Research Topics
| Myron J LevinSummaryAffiliation: University of Colorado Health Sciences Center Country: USA Publications
| Collaborators
|
Detail Information
Publications
Comparison of a live attenuated and an inactivated varicella vaccine to boost the varicella-specific immune response in seropositive people 55 years of age and olderM J Levine
Department of Pediatrics Pediatric Infectious Diseases, University of Colorado School of Medicine, Denver 80262, USA
Vaccine 18:2915-20. 2000..5-21.3 months. There were no differences in immune response to either vaccine in this older age cohort...- Administration of live varicella vaccine to HIV-infected children with current or past significant depression of CD4(+) T cellsMyron J Levin
University of Colorado School of Medicine, Denver, Denver, CO 80262, USA
J Infect Dis 194:247-55. 2006..The licensed, live attenuated varicella vaccine is safe and immunogenic in HIV-infected children with minimal symptoms and good preservation of CD4(+) T cells (Centers for Disease Control and Prevention immunologic category 1)... - Prevention strategies: herpes zoster, post-herpetic neuralgia and immunogenicityMyron J Levin
Section of Pediatric Infectious Diseases, Department of Pediatrics, University of Colorado School of Medicine, Denver, CO 80262, USA
Herpes 14:45-7. 2007..It is likely that the vaccine-induced boost in VZV-specific CMI reversed the natural decline in these responses that occurs as part of the ageing process, thereby protecting vaccine recipients against herpes zoster and its complications... 
Varicella-zoster virus-specific immune responses in elderly recipients of a herpes zoster vaccineM J Levin
University of Colorado Health Sciences Center, Denver, Colorado, USA
J Infect Dis 197:825-35. 2008..The trial included an immunology substudy to determine the relationship of VZV-specific immune responses to vaccination and clinical outcome...- Varicella vaccination of immunocompromised childrenMyron J Levin
Department of Pediatrics, Section of Infectious Diseases, University of Colorado School of Medicine, Denver, USA
J Infect Dis 197:S200-6. 2008..Numerous trials have been undertaken to vaccinate children who are immunocompromised by a variety of conditions and therapies that depress their immune function... 
Shedding of live vaccine virus, comparative safety, and influenza-specific antibody responses after administration of live attenuated and inactivated trivalent influenza vaccines to HIV-infected childrenMyron J Levin
University of Colorado School of Medicine, Aurora, CO 80045 0508, United States
Vaccine 26:4210-7. 2008..LAIV should be further evaluated for a role in immunizing HIV-infected children...- Decline in varicella-zoster virus (VZV)-specific cell-mediated immunity with increasing age and boosting with a high-dose VZV vaccineMyron J Levin
Department of Pediatrics, Section of Infectious Diseases, University of Colorado School of Medicine, Denver, Colorado, USA
J Infect Dis 188:1336-44. 2003..A live attenuated VZV vaccine is safe and immunogenic in an elderly population, and the vaccine-induced immunity may be monitored by the IFN-gamma ELISPOT assay... - Herpes zoster with skin lesions and meningitis caused by 2 different genotypes of the Oka varicella-zoster virus vaccineMyron J Levin
Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO 80045 0508, USA
J Infect Dis 198:1444-7. 2008..The presence of distinct strains in skin lesions and cerebrospinal fluid indicate that >1 variant strain may reactivate to cause herpes zoster... - Development of resistance to acyclovir during chronic infection with the Oka vaccine strain of varicella-zoster virus, in an immunosuppressed childMyron J Levin
Section of Pediatric Infectious Diseases, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Infect Dis 188:954-9. 2003..This is the first report of Oka-strain varicella virus causing severe disease after reactivation and of resistance to acyclovir during an infection caused by this virus... - Varicella-zoster virus DNA in cells isolated from human trigeminal gangliaMyron J Levin
Section of Pediatric Infectious Diseases, School of Medicine, University of Colorado, Denver, Colorado 80262, USA
