Research Topics
| Myron J LevinSummaryAffiliation: University of Colorado Denver Country: USA Publications
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Publications
Immune senescence and vaccines to prevent herpes zoster in older personsMyron J Levin
Section of Pediatric Infectious Diseases, University of Colorado Denver School of Medicine and Health Sciences Center, C227, Building 401, 1784 Racine Street, Aurora, CO 80045, USA
Curr Opin Immunol 24:494-500. 2012..Based on information from these studies some potential approaches to improving prevention of herpes zoster are discussed...
Safety and immunogenicity of a quadrivalent human papillomavirus (types 6, 11, 16, and 18) vaccine in HIV-infected children 7 to 12 years oldMyron J Levin
Department of Pediatrics, University of Colorado Denver School of Medicine, Aurora, CO, USA
J Acquir Immune Defic Syndr 55:197-204. 2010..Quadrivalent human papillomavirus vaccine (QHPV) is > 95% effective in preventing infection with vaccine-type human papillomavirus. The safety and immunogenicity of QHPV are unknown in HIV-infected children...- Prevention strategies for herpes zoster and post-herpetic neuralgiaMyron J Levin
Pediatric Infectious Diseases, University of Colorado Denver, Mail Stop C227, Building 401, 1784 Racine Street, Room R09 108, Aurora, CO 80045, USA
J Clin Virol 48:S14-9. 2010..Other strategies focus on preventing the major complication of HZ--post-herpetic neuralgia. These strategies include pre-emptive treatment with drugs such as tricyclic antidepressants, anticonvulsants and analgesics... - Kinetics and determining factors of the virologic response to antiretrovirals during pregnancyAdriana Weinberg
Department of Pediatrics, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA
Infect Dis Obstet Gynecol 2009:621780. 2009..In conclusion, the virologic responses of pregnant and nonpregnant adults share similar characteristics... - Influence of age and nature of primary infection on varicella-zoster virus-specific cell-mediated immune responsesAdriana Weinberg
Department of Pediatrics, University of Colorado Denver, Aurora, Colorado, USA
J Infect Dis 201:1024-30. 2010..We studied the relationship between VZV cell-mediated immunity and age after varicella or VZV vaccination in healthy and human immunodeficiency virus (HIV)-infected individuals... 
Cytomegalovirus-specific cell-mediated immunity in HIV-infected children on HAARTAdriana Weinberg
Section of Pediatric Infectious Diseases, University of Colorado School of Medicine, Denver, Colorado 80262, USA
AIDS Res Hum Retroviruses 22:283-8. 2006....- Safety and tolerability of antiretrovirals during pregnancyAdriana Weinberg
School of Medicine University of Colorado Denver, Research Complex, Aurora, CO 80045, USA
Infect Dis Obstet Gynecol 2011:867674. 2011..Our data emphasize the need to revise the treatment recommendations for pregnant women to include safer and better-tolerated drugs... - A phase I-II study of live attenuated varicella-zoster virus vaccine to boost immunity in human immunodeficiency virus-infected children with previous varicellaAnne A Gershon
Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Pediatr Infect Dis J 28:653-5. 2009..There were no serious adverse events. Two years after vaccination 82% of subjects remained VZV-antibody positive and 60% had VZV-specific cell-mediated immunity. No child developed herpes zoster... - T cell responses of HIV-infected children after administration of inactivated or live attenuated influenza vaccinesAdriana Weinberg
University of Colorado Denver, Aurora, 80045, USA
AIDS Res Hum Retroviruses 26:51-9. 2010..LAIV administration suppressed ELISPOT responses less. The clinical significance of these findings deserves further study... - Immunogenicity, immunologic memory, and safety following measles revaccination in HIV-infected children receiving highly active antiretroviral therapyMark J Abzug
Pediatric Infectious Diseases, Box B055, Children s Hospital Colorado, 13123 East 16th Ave, Aurora, CO 80045, USA
J Infect Dis 206:512-22. 2012..Response rates and immunologic memory following measles vaccination are reduced in human immunodeficiency virus (HIV)-infected children in the absence of highly active antiretroviral therapy (HAART)... - Factors that affect in vitro measurement of the susceptibility of herpes simplex virus to nucleoside analoguesAdriana Weinberg
Pediatric Infectious Diseases, University of Colorado Health Sciences Center, Denver, CO, United States
J Clin Virol 38:139-45. 2007..To identify factors that contribute to variability of HSV antiviral susceptibility breakpoints... - Varicella-Zoster virus-specific cell-mediated immunity in HIV-infected children receiving highly active antiretroviral therapyAdriana Weinberg
Section of Pediatric Infectious Diseases, and Department of Medicine, University of Colorado School of Medicine, Denver, Colorado, USA
