John R Lever

Summary

Affiliation: University of Missouri
Country: USA

Publications

  1. ncbi request reprint Novel azido and isothiocyanato analogues of [3-(4-phenylalkylpiperazin-1-yl)propyl]bis(4-fluorophenyl)amines as potential irreversible ligands for the dopamine transporter
    Jianjing Cao
    Medicinal Chemistry and Psychobiology Sections, Intramural Research Program, National Institute on Drug Abuse, 5500 Nathan Shock Drive, Baltimore, Maryland 21224, USA
    J Med Chem 47:6128-36. 2004
  2. ncbi request reprint Radioiodinated azide and isothiocyanate derivatives of cocaine for irreversible labeling of dopamine transporters: synthesis and covalent binding studies
    John R Lever
    Departments of Radiology, University of Missouri Columbia, Missouri 65212, USA
    Bioconjug Chem 16:644-9. 2005
  3. ncbi request reprint Sigma1 and sigma2 receptor binding affinity and selectivity of SA4503 and fluoroethyl SA4503
    John R Lever
    Department of Radiology, University of Missouri Columbia, 65211, USA
    Synapse 59:350-8. 2006
  4. ncbi request reprint PET and SPECT imaging of the opioid system: receptors, radioligands and avenues for drug discovery and development
    John R Lever
    Department of Radiology, University of Missouri Columbia and Harry S Truman Veterans Administration Medical Center, Columbia, Missouri 65212, USA
    Curr Pharm Des 13:33-49. 2007
  5. doi request reprint Synthesis, radioiodination and in vitro and in vivo sigma receptor studies of N-1-allyl-N´-4-phenethylpiperazine analogs
    Susan Z Lever
    Department of Chemistry, University of Missouri Columbia, Columbia, MO 65211, USA
    Nucl Med Biol 39:401-14. 2012
  6. pmc Laminin receptor specific therapeutic gold nanoparticles (198AuNP-EGCg) show efficacy in treating prostate cancer
    Ravi Shukla
    Department of Radiology, Harry S Truman Veterans Administration Medical Center, and Missouri University Research Reactor, University of Missouri, Columbia, MO 65212, USA
    Proc Natl Acad Sci U S A 109:12426-31. 2012
  7. ncbi request reprint Indium-labeled macrocyclic conjugates of naltrindole: high-affinity radioligands for in vivo studies of peripheral delta opioid receptors
    Romain A Duval
    Departments of Radiology and the Radiopharmaceutical Sciences Institute, and Medical Pharmacology and Physiology, University of Missouri Columbia, Columbia, Missouri 65212, USA
    J Med Chem 50:2144-56. 2007
  8. doi request reprint Radioactive gold nanoparticles in cancer therapy: therapeutic efficacy studies of GA-198AuNP nanoconstruct in prostate tumor-bearing mice
    Nripen Chanda
    Department of Radiology, University of Missouri, Columbia, Missouri 65211, USA
    Nanomedicine 6:201-9. 2010
  9. pmc The sigma receptor agonist SA4503 both attenuates and enhances the effects of methamphetamine
    Kelli R Rodvelt
    Department of Psychological Sciences, University of Missouri, Columbia, MO 65211, USA
    Drug Alcohol Depend 116:203-10. 2011
  10. ncbi request reprint Lobeline, a potential pharmacotherapy for drug addiction, binds to mu opioid receptors and diminishes the effects of opioid receptor agonists
    Dennis K Miller
    Department of Psychological Sciences, 212 C McAlester Hall, University of Missouri, Columbia, MO 65211, USA
    Drug Alcohol Depend 89:282-91. 2007

