A Joan Levine

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. doi request reprint Genetic variation in insulin pathway genes and distal colorectal adenoma risk
    A Joan Levine
    Department of Preventive Medicine, Genetic Epidemiology, University of Southern California Keck School of Medicine, NRT 1450 Biggy Street Room 1509A, Los Angeles, CA 90033, USA
    Int J Colorectal Dis 27:1587-95. 2012
  2. pmc Baseline plasma total homocysteine and adenoma recurrence: results from a double blind randomized clinical trial of aspirin and folate supplementation
    A Joan Levine
    USC Keck School of Medicine, Department of Preventive Medicine, Genetic Epidemiology, NRT 1450 Biggy Street Room 1509A, Los Angeles, CA 90033, USA
    Cancer Epidemiol Biomarkers Prev 19:2541-8. 2010
  3. pmc MTHFR genotype and colorectal adenoma recurrence: data from a double-blind placebo-controlled clinical trial
    A Joan Levine
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Cancer Epidemiol Biomarkers Prev 17:2409-15. 2008
  4. pmc Cancer risks for the relatives of colorectal cancer cases with a methylated MLH1 promoter region: data from the Colorectal Cancer Family Registry
    A Joan Levine
    Department of Preventive Medicine, Genetic Epidemiology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Cancer Prev Res (Phila) 5:328-35. 2012
  5. pmc A candidate gene study of folate-associated one carbon metabolism genes and colorectal cancer risk
    A Joan Levine
    USC Keck School of Medicine, Department of Preventive Medicine, Genetic Epidemiology, NRT 1450 Biggy Street Room 1509A, Los Angeles, CA 90033, USA
    Cancer Epidemiol Biomarkers Prev 19:1812-21. 2010
  6. pmc Genetic variability in the MTHFR gene and colorectal cancer risk using the colorectal cancer family registry
    A Joan Levine
    USC Keck School of Medicine, Department of Preventive Medicine, Genetic Epidemiology, NRT 1450 Biggy Street, Room 1509A, Los Angeles, CA 90033, USA
    Cancer Epidemiol Biomarkers Prev 19:89-100. 2010
  7. pmc Variation in folate pathway genes and distal colorectal adenoma risk: a sigmoidoscopy-based case-control study
    A Joan Levine
    Department of Preventive Medicine, Genetic Epidemiology, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    Cancer Causes Control 22:541-52. 2011
  8. pmc Vitamins B2, B6, and B12 and risk of new colorectal adenomas in a randomized trial of aspirin use and folic acid supplementation
    Jane C Figueiredo
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Harlyne J Norris Cancer Research Tower, 1450 Biggy Street Room 1509B, Los Angeles CA 90033, USA
    Cancer Epidemiol Biomarkers Prev 17:2136-45. 2008
  9. pmc Colorectal adenomas in a randomized folate trial: the role of baseline dietary and circulating folate levels
    Jane C Figueiredo
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Cancer Epidemiol Biomarkers Prev 17:2625-31. 2008
  10. pmc Global DNA hypomethylation (LINE-1) in the normal colon and lifestyle characteristics and dietary and genetic factors
    Jane C Figueiredo
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Cancer Epidemiol Biomarkers Prev 18:1041-9. 2009

