J B Leverenz

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. pmc From model system to clinical medicine: pathophysiologic links of common proteinopathies
    Pamela J McMillan
    Mental Illness Research Education and Clinical Center, Veterans Administration Puget Sound Health Care System, 1660 South Columbian Way, Seattle, WA, 98108, USA
    Alzheimers Res Ther 2:26. 2010
  2. ncbi request reprint Dementia with Lewy bodies
    James B Leverenz
    Department of Veterans Affairs, Northwest Network Mental Illness and Parkinson s Disease Research, Education and Clinical Centers, Seattle, WA, 98108 USA
    Med Clin North Am 86:519-35. 2002
  3. pmc Lewy body pathology in familial Alzheimer disease: evidence for disease- and mutation-specific pathologic phenotype
    James B Leverenz
    Parkinson s Disease, Mental Illness Research, Education, and Clinical Centers, Veterans Affairs Puget Sound Health Care System, Seattle, Wash, USA
    Arch Neurol 63:370-6. 2006
  4. pmc Empiric refinement of the pathologic assessment of Lewy-related pathology in the dementia patient
    James B Leverenz
    Department of Veterans Affairs Northwest Network Mental Illness and Parkinson s Disease Research, University of Washington, Seattle, WA 98108, USA
    Brain Pathol 18:220-4. 2008
  5. ncbi request reprint Clinical and neuropathological characteristics of hippocampal sclerosis: a community-based study
    James B Leverenz
    Veterans Affairs Northwest Network Mental Illness Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, 1660 S Columbian Way, 116 MIRECC, Seattle, WA 98108, USA
    Arch Neurol 59:1099-106. 2002
  6. ncbi request reprint Increased alpha 2-adrenergic receptor binding in locus coeruleus projection areas in dementia with Lewy bodies
    J B Leverenz
    Northwest Network Mental Illness Research, Education and Clinical Center MIRECC, VA Puget Sound Health Care System, Seattle, WA 98108, USA
    Neurobiol Aging 22:555-61. 2001
  7. ncbi request reprint The utility of apolipoprotein E genotyping in the diagnosis of Alzheimer disease in a community-based case series
    D Tsuang
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, USA
    Arch Neurol 56:1489-95. 1999
  8. pmc Amyloid precursor protein (APP) processing genes and cerebrospinal fluid APP cleavage product levels in Alzheimer's disease
    L M Bekris
    Geriatric Research, Education and Clinical Center GRECC, VA Puget Sound Health Care System, Seattle, WA, USA
    Neurobiol Aging 32:556.e13-23. 2011
  9. ncbi request reprint CSF tau/Abeta42 ratio for increased risk of mild cognitive impairment: a follow-up study
    G Li
    Mental Illness Research, Education, and Clinical Center and Department of Psychiatry, VA Puget Sound Health Care System, University of Washington, Seattle, WA, USA
    Neurology 69:631-9. 2007
  10. ncbi request reprint Specific downregulation of presenilin 2 gene expression is prominent during early stages of sporadic late-onset Alzheimer's disease
    P J McMillan
    Department of Psychiatry and Behavioral Sciences, Box 356560, University of Washington, Seattle, WA 98195, USA
    Brain Res Mol Brain Res 78:138-45. 2000

Detail Information

Publications61

  1. pmc From model system to clinical medicine: pathophysiologic links of common proteinopathies
    Pamela J McMillan
    Mental Illness Research Education and Clinical Center, Veterans Administration Puget Sound Health Care System, 1660 South Columbian Way, Seattle, WA, 98108, USA
    Alzheimers Res Ther 2:26. 2010
    ..These data indicate shared pathogenic mechanisms and suggest the possibility that therapeutic interventions successfully targeting one of these pathogenic proteins have implications for a number of related neurodegenerative disorders...
  2. ncbi request reprint Dementia with Lewy bodies
    James B Leverenz
    Department of Veterans Affairs, Northwest Network Mental Illness and Parkinson s Disease Research, Education and Clinical Centers, Seattle, WA, 98108 USA
    Med Clin North Am 86:519-35. 2002
    ..Further research is needed to improve our understanding of the pathophysiology of this important dementing disorder, with the ultimate goal of improving clinical management of this disease...