J Virol 77:6979-87. 2003..There was an average of 4.7 (range of 2 to 9) copies of VZV DNA per latently infected neuron. Latent VZV DNA was primarily present in large neurons, whereas the size distribution of herpes simplex virus DNA was markedly different... - Short-term and long-term effects of highly active antiretroviral therapy on the incidence of herpes zoster in HIV-infected childrenMyron J Levin
Pediatric Infectious Diseases Section, University of Colorado at Denver Health Sciences Center, Mailstop C227, Building 401, Room R09 108, 1784 Racine Street, Aurora, CO 80045 0508, USA
J Acquir Immune Defic Syndr 50:182-91. 2009..Highly active antiretroviral therapy (HAART) has reduced herpes zoster (HZ) incidence in HIV-infected children, yet it remains common... - Pertussis booster vaccination in HIV-infected children receiving highly active antiretroviral therapyMark J Abzug
School of Medicine, University of Colorado and Children s Hospital, Denver, Colorado, USA
Pediatrics 120:e1190-202. 2007..Our goal was to evaluate the immunogenicity and safety of pertussis booster vaccination in children infected with HIV on highly active antiretroviral therapy (HAART)... - Influence of age and nature of primary infection on varicella-zoster virus-specific cell-mediated immune responsesAdriana Weinberg
Department of Pediatrics, University of Colorado Denver, Aurora, Colorado, USA
J Infect Dis 201:1024-30. 2010..We studied the relationship between VZV cell-mediated immunity and age after varicella or VZV vaccination in healthy and human immunodeficiency virus (HIV)-infected individuals... - Kinetics and determining factors of the virologic response to antiretrovirals during pregnancyAdriana Weinberg
Department of Pediatrics, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA
Infect Dis Obstet Gynecol 2009:621780. 2009..In conclusion, the virologic responses of pregnant and nonpregnant adults share similar characteristics... - Immunogenicity and immunologic memory after hepatitis B virus booster vaccination in HIV-infected children receiving highly active antiretroviral therapyMark J Abzug
University of Colorado Denver School of Medicine and The Children s Hospital, 13123 E 16th Avenue, Aurora, CO 80045, USA
J Infect Dis 200:935-46. 2009..The immunogenicity of HBV vaccination in children receiving highly active antiretroviral therapy (HAART) was investigated... - Cytomegalovirus-specific cell-mediated immunity in HIV-infected children on HAARTAdriana Weinberg
Section of Pediatric Infectious Diseases, University of Colorado School of Medicine, Denver, Colorado 80262, USA
AIDS Res Hum Retroviruses 22:283-8. 2006.... - T cell responses of HIV-infected children after administration of inactivated or live attenuated influenza vaccinesAdriana Weinberg
University of Colorado Denver, Aurora, 80045, USA
AIDS Res Hum Retroviruses 26:51-9. 2010..LAIV administration suppressed ELISPOT responses less. The clinical significance of these findings deserves further study... - A phase I-II study of live attenuated varicella-zoster virus vaccine to boost immunity in human immunodeficiency virus-infected children with previous varicellaAnne A Gershon
Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Pediatr Infect Dis J 28:653-5. 2009..There were no serious adverse events. Two years after vaccination 82% of subjects remained VZV-antibody positive and 60% had VZV-specific cell-mediated immunity. No child developed herpes zoster... - Safety and tolerability of antiretrovirals during pregnancyAdriana Weinberg
School of Medicine University of Colorado Denver, Research Complex, Aurora, CO 80045, USA
Infect Dis Obstet Gynecol 2011:867674. 2011..Our data emphasize the need to revise the treatment recommendations for pregnant women to include safer and better-tolerated drugs... - Factors that affect in vitro measurement of the susceptibility of herpes simplex virus to nucleoside analoguesAdriana Weinberg
Pediatric Infectious Diseases, University of Colorado Health Sciences Center, Denver, CO, United States