Collaborators

Detail Information

Publications22

  1. doi request reprint Genetic variation in insulin pathway genes and distal colorectal adenoma risk
    A Joan Levine
    Department of Preventive Medicine, Genetic Epidemiology, University of Southern California Keck School of Medicine, NRT 1450 Biggy Street Room 1509A, Los Angeles, CA 90033, USA
    Int J Colorectal Dis 27:1587-95. 2012
    ....
  2. pmc Baseline plasma total homocysteine and adenoma recurrence: results from a double blind randomized clinical trial of aspirin and folate supplementation
    A Joan Levine
    USC Keck School of Medicine, Department of Preventive Medicine, Genetic Epidemiology, NRT 1450 Biggy Street Room 1509A, Los Angeles, CA 90033, USA
    Cancer Epidemiol Biomarkers Prev 19:2541-8. 2010
    ..It is uncertain whether plasma tHcy is associated with risk at the low levels common in a folate-fortified population...
  3. pmc MTHFR genotype and colorectal adenoma recurrence: data from a double-blind placebo-controlled clinical trial
    A Joan Levine
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Cancer Epidemiol Biomarkers Prev 17:2409-15. 2008
    ..Our findings indicate that the MTHFR genotype does not change adenoma risk in a manner similar to its effect on colorectal cancer, and does not modify the effect of folate supplementation on metachronous adenoma risk...
  4. pmc Cancer risks for the relatives of colorectal cancer cases with a methylated MLH1 promoter region: data from the Colorectal Cancer Family Registry
    A Joan Levine
    Department of Preventive Medicine, Genetic Epidemiology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Cancer Prev Res (Phila) 5:328-35. 2012
    ....
  5. pmc A candidate gene study of folate-associated one carbon metabolism genes and colorectal cancer risk
    A Joan Levine
    USC Keck School of Medicine, Department of Preventive Medicine, Genetic Epidemiology, NRT 1450 Biggy Street Room 1509A, Los Angeles, CA 90033, USA
    Cancer Epidemiol Biomarkers Prev 19:1812-21. 2010
    ..Folate-associated one-carbon metabolism (FOCM) may play an important role in colorectal carcinogenesis. Variation in FOCM genes may explain some of the underlying risk of colorectal cancer...
  6. pmc Genetic variability in the MTHFR gene and colorectal cancer risk using the colorectal cancer family registry
    A Joan Levine
    USC Keck School of Medicine, Department of Preventive Medicine, Genetic Epidemiology, NRT 1450 Biggy Street, Room 1509A, Los Angeles, CA 90033, USA
    Cancer Epidemiol Biomarkers Prev 19:89-100. 2010
    ..The MTHFR C677T TT genotype is associated with a 15% to 18% reduction in colorectal cancer risk, but it is not clear if other variants of the gene are associated with colorectal cancer risk...
  7. pmc Variation in folate pathway genes and distal colorectal adenoma risk: a sigmoidoscopy-based case-control study
    A Joan Levine
    Department of Preventive Medicine, Genetic Epidemiology, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    Cancer Causes Control 22:541-52. 2011
    ..Folate-associated one-carbon metabolism (FOCM) is an important pathway in colorectal neoplasia risk but data on genetic variation in this pathway are largely limited to studies of single SNPs in selected genes...
  8. pmc Vitamins B2, B6, and B12 and risk of new colorectal adenomas in a randomized trial of aspirin use and folic acid supplementation
    Jane C Figueiredo
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Harlyne J Norris Cancer Research Tower, 1450 Biggy Street Room 1509B, Los Angeles CA 90033, USA
    Cancer Epidemiol Biomarkers Prev 17:2136-45. 2008
    ..In this study, we examined the associations between dietary and circulating plasma levels of vitamins B(2), B(6), and B(12) and risk colorectal adenomas...
  9. pmc Colorectal adenomas in a randomized folate trial: the role of baseline dietary and circulating folate levels
    Jane C Figueiredo
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Cancer Epidemiol Biomarkers Prev 17:2625-31. 2008
    ..Our findings support the idea that although moderate doses of folate may be protective compared with deficiency, at some point of sufficiency, supplementation provides no additional benefit...
  10. pmc Global DNA hypomethylation (LINE-1) in the normal colon and lifestyle characteristics and dietary and genetic factors
    Jane C Figueiredo
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Cancer Epidemiol Biomarkers Prev 18:1041-9. 2009
    ..Little is known about the relationships between global hypomethylation and lifestyle, demographics, dietary measures, and genetic factors...
  11. pmc Genes involved with folate uptake and distribution and their association with colorectal cancer risk
    Jane C Figueiredo
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1450 Biggy Street Room 1509J, Los Angeles, CA 90033, USA
    Cancer Causes Control 21:597-608. 2010