  3. pmc Lewy body pathology in familial Alzheimer disease: evidence for disease- and mutation-specific pathologic phenotype
    James B Leverenz
    Parkinson s Disease, Mental Illness Research, Education, and Clinical Centers, Veterans Affairs Puget Sound Health Care System, Seattle, Wash, USA
    Arch Neurol 63:370-6. 2006
    ..The origin and significance of Lewy bodies and neurites (Lewy body pathology [LBP]) in Alzheimer disease (AD) are poorly understood...
  4. pmc Empiric refinement of the pathologic assessment of Lewy-related pathology in the dementia patient
    James B Leverenz
    Department of Veterans Affairs Northwest Network Mental Illness and Parkinson s Disease Research, University of Washington, Seattle, WA 98108, USA
    Brain Pathol 18:220-4. 2008
    ..In addition, this modification allows for more limited sampling of brain regions for classification of LRP. We propose that these modified criteria for the categorization of LRP be utilized in patients with a history of dementia...
  5. ncbi request reprint Clinical and neuropathological characteristics of hippocampal sclerosis: a community-based study
    James B Leverenz
    Veterans Affairs Northwest Network Mental Illness Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, 1660 S Columbian Way, 116 MIRECC, Seattle, WA 98108, USA
    Arch Neurol 59:1099-106. 2002
    ..However, these studies were from selected samples and therefore are not necessarily representative of patients seen in the general medical community...
  6. ncbi request reprint Increased alpha 2-adrenergic receptor binding in locus coeruleus projection areas in dementia with Lewy bodies
    J B Leverenz
    Northwest Network Mental Illness Research, Education and Clinical Center MIRECC, VA Puget Sound Health Care System, Seattle, WA 98108, USA
    Neurobiol Aging 22:555-61. 2001
    ..Either mechanism could lower the threshold for increased agitation in response to noradrenergic outflow in these dementing disorders...
  7. ncbi request reprint The utility of apolipoprotein E genotyping in the diagnosis of Alzheimer disease in a community-based case series
    D Tsuang
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, USA
    Arch Neurol 56:1489-95. 1999
    ..Since these samples are particularly enriched with patients with AD and the APOE epsilon4 allele, results may not be generalizable to patients seen in the general medical community...
  8. pmc Amyloid precursor protein (APP) processing genes and cerebrospinal fluid APP cleavage product levels in Alzheimer's disease
    L M Bekris
    Geriatric Research, Education and Clinical Center GRECC, VA Puget Sound Health Care System, Seattle, WA, USA
    Neurobiol Aging 32:556.e13-23. 2011
    ..These results suggest that genetic variation within ADAM10, an APP processing gene, influences CSF APPĪ± levels in an AD specific manner...
  9. ncbi request reprint CSF tau/Abeta42 ratio for increased risk of mild cognitive impairment: a follow-up study
    G Li
    Mental Illness Research, Education, and Clinical Center and Department of Psychiatry, VA Puget Sound Health Care System, University of Washington, Seattle, WA, USA
    Neurology 69:631-9. 2007
    ..While many studies have evaluated CSF tau and Abeta(42) as biomarkers of the dementia or prodromal stages of AD, we are unaware of any study to evaluate these potential CSF biomarkers of latent AD...
  10. ncbi request reprint Specific downregulation of presenilin 2 gene expression is prominent during early stages of sporadic late-onset Alzheimer's disease
    P J McMillan
    Department of Psychiatry and Behavioral Sciences, Box 356560, University of Washington, Seattle, WA 98195, USA
    Brain Res Mol Brain Res 78:138-45. 2000
    ..These results suggest that the specific downregulation of PS2 gene expression is an early event in sporadic late-onset AD...
  11. ncbi request reprint Tyrosine hydroxylase and norepinephrine transporter mRNA expression in the locus coeruleus in Alzheimer's disease
    P Szot
    Northwest Network Mental Illness Research, Education and Clinical Center, Veterans Administration Puget Sound Health Care System, Seattle, WA 98108, USA
    Brain Res Mol Brain Res 84:135-40. 2000
    ..These preliminary results suggest an upregulation of NE biosynthetic capacity in at least some LC neurons in AD prior to the very late stage of the disease...
