BETH C LEVINE

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi request reprint Unraveling the role of autophagy in cancer
    Beth Levine
    Department of Internal Medicine and Microbiology, UT Southwestern Medical Center at Dallas, Texas 75390, USA
    Autophagy 2:65-6. 2006
  2. ncbi request reprint Unveiling the roles of autophagy in innate and adaptive immunity
    Beth Levine
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Nat Rev Immunol 7:767-77. 2007
  3. pmc Exercise induces autophagy in peripheral tissues and in the brain
    Congcong He
    Howard Hughes Medical Institute, Department of Internal Medicine, Center for Autophagy Research, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Autophagy 8:1548-51. 2012
  4. pmc Image-based genome-wide siRNA screen identifies selective autophagy factors
    Anthony Orvedahl
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9113, USA
    Nature 480:113-7. 2011
  5. pmc Bcl-2 family members: dual regulators of apoptosis and autophagy
    Beth Levine
    Howard Hughes Medical Institute, Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9113, USA
    Autophagy 4:600-6. 2008
  6. pmc Autophagy in the pathogenesis of disease
    Beth Levine
    Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Cell 132:27-42. 2008
  7. pmc HIV and CXCR4 in a kiss of autophagic death
    Beth Levine
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9113, USA
    J Clin Invest 116:2078-80. 2006
  8. pmc Autophagy in immunity and inflammation
    Beth Levine
    Department of Microbiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9113, USA
    Nature 469:323-35. 2011
  9. ncbi request reprint Eating oneself and uninvited guests: autophagy-related pathways in cellular defense
    Beth Levine
    Department of Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75330, USA
    Cell 120:159-62. 2005
  10. ncbi request reprint HSV-1 ICP34.5 confers neurovirulence by targeting the Beclin 1 autophagy protein
    Anthony Orvedahl
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell Host Microbe 1:23-35. 2007

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Unraveling the role of autophagy in cancer
    Beth Levine
    Department of Internal Medicine and Microbiology, UT Southwestern Medical Center at Dallas, Texas 75390, USA
    Autophagy 2:65-6. 2006
  2. ncbi request reprint Unveiling the roles of autophagy in innate and adaptive immunity
    Beth Levine
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Nat Rev Immunol 7:767-77. 2007
    ..This Review describes the mechanisms of autophagy and highlights recent advances relevant to the role of autophagy in innate and adaptive immunity...
  3. pmc Exercise induces autophagy in peripheral tissues and in the brain
    Congcong He
    Howard Hughes Medical Institute, Department of Internal Medicine, Center for Autophagy Research, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Autophagy 8:1548-51. 2012
    ..This observation raises the intriguing question of whether autophagy may in part mediate the beneficial effects of exercise in neurodegeneration, adult neurogenesis and improved cognitive function...
  4. pmc Image-based genome-wide siRNA screen identifies selective autophagy factors
    Anthony Orvedahl
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9113, USA
    Nature 480:113-7. 2011
    ..Thus, our study identifies candidate determinants of selective autophagy, and defines SMURF1 as a newly recognized mediator of both viral autophagy and mitophagy...
  5. pmc Bcl-2 family members: dual regulators of apoptosis and autophagy
    Beth Levine
    Howard Hughes Medical Institute, Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9113, USA
    Autophagy 4:600-6. 2008
    ..This hitherto neglected crosstalk between the core machineries regulating autophagy and apoptosis may redefine the role of Bcl-2 family proteins in oncogenesis and tumor progression...
  6. pmc Autophagy in the pathogenesis of disease
    Beth Levine
    Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Cell 132:27-42. 2008
    ..This Review summarizes recent advances in understanding the physiological functions of autophagy and its possible roles in the causation and prevention of human diseases...
  7. pmc HIV and CXCR4 in a kiss of autophagic death
    Beth Levine
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9113, USA
    J Clin Invest 116:2078-80. 2006
    ..The HIV envelope glycoprotein interacts with CXC chemokine receptor 4 to activate the lysosomal degradation pathway of autophagy, which is necessary for both apoptotic and nonapoptotic cell death...
  8. pmc Autophagy in immunity and inflammation
    Beth Levine
    Department of Microbiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9113, USA
    Nature 469:323-35. 2011
    ..They balance the beneficial and detrimental effects of immunity and inflammation, and thereby may protect against infectious, autoimmune and inflammatory diseases...