J Infect Dis 190:267-70. 2004..After developing HZ, only the 2 HAART-compliant patients developed VZV-CMI. Thus, VZV-specific immune reconstitution in HIV infection may require antigenic reexposure, in addition to control of HIV replication... - Varicella-zoster virus-specific immune responses to herpes zoster in elderly participants in a trial of a clinically effective zoster vaccineAdriana Weinberg
University of Colorado Denver, Denver, CO, USA
J Infect Dis 200:1068-77. 2009.... - Safety and immunogenicity of a live attenuated varicella vaccine in VZV-seropositive HIV-infected adultsAdriana Weinberg
University of Colorado Denver School of Medicine, Aurora, CO, USA
Hum Vaccin 6:318-21. 2010..We evaluated the safety and immunogenicity of a live attenuated varicella-zoster virus (VZV) vaccine as a candidate for protecting HIV-infected adults against herpes-zoster... - Postentry events are responsible for restriction of productive varicella-zoster virus infection in Chinese hamster ovary cellsRenée L Finnen
Department of Pediatrics, Infectious Diseases Section, Biomedical Research Building 851, C227, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
J Virol 80:10325-34. 2006..Infection of CHO-K1 cells by VZV resulted in the production of both immediate early and late gene products, indicating that a block to progeny virus production occurs after the initiation of virus gene expression... - Humoral, mucosal, and cell-mediated immunity against vaccine and nonvaccine genotypes after administration of quadrivalent human papillomavirus vaccine to HIV-infected childrenAdriana Weinberg
University of Colorado Denver School of Medicine, Aurora, CO 80045, USA
J Infect Dis 206:1309-18. 2012..To characterize the immunogenicity of a quadrivalent human papillomavirus vaccine (QHPV) in human immunodeficiency virus (HIV)-infected children, we studied their immune responses to 3 or 4 doses... - Herpes zoster with skin lesions and meningitis caused by 2 different genotypes of the Oka varicella-zoster virus vaccineMyron J Levin
Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO 80045 0508, USA
J Infect Dis 198:1444-7. 2008..The presence of distinct strains in skin lesions and cerebrospinal fluid indicate that >1 variant strain may reactivate to cause herpes zoster... - Kinetics of viral shedding and immune responses in adults following administration of cold-adapted influenza vaccineLaura L Hammitt
Section of Infectious Diseases, Department of Pediatrics, University of Colorado Denver, Denver, CO, United States
Vaccine 27:7359-66. 2009..PBMCs from subjects receiving CAIV showed a higher proportion of functional, tissue-tropic T-cells (CD4+CD69+CD18+MIP1alpha+) specific for homotypic and heterosubtypic strains of influenza by flow cytometry... - Short-term and long-term effects of highly active antiretroviral therapy on the incidence of herpes zoster in HIV-infected childrenMyron J Levin
Pediatric Infectious Diseases Section, University of Colorado at Denver Health Sciences Center, Mailstop C227, Building 401, Room R09 108, 1784 Racine Street, Aurora, CO 80045 0508, USA
J Acquir Immune Defic Syndr 50:182-91. 2009..Highly active antiretroviral therapy (HAART) has reduced herpes zoster (HZ) incidence in HIV-infected children, yet it remains common... - VZV T cell-mediated immunityAdriana Weinberg
University of Colorado Denver, Aurora, CO 80045, USA
Curr Top Microbiol Immunol 342:341-57. 2010..Similarly, the magnitude of these responses early after the onset of herpes zoster correlates with the extent of zoster-associated pain. These essential immune responses are boosted by the VZV vaccine developed to prevent herpes zoster... - Advances in the understanding of the pathogenesis and epidemiology of herpes zosterAnne A Gershon
Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
J Clin Virol 48:S2-7. 2010..Understanding the risk factors for developing HZ and the complications associated with infection, particularly in older people, is important for prompt diagnosis and management of HZ in primary care, and they are therefore also reviewed... - Virologic and immunologic correlates with the magnitude of antibody responses to the hepatitis A vaccine in HIV-infected children on highly active antiretroviral treatmentAdriana Weinberg
Department of Pediatrics, University of Colorado Denver, Aurora, CO 80045, USA
J Acquir Immune Defic Syndr 52:17-24. 2009..We sought to identify the immunologic and virologic factors associated with a robust response to hepatitis A virus (HAV) vaccine in children on highly active antiretroviral treatment... - Resistance of herpes simplex virus infections to nucleoside analogues in HIV-infected patientsMyron J Levin
Pediatric Infectious Diseases, University of Colorado Health Sciences Center, Denver, USA
Clin Infect Dis 39:S248-57. 2004..This article reviews the prevalence, pathogenesis, and implications of drug-resistant HSV infections in HIV-infected patients... - Development of resistance to acyclovir during chronic infection with the Oka vaccine strain of varicella-zoster virus, in an immunosuppressed childMyron J Levin