  12. pmc Cognitive differences in dementia patients with autopsy-verified AD, Lewy body pathology, or both
    M L Kraybill
    Mental Illness Research, Education, and Clinical Center, Veterans Administration Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA 98108, USA
    Neurology 64:2069-73. 2005
    ..To examine the neuropsychological profile of dementia patients from a community-based autopsy sample of dementia, comparing Alzheimer disease (AD), Lewy body pathology (LBP) alone, and LBP with coexistent AD (AD/LBP)...
  13. ncbi request reprint Neural transplantation in Huntington disease: long-term grafts in two patients
    C D Keene
    Department of Pathology, Division of Neuropathology, University of Washington Medical Center, Seattle, WA 98104, USA
    Neurology 68:2093-8. 2007
    ..However, no long-term analysis of graft survival and integration has been published. Here, we report the pathologic findings in two patients with HD who died 74 and 79 months after transplantation...
  14. pmc Changes in adrenoreceptors in the prefrontal cortex of subjects with dementia: evidence of compensatory changes
    P Szot
    Northwest Network for Mental Illness Research, Education, and Clinical Center, Veterans Administration Puget Sound Health Care System, and Department of Psychiatry and Behavioral Science, University of Washington, Seattle 98195, USA
    Neuroscience 146:471-80. 2007
    ..These changes in postsynaptic AR would suggest a reduced function of the PFC. Consequence of this reduced function of the PFC in dementia is still unknown but it may affect memory and behavior...
  15. pmc Genetic association between the APOE*4 allele and Lewy bodies in Alzheimer disease
    D W Tsuang
    Department of Psychiatry and Behavioral Sciences, School of Public Health, University of Washington, Seattle, USA
    Neurology 64:509-13. 2005
    ..To explore the association between APOE*4 and pathologically confirmed cases of the Lewy body (LB) variant of Alzheimer disease (AD)...
  16. pmc Glucocerebrosidase gene mutations: a risk factor for Lewy body disorders
    Ignacio F Mata
    Department of Neurology, University of Washington School of Medicine, Seattle, USA
    Arch Neurol 65:379-82. 2008
    ..However, these findings have not been consistently replicated, and most studies have had substantial methodological shortcomings...
  17. ncbi request reprint A novel progranulin mutation associated with variable clinical presentation and tau, TDP43 and alpha-synuclein pathology
    J B Leverenz
    Mental Illness Research, Education, and Clinical Centers, Veteran Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
    Brain 130:1360-74. 2007
    ..All cases had ubiquitin/TDP43 immuno-positive inclusions and most had additional tau pathology. Two cases had SNCA pathology. These findings suggest a link between mutations in GRN and aggregation of tau, TDP43 and SNCA...
  18. ncbi request reprint Predicting lewy body pathology in a community-based sample with clinical diagnosis of Alzheimer's disease
    Debby Tsuang
    University of Washington Departments of Psychiatry and Behavioral Sciences, Seattle, WA, USA
    J Geriatr Psychiatry Neurol 19:195-201. 2006
    ..The model also identified other demographic and clinical characteristics that might enhance the prediction of Lewy body pathology...
  19. ncbi request reprint Lewy body pathology in late-onset familial Alzheimer's disease: a clinicopathological case series
    Debby W Tsuang
    Mental Illness Research, Education, and Clinical Centers, Veteran Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
    J Alzheimers Dis 9:235-42. 2006
    ..Lewy body pathology (LBP) is a common finding in Alzheimer's disease (AD), but the pathophysiology for this coexistent pathology remains unclear...
  20. pmc The spectrum of mutations in progranulin: a collaborative study screening 545 cases of neurodegeneration
    Chang En Yu
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA 98108, USA
    Arch Neurol 67:161-70. 2010
    ..However, it is unclear whether some rare FTD-related GRN variants are pathogenic and whether neurodegenerative disorders other than FTD can also be caused by GRN mutations...
