Leonard Levin

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. pmc Differential production of superoxide by neuronal mitochondria
    Mark J Hoegger
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, USA
    BMC Neurosci 9:4. 2008
  2. ncbi request reprint History of neuroprotection and rationale as a therapy for glaucoma
    Leonard A Levin
    University of Wisconsin School of Medicine and Public Health, 600 Highland Ave, Madison, WI 53792 4673, USA
    Am J Manag Care 14:S11-4. 2008
  3. ncbi request reprint Lessons from the ischemic optic neuropathy decompression trial: a decade later
    Leonard A Levin
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, 600 Highland Ave, Madison, WI 53792, USA
    Arch Ophthalmol 125:1570-1. 2007
  4. pmc Serial multifocal electroretinograms during long-term elevation and reduction of intraocular pressure in non-human primates
    T Michael Nork
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, 600 Highland Ave F4 336, Madison, WI 53792 3220, USA
    Doc Ophthalmol 120:273-89. 2010
  5. ncbi request reprint Multifocal visual evoked potentials in the anesthetized non-human primate
    Nathan A Maertz
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53792 3220, USA
    Curr Eye Res 31:885-93. 2006
  6. ncbi request reprint Retinal ganglion cells and neuroprotection for glaucoma
    Leonard A Levin
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, Wisconsin 53792, USA
    Surv Ophthalmol 48:S21-4. 2003
  7. ncbi request reprint Neuroprotection and regeneration in glaucoma
    Leonard A Levin
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, 600 Highland Avenue, Madison, WI 53792, USA
    Ophthalmol Clin North Am 18:585-96, vii. 2005
  8. ncbi request reprint Neuroprotective effect of sulfhydryl reduction in a rat optic nerve crush model
    Kyle I Swanson
    Department of Ophthalmology and Visual Science, University of Wisconsin Medical School, Madison, 53792, USA
    Invest Ophthalmol Vis Sci 46:3737-41. 2005
  9. ncbi request reprint Pathophysiology of the progressive optic neuropathy of glaucoma
    Leonard A Levin
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, 600 Highland Avenue, Madison, WI 53792, USA
    Ophthalmol Clin North Am 18:355-64, v. 2005
  10. ncbi request reprint Synthesis and characterization of a novel class of reducing agents that are highly neuroprotective for retinal ganglion cells
    Christopher R Schlieve
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, 600 Highland Avenue, Madison, WI 52792, USA
    Exp Eye Res 83:1252-9. 2006

Research Grants

Collaborators

  • Charlene B Y Kim
  • T Nork
  • PAUL LEON KAUFMAN
  • N R Miller
  • Helen V Danesh-Meyer
  • A C Arnold
  • Christopher J Lieven
  • Christopher R Schlieve
  • Mark J Hoegger
  • Steve M Nguyen
  • Colin J Scott
  • Joshua P Vrabec
  • Brandon R Schwechter
  • Lucia E Millet
  • Nathan A Maertz
  • Laura J Frassetto
  • Kyle I Swanson
  • Claron D Alldredge
  • Rachel A Tesser
  • Francine B Wein
  • Emily A Seidler
  • Mathew V Jones
  • Annie Tam
  • Bradley L Nilsson
  • Mark J Lucarelli
  • Amy A Utter
  • James N Ver Hoeve
  • Neeraj Agarwal
  • Ronald T Raines
  • Eric R Niendorf
  • Christa N Alexejun