  9. ncbi request reprint Eating oneself and uninvited guests: autophagy-related pathways in cellular defense
    Beth Levine
    Department of Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75330, USA
    Cell 120:159-62. 2005
    ..2005). Other recent studies indicate that the autophagy machinery is also used to degrade foreign microbial invaders (xenophagy)...
  10. ncbi request reprint HSV-1 ICP34.5 confers neurovirulence by targeting the Beclin 1 autophagy protein
    Anthony Orvedahl
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell Host Microbe 1:23-35. 2007
    ..Our findings suggest that autophagy inhibition is a novel molecular mechanism by which viruses evade innate immunity and cause fatal disease...
  11. pmc Autophagy in cell death: an innocent convict?
    Beth Levine
    Division of Infectious Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9113, USA
    J Clin Invest 115:2679-88. 2005
    ..This review summarizes the evidence linking autophagy to cell survival and cell death, the complex interplay between autophagy and apoptosis pathways, and the role of autophagy-dependent survival and death pathways in clinical diseases...
  12. pmc Molecular basis of the regulation of Beclin 1-dependent autophagy by the gamma-herpesvirus 68 Bcl-2 homolog M11
    Sangita Sinha
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9113, USA
    Autophagy 4:989-97. 2008
    ..Thus, our results suggest that M11 inhibits autophagy through a mechanism that involves the binding of the Beclin 1 BH3 domain in the M11 hydrophobic surface groove...
  13. ncbi request reprint Bcl-2 inhibition of autophagy: a new route to cancer?
    Sophie Pattingre
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9113, USA
    Cancer Res 66:2885-8. 2006
    ..These findings raise the possibility that Bcl-2 family members may function as oncogenes not only by blocking apoptosis but also by blocking autophagy...
  14. pmc JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy
    Yongjie Wei
    Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Mol Cell 30:678-88. 2008
    ..These findings define a mechanism that cells use to regulate autophagic activity in response to nutrient status...
  15. pmc Age-dependent resistance to lethal alphavirus encephalitis in mice: analysis of gene expression in the central nervous system and identification of a novel interferon-inducible protective gene, mouse ISG12
    Lucia Labrada
    Department of Medicine, Columbia University College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Virol 76:11688-703. 2002
    ..Together, our data identify genes that are developmentally regulated in the CNS and genes that are differentially regulated in the brains of different aged mice in response to Sindbis virus infection...
  16. pmc Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene
    Xueping Qu
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Clin Invest 112:1809-20. 2003
    ..Thus, mutation of beclin 1 or other autophagy genes may contribute to the pathogenesis of human cancers...
  17. ncbi request reprint The evolutionarily conserved domain of Beclin 1 is required for Vps34 binding, autophagy and tumor suppressor function
    Norihiko Furuya
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Autophagy 1:46-52. 2005
    ..Furthermore, they suggest a connection between Beclin 1-associated Class III PI3K/Vps34-dependent autophagy, but not VPS, function and the mechanism of Beclin 1 tumor suppressor action in human breast cancer cells...
  18. ncbi request reprint Autophagy genes are essential for dauer development and life-span extension in C. elegans
    Alicia Melendez
    Department of Medicine, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
    Science 301:1387-91. 2003
    ..elegans orthologs of the yeast autophagy genes APG1, APG7, APG8, and AUT10. Thus, autophagy is a cellular pathway essential for dauer development and life-span extension in C. elegans...
  19. ncbi request reprint Development by self-digestion: molecular mechanisms and biological functions of autophagy
    Beth Levine
    Department of Medicine, Columbia University, New York, NY 10032, USA
    Dev Cell 6:463-77. 2004
    ..In this review, we summarize our current knowledge about the molecular machinery of autophagy and the role of the autophagic machinery in eukaryotic development...
  20. ncbi request reprint Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy
    Sophie Pattingre
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Cell 122:927-39. 2005
    ..This antiautophagy function of Bcl-2 may help maintain autophagy at levels that are compatible with cell survival, rather than cell death...
  21. pmc Dual role of JNK1-mediated phosphorylation of Bcl-2 in autophagy and apoptosis regulation
    Yongjie Wei
    Howard Hughes Medical Institute, USA
    Autophagy 4:949-51. 2008
    ..At a certain point when autophagy is no longer able to keep the cell alive, Bcl-2 phosphorylation might then serve to inactivate its antiapoptotic function...