  21. ncbi request reprint Proteomic identification of novel proteins in cortical lewy bodies
    James B Leverenz
    Department of Neurology, School of Medicine, University of Washington, Seattle, WA 98104, USA
    Brain Pathol 17:139-45. 2007
    ..Further investigation of these novel candidates is also necessary to ensure that the potential proteins in cortical LBs are not identified incorrectly because of incomplete current human protein database...
  22. pmc Cognitive impairment in older adults without dementia: clinical and pathologic outcomes in a community-based sample
    Lucy Y Wang
    Mental Illness Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle, Washington, USA
    J Geriatr Psychiatry Neurol 22:256-65. 2009
    ..4 +/- 2.1 vs 3.1 +/- 2.7, P = .02). These observations are consistent with the view that nondemented patients with underlying AD may be more likely to present with memory than nonmemory cognitive impairment...
  23. ncbi request reprint Pathological correlates of dementia in a longitudinal, population-based sample of aging
    Joshua A Sonnen
    Department of Pathology, University of Washington, Seattle, WA, USA
    Ann Neurol 62:406-13. 2007
    ..Our goal was to determine the independent pathological correlates associated with dementia in a typical US population...
  24. pmc A patient with Huntington's disease and long-surviving fetal neural transplants that developed mass lesions
    C Dirk Keene
    Department of Pathology, Harborview Medical Center, University of Washington Medical Center, Seattle, 98104, USA
    Acta Neuropathol 117:329-38. 2009
    ..This report, for the first time, highlights the potential for graft overgrowth in a patient receiving fetal neural transplantation...
  25. pmc Visual hallucinations in dementia: a prospective community-based study with autopsy
    Debby Tsuang
    Veterans Affairs Northwest Network Mental Illness Research, Education, and Clinical Center, USA
    Am J Geriatr Psychiatry 17:317-23. 2009
    ..This study seeks to investigate the demographic, clinical, and neuropathologic features of community-based dementia subjects with and without visual hallucations...
  26. doi request reprint Application of targeted quantitative proteomics analysis in human cerebrospinal fluid using a liquid chromatography matrix-assisted laser desorption/ionization time-of-flight tandem mass spectrometer (LC MALDI TOF/TOF) platform
    Sheng Pan
    Department of Pathology, University of Washington, Seattle, Washington 98195, USA
    J Proteome Res 7:720-30. 2008
    ....
  27. pmc Effect of vascular lesions on cognition in Alzheimer's disease: a community-based study
    Robert G Riekse
    Department of Medicine, University of Washington, Seattle, Washington, USA
    J Am Geriatr Soc 52:1442-8. 2004
    ....
  28. ncbi request reprint Chronic cortisol exposure promotes the development of a GABAergic phenotype in the primate hippocampus
    Pamela J McMillan
    Department of Psychiatry, University of Washington School of Medicine, Seattle, Washington, USA
    J Neurochem 91:843-51. 2004
    ....
  29. ncbi request reprint Familial dementia with lewy bodies: a clinical and neuropathological study of 2 families
    Debby W Tsuang
    Department of Veterans Affairs Northwest Network Mental Illness Research, Education, and Clinical Center, VA Puget Sound Health Care System, 1660 S Columbian Way, Mailstop 116MIRECC, Seattle, WA 98108, USA
    Arch Neurol 59:1622-30. 2002
    ..Few families with DLB have been described with detailed clinical, pathological, and genetic assessments...
  30. pmc Evaluation of selection bias in an incident-based dementia autopsy case series
    Debby Tsuang
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, USA
    Alzheimer Dis Assoc Disord 19:67-73. 2005
    ....
  31. ncbi request reprint Alpha1-adrenoreceptor in human hippocampus: binding and receptor subtype mRNA expression
    Patricia Szot
    Northwest Network Mental Illness Research, Education and Clinical Center S 116, VA Puget Sound Health Care System, S 116 MIRECC, 1660 S Columbian Way, Seattle, WA 98108, USA
    Brain Res Mol Brain Res 139:367-71. 2005
    ..These results confirm a difference in hippocampal alpha1-AR localization between rat and humans and further describe a difference in the localization of the alpha1A- and alpha1D-AR mRNA subtype between rats and humans...
