Beth Levine

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. pmc Autophagy in cell death: an innocent convict?
    Beth Levine
    Division of Infectious Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9113, USA
    J Clin Invest 115:2679-88. 2005
  2. ncbi request reprint HSV-1 ICP34.5 confers neurovirulence by targeting the Beclin 1 autophagy protein
    Anthony Orvedahl
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell Host Microbe 1:23-35. 2007
  3. pmc Autophagy in immunity and inflammation
    Beth Levine
    Department of Microbiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9113, USA
    Nature 469:323-35. 2011
  4. ncbi request reprint Unveiling the roles of autophagy in innate and adaptive immunity
    Beth Levine
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Nat Rev Immunol 7:767-77. 2007
  5. pmc Bcl-2 family members: dual regulators of apoptosis and autophagy
    Beth Levine
    Howard Hughes Medical Institute, Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9113, USA
    Autophagy 4:600-6. 2008
  6. pmc HIV and CXCR4 in a kiss of autophagic death
    Beth Levine
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9113, USA
    J Clin Invest 116:2078-80. 2006
  7. ncbi request reprint Unraveling the role of autophagy in cancer
    Beth Levine
    Department of Internal Medicine and Microbiology, UT Southwestern Medical Center at Dallas, Texas 75390, USA
    Autophagy 2:65-6. 2006
  8. pmc Molecular basis of the regulation of Beclin 1-dependent autophagy by the gamma-herpesvirus 68 Bcl-2 homolog M11
    Sangita Sinha
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9113, USA
    Autophagy 4:989-97. 2008
  9. pmc Autophagy in the pathogenesis of disease
    Beth Levine
    Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Cell 132:27-42. 2008
  10. ncbi request reprint Eating oneself and uninvited guests: autophagy-related pathways in cellular defense
    Beth Levine
    Department of Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75330, USA
    Cell 120:159-62. 2005

