Research Topics
Genomes and Genes
Species | A Joan LevineSummaryAffiliation: University of Southern California Country: USA Publications
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Detail Information
Publications
Genetic variation in insulin pathway genes and distal colorectal adenoma riskA Joan Levine
Department of Preventive Medicine, Genetic Epidemiology, University of Southern California Keck School of Medicine, NRT 1450 Biggy Street Room 1509A, Los Angeles, CA 90033, USA
Int J Colorectal Dis 27:1587-95. 2012....
Genetic variability in the MTHFR gene and colorectal cancer risk using the colorectal cancer family registryA Joan Levine
USC Keck School of Medicine, Department of Preventive Medicine, Genetic Epidemiology, NRT 1450 Biggy Street, Room 1509A, Los Angeles, CA 90033, USA
Cancer Epidemiol Biomarkers Prev 19:89-100. 2010..The MTHFR C677T TT genotype is associated with a 15% to 18% reduction in colorectal cancer risk, but it is not clear if other variants of the gene are associated with colorectal cancer risk...- A candidate gene study of folate-associated one carbon metabolism genes and colorectal cancer riskA Joan Levine
USC Keck School of Medicine, Department of Preventive Medicine, Genetic Epidemiology, NRT 1450 Biggy Street Room 1509A, Los Angeles, CA 90033, USA
Cancer Epidemiol Biomarkers Prev 19:1812-21. 2010..Folate-associated one-carbon metabolism (FOCM) may play an important role in colorectal carcinogenesis. Variation in FOCM genes may explain some of the underlying risk of colorectal cancer... - Baseline plasma total homocysteine and adenoma recurrence: results from a double blind randomized clinical trial of aspirin and folate supplementationA Joan Levine
USC Keck School of Medicine, Department of Preventive Medicine, Genetic Epidemiology, NRT 1450 Biggy Street Room 1509A, Los Angeles, CA 90033, USA
Cancer Epidemiol Biomarkers Prev 19:2541-8. 2010..It is uncertain whether plasma tHcy is associated with risk at the low levels common in a folate-fortified population... - MTHFR genotype and colorectal adenoma recurrence: data from a double-blind placebo-controlled clinical trialA Joan Levine
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
Cancer Epidemiol Biomarkers Prev 17:2409-15. 2008..Our findings indicate that the MTHFR genotype does not change adenoma risk in a manner similar to its effect on colorectal cancer, and does not modify the effect of folate supplementation on metachronous adenoma risk... - Cancer risks for the relatives of colorectal cancer cases with a methylated MLH1 promoter region: data from the Colorectal Cancer Family RegistryA Joan Levine
Department of Preventive Medicine, Genetic Epidemiology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
Cancer Prev Res (Phila) 5:328-35. 2012.... - Variation in folate pathway genes and distal colorectal adenoma risk: a sigmoidoscopy-based case-control studyA Joan Levine
Department of Preventive Medicine, Genetic Epidemiology, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
Cancer Causes Control 22:541-52. 2011..Folate-associated one-carbon metabolism (FOCM) is an important pathway in colorectal neoplasia risk but data on genetic variation in this pathway are largely limited to studies of single SNPs in selected genes... - Vitamins B2, B6, and B12 and risk of new colorectal adenomas in a randomized trial of aspirin use and folic acid supplementationJane C Figueiredo
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Harlyne J Norris Cancer Research Tower, 1450 Biggy Street Room 1509B, Los Angeles CA 90033, USA
Cancer Epidemiol Biomarkers Prev 17:2136-45. 2008..In this study, we examined the associations between dietary and circulating plasma levels of vitamins B(2), B(6), and B(12) and risk colorectal adenomas... - Colorectal adenomas in a randomized folate trial: the role of baseline dietary and circulating folate levelsJane C Figueiredo
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
Cancer Epidemiol Biomarkers Prev 17:2625-31. 2008..Our findings support the idea that although moderate doses of folate may be protective compared with deficiency, at some point of sufficiency, supplementation provides no additional benefit... - Global DNA hypomethylation (LINE-1) in the normal colon and lifestyle characteristics and dietary and genetic factorsJane C Figueiredo
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