  32. ncbi request reprint Interrater reliability and accuracy in identifying ischemic strokes using computed tomography scans in people with dementia
    James D Bowen
    Department of Neurology, University of Washington, Seattle, Washington 98195, USA
    J Am Geriatr Soc 53:1743-7. 2005
    ..To assess the reliability and interobserver agreement of stroke identification on neuroimaging in patients presenting with dementia...
  33. ncbi request reprint Compensatory changes in the noradrenergic nervous system in the locus ceruleus and hippocampus of postmortem subjects with Alzheimer's disease and dementia with Lewy bodies
    Patricia Szot
    Northwest Network for Mental Illness Research, Education, and Clinical Center, Veterans Administration Puget Sound Health Care System, Seattle, Washington 98108, USA
    J Neurosci 26:467-78. 2006
    ....
  34. pmc DJ-1 and alpha-synuclein in human cerebrospinal fluid as biomarkers of Parkinson's disease
    Zhen Hong
    Department of Pathology, University of Washington School of Medicine, HMC Box 359635, 325 9th Avenue, Seattle, WA 98104, USA
    Brain 133:713-26. 2010
    ..We have demonstrated that total DJ-1 and alpha-synuclein in human cerebrospinal fluid are helpful diagnostic markers for Parkinson's disease, if variables such as blood contamination and age are taken into consideration...
  35. pmc Cognitive impairment and dementia in patients with Parkinson disease
    James B Leverenz
    Mental Illness Research, Education, and Clinical Centers of Veterans Administration, Department of Neurology, Oregon Health and Sciences University, Portland, OR, USA
    Curr Top Med Chem 9:903-12. 2009
    ..Here we review clinical presentation and progression, pathological bases, identification of genetic risk factors, development of small molecule biomarkers, and emerging treatments for cognitive impairment in patients with PD...
  36. pmc Alzheimer's disease phenotypes and genotypes associated with mutations in presenilin 2
    Suman Jayadev
    Department of Neurology, University of Washington, 1660 S Columbian Way, 182 GRECC, Seattle, WA 98108, USA
    Brain 133:1143-54. 2010
    ..A novel premature termination mutation supports loss of function or haploinsufficiency as pathogenic mechanisms in presenilin 2 associated Alzheimer's disease...
  37. pmc Reduced hippocampal insulin-degrading enzyme in late-onset Alzheimer's disease is associated with the apolipoprotein E-epsilon4 allele
    David G Cook
    Geriatric Research, Education, and Clinical Center, Veteran Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA
    Am J Pathol 162:313-9. 2003
    ..These findings show that reduced IDE expression is associated with a significant risk factor for AD and suggest that IDE may interact with APOE status to affect Abeta metabolism...
  38. pmc Detergent-insoluble EAAC1/EAAT3 aberrantly accumulates in hippocampal neurons of Alzheimer's disease patients
    Kevin Duerson
    Geriatric Research Education and Clinical Center, VA Medical Center, 1660 S Columbian Way, Seattle, WA 98108, USA
    Brain Pathol 19:267-78. 2009
    ....
  39. pmc Apolipoprotein E highly correlates with AbetaPP- and tau-related markers in human cerebrospinal fluid
    Simona Vuletic
    Northwest Lipid Metabolism and Diabetes Research Laboratories, University of Washington School of Medicine, Seattle, WA 98109, USA
    J Alzheimers Dis 15:409-17. 2008
    ..Our data suggest that there is a significant physiological link between apoE and AbetaPP, as well as between apoE and tau in neurologically healthy, cognitively intact individuals...
  40. ncbi request reprint Hyperphosphorylation of RNA polymerase II and reduced neuronal RNA levels precede neurofibrillary tangles in Alzheimer disease
    J W Husseman
    Department of Pathology and the Nathan Shock Center of Excellence for Biology of Aging, University of Washington, Seattle 98195, USA
    J Neuropathol Exp Neurol 60:1219-32. 2001
    ....
  41. ncbi request reprint Selective dendritic degeneration of medium spiny neurons in dementia with Lewy bodies
    S Zaja-Milatovic
    University of Washington, Seattle, WA 98104, USA
    Neurology 66:1591-3. 2006
    ....