Collaborators

Detail Information

Publications35

  1. pmc Autophagy in cell death: an innocent convict?
    Beth Levine
    Division of Infectious Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9113, USA
    J Clin Invest 115:2679-88. 2005
    ..This review summarizes the evidence linking autophagy to cell survival and cell death, the complex interplay between autophagy and apoptosis pathways, and the role of autophagy-dependent survival and death pathways in clinical diseases...
  2. ncbi request reprint HSV-1 ICP34.5 confers neurovirulence by targeting the Beclin 1 autophagy protein
    Anthony Orvedahl
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell Host Microbe 1:23-35. 2007
    ..Our findings suggest that autophagy inhibition is a novel molecular mechanism by which viruses evade innate immunity and cause fatal disease...
  3. pmc Autophagy in immunity and inflammation
    Beth Levine
    Department of Microbiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9113, USA
    Nature 469:323-35. 2011
    ..They balance the beneficial and detrimental effects of immunity and inflammation, and thereby may protect against infectious, autoimmune and inflammatory diseases...
  4. ncbi request reprint Unveiling the roles of autophagy in innate and adaptive immunity
    Beth Levine
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Nat Rev Immunol 7:767-77. 2007
    ..This Review describes the mechanisms of autophagy and highlights recent advances relevant to the role of autophagy in innate and adaptive immunity...
  5. pmc Bcl-2 family members: dual regulators of apoptosis and autophagy
    Beth Levine
    Howard Hughes Medical Institute, Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9113, USA
    Autophagy 4:600-6. 2008
    ..This hitherto neglected crosstalk between the core machineries regulating autophagy and apoptosis may redefine the role of Bcl-2 family proteins in oncogenesis and tumor progression...
  6. pmc HIV and CXCR4 in a kiss of autophagic death
    Beth Levine
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9113, USA
    J Clin Invest 116:2078-80. 2006
    ..The HIV envelope glycoprotein interacts with CXC chemokine receptor 4 to activate the lysosomal degradation pathway of autophagy, which is necessary for both apoptotic and nonapoptotic cell death...
  7. ncbi request reprint Unraveling the role of autophagy in cancer
    Beth Levine
    Department of Internal Medicine and Microbiology, UT Southwestern Medical Center at Dallas, Texas 75390, USA
    Autophagy 2:65-6. 2006
  8. pmc Molecular basis of the regulation of Beclin 1-dependent autophagy by the gamma-herpesvirus 68 Bcl-2 homolog M11
    Sangita Sinha
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9113, USA
    Autophagy 4:989-97. 2008
    ..Thus, our results suggest that M11 inhibits autophagy through a mechanism that involves the binding of the Beclin 1 BH3 domain in the M11 hydrophobic surface groove...
  9. pmc Autophagy in the pathogenesis of disease
    Beth Levine
    Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Cell 132:27-42. 2008
    ..This Review summarizes recent advances in understanding the physiological functions of autophagy and its possible roles in the causation and prevention of human diseases...
  10. ncbi request reprint Eating oneself and uninvited guests: autophagy-related pathways in cellular defense
    Beth Levine
    Department of Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75330, USA
    Cell 120:159-62. 2005
    ..2005). Other recent studies indicate that the autophagy machinery is also used to degrade foreign microbial invaders (xenophagy)...
  11. ncbi request reprint Bcl-2 inhibition of autophagy: a new route to cancer?
    Sophie Pattingre
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9113, USA
    Cancer Res 66:2885-8. 2006
    ..These findings raise the possibility that Bcl-2 family members may function as oncogenes not only by blocking apoptosis but also by blocking autophagy...
  12. pmc JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy
    Yongjie Wei
    Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Mol Cell 30:678-88. 2008
    ..These findings define a mechanism that cells use to regulate autophagic activity in response to nutrient status...
  13. pmc Autophagy protects against Sindbis virus infection of the central nervous system
    Anthony Orvedahl
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, 75390, USA
    Cell Host Microbe 7:115-27. 2010
    ..These results suggest a function for autophagy in mammalian antiviral defense: a cell-autonomous mechanism in which p62 adaptor-mediated autophagic viral protein clearance promotes cell survival...
  14. pmc Autophagy genes protect against Salmonella typhimurium infection and mediate insulin signaling-regulated pathogen resistance
    Kailiang Jia
    Department of Internal Medicine, The Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 106:14564-9. 2009
    ..Thus, autophagy genes play an essential role in host defense in vivo against an intracellular bacterial pathogen and mediate pathogen resistance in long-lived mutant nematodes...
  15. pmc The Beclin 1 interactome
    Congcong He
    Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, United States
    Curr Opin Cell Biol 22:140-9. 2010
    ....
  16. pmc Cardiac autophagy is a maladaptive response to hemodynamic stress
    Hongxin Zhu
    Department of Internal Medicine and Donald W Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390 8573, USA
    J Clin Invest 117:1782-93. 2007
    ..Taken together, these findings implicate autophagy in the pathogenesis of load-induced heart failure and suggest it may be a target for novel therapeutic intervention...
  17. pmc Autophagy in cellular growth control
    Richard C Wang
    Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    FEBS Lett 584:1417-26. 2010
    ..Here we give an overview of how TOR signaling and autophagy integrate nutritional status to regulate cell growth, how these pathways are coordinately regulated, and how dysfunction of this regulation might result in tumorigenesis...
  18. pmc Autophagy fights disease through cellular self-digestion