    ..In conclusion, we found no significant evidence that genetic variants in FOLR1, GGH, FPGS and SLC19A1 are associated with the risk of colorectal cancer...
  12. pmc Molecular characterization of MSI-H colorectal cancer by MLHI promoter methylation, immunohistochemistry, and mismatch repair germline mutation screening
    Jenny N Poynter
    Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90033 9176, USA
    Cancer Epidemiol Biomarkers Prev 17:3208-15. 2008
    ..These results reinforce the importance of distinguishing between the underlying causes of MSI in studies of etiology and prognosis...
  13. pmc Genetic variation in the vitamin D receptor (VDR) and the vitamin D-binding protein (GC) and risk for colorectal cancer: results from the Colon Cancer Family Registry
    Jenny N Poynter
    Department of Preventive Medicine, University of Southern California, Los Angeles, California, USA
    Cancer Epidemiol Biomarkers Prev 19:525-36. 2010
    ..Overall, our results do not provide evidence for a role of common genetic variants in VDR or GC in susceptibility to CRC...
  14. pmc Environmental epigenetics: prospects for studying epigenetic mediation of exposure-response relationships
    Victoria K Cortessis
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, USC Norris Comprehensive Cancer Center, Los Angeles, CA 90089, USA
    Hum Genet 131:1565-89. 2012
    ..We discuss some of the challenges in studying epigenetic mediation of pathogenesis and describe some unique opportunities for exploring these phenomena...
  15. ncbi request reprint The MnSOD A16V mitochondrial targeting sequence polymorphism is not associated with increased risk of distal colorectal adenomas: data from a sigmoidoscopy-based case control study
    A Joan Levine
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, California 90089 9175, USA
    Cancer Epidemiol Biomarkers Prev 11:1140-1. 2002
  16. ncbi request reprint Modeling exposures for DNA methylation profiles
    Kimberly D Siegmund
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1540 Alcazar Street, CHP 220, Los Angeles, CA 90089, USA
    Cancer Epidemiol Biomarkers Prev 15:567-72. 2006
    ..Thus, when the clusters are not identified with certainty, the extended mixture model is preferred for valid estimation of the OR and CI...
  17. ncbi request reprint BRCA1 and BRCA2 mutation carriers, oral contraceptive use, and breast cancer before age 50
    Robert W Haile
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, 1441 Eastlake Avenue, MS 9175, Los Angeles, CA 90089 9175, USA
    Cancer Epidemiol Biomarkers Prev 15:1863-70. 2006
    ..Understanding the effect of oral contraceptives on risk of breast cancer in BRCA1 or BRCA2 mutation carriers is important because oral contraceptive use is a common, modifiable practice...
  18. pmc Genetic variation in the base excision repair pathway, environmental risk factors, and colorectal adenoma risk
    Roman Corral
    Department of Preventive Medicine, Keck School of Medicine of USC, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, United States of America
    PLoS ONE 8:e71211. 2013
    ..Our findings strengthen the role of oxidative damage induced by key lifestyle and dietary risk factors in colorectal adenoma formation. ..
  19. doi request reprint A review of cancer in U.S. Hispanic populations
    Robert W Haile
    Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Cancer Prev Res (Phila) 5:150-63. 2012
    ..We review the literature and discuss study design options and features that should be considered in future studies...
  20. ncbi request reprint A molecular/epidemiologic analysis of expression of cyclooxygenases 1 and 2, use of nonsteroidal antiinflammatory drugs, and risk of colorectal adenoma
    Robert W Haile
    USC Norris Cancer Center, Keck School of Medicine, Department of Preventive Medicine, University of Southern California, 1441 Eastlake Ave, Suite 4455, Los Angeles, CA 90033, USA
    Clin Colorectal Cancer 4:390-5. 2005
    ..The results suggest that at least part of the protective effect of NSAIDs on the risk of colorectal adenoma involves a COX-mediated pathway...
  21. doi request reprint Folate-genetics and colorectal neoplasia: what we know and need to know next
    Jane C Figueiredo
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Mol Nutr Food Res 57:607-27. 2013
    ....
  22. pmc Hematopoietic prostaglandin D synthase (HPGDS): a high stability, Val187Ile isoenzyme common among African Americans and its relationship to risk for colorectal cancer
    Brigette L Tippin
    Division of Medical Genetics, Harbor UCLA Medical Center and Los Angeles Biomedical Research Institute, Torrance, CA, USA
    Prostaglandins Other Lipid Mediat 97:22-8. 2012
    ..Other approaches will be needed to establish a role for HPGDS in occurrence of human intestinal tumors, as indicated by a mouse model...