J Clin Virol 38:139-45. 2007..To identify factors that contribute to variability of HSV antiviral susceptibility breakpoints... - Safety and immunogenicity of a quadrivalent human papillomavirus (types 6, 11, 16, and 18) vaccine in HIV-infected children 7 to 12 years oldMyron J Levin
Department of Pediatrics, University of Colorado Denver School of Medicine, Aurora, CO, USA
J Acquir Immune Defic Syndr 55:197-204. 2010..Quadrivalent human papillomavirus vaccine (QHPV) is > 95% effective in preventing infection with vaccine-type human papillomavirus. The safety and immunogenicity of QHPV are unknown in HIV-infected children... - Kinetics of viral shedding and immune responses in adults following administration of cold-adapted influenza vaccineLaura L Hammitt
Section of Infectious Diseases, Department of Pediatrics, University of Colorado Denver, Denver, CO, United States
Vaccine 27:7359-66. 2009..PBMCs from subjects receiving CAIV showed a higher proportion of functional, tissue-tropic T-cells (CD4+CD69+CD18+MIP1alpha+) specific for homotypic and heterosubtypic strains of influenza by flow cytometry... - Immunogenicity, immunologic memory, and safety following measles revaccination in HIV-infected children receiving highly active antiretroviral therapyMark J Abzug
Pediatric Infectious Diseases, Box B055, Children s Hospital Colorado, 13123 East 16th Ave, Aurora, CO 80045, USA
J Infect Dis 206:512-22. 2012..Response rates and immunologic memory following measles vaccination are reduced in human immunodeficiency virus (HIV)-infected children in the absence of highly active antiretroviral therapy (HAART)... - Varicella-Zoster virus-specific cell-mediated immunity in HIV-infected children receiving highly active antiretroviral therapyAdriana Weinberg
Section of Pediatric Infectious Diseases, and Department of Medicine, University of Colorado School of Medicine, Denver, Colorado, USA
J Infect Dis 190:267-70. 2004..After developing HZ, only the 2 HAART-compliant patients developed VZV-CMI. Thus, VZV-specific immune reconstitution in HIV infection may require antigenic reexposure, in addition to control of HIV replication... - Safety and immunogenicity of a live attenuated varicella vaccine in VZV-seropositive HIV-infected adultsAdriana Weinberg
University of Colorado Denver School of Medicine, Aurora, CO, USA
Hum Vaccin 6:318-21. 2010..We evaluated the safety and immunogenicity of a live attenuated varicella-zoster virus (VZV) vaccine as a candidate for protecting HIV-infected adults against herpes-zoster... - Virologic and immunologic correlates with the magnitude of antibody responses to the hepatitis A vaccine in HIV-infected children on highly active antiretroviral treatmentAdriana Weinberg
Department of Pediatrics, University of Colorado Denver, Aurora, CO 80045, USA
J Acquir Immune Defic Syndr 52:17-24. 2009..We sought to identify the immunologic and virologic factors associated with a robust response to hepatitis A virus (HAV) vaccine in children on highly active antiretroviral treatment... - Varicella-zoster virus-specific immune responses to herpes zoster in elderly participants in a trial of a clinically effective zoster vaccineAdriana Weinberg
University of Colorado Denver, Denver, CO, USA
J Infect Dis 200:1068-77. 2009.... - Prevention strategies for herpes zoster and post-herpetic neuralgiaMyron J Levin
Pediatric Infectious Diseases, University of Colorado Denver, Mail Stop C227, Building 401, 1784 Racine Street, Room R09 108, Aurora, CO 80045, USA
J Clin Virol 48:S14-9. 2010..Other strategies focus on preventing the major complication of HZ--post-herpetic neuralgia. These strategies include pre-emptive treatment with drugs such as tricyclic antidepressants, anticonvulsants and analgesics... - Postentry events are responsible for restriction of productive varicella-zoster virus infection in Chinese hamster ovary cellsRenée L Finnen
Department of Pediatrics, Infectious Diseases Section, Biomedical Research Building 851, C227, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
J Virol 80:10325-34. 2006..Infection of CHO-K1 cells by VZV resulted in the production of both immediate early and late gene products, indicating that a block to progeny virus production occurs after the initiation of virus gene expression... - Resistance of herpes simplex virus infections to nucleoside analogues in HIV-infected patientsMyron J Levin
