma or CSF Ca and Mg does not seem to refute the findings of this study. We further discuss our findings in their relation to the acuteness of the depressive disorders...
  2. ncbi request reprint Low CSF soluble interleukin 2 receptor levels in acute depression. Short communication
    J Levine
    Beersheva Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Israel
    J Neural Transm 106:1011-5. 1999
    ..CSF was withdrawn from all subjects for the measurement of soluble interleukin 2 receptor (sIL-2R). CSF sIL-2R levels were found to be lower in patients as compared to controls (df = 1, 20; F = 84; p<0.000001)...
  3. ncbi request reprint Stability of CSF metabolites measured by proton NMR
    J Levine
    Department of Psychiatry, School of Medicine, University of Pittsburgh, Pennsylvania 15213, USA
    J Neural Transm 107:843-8. 2000
    ..No effect of exposure was found on myoinositol, glucose, acetate, and alanine CSF levels and there was a substantial decrease of citrate (>50%) and increase in lactate, glutamine, creatine, and creatinine levels...
  4. ncbi request reprint Psychotropic drug prescription patterns among patients with bipolar I disorder
    J Levine
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA, USA
    Bipolar Disord 2:120-30. 2000
    ..We evaluated prescription patterns and the influence of demographic variables on these patterns in a voluntary registry of subjects with bipolar disorder...
  5. ncbi request reprint Topiramate as add-on treatment for patients with bipolar mania
    K N Chengappa
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, PA 15215 2593, USA
    Bipolar Disord 1:42-53. 1999
    ..Topiramate (Topamax), a new antiepileptic agent, is a candidate drug for bipolar disorder. We evaluated topiramate as adjunctive treatment for bipolar patients...
  6. ncbi request reprint Clozapine reduces severe self-mutilation and aggression in psychotic patients with borderline personality disorder
    K N Chengappa
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, PA 15213 2593, USA
    J Clin Psychiatry 60:477-84. 1999
    ..This article describes the impact of clozapine on severe self-mutilation among patients with the dual diagnoses of borderline personality disorder and persistent psychoses...
  7. ncbi request reprint Illness characteristics and their association with prescription patterns for bipolar I disorder
    J Levine
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA 15213-2593, USA
    Bipolar Disord 3:41-9. 2001
    ..CONCLUSIONS: Our results suggest that subjects with bipolar I disorder have high rate of suicidal attempts and may have serious functional impairments...
  8. doi request reprint Global leukocyte DNA methylation is not altered in euthymic bipolar patients
    A Bromberg
    Psychiatry Research Unit, Faculty of Health Sciences, Ben Gurion University of the Negev and Mental Health Center, PO Box 4600 Beer Sheva 84170, Israel
    J Affect Disord 118:234-9. 2009
    ....
  9. ncbi request reprint Effects of chronic lithium administration on rat brain phosphatidylinositol cycle constituents, membrane phospholipids and amino acids
    J W Pettegrew
    Neurophysics Laboratory, Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Bipolar Disord 3:189-201. 2001
    ..This study examines lithium effects on rat brain metabolites associated with the above systems and their reversal by myo-inositol...
  10. ncbi request reprint Chronic myo-inositol increases rat brain phosphatidylethanolamine plasmalogen
    J W Pettegrew
    Neurophysics Laboratory, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 49:444-53. 2001
    ..CONCLUSIONS: The observed alteration in the PtdEtn-Plas/PtdEtn ratio could provide insights into the therapeutic effect of myo-inositol in affective disorders...
  11. ncbi request reprint Inositol as an add-on treatment for bipolar depression
    K N Chengappa
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA, USA
    Bipolar Disord 2:47-55. 2000
    ..Inositol crosses the blood-brain barrier in pharmacological doses, and has shown efficacy in a small double-blind study of unipolar depression. This pilot study evaluated its potential efficacy and safety in bipolar depression...
  12. ncbi request reprint Anticholinergic differences among patients receiving standard clinical doses of olanzapine or clozapine
    K N Chengappa
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pennsylvania 15213 2593, USA
    J Clin Psychopharmacol 20:311-6. 2000
    ..However, none of the patients in either group expressed any desire to discontinue these medications as a result of the anticholinergic side effects...
  13. ncbi request reprint Impact of risperidone on seclusion and restraint at a state psychiatric hospital
    K N Chengappa
    University of Pittsburgh, Western Psychiatric Institute and Clinic, Special Studies Center Mayview State Hospital, 3811 O Hara Street, Pittsburgh, PA 15213 2593, USA
    Can J Psychiatry 45:827-32. 2000
    ..To evaluate the impact of risperidone on seclusion and restraint in patients at a state psychiatric facility, shortly after risperidone's release...
  14. ncbi request reprint Lifetime prevalence of substance or alcohol abuse and dependence among subjects with bipolar I and II disorders in a voluntary registry
    K N Chengappa
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, School of Medicine, PA 15213 2593, USA
    Bipolar Disord 2:191-5. 2000
    ..To evaluate the prevalence of substance abuse dependence and/or alcohol abuse dependence among subjects with bipolar I versus bipolar II disorder in a voluntary registry...
  15. ncbi request reprint Brain metabolic effects of acute nicotine
    J W Pettegrew
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pennsylvania, USA
    Neurochem Res 26:181-5. 2001
    ..These metabolic responses to (-)nicotine could contribute to nicotine's behavioral effects...
  16. ncbi request reprint Response to placebo among bipolar I disorder patients experiencing their first manic episode
    K N Chengappa
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Special Studies Center at Mayview State Hospital, PA 15213 2593, USA
    Bipolar Disord 2:332-5. 2000
    ..Olanzapine versus placebo in the treatment of acute mania. Am J Psychiatry 1999; 156: 702-709)...