Detail Information

Publications32

  1. pmc Differential production of superoxide by neuronal mitochondria
    Mark J Hoegger
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, USA
    BMC Neurosci 9:4. 2008
    ..To study this, we compared superoxide production and mitochondrial electron transport chain (METC) components in isolated RGC mitochondria to mitochondria isolated from cerebral cortex and neuroblastoma SK-N-AS cells...
  2. ncbi request reprint History of neuroprotection and rationale as a therapy for glaucoma
    Leonard A Levin
    University of Wisconsin School of Medicine and Public Health, 600 Highland Ave, Madison, WI 53792 4673, USA
    Am J Manag Care 14:S11-4. 2008
    ..Therapies that prevent death of the retinal ganglion cell (neuroprotection), its axon (axoprotection), or both, theoretically should be useful in treating glaucoma...
  3. ncbi request reprint Lessons from the ischemic optic neuropathy decompression trial: a decade later
    Leonard A Levin
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, 600 Highland Ave, Madison, WI 53792, USA
    Arch Ophthalmol 125:1570-1. 2007
  4. pmc Serial multifocal electroretinograms during long-term elevation and reduction of intraocular pressure in non-human primates
    T Michael Nork
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, 600 Highland Ave F4 336, Madison, WI 53792 3220, USA
    Doc Ophthalmol 120:273-89. 2010
    ..These results demonstrate species-specific changes in cone-driven retinal function during periods of elevated IOP. These IOP-related effects can occur in the absence of retinal ganglion cells and may be reversible...
  5. ncbi request reprint Multifocal visual evoked potentials in the anesthetized non-human primate
    Nathan A Maertz
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53792 3220, USA
    Curr Eye Res 31:885-93. 2006
    ..To evaluate monkey multifocal visual evoked cortical potentials (mfVEPs) recorded from central and peripheral fields for reliability and isolation from electroretinographic (ERG) activity...
  6. ncbi request reprint Retinal ganglion cells and neuroprotection for glaucoma
    Leonard A Levin
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, Wisconsin 53792, USA
    Surv Ophthalmol 48:S21-4. 2003
    ..This article discusses three commonly asked questions about neuroprotection and attempts to answer them in the context of our current understanding of the pathophysiology of RGC loss in glaucomatous optic neuropathy...
  7. ncbi request reprint Neuroprotection and regeneration in glaucoma
    Leonard A Levin
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, 600 Highland Avenue, Madison, WI 53792, USA
    Ophthalmol Clin North Am 18:585-96, vii. 2005
    ..This review surveys recent developments in neuroprotection and regeneration from the standpoint of eventual applicability to treatment of patients who have glaucoma...
  8. ncbi request reprint Neuroprotective effect of sulfhydryl reduction in a rat optic nerve crush model
    Kyle I Swanson
    Department of Ophthalmology and Visual Science, University of Wisconsin Medical School, Madison, 53792, USA
    Invest Ophthalmol Vis Sci 46:3737-41. 2005
    ..The hypothesis for the current study was that tris(2-carboxyethyl)phosphine (TCEP), a sulfhydryl reductant, would protect RGCs in a rat optic nerve crush model of axotomy...
  9. ncbi request reprint Pathophysiology of the progressive optic neuropathy of glaucoma
    Leonard A Levin
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, 600 Highland Avenue, Madison, WI 53792, USA
    Ophthalmol Clin North Am 18:355-64, v. 2005
    ..The primary goal is to distinguish glaucoma from other optic neuropathies and, in so doing, to suggest some hypotheses for its etiology...
  10. ncbi request reprint Synthesis and characterization of a novel class of reducing agents that are highly neuroprotective for retinal ganglion cells
    Christopher R Schlieve
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, 600 Highland Avenue, Madison, WI 52792, USA
    Exp Eye Res 83:1252-9. 2006
    ..We propose that these novel molecules may act by inhibiting the sulfhydryl oxidation effect of an intracellular superoxide burst...
  11. ncbi request reprint Retinal ganglion cell axotomy induces an increase in intracellular superoxide anion
    Christopher J Lieven
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, Wisconsin 53792, USA
    Invest Ophthalmol Vis Sci 47:1477-85. 2006
    ..It was hypothesized that a specific ROS, superoxide anion, acts as an intracellular signaling molecule for RGC death after axotomy...
  12. ncbi request reprint Retinal ganglion cells and supporting elements in culture
    Leonard A Levin
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, Wisconsin 53792, USA
    J Glaucoma 14:305-7. 2005
    ....
  13. ncbi request reprint Pathophysiology of the optic neuropathy associated with Friedreich ataxia
    Claron D Alldredge
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, 53792, USA
    Arch Ophthalmol 121:1582-5. 2003
    ..To describe the optic neuropathy associated with the genetic defect in Friedreich ataxia and suggest a pathophysiologic mechanism...
  14. pmc Histone deacetylase inhibition-mediated differentiation of RGC-5 cells and interaction with survival
    Brandon R Schwechter
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, Wisconsin 53792, USA
    Invest Ophthalmol Vis Sci 48:2845-57. 2007
    ..The authors studied the relationship between histone acetylation and the differentiation and survival of the RGC-5 cell line and compared it with nontranscriptional-dependent differentiation with staurosporine...
  15. ncbi request reprint Cell-type-specific opening of the retinal ganglion cell mitochondrial permeability transition pore
    Joshua P Vrabec
    University of Wisconsin Medical School, Department of Ophthalmology and Visual Sciences, Madison, Wisconsin 53792 4673, USA
    Invest Ophthalmol Vis Sci 44:2774-82. 2003