    Noboru Mizushima
    Department of Physiology and Cell Biology, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
    Nature 451:1069-75. 2008
    ..Understanding autophagy may ultimately allow scientists and clinicians to harness this process for the purpose of improving human health...
  19. pmc The role of autophagy in mammalian development: cell makeover rather than cell death
    Francesco Cecconi
    Dulbecco Telethon Institute at the Department of Biology, University of Rome Tor Vergata, 00133 Rome, Italy
    Dev Cell 15:344-57. 2008
    ..Thus, autophagy is a process of cytosolic "renovation," crucial in cell fate decisions...
  20. ncbi request reprint 4th International Symposium on Autophagy: exploiting the frontiers of autophagy research
    Eeva Liisa Eskelinen
    Department of Biological and Environmental Sciences, Division of Biochemistry, University of Helsinki, Helsinki, Finland
    Autophagy 3:166-73. 2007
    ..Two themes were discussed in many sessions during the symposium: the role of autophagy in the degradation of aggregate-prone proteins and protein aggregates, and the possible role of p62 in autophagy...
  21. pmc Dual role of JNK1-mediated phosphorylation of Bcl-2 in autophagy and apoptosis regulation
    Yongjie Wei
    Howard Hughes Medical Institute, USA
    Autophagy 4:949-51. 2008
    ..At a certain point when autophagy is no longer able to keep the cell alive, Bcl-2 phosphorylation might then serve to inactivate its antiapoptotic function...
  22. pmc p53: The Janus of autophagy?
    Beth Levine
    Nat Cell Biol 10:637-9. 2008
    ..The p53 tumour suppressor, previously thought to positively regulate autophagy, may also inhibit it. This dual interplay between p53 and autophagy regulation is enigmatic, but may underlie key aspects of metabolism and cancer biology...
  23. pmc Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes
    Daniel J Klionsky
    Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109 2216, USA
    Autophagy 4:151-75. 2008
    ..In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to verify an autophagic response...
  24. ncbi request reprint Autophagy genes are essential for dauer development and life-span extension in C. elegans
    Alicia Melendez
    Department of Medicine, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
    Science 301:1387-91. 2003
    ..elegans orthologs of the yeast autophagy genes APG1, APG7, APG8, and AUT10. Thus, autophagy is a cellular pathway essential for dauer development and life-span extension in C. elegans...
  25. pmc Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene
    Xueping Qu
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Clin Invest 112:1809-20. 2003
    ..Thus, mutation of beclin 1 or other autophagy genes may contribute to the pathogenesis of human cancers...
  26. ncbi request reprint Development by self-digestion: molecular mechanisms and biological functions of autophagy
    Beth Levine
    Department of Medicine, Columbia University, New York, NY 10032, USA
    Dev Cell 6:463-77. 2004
    ..In this review, we summarize our current knowledge about the molecular machinery of autophagy and the role of the autophagic machinery in eukaryotic development...
  27. ncbi request reprint Autophagy regulates programmed cell death during the plant innate immune response
    Yule Liu
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520, USA
    Cell 121:567-77. 2005
    ..Thus, the evolutionarily conserved autophagy pathway plays an essential role in plant innate immunity and negatively regulates PCD...
  28. ncbi request reprint Autophagy in development, tumor suppression, and innate immunity
    Beth Levine
    Department of Medicine, Columbia University College of Physicians and Surgeons, USA
    Harvey Lect 99:47-76. 2003
  29. ncbi request reprint Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy
    Sophie Pattingre
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Cell 122:927-39. 2005
    ..This antiautophagy function of Bcl-2 may help maintain autophagy at levels that are compatible with cell survival, rather than cell death...
  30. pmc Identification of interferon-stimulated gene 15 as an antiviral molecule during Sindbis virus infection in vivo
    Deborah J Lenschow
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Virol 79:13974-83. 2005
    ..Finally, we demonstrate that ISG15's LRLRGG motif is also required for its antiviral activity. We conclude that ISG15 can be directly antiviral...
  31. pmc IFN-stimulated gene 15 functions as a critical antiviral molecule against influenza, herpes, and Sindbis viruses
    Deborah J Lenschow
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 104:1371-6. 2007
    ..The demonstration of ISG15 as a novel antiviral molecule with activity against both RNA and DNA viruses provides a target for the development of therapies against important human pathogens...
  32. ncbi request reprint Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy
    Yutaka Matsui
    Department of Cell Biology and Molecular Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA
    Circ Res 100:914-22. 2007
    ..Furthermore, autophagy plays distinct roles during ischemia and reperfusion: autophagy may be protective during ischemia, whereas it may be detrimental during reperfusion...
  33. ncbi request reprint Cell biology: autophagy and cancer
    Beth Levine
    Nature 446:745-7. 2007
  34. ncbi request reprint How shall I eat thee?
    Daniel J Klionsky
    Life Sciences Institute and Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109 2216, USA
    Autophagy 3:413-6. 2007
  35. pmc Age-dependent resistance to lethal alphavirus encephalitis in mice: analysis of gene expression in the central nervous system and identification of a novel interferon-inducible protective gene, mouse ISG12
    Lucia Labrada
    Department of Medicine, Columbia University College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Virol 76:11688-703. 2002
    ..Together, our data identify genes that are developmentally regulated in the CNS and genes that are differentially regulated in the brains of different aged mice in response to Sindbis virus infection...