Pediatric Infectious Diseases, University of Colorado Health Sciences Center, Denver, USA
Clin Infect Dis 39:S248-57. 2004..This article reviews the prevalence, pathogenesis, and implications of drug-resistant HSV infections in HIV-infected patients... - Humoral, mucosal, and cell-mediated immunity against vaccine and nonvaccine genotypes after administration of quadrivalent human papillomavirus vaccine to HIV-infected childrenAdriana Weinberg
University of Colorado Denver School of Medicine, Aurora, CO 80045, USA
J Infect Dis 206:1309-18. 2012..To characterize the immunogenicity of a quadrivalent human papillomavirus vaccine (QHPV) in human immunodeficiency virus (HIV)-infected children, we studied their immune responses to 3 or 4 doses... - Immune correlates of herpes zoster in HIV-infected children and youthAdriana Weinberg
University of Colorado Denver, Aurora, Colorado, USA
J Virol 86:2878-81. 2012..In contrast, high nonspecific regulatory and activated T cells were associated with an increased risk of HZ... - Immunogenicity, safety, and predictors of response after a pneumococcal conjugate and pneumococcal polysaccharide vaccine series in human immunodeficiency virus-infected children receiving highly active antiretroviral therapyMark J Abzug
University of Colorado School of Medicine, Pediatric Infectious Disease, The Children s Hospital, Denver, CO 80218, USA
Pediatr Infect Dis J 25:920-9. 2006.... - VZV T cell-mediated immunityAdriana Weinberg
University of Colorado Denver, Aurora, CO 80045, USA
Curr Top Microbiol Immunol 342:341-57. 2010..Similarly, the magnitude of these responses early after the onset of herpes zoster correlates with the extent of zoster-associated pain. These essential immune responses are boosted by the VZV vaccine developed to prevent herpes zoster... - Susceptibility of herpes simplex virus isolates to nucleoside analogues and the proportion of nucleoside-resistant variants after repeated topical application of penciclovir to recurrent herpes labialisYoung Kyoo Shin
Section of Pediatric Infectious Diseases, School of Medicine, University of Colorado, Denver, Colorado, USA
J Infect Dis 187:1241-5. 2003..We conclude that antiviral-resistant variants, which are readily detected in HSV isolates from peripheral lesions, do not accumulate in the sensory ganglia of immunocompetent patients receiving multiple courses of nucleoside analogues... - Fractionation of neurons and satellite cells from human sensory ganglia in order to study herpesvirus latencyGuang-Yun Cai
Department of Pediatrics, Section of Pediatric Infectious Diseases, School of Medicine, University of Colorado, Box C-227, 4200 East Ninth Avenue, Denver, CO 80262, USA
J Virol Methods 104:21-32. 2002.... - Phenotypic and functional characterization of ex vivo T cell responses to the live attenuated herpes zoster vaccineJulie Patterson Bartlett
Department of Pediatrics of the University of Colorado School of Medicine, Denver, CO 80262, USA
Vaccine 25:7087-93. 2007..The vaccine significantly increased VZV-specific Th1, memory, early effector, and cutaneous homing receptor-bearing T cells... - Early treatment of cold sores with topical ME-609 decreases the frequency of ulcerative lesions: a randomized, double-blind, placebo-controlled, patient-initiated clinical trialChristopher M Hull
Department of Dermatology, School of Medicine, University of Utah, Salt Lake City, Utah 84132 2409, USA
J Am Acad Dermatol 64:696.e1-11. 2011..ME-609 (Xerese, Xerclear) is a combination of 5% acyclovir and 1% hydrocortisone developed for the topical treatment of HSL... - Varicella vaccine in the United States: a decade of prevention and the way forwardAnne A Gershon
Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, New York, USA
J Infect Dis 197:S39-40. 2008 - Advances in the understanding of the pathogenesis and epidemiology of herpes zosterAnne A Gershon
Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