  22. pmc Autophagy protects against Sindbis virus infection of the central nervous system
    Anthony Orvedahl
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, 75390, USA
    Cell Host Microbe 7:115-27. 2010
    ..These results suggest a function for autophagy in mammalian antiviral defense: a cell-autonomous mechanism in which p62 adaptor-mediated autophagic viral protein clearance promotes cell survival...
  23. pmc The Beclin 1 interactome
    Congcong He
    Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, United States
    Curr Opin Cell Biol 22:140-9. 2010
    ....
  24. pmc Autophagy in cellular growth control
    Richard C Wang
    Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    FEBS Lett 584:1417-26. 2010
    ..Here we give an overview of how TOR signaling and autophagy integrate nutritional status to regulate cell growth, how these pathways are coordinately regulated, and how dysfunction of this regulation might result in tumorigenesis...
  25. pmc Autophagy genes protect against Salmonella typhimurium infection and mediate insulin signaling-regulated pathogen resistance
    Kailiang Jia
    Department of Internal Medicine, The Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 106:14564-9. 2009
    ..Thus, autophagy genes play an essential role in host defense in vivo against an intracellular bacterial pathogen and mediate pathogen resistance in long-lived mutant nematodes...
  26. pmc Cardiac autophagy is a maladaptive response to hemodynamic stress
    Hongxin Zhu
    Department of Internal Medicine and Donald W Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390 8573, USA
    J Clin Invest 117:1782-93. 2007
    ..Taken together, these findings implicate autophagy in the pathogenesis of load-induced heart failure and suggest it may be a target for novel therapeutic intervention...
  27. ncbi request reprint PKR-dependent autophagic degradation of herpes simplex virus type 1
    Zsolt Talloczy
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Autophagy 2:24-9. 2006
    ..5. Thus, autophagy-related pathways are involved in degrading not only cellular constituents and intracellular bacteria, but also viruses...
  28. ncbi request reprint Autophagy in development, tumor suppression, and innate immunity
    Beth Levine
    Department of Medicine, Columbia University College of Physicians and Surgeons, USA
    Harvey Lect 99:47-76. 2003
  29. pmc Regulation of starvation- and virus-induced autophagy by the eIF2alpha kinase signaling pathway
    Zsolt Talloczy
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 99:190-5. 2002
    ..5. Thus, autophagy is a novel evolutionarily conserved function of the eIF2alpha kinase pathway that is targeted by viral virulence gene products...

Research Grants32

  1. BCL2 AND BECLIN AND ALPHAVIRUS PATHOGENESIS
    Beth Levine; Fiscal Year: 2003
    ..The proposed studies will provide novel insights into host cellular mechanisms that regulate whether neurons live or die in responses to viral infection. ..
  2. ANALYSIS OF BECLIN 1 IN AUTOPHAGY AND TUMOR SUPPRESSION
    Beth Levine; Fiscal Year: 2009
    ..abstract_text> ..
  3. ANALYSIS OF BECLIN 1 IN AUTOPHAGY AND TUMOR SUPPRESSION
    Beth Levine; Fiscal Year: 2006
    ..abstract_text> ..
  4. ANALYSIS OF BECLIN 1 IN AUTOPHAGY AND TUMOR SUPPRESSION
    Beth Levine; Fiscal Year: 2007
    ..abstract_text> ..
  5. ANALYSIS OF BECLIN 1 IN AUTOPHAGY AND TUMOR SUPPRESSION
    Beth Levine; Fiscal Year: 2009
    ..abstract_text> ..
  6. BCL2 AND BECLIN AND ALPHAVIRUS PATHOGENESIS
    Beth Levine; Fiscal Year: 2001
    ..The proposed studies will provide novel insights into host cellular mechanisms that regulate whether neurons live or die in responses to viral infection. ..
  7. BCL2 AND BECLIN AND ALPHAVIRUS PATHOGENESIS
    Beth Levine; Fiscal Year: 2000
    ..The proposed studies will provide novel insights into host cellular mechanisms that regulate whether neurons live or die in responses to viral infection. ..
  8. ANALYSIS OF BECLIN 1 IN AUTOPHAGY AND TUMOR SUPPRESSION
    Beth Levine; Fiscal Year: 2005
    ..abstract_text> ..
  9. Autophagy: A Novel Antiviral Host Defense Pathway
    Beth Levine; Fiscal Year: 2006
    ..Together, these studies will provide novel insights about the role of autophagy in antiviral host defense and the role of viral evasion of autophagy in neurovirulence. ..
