Genomes and Genes
A Joan Levine
Affiliation: University of Southern California
- Levine A, Figueiredo J, Lee W, Poynter J, Conti D, Duggan D, et al. Genetic variability in the MTHFR gene and colorectal cancer risk using the colorectal cancer family registry. Cancer Epidemiol Biomarkers Prev. 2010;19:89-100 pubmed publisher..The 677 TT and 1298 CC genotypes may each be associated with a decrease in colorectal cancer risk. We observed little evidence of additional genetic variability in the MTHFR gene relevant to colorectal cancer risk. ..
- Levine A, Figueiredo J, Lee W, Conti D, Kennedy K, Duggan D, et al. A candidate gene study of folate-associated one carbon metabolism genes and colorectal cancer risk. Cancer Epidemiol Biomarkers Prev. 2010;19:1812-21 pubmed publisher..This study suggests that multivitamin supplement use may modify the association between folate pathway genes and colorectal cancer risk in a post-folic-acid-supplemented population. ..
- Levine A, Lee W, Figueiredo J, Conti D, Vandenberg D, Davis B, et al. Variation in folate pathway genes and distal colorectal adenoma risk: a sigmoidoscopy-based case-control study. Cancer Causes Control. 2011;22:541-52 pubmed publisher..043). The non-synonymous SLC19A1 SNP G80A interacted significantly with the MTHFR C677T genotype (interaction p value = 0.018). Our data suggest that genetic variation in SLC19A1 may modify the risk of distal colorectal adenoma. ..