J Clin Virol 48:S2-7. 2010..Understanding the risk factors for developing HZ and the complications associated with infection, particularly in older people, is important for prompt diagnosis and management of HZ in primary care, and they are therefore also reviewed... - Resistance to antiretrovirals in HIV-infected pregnant womenAdriana Weinberg
University of Colorado Denver School of Medicine, Aurora, CO 80045, USA
J Clin Virol 45:39-42. 2009..Antiretrovirals suppress HIV replication and prevent mother-to-child-transmission of HIV (PMTCT). Resistance to antiretrovirals may reduce the efficacy of PMTCT and/or complicate treatment of maternal or infant infection... - Nectin-1/HveC Mediates herpes simplex virus type 1 entry into primary human sensory neurons and fibroblastsScott A Simpson
Department of Pediatrics, Section of Infectious Diseases, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Neurovirol 11:208-18. 2005..However, in contrast to the results obtained with neurons, antibodies against receptors failed to inhibit entry into fibroblasts, indicating that unlike neurons, fibroblasts have multiple receptors or mechanisms for HSV-1 entry... - Clinical and in vitro evaluation of cidofovir for treatment of adenovirus infection in pediatric hematopoietic stem cell transplant recipientsWilliam J Muller
Department of Pediatrics, Division of Infectious Diseases, University of Washington, Seattle, USA
Clin Infect Dis 41:1812-6. 2005..In vitro susceptibility to cidofovir was demonstrated in 12 clinical adenovirus isolates. Cidofovir is a promising treatment option for this population... - Responder cell frequency estimation and binomial three-level nonlinear mixed effects model in limiting dilution assaysMisoo C Ellison
Division of Biostatistics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
J Biopharm Stat 15:165-78. 2005..In this article, an algorithm for the three-level nonlinear mixed-effects model, which can be inserted into the code in the SAS procedure NLMIXED, is suggested... - Workshop on immunizations in older adults: identifying future research agendasKevin P High
Division of Infectious Diseases, Department of Internal Medicine, School of Medicine, Wake Forest University, Winston Salem, North Carolina 27157, USA
J Am Geriatr Soc 58:765-76. 2010.... - Human sensory neurons derived from induced pluripotent stem cells support varicella-zoster virus infectionKatherine S Lee
Department of Pediatrics, Section of Infectious Diseases, University of Colorado Denver, Aurora, Colorado, United States of America
PLoS ONE 7:e53010. 2012..Since limited neuronal populations are capable of supporting the entire VZV and HSV life cycles, our iPS-derived sensory neuron model may prove useful for studying alphaherpesvirus latency and reactivation... - Immune senescence and vaccines to prevent herpes zoster in older personsMyron J Levin
Section of Pediatric Infectious Diseases, University of Colorado Denver School of Medicine and Health Sciences Center, C227, Building 401, 1784 Racine Street, Aurora, CO 80045, USA
Curr Opin Immunol 24:494-500. 2012..Based on information from these studies some potential approaches to improving prevention of herpes zoster are discussed... - Phase I/II trial of intravenous recombinant interleukin-2 in HIV-infected childrenStuart E Starr
Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, USA
AIDS 17:2181-9. 2003..Controlled trials of rIL-2 in this patient population are warranted... - Susceptibilities of herpes simplex viruses to penciclovir and acyclovir in eight cell linesJeffry J Leary
GlaxoSmithKline, The Antimicrobial and Host Defense Center of Excellence for Drug Discovery, Department of Host Defense, Collegeville, Pennsylvania, USA
Antimicrob Agents Chemother 46:762-8. 2002..Comparison experiments with a yield reduction format indicated that the use of assays of this type might allow some of the cell-specific properties observed in plaque reduction assays to be avoided... - Herpes simplex virus resistance to acyclovir and penciclovir after two decades of antiviral therapyTeresa H Bacon
GlaxoSmithKline Consumer Healthcare, Weybridge, Surrey KT15 0DE, United Kingdom
