Research Topics
| BETH C LEVINESummaryAffiliation: University of Texas Southwestern Medical Center Country: USA Publications
Research Grants
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Detail Information
Publications
Unraveling the role of autophagy in cancerBeth Levine
Department of Internal Medicine and Microbiology, UT Southwestern Medical Center at Dallas, Texas 75390, USA
Autophagy 2:65-6. 2006- Unveiling the roles of autophagy in innate and adaptive immunityBeth Levine
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Nat Rev Immunol 7:767-77. 2007..This Review describes the mechanisms of autophagy and highlights recent advances relevant to the role of autophagy in innate and adaptive immunity... 
Autophagy in immunity and inflammationBeth Levine
Department of Microbiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9113, USA
Nature 469:323-35. 2011..They balance the beneficial and detrimental effects of immunity and inflammation, and thereby may protect against infectious, autoimmune and inflammatory diseases...- Bcl-2 family members: dual regulators of apoptosis and autophagyBeth Levine
Howard Hughes Medical Institute, Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9113, USA
Autophagy 4:600-6. 2008..This hitherto neglected crosstalk between the core machineries regulating autophagy and apoptosis may redefine the role of Bcl-2 family proteins in oncogenesis and tumor progression... - Autophagy in the pathogenesis of diseaseBeth Levine
Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
Cell 132:27-42. 2008..This Review summarizes recent advances in understanding the physiological functions of autophagy and its possible roles in the causation and prevention of human diseases... - HIV and CXCR4 in a kiss of autophagic deathBeth Levine
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9113, USA
J Clin Invest 116:2078-80. 2006..The HIV envelope glycoprotein interacts with CXC chemokine receptor 4 to activate the lysosomal degradation pathway of autophagy, which is necessary for both apoptotic and nonapoptotic cell death... - Eating oneself and uninvited guests: autophagy-related pathways in cellular defenseBeth Levine
Department of Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75330, USA
Cell 120:159-62. 2005..2005). Other recent studies indicate that the autophagy machinery is also used to degrade foreign microbial invaders (xenophagy)... - HSV-1 ICP34.5 confers neurovirulence by targeting the Beclin 1 autophagy proteinAnthony Orvedahl
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Cell Host Microbe 1:23-35. 2007..Our findings suggest that autophagy inhibition is a novel molecular mechanism by which viruses evade innate immunity and cause fatal disease... - Molecular basis of the regulation of Beclin 1-dependent autophagy by the gamma-herpesvirus 68 Bcl-2 homolog M11Sangita Sinha
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9113, USA
Autophagy 4:989-97. 2008..Thus, our results suggest that M11 inhibits autophagy through a mechanism that involves the binding of the Beclin 1 BH3 domain in the M11 hydrophobic surface groove... - Autophagy in cell death: an innocent convict?Beth Levine
Division of Infectious Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9113, USA
J Clin Invest 115:2679-88. 2005..This review summarizes the evidence linking autophagy to cell survival and cell death, the complex interplay between autophagy and apoptosis pathways, and the role of autophagy-dependent survival and death pathways in clinical diseases... - Bcl-2 inhibition of autophagy: a new route to cancer?Sophie Pattingre
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9113, USA
Cancer Res 66:2885-8. 2006..These findings raise the possibility that Bcl-2 family members may function as oncogenes not only by blocking apoptosis but also by blocking autophagy... - JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagyYongjie Wei
Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Mol Cell 30:678-88. 2008..These findings define a mechanism that cells use to regulate autophagic activity in response to nutrient status... - Age-dependent resistance to lethal alphavirus encephalitis in mice: analysis of gene expression in the central nervous system and identification of a novel interferon-inducible protective gene, mouse ISG12Lucia Labrada
Department of Medicine, Columbia University College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
J Virol 76:11688-703. 2002..Together, our data identify genes that are developmentally regulated in the CNS and genes that are differentially regulated in the brains of different aged mice in response to Sindbis virus infection... - Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy geneXueping Qu
Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
J Clin Invest 112:1809-20. 2003..Thus, mutation of beclin 1 or other autophagy genes may contribute to the pathogenesis of human cancers... - The evolutionarily conserved domain of Beclin 1 is required for Vps34 binding, autophagy and tumor suppressor functionNorihiko Furuya
Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York, USA