  17. ncbi request reprint Effects of acetyl-L-carnitine and myo-inositol on high-energy phosphate and membrane phospholipid metabolism in zebra fish: a 31P-NMR-spectroscopy study
    J Levine
    Neurophysics Laboratory, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Neurochem Res 28:687-90. 2003
    ..These findings demonstrate both ALCAR and myo-inositol modulate membrane phospholipid and high-energy phosphate metabolism in free-swimming zebra fish...
  18. doi request reprint No association between global leukocyte DNA methylation and homocysteine levels in schizophrenia patients
    A Bromberg
    Faculty of Health Sciences, Stanley Research Center, Ben Gurion University of the Negev and Beersheva Mental Health Center, Beersheva, Israel
    Schizophr Res 101:50-7. 2008
    ..032). Although leukocytes may be a useful cell model to evaluate epigenetic changes such as global DNA methylation in brain, future studies should compare global DNA methylation in peripheral tissue vs. brain in laboratory animals...
  19. ncbi request reprint Differentiating primary pathophysiologic from secondary adaptational processes
    J Levine
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Depress Anxiety 14:105-11. 2001
    ..Also, the first example relates to a biological perturbation associated with a primary pathophysiological mechanism, while the second represents a biological alteration associated with secondary adaptational processes...
  20. ncbi request reprint Bupropion sustained release as a smoking cessation treatment in remitted depressed patients maintained on treatment with selective serotonin reuptake inhibitor antidepressants
    K N Chengappa
    Western Psychiatric Institute and Clinic, University of Pittsburgh, Mayview State Hospital, PA 15213, USA
    J Clin Psychiatry 62:503-8. 2001
    ....
  21. ncbi request reprint Acetyl-L-carnitine physical-chemical, metabolic, and therapeutic properties: relevance for its mode of action in Alzheimer's disease and geriatric depression
    J W Pettegrew
    Department of Psychiatry, School of Medicine, University of Pittsburgh, PA 15213, USA
    Mol Psychiatry 5:616-32. 2000
    ..ALCAR is reported in double-blind controlled studies to have beneficial effects in major depressive disorders and Alzheimer's disease (AD), both of which are highly prevalent in the geriatric population...
  22. ncbi request reprint Long-term effects of topiramate on bipolar mood instability, weight change and glycemic control: a case-series
    K N Roy Chengappa
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, 3811 O Hara Street, Pittsburgh, PA 15213 2593, USA
    Eur Psychiatry 16:186-90. 2001
    ..In addition to improved mood stability, these individuals lost between 16 to 20.5% of their pre-topiramate body weight and also achieved significant glycemic control...
  23. ncbi request reprint Anxiety disorders and major depression, together or apart
    J Levine
    Stanley Center for the Innovative Treatment of Bipolar Disorder, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania, USA
    Depress Anxiety 14:94-104. 2001
    ....
  24. ncbi request reprint Time-dependent sensitization: the odyssey of a scientific heresy from the laboratory to the door of the clinic
    S M Antelman
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, School of Medicine, Pittsburgh, PA 15213, USA
    Mol Psychiatry 5:350-6. 2000
    ....
  25. ncbi request reprint Nutritional and life style determinants of plasma homocysteine in schizophrenia patients
    Z Stahl
    Stanley Research Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beersheva, Israel
    Eur Neuropsychopharmacol 15:291-5. 2005
    ..Only 24% of the variance in male patients was explained by the model. The reason for elevated plasma homocysteine in some schizophrenic populations remains unclear...
  26. ncbi request reprint CSF homocysteine is not elevated in schizophrenia
    J Levine
    Stanley Research Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beersheva, Israel
    J Neural Transm 112:297-302. 2005
    ..No difference was found for CSF homocysteine levels between schizophrenia patients and controls (p=.041 for Study A and p=.52 for Study B)...
  27. ncbi request reprint Effect of inositol on bulimia nervosa and binge eating
    D Gelber
    Ministry of Health Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, P.O. Box 4600, Beersheva, Israel
    Int J Eat Disord 29:345-8. 2001
    ..This increases its parallelism with serotonin selective reuptake inhibitors...
  28. ncbi request reprint Inositol treatment has no effect on the dexamethasone suppression test
    J Levine
    Ministry of Health Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beersheva, Israel
    World J Biol Psychiatry 2:190-2. 2001
    ..However, after two weeks on inositol, when substantial clinical improvement was noted, he converted to a normal DST. Chronic inositol treatment does not seem to induce false positive DST results...
  29. ncbi request reprint GSK-3beta in cerebrospinal fluid of schizophrenia patients
    N Kozlovsky
    Stanley Research Center, Department of Clinical Biochemistry, Faculty of Health Sciences, Ben Gurion University of the Negev and Mental Health Center, Beersheva, Israel
    J Neural Transm 111:1093-8. 2004
    ..Our results corroborate other studies in which CSF protein levels reflect the alteration found in these proteins in schizophrenia patients' postmortem brain...
  30. ncbi request reprint Task set switching in schizophrenia
    N Meiran
    Department of Behavioral Sciences and Zlotowski Center for Neuroscience, Ben Gurion University of the Negev, Beer Sheva, Israel
    Neuropsychology 14:471-82. 2000
    ..Results suggest that set switching difficulties in schizophrenia, as exhibited in the present paradigm, reflect poor memory for task context information...
  31. ncbi request reprint Clozapine: its impact on aggressive behavior among patients in a state psychiatric hospital
    K N R Chengappa
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213 2593, USA
    Schizophr Res 53:1-6. 2002
    ..Preliminary data suggests other second generation antipsychotic agents may have similar effects...