Clin Microbiol Rev 16:114-28. 2003..These observations are examined in the light of characteristics of the virus, the drugs, and host factors... - Varicella-zoster virus activates inflammatory cytokines in human monocytes and macrophages via Toll-like receptor 2Jennifer P Wang
Department of Medicine, University of Massachusetts Medical Center, Worcester, 01605, USA
J Virol 79:12658-66. 2005..Together, these results suggest that TLR2 may play a role in the inflammatory response to VZV infection... - Recommendations for the management of herpes zosterRobert H Dworkin
Department of Anesthesiology, University of Rochester School of Medicine and Dentistry, Rochester, NY, 14642, USA
Clin Infect Dis 44:S1-26. 2007..Specific recommendations for the use of these medications are provided. In addition, suggestions are made for treatments that, when used in combination with antiviral therapy, may further reduce pain and other complications of HZ... - DNA sequence variability in isolates recovered from patients with postvaccination rash or herpes zoster caused by Oka varicella vaccineVladimir N Loparev
National Center for Immunizations and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
J Infect Dis 195:502-10. 2007..5%-97.4% of isolates (mean frequency, 67.7%). No 2 clinical isolates had identical SNP profiles; as such, vaccine latency usually involves >1 strain... - Vaccination against Herpes Zoster and Postherpetic NeuralgiaMichael N Oxman
VA San Diego Healthcare System, San Diego, California, USA
J Infect Dis 197:S228-36. 2008..VZV vaccines can boost VZV-CMI. Therefore, we tested the hypothesis that VZV vaccination would protect older adults against HZ and PHN... - Cost-effectiveness of herpes zoster vaccine: flawed assumptions regarding efficacy against postherpetic neuralgiaMarc Brisson
Clin Infect Dis 45:1527-9. 2007 - Prevention of herpes zoster: recommendations of the Advisory Committee on Immunization Practices (ACIP)Rafael Harpaz
Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, USA
MMWR Recomm Rep 57:1-30; quiz CE2-4. 2008..Before administration of zoster vaccine, patients do not need to be asked about their history of varicella (chickenpox) or to have serologic testing conducted to determine varicella immunity... - Development of a measure of the burden of pain due to herpes zoster and postherpetic neuralgia for prevention trials: adaptation of the brief pain inventoryPaul M Coplan
Merck Research Laboratories, West Point, Pennsylvania 19486, USA
J Pain 5:344-56. 2004..The ZBPI measure appears useful for quantifying herpes zoster pain, postherpetic neuralgia, and impairment in daily living activities for clinical trials of herpes zoster prevention... - Hepatitis C prevalence in children with perinatal human immunodeficiency virus infection enrolled in a long-term follow-up protocolSusan Schuval
Schneider Children s Hospital, Long Island Jewish Medical Center, New Hyde Park, NY 11042, USA
Arch Pediatr Adolesc Med 158:1007-13. 2004..To evaluate the prevalence of hepatitis C virus (HCV) infection in children with perinatal human immunodeficiency virus (HIV) infection... - GB virus C infection in children with perinatal human immunodeficiency virus infectionSusan Schuval
Schneider Children s Hospital, Long Island Jewish Medical Center, New Hyde Park, NY 11042, USA
Pediatr Infect Dis J 24:417-22. 2005..GB virus C (GBV-C) infection occurs in 20-40% of human immunodeficiency virus (HIV)-infected adults, and coinfection is associated with improved HIV disease outcome... - The impact of acute herpes zoster pain and discomfort on functional status and quality of life in older adultsKenneth E Schmader
Duke University, Durham, NC, USA
Clin J Pain 23:490-6. 2007.... - Evaluation of the cost-effectiveness in the United States of a vaccine to prevent herpes zoster and postherpetic neuralgia in older adultsJames M Pellissier
Merck Research Laboratories, Blue Bell, PA, United States
Vaccine 25:8326-37. 2007..s.)... - The prevention and management of herpes zosterAnthony L Cunningham
University of Sydney, Sydney, NSW, Australia
Med J Aust 188:171-6. 2008..Clinicians should refer to the Australian immunisation handbook for advice on the use of the live vaccine in immunosuppressed individuals...