  10. Beclin 1-Bcl-2 Interactions: Effects on Autophagy
    BETH C LEVINE; Fiscal Year: 2010
    ..The goal of our studies is to understand how the interaction between these proteins is regulated and how this interaction contributes to the ability of mammals to successfully adapt to stress, to develop normally, and to avoid cancer. ..
  11. Beclin 1 Bcl-2 Interactions: Effects on Apoptosis
    Beth Levine; Fiscal Year: 2006
    ..abstract_text> ..
  12. Autophagy: A Novel Antiviral Host Defense Pathway
    Beth Levine; Fiscal Year: 2007
    ..Together, these studies will provide novel insights about the role of autophagy in antiviral host defense and the role of viral evasion of autophagy in neurovirulence. ..
  13. Beclin 1 Bcl-2 Interactions: Effects on Apoptosis
    Beth Levine; Fiscal Year: 2007
    ..abstract_text> ..
  14. Beclin 1 Bcl-2 Interactions: Effects on Apoptosis
    Beth Levine; Fiscal Year: 2005
    ..abstract_text> ..
  15. Autophagy: A Novel Antiviral Host Defense Pathway
    Beth Levine; Fiscal Year: 2005
    ..Together, these studies will provide novel insights about the role of autophagy in antiviral host defense and the role of viral evasion of autophagy in neurovirulence. ..
  16. Beclin 1 Bcl-2 Interactions: Effects on Apoptosis
    Beth Levine; Fiscal Year: 2004
    ..abstract_text> ..
  17. ANALYSIS OF BECLIN 1 IN AUTOPHAGY AND TUMOR SUPPRESSION
    Beth Levine; Fiscal Year: 2001
    ....
  18. ANALYSIS OF BECLIN 1 IN AUTOPHAGY AND TUMOR SUPPRESSION
    Beth Levine; Fiscal Year: 2001
    ....
  19. BCL2 AND BECLIN AND ALPHAVIRUS PATHOGENESIS
    Beth Levine; Fiscal Year: 1999
    ..The proposed studies will provide novel insights into host cellular mechanisms that regulate whether neurons live or die in responses to viral infection. ..
  20. ANALYSIS OF BECLIN 1 IN AUTOPHAGY AND TUMOR SUPPRESSION
    Beth Levine; Fiscal Year: 2002
    ....
  21. ANALYSIS OF BECLIN 1 IN AUTOPHAGY AND TUMOR SUPPRESSION
    Beth Levine; Fiscal Year: 2004
    ....
  22. ANALYSIS OF BECLIN 1 IN AUTOPHAGY AND TUMOR SUPPRESSION
    Beth Levine; Fiscal Year: 2003
    ....
  23. Autophagy: A Novel Antiviral Host Defense Pathway
    Beth Levine; Fiscal Year: 2004
    ..Together, these studies will provide novel insights about the role of autophagy in antiviral host defense and the role of viral evasion of autophagy in neurovirulence. ..
  24. Autophagy: A Novel Antiviral Host Defense Pathway
    Beth Levine; Fiscal Year: 2003
    ..Together, these studies will provide novel insights about the role of autophagy in antiviral host defense and the role of viral evasion of autophagy in neurovirulence. ..
  25. ANALYSIS OF BECLIN 1 IN AUTOPHAGY AND TUMOR SUPPRESSION
    Beth Levine; Fiscal Year: 2002
    ....
  26. BCL2 AND BECLIN AND ALPHAVIRUS PATHOGENESIS
    Beth Levine; Fiscal Year: 2002
    ..The proposed studies will provide novel insights into host cellular mechanisms that regulate whether neurons live or die in responses to viral infection. ..
  27. ANALYSIS OF BECLIN 1 IN AUTOPHAGY AND TUMOR SUPPRESSION
    Beth Levine; Fiscal Year: 2004
    ....
  28. Autophagy: A Novel Antiviral Host Defense Pathway
    Beth Levine; Fiscal Year: 2004
    ..Together, these studies will provide novel insights about the role of autophagy in antiviral host defense and the role of viral evasion of autophagy in neurovirulence. ..
  29. ANALYSIS OF BECLIN 1 IN AUTOPHAGY AND TUMOR SUPPRESSION
    Beth Levine; Fiscal Year: 2000
    ....
  30. ANALYSIS OF BECLIN 1 IN AUTOPHAGY AND TUMOR SUPPRESSION
    Beth Levine; Fiscal Year: 2003
    ....