Autophagy 1:46-52. 2005..Furthermore, they suggest a connection between Beclin 1-associated Class III PI3K/Vps34-dependent autophagy, but not VPS, function and the mechanism of Beclin 1 tumor suppressor action in human breast cancer cells... - Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagySophie Pattingre
Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
Cell 122:927-39. 2005..This antiautophagy function of Bcl-2 may help maintain autophagy at levels that are compatible with cell survival, rather than cell death... - Development by self-digestion: molecular mechanisms and biological functions of autophagyBeth Levine
Department of Medicine, Columbia University, New York, NY 10032, USA
Dev Cell 6:463-77. 2004..In this review, we summarize our current knowledge about the molecular machinery of autophagy and the role of the autophagic machinery in eukaryotic development... - Autophagy genes are essential for dauer development and life-span extension in C. elegansAlicia Melendez
Department of Medicine, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
Science 301:1387-91. 2003..elegans orthologs of the yeast autophagy genes APG1, APG7, APG8, and AUT10. Thus, autophagy is a cellular pathway essential for dauer development and life-span extension in C. elegans... - Dual role of JNK1-mediated phosphorylation of Bcl-2 in autophagy and apoptosis regulationYongjie Wei
Howard Hughes Medical Institute, USA
Autophagy 4:949-51. 2008..At a certain point when autophagy is no longer able to keep the cell alive, Bcl-2 phosphorylation might then serve to inactivate its antiapoptotic function... - Autophagy in cellular growth controlRichard C Wang
Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
FEBS Lett 584:1417-26. 2010..Here we give an overview of how TOR signaling and autophagy integrate nutritional status to regulate cell growth, how these pathways are coordinately regulated, and how dysfunction of this regulation might result in tumorigenesis... - Autophagy protects against Sindbis virus infection of the central nervous systemAnthony Orvedahl
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, 75390, USA
Cell Host Microbe 7:115-27. 2010..These results suggest a function for autophagy in mammalian antiviral defense: a cell-autonomous mechanism in which p62 adaptor-mediated autophagic viral protein clearance promotes cell survival... - The Beclin 1 interactomeCongcong He
Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, United States
Curr Opin Cell Biol 22:140-9. 2010.... - Autophagy genes protect against Salmonella typhimurium infection and mediate insulin signaling-regulated pathogen resistanceKailiang Jia
Department of Internal Medicine, The Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Proc Natl Acad Sci U S A 106:14564-9. 2009..Thus, autophagy genes play an essential role in host defense in vivo against an intracellular bacterial pathogen and mediate pathogen resistance in long-lived mutant nematodes... - Autophagy in development, tumor suppression, and innate immunityBeth Levine
Department of Medicine, Columbia University College of Physicians and Surgeons, USA
Harvey Lect 99:47-76. 2003 - Cardiac autophagy is a maladaptive response to hemodynamic stressHongxin Zhu
Department of Internal Medicine and Donald W Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390 8573, USA
J Clin Invest 117:1782-93. 2007..Taken together, these findings implicate autophagy in the pathogenesis of load-induced heart failure and suggest it may be a target for novel therapeutic intervention... - PKR-dependent autophagic degradation of herpes simplex virus type 1Zsolt Talloczy
Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York, USA
Autophagy 2:24-9. 2006..5. Thus, autophagy-related pathways are involved in degrading not only cellular constituents and intracellular bacteria, but also viruses... - Regulation of starvation- and virus-induced autophagy by the eIF2alpha kinase signaling pathwayZsolt Talloczy
Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Proc Natl Acad Sci U S A 99:190-5. 2002..5. Thus, autophagy is a novel evolutionarily conserved function of the eIF2alpha kinase pathway that is targeted by viral virulence gene products...
Research Grants
- BCL2 AND BECLIN AND ALPHAVIRUS PATHOGENESISBeth Levine; Fiscal Year: 2003..The proposed studies will provide novel insights into host cellular mechanisms that regulate whether neurons live or die in responses to viral infection. ..
- ANALYSIS OF BECLIN 1 IN AUTOPHAGY AND TUMOR SUPPRESSIONBeth Levine; Fiscal Year: 2004....
- Autophagy: A Novel Antiviral Host Defense PathwayBeth Levine; Fiscal Year: 2007..Together, these studies will provide novel insights about the role of autophagy in antiviral host defense and the role of viral evasion of autophagy in neurovirulence. ..
- Beclin 1 Bcl-2 Interactions: Effects on ApoptosisBeth Levine; Fiscal Year: 2007..abstract_text> ..
- Beclin 1-Bcl-2 Interactions: Effects on AutophagyBETH C LEVINE; Fiscal Year: 2010..The goal of our studies is to understand how the interaction between these proteins is regulated and how this interaction contributes to the ability of mammals to successfully adapt to stress, to develop normally, and to avoid cancer. ..
- ANALYSIS OF BECLIN 1 IN AUTOPHAGY AND TUMOR SUPPRESSIONBeth Levine; Fiscal Year: 2009..abstract_text> ..