Cancer Epidemiol Biomarkers Prev 18:1041-9. 2009..Little is known about the relationships between global hypomethylation and lifestyle, demographics, dietary measures, and genetic factors... - Genes involved with folate uptake and distribution and their association with colorectal cancer riskJane C Figueiredo
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1450 Biggy Street Room 1509J, Los Angeles, CA 90033, USA
Cancer Causes Control 21:597-608. 2010..In conclusion, we found no significant evidence that genetic variants in FOLR1, GGH, FPGS and SLC19A1 are associated with the risk of colorectal cancer... - Molecular characterization of MSI-H colorectal cancer by MLHI promoter methylation, immunohistochemistry, and mismatch repair germline mutation screeningJenny N Poynter
Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90033 9176, USA
Cancer Epidemiol Biomarkers Prev 17:3208-15. 2008..These results reinforce the importance of distinguishing between the underlying causes of MSI in studies of etiology and prognosis... - Genetic variation in the vitamin D receptor (VDR) and the vitamin D-binding protein (GC) and risk for colorectal cancer: results from the Colon Cancer Family RegistryJenny N Poynter
Department of Preventive Medicine, University of Southern California, Los Angeles, California, USA
Cancer Epidemiol Biomarkers Prev 19:525-36. 2010..Overall, our results do not provide evidence for a role of common genetic variants in VDR or GC in susceptibility to CRC... - Environmental epigenetics: prospects for studying epigenetic mediation of exposure-response relationshipsVictoria K Cortessis
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, USC Norris Comprehensive Cancer Center, Los Angeles, CA 90089, USA
Hum Genet 131:1565-89. 2012..We discuss some of the challenges in studying epigenetic mediation of pathogenesis and describe some unique opportunities for exploring these phenomena... 
The MnSOD A16V mitochondrial targeting sequence polymorphism is not associated with increased risk of distal colorectal adenomas: data from a sigmoidoscopy-based case control studyA Joan Levine
Department of Preventive Medicine, University of Southern California-Keck School of Medicine, Los Angeles, California 90089-9175, USA
Cancer Epidemiol Biomarkers Prev 11:1140-1. 2002- Modeling exposures for DNA methylation profilesKimberly D Siegmund
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1540 Alcazar Street, CHP 220, Los Angeles, CA 90089, USA
Cancer Epidemiol Biomarkers Prev 15:567-72. 2006..Thus, when the clusters are not identified with certainty, the extended mixture model is preferred for valid estimation of the OR and CI... - BRCA1 and BRCA2 mutation carriers, oral contraceptive use, and breast cancer before age 50Robert W Haile
Department of Preventive Medicine, University of Southern California Keck School of Medicine, 1441 Eastlake Avenue, MS 9175, Los Angeles, CA 90089 9175, USA
Cancer Epidemiol Biomarkers Prev 15:1863-70. 2006..Understanding the effect of oral contraceptives on risk of breast cancer in BRCA1 or BRCA2 mutation carriers is important because oral contraceptive use is a common, modifiable practice... - A review of cancer in U.S. Hispanic populationsRobert W Haile
Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90033, USA
Cancer Prev Res (Phila) 5:150-63. 2012..We review the literature and discuss study design options and features that should be considered in future studies... - A molecular/epidemiologic analysis of expression of cyclooxygenases 1 and 2, use of nonsteroidal antiinflammatory drugs, and risk of colorectal adenomaRobert W Haile
USC Norris Cancer Center, Keck School of Medicine, Department of Preventive Medicine, University of Southern California, 1441 Eastlake Ave, Suite 4455, Los Angeles, CA 90033, USA
Clin Colorectal Cancer 4:390-5. 2005..The results suggest that at least part of the protective effect of NSAIDs on the risk of colorectal adenoma involves a COX-mediated pathway... - Folate-genetics and colorectal neoplasia: What we know and need to know nextJane C Figueiredo
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
Mol Nutr Food Res 57:607-27. 2013.... - Hematopoietic prostaglandin D synthase (HPGDS): a high stability, Val187Ile isoenzyme common among African Americans and its relationship to risk for colorectal cancerBrigette L Tippin
Division of Medical Genetics, Harbor UCLA Medical Center and Los Angeles Biomedical Research Institute, Torrance, CA, USA
Prostaglandins Other Lipid Mediat 97:22-8. 2012..Other approaches will be needed to establish a role for HPGDS in occurrence of human intestinal tumors, as indicated by a mouse model...