  42. pmc SNCA variant associated with Parkinson disease and plasma alpha-synuclein level
    Ignacio F Mata
    Geriatric Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Mailstop S 182, 1660 S Columbian Way, Seattle, WA 98108, USA
    Arch Neurol 67:1350-6. 2010
    ..A functional repeat polymorphism in the SNCA promoter (REP1) conveys susceptibility for Parkinson disease (PD). There is also increasing evidence that single-nucleotide polymorphisms (SNPs) elsewhere in the gene are associated with PD risk...
  43. pmc A novel X-linked four-repeat tauopathy with Parkinsonism and spasticity
    Parvoneh Poorkaj
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington 98195, USA
    Mov Disord 25:1409-17. 2010
    ..In conclusion, we have identified a unique X-linked parkinsonian syndrome with variable spasticity and four-repeat tau pathology, and defined a novel candidate gene locus spanning approximately 28 Mb from Xp11.2-Xq13.3...
  44. pmc Significance and confounders of peripheral DJ-1 and alpha-synuclein in Parkinson's disease
    Min Shi
    Department of Pathology, University of Washington School of Medicine, Seattle, WA 98104, USA
    Neurosci Lett 480:78-82. 2010
    ..In conclusion, unlike in cerebrospinal fluid, total DJ-1 or alpha-synuclein in plasma alone is not useful as biomarkers for Parkinson's disease diagnosis or progression/severity...
  45. pmc Familial dementia with Lewy bodies with an atypical clinical presentation
    Lauren T Bonner
    Department of Veterans Affairs Northwest Network Mental Illness Research, Education, and Clinical Center, University of Washington, Seattle 98108, USA
    J Geriatr Psychiatry Neurol 16:59-64. 2003
    ..Family history revealed 7 relatives with a history of dementia including 4 with possible or probable DLB. This case is unique because of the FTLD-like presentation, positive family history of dementia, and autopsy confirmation of DLB...
  46. ncbi request reprint Chronic cortisol suppresses pituitary and hypothalamic peptide message expression in pigtailed macaques
    P Szot
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98195, USA
    Neuroscience 126:241-6. 2004
    ..Chronic therapeutic administration of glucocorticoids in humans may have unintended consequences for hypothalamic and pituitary function...
  47. pmc Quantitative proteomics identifies surfactant-resistant alpha-synuclein in cerebral cortex of Parkinsonism-dementia complex of Guam but not Alzheimer's disease or progressive supranuclear palsy
    Wan Yang
    Department of Pathology, University of Washington, Harborview Medical Center, Box 359791, Seattle, WA 98104, USA
    Am J Pathol 171:993-1002. 2007
    ..These results show that frontal and temporal cortex in PDC is distinguished from AD and PSP by its accumulation of abnormal SNCA and suggest that PDC be considered a synucleinopathy as well as a tauopathy...
  48. ncbi request reprint Effects of chronic glucocorticoid administration on insulin-degrading enzyme and amyloid-beta peptide in the aged macaque
    J Jacob Kulstad
    Geriatric Research, Education, and Clinical Center, Veteran s Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA
    J Neuropathol Exp Neurol 64:139-46. 2005
    ..These findings support the notion that glucocorticoids regulate IDE and provide a mechanism whereby increased glucocorticoid levels may contribute to AD pathology...
  49. pmc Association between lifetime cigarette smoking and lewy body accumulation
    Debby Tsuang
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98104, USA
    Brain Pathol 20:412-8. 2010
    ..Although cigarette smoking is too toxic to suggest as a treatment, if confirmed, these findings may guide future therapeutic strategies that attempt to suppress LRP in human brain by other means...
  50. pmc Glycoproteomics in neurodegenerative diseases
    Hyejin Hwang
    Department of Pathology, University of Washington, Seattle, WA 98104, USA
    Mass Spectrom Rev 29:79-125. 2010
    ....