    ..To study the role of the mitochondrial permeability transition pore (PTP) in apoptosis of axotomized retinal ganglion cells (RGCs) in vitro...
  16. pmc Simultaneous labeling of projecting neurons and apoptotic state
    Steve M Nguyen
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, Wisconsin 53792, USA
    J Neurosci Methods 161:281-4. 2007
    ..The use of a single dye not only eliminates the need for secondary staining for apoptosis, but also allows for the use of a wider variety of non-overlapping fluorescent dyes for other studies...
  17. ncbi request reprint The morphology of an infarct in nonarteritic anterior ischemic optic neuropathy
    Rachel A Tesser
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, 600 Highland Avenue, Madison, WI 53792, USA
    Ophthalmology 110:2031-5. 2003
    ..We studied the three-dimensional anatomic configuration of a NAION infarct to better elucidate its pathophysiology...
  18. ncbi request reprint Biochemical activity of reactive oxygen species scavengers do not predict retinal ganglion cell survival
    Christopher R Schlieve
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, Wisconsin 53792, USA
    Invest Ophthalmol Vis Sci 47:3878-86. 2006
    ..The pro- or anti-cell-death effect of several ROS generating and scavenging systems in cultured RGCs was correlated with their activity in cell-free assays...
  19. ncbi request reprint Management of traumatic optic neuropathy
    Leonard A Levin
    University of Wisconsin, Madison, USA
    J Neuroophthalmol 23:72-5. 2003
  20. ncbi request reprint Retinal ganglion cell disorders: types and treatments
    Leonard A Levin
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, 600 Highland Avenue, Madison, WI 53792, USA
    Prog Retin Eye Res 21:465-84. 2002
  21. ncbi request reprint Kinase-dependent differentiation of a retinal ganglion cell precursor
    Laura J Frassetto
    Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, WI 53792, USA
    Invest Ophthalmol Vis Sci 47:427-38. 2006
    ....
  22. pmc Cell-autonomous generation of mitochondrial superoxide is a signal for cell death in differentiated neuronal precursor cells
    Colin J Scott
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    Brain Res 1306:142-8. 2010
    ..Dysregulation of mitochondrial superoxide in differentiated RGC-5 cells is likely a potent signal for cell death, consistent with a role of this reactive oxygen species in apoptosis signaling after axonal injury...
  23. pmc Induction of axon and dendrite formation during early RGC-5 cell differentiation
    Christopher J Lieven
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    Exp Eye Res 85:678-83. 2007
    ....
  24. ncbi request reprint Current understanding of neuroprotection in glaucoma
    Francine B Wein
    Department of Ophthalmology, McGill University Health Center, Montreal, Canada
    Curr Opin Ophthalmol 13:61-7. 2002
    ..This article reviews the recent basic science relevant to neuroprotection, particularly with respect to retinal ganglion cell death in glaucomatous and other optic neuropathies...
  25. ncbi request reprint Axonal loss and neuroprotection in optic neuropathies
    Leonard A Levin
    Department of Ophthalmology, University of Montreal, Canada
    Can J Ophthalmol 42:403-8. 2007
    ..This review emphasizes that most optic neuropathies are axonal and thus good targets for neuroprotection...
  26. pmc Erectile dysfunction drugs and risk of anterior ischaemic optic neuropathy: casual or causal association?
    Helen V Danesh-Meyer
    Department of Ophthalmology, University of Auckland, Private Bag 92019, Auckland New Zealand
    Br J Ophthalmol 91:1551-5. 2007
    ..This paper reviews all the recent evidence on PDE5 inhibitors and the risk of NAION...
  27. ncbi request reprint Amplification of a reactive oxygen species signal in axotomized retinal ganglion cells
    Steve M Nguyen
    Antioxid Redox Signal 5:629-34. 2003
    ..These results are consistent with RGC axotomy inducing synthesis of one or more proteins that mediate oxidative amplification. This could be an early event in signaling of RGC apoptosis after axonal injury...
  28. ncbi request reprint The effects of oxidative stress on mitochondrial transmembrane potential in retinal ganglion cells
    Christopher J Lieven
    Antioxid Redox Signal 5:641-6. 2003
    ..This suggests that the hydrogen peroxide-induced depolarization may act through mitochondrial permeability transition pore opening independent of thiol oxidation, and may be preventable under certain conditions...
  29. pmc Mechanisms of retinal ganglion specific-cell death in Leber hereditary optic neuropathy
    Leonard A Levin
    Trans Am Ophthalmol Soc 105:379-91. 2007
    ....
  30. doi request reprint Hypothesis: a venous etiology for nonarteritic anterior ischemic optic neuropathy
    Leonard A Levin
    Department of Ophthalmology, University of Montreal, Montreal, Quebec, Canada
    Arch Ophthalmol 126:1582-5. 2008
  31. ncbi request reprint Extrapolation of animal models of optic nerve injury to clinical trial design
    Leonard A Levin
    J Glaucoma 13:1-5. 2004
  32. ncbi request reprint Treatment of ischemic optic neuropathy
    Anthony C Arnold
    Jules Stein Eye Institue, Department of Ophthalmology, University of California, 100 Stein Plaza, Los Angeles, CA 90095 7005, USA
    Semin Ophthalmol 17:39-46. 2002
    ..Neuroprotective strategies are under intense investigation for optic neuropathies including NAION, and clinical trials in humans are in progress. Optic nerve regeneration studies are ongoing in animals. Prophylaxis in NAION is unproven...

Research Grants7

  1. GENE EXPRESSION IN AXOTOMIZED RETINAL GANGLION CELLS
    Leonard Levin; Fiscal Year: 2004
    ..As many of these diseases (e.g., normal-tension glaucoma and ischemic optic neuropathy) are not easily treatable, determination of the regulation of cell destructive and protective mechanisms could lead to innovative new therapies. ..
  2. Novel Mitochondrial Targeted Neuroprotectants for Glaucoma
    Leonard Levin; Fiscal Year: 2007
    ....