Section of Pediatric Infectious Diseases, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Infect Dis 188:954-9. 2003..This is the first report of Oka-strain varicella virus causing severe disease after reactivation and of resistance to acyclovir during an infection caused by this virus... - Immune correlates of herpes zoster in HIV-infected children and youthAdriana Weinberg
University of Colorado Denver, Aurora, Colorado, USA
J Virol 86:2878-81. 2012..In contrast, high nonspecific regulatory and activated T cells were associated with an increased risk of HZ... - Immunogenicity and immunologic memory after hepatitis B virus booster vaccination in HIV-infected children receiving highly active antiretroviral therapyMark J Abzug
University of Colorado Denver School of Medicine and The Children s Hospital, 13123 E 16th Avenue, Aurora, CO 80045, USA
J Infect Dis 200:935-46. 2009..The immunogenicity of HBV vaccination in children receiving highly active antiretroviral therapy (HAART) was investigated... - Decline in varicella-zoster virus (VZV)-specific cell-mediated immunity with increasing age and boosting with a high-dose VZV vaccineMyron J Levin
Department of Pediatrics, Section of Infectious Diseases, University of Colorado School of Medicine, Denver, Colorado, USA
J Infect Dis 188:1336-44. 2003..A live attenuated VZV vaccine is safe and immunogenic in an elderly population, and the vaccine-induced immunity may be monitored by the IFN-gamma ELISPOT assay... - Varicella vaccine in the United States: a decade of prevention and the way forwardAnne A Gershon
Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, New York, USA
J Infect Dis 197:S39-40. 2008 - Varicella vaccination of immunocompromised childrenMyron J Levin
Department of Pediatrics, Section of Infectious Diseases, University of Colorado School of Medicine, Denver, USA
J Infect Dis 197:S200-6. 2008..Numerous trials have been undertaken to vaccinate children who are immunocompromised by a variety of conditions and therapies that depress their immune function... - Resistance to antiretrovirals in HIV-infected pregnant womenAdriana Weinberg
University of Colorado Denver School of Medicine, Aurora, CO 80045, USA
J Clin Virol 45:39-42. 2009..Antiretrovirals suppress HIV replication and prevent mother-to-child-transmission of HIV (PMTCT). Resistance to antiretrovirals may reduce the efficacy of PMTCT and/or complicate treatment of maternal or infant infection... - Human sensory neurons derived from induced pluripotent stem cells support varicella-zoster virus infectionKatherine S Lee
Department of Pediatrics, Section of Infectious Diseases, University of Colorado Denver, Aurora, Colorado, United States of America
PLoS ONE 7:e53010. 2012..Since limited neuronal populations are capable of supporting the entire VZV and HSV life cycles, our iPS-derived sensory neuron model may prove useful for studying alphaherpesvirus latency and reactivation... - Prevention strategies: herpes zoster, post-herpetic neuralgia and immunogenicityMyron J Levin
Section of Pediatric Infectious Diseases, Department of Pediatrics, University of Colorado School of Medicine, Denver, CO 80262, USA
Herpes 14:45-7. 2007..It is likely that the vaccine-induced boost in VZV-specific CMI reversed the natural decline in these responses that occurs as part of the ageing process, thereby protecting vaccine recipients against herpes zoster and its complications... - Clinical and in vitro evaluation of cidofovir for treatment of adenovirus infection in pediatric hematopoietic stem cell transplant recipientsWilliam J Muller
Department of Pediatrics, Division of Infectious Diseases, University of Washington, Seattle, USA
Clin Infect Dis 41:1812-6. 2005..In vitro susceptibility to cidofovir was demonstrated in 12 clinical adenovirus isolates. Cidofovir is a promising treatment option for this population... - Nectin-1/HveC Mediates herpes simplex virus type 1 entry into primary human sensory neurons and fibroblastsScott A Simpson
Department of Pediatrics, Section of Infectious Diseases, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Neurovirol 11:208-18. 2005..However, in contrast to the results obtained with neurons, antibodies against receptors failed to inhibit entry into fibroblasts, indicating that unlike neurons, fibroblasts have multiple receptors or mechanisms for HSV-1 entry... - Varicella-zoster virus DNA in cells isolated from human trigeminal gangliaMyron J Levin
Section of Pediatric Infectious Diseases, School of Medicine, University of Colorado, Denver, Colorado 80262, USA
J Virol 77:6979-87. 2003..There was an average of 4.7 (range of 2 to 9) copies of VZV DNA per latently infected neuron. Latent VZV DNA was primarily present in large neurons, whereas the size distribution of herpes simplex virus DNA was markedly different...