  51. ncbi request reprint Increased galanin receptor occupancy in Alzheimer's disease
    Pamela J McMillan
    Mental Illness Research, Education, and Clinical Centers, Veteran Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
    Neurobiol Aging 25:1309-14. 2004
    ..The regional differences in GALR density and receptor occupancy between normal and AD subjects may play a role in the cognitive disturbances associated with the disease...
  52. ncbi request reprint Alpha-synuclein in motor neuron disease: an immunohistologic study
    M J Doherty
    Department of Neurology, University of Washington, Seattle, Washington, USA
    Acta Neuropathol 107:169-75. 2004
    ..Significant ASN abnormalities were observed in MND. These findings suggest a possible role for ASN in MND; however, the precise nature of this association is unclear...
  53. ncbi request reprint Diet-induced hypercholesterolemia enhances brain A beta accumulation in transgenic mice
    Feng Shiun Shie
    Nutritional Sciences Interdisciplinary Program and Department of Pathology, Box 353410, Raitt Hall, Room 305, University of Washington, Seattle, WA 98195, USA
    Neuroreport 13:455-9. 2002
    ..Overall, plasma lipoproteins may be an important factor in induction of AD-like plaques in mice. The lowering of plasma lipids may be therapeutic for AD patients...
  54. ncbi request reprint Effect of statins on Alzheimer's disease biomarkers in cerebrospinal fluid
    Robert G Riekse
    Department of Medicine, Division of Geriatric Medicine, University of Washington School of Medicine, and VA Puget Sound Health Care System, Seattle, WA 98108, USA
    J Alzheimers Dis 10:399-406. 2006
    ..Putative neuroprotective effects of statins may vary in relation to their ability to penetrate into the central nervous system (CNS)...
  55. ncbi request reprint Rosiglitazone attenuates learning and memory deficits in Tg2576 Alzheimer mice
    Ward A Pedersen
    Department of Pathology, Creighton University Medical Center, 601 N 30th Street, Suite 2469, Omaha, NE 68131, USA
    Exp Neurol 199:265-73. 2006
    ....
  56. ncbi request reprint Detection of biomarkers with a multiplex quantitative proteomic platform in cerebrospinal fluid of patients with neurodegenerative disorders
    Fadi Abdi
    Applied Biosystems, Framingham, MA, USA
    J Alzheimers Dis 9:293-348. 2006
    ....
  57. ncbi request reprint Co-morbidity of TDP-43 proteinopathy in Lewy body related diseases
    Hanae Nakashima-Yasuda
    Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, HUP Maloney 3rd Floor, Philadelphia, PA 19104 4283, USA
    Acta Neuropathol 114:221-9. 2007
    ..This study expands the concept of TDP-43 proteinopathies by implicating TDP-43 lesions in mechanisms of neurodegeneration in LB disorders...
  58. pmc Clinicopathological concordance and discordance in three monozygotic twin pairs with familial Alzheimer's disease
    Kiri L Brickell
    Neurological Foundation of New Zealand, New Zealand
    J Neurol Neurosurg Psychiatry 78:1050-5. 2007
    ..We had the opportunity to assess the concordance and discordance of clinical presentation and neuropathology in three MZ twin pairs with AD...
  59. pmc Analysis of the LRRK2 G2019S mutation in Alzheimer Disease
    Cyrus P Zabetian
    Arch Neurol 63:156-7. 2006
  60. pmc Evaluation of alpha-synuclein immunohistochemical methods used by invited experts
    Thomas G Beach
    Civin Laboratory for Neuropathology, Sun Health Research Institute, 10515 West Santa Fe Drive, Sun City, AZ 85351, USA
    Acta Neuropathol 116:277-88. 2008
    ..Some methods, however, achieved relatively high sensitivities with optimized formic acid protocols combined with a hydrolytic step. One method was developed that allows high sensitivity with commercially available reagents...
  61. pmc TARDBP mutations in amyotrophic lateral sclerosis with TDP-43 neuropathology: a genetic and histopathological analysis
    Vivianna M Van Deerlin
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Lancet Neurol 7:409-16. 2008
    ..Our aim was to investigate whether TARDBP is a candidate disease gene for familial ALS that is not associated with mutations in superoxide dismutase 1 (SOD1)...