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Novel azido and isothiocyanato analogues of [3-(4-phenylalkylpiperazin-1-yl)propyl]bis(4-fluorophenyl)amines as potential irreversible ligands for the dopamine transporter
    Jianjing Cao
    Medicinal Chemistry and Psychobiology Sections, Intramural Research Program, National Institute on Drug Abuse, 5500 Nathan Shock Drive, Baltimore, Maryland 21224, USA
    J Med Chem 47:6128-36. 2004
    ....
  2. ncbi request reprint Radioiodinated azide and isothiocyanate derivatives of cocaine for irreversible labeling of dopamine transporters: synthesis and covalent binding studies
    John R Lever
    Departments of Radiology, University of Missouri Columbia, Missouri 65212, USA
    Bioconjug Chem 16:644-9. 2005
    ..The utility of the radioligands was demonstrated by their covalent linkage to rat striatal membranes, and immunoprecipitation of a single radiolabeled band at 80 kDa corresponding to the full-length DAT...
  3. ncbi request reprint Sigma1 and sigma2 receptor binding affinity and selectivity of SA4503 and fluoroethyl SA4503
    John R Lever
    Department of Radiology, University of Missouri Columbia, 65211, USA
    Synapse 59:350-8. 2006
    ..The findings have bearing on structure-activity relationships for this active series, and on conclusions that might be drawn from experiments relying upon defined sigma(1)/sigma(2) binding selectivity...
  4. ncbi request reprint PET and SPECT imaging of the opioid system: receptors, radioligands and avenues for drug discovery and development
    John R Lever
    Department of Radiology, University of Missouri Columbia and Harry S Truman Veterans Administration Medical Center, Columbia, Missouri 65212, USA
    Curr Pharm Des 13:33-49. 2007
    ..Selected studies are discussed to illustrate the power of molecular imaging for facilitating opioid drug discovery and development...
  5. doi request reprint Synthesis, radioiodination and in vitro and in vivo sigma receptor studies of N-1-allyl-N´-4-phenethylpiperazine analogs
    Susan Z Lever
    Department of Chemistry, University of Missouri Columbia, Columbia, MO 65211, USA
    Nucl Med Biol 39:401-14. 2012
    ..We derived a hybrid structure, N-1-allyl-N´-4-phenethylpiperazine, from known ligands TPCNE and SA4503 for use as a scaffold for development of radioiodinated σ(1) receptor ligands...
  6. pmc Laminin receptor specific therapeutic gold nanoparticles (198AuNP-EGCg) show efficacy in treating prostate cancer
    Ravi Shukla
    Department of Radiology, Harry S Truman Veterans Administration Medical Center, and Missouri University Research Reactor, University of Missouri, Columbia, MO 65212, USA
    Proc Natl Acad Sci U S A 109:12426-31. 2012
    ..This novel intratumorally injectable (198)AuNP-EGCg nanotherapeutic agent may provide significant advances in oncology for use as an effective treatment for prostate and other solid tumors...
  7. ncbi request reprint Indium-labeled macrocyclic conjugates of naltrindole: high-affinity radioligands for in vivo studies of peripheral delta opioid receptors
    Romain A Duval
    Departments of Radiology and the Radiopharmaceutical Sciences Institute, and Medical Pharmacology and Physiology, University of Missouri Columbia, Columbia, Missouri 65212, USA
    J Med Chem 50:2144-56. 2007
    ..Uptakes of radioactivity are saturable by the non-radioactive complexes, inhibited by naltrexone, and blocked by NTI. Thus, these radiometal-labeled NTI analogues warrant further study by single-photon emission computed tomography...
  8. doi request reprint Radioactive gold nanoparticles in cancer therapy: therapeutic efficacy studies of GA-198AuNP nanoconstruct in prostate tumor-bearing mice
    Nripen Chanda
    Department of Radiology, University of Missouri, Columbia, Missouri 65211, USA
    Nanomedicine 6:201-9. 2010
    ....
  9. pmc The sigma receptor agonist SA4503 both attenuates and enhances the effects of methamphetamine
    Kelli R Rodvelt
    Department of Psychological Sciences, University of Missouri, Columbia, MO 65211, USA
    Drug Alcohol Depend 116:203-10. 2011
    ..Methamphetamine's behavioral effects have been attributed to its interaction with monoamine transporters; however, methamphetamine also has affinity for sigma receptors...
  10. ncbi request reprint Lobeline, a potential pharmacotherapy for drug addiction, binds to mu opioid receptors and diminishes the effects of opioid receptor agonists
    Dennis K Miller
    Department of Psychological Sciences, 212 C McAlester Hall, University of Missouri, Columbia, MO 65211, USA
    Drug Alcohol Depend 89:282-91. 2007
    ..The ability of lobeline to block psychostimulant effects may be mediated by opioid receptor antagonism, and lobeline could be investigated as a treatment for opiate addiction...
  11. pmc SA 4503 attenuates cocaine-induced hyperactivity and enhances methamphetamine substitution for a cocaine discriminative stimulus
    Kelli R Rodvelt
    Department of Psychological Sciences, University of Missouri, Columbia, MO 65211, USA
    Pharmacol Biochem Behav 97:676-82. 2011
    ..The data also suggest sigma receptors mediate the activity of different dopamine pathways responsible for the behavioral effects of psychostimulants...
  12. pmc Synthesis and in vitro evaluation of tetrahydroisoquinolinyl benzamides as ligands for sigma receptors
    Rong Xu
    Department of Chemistry, University of Missouri Columbia, Columbia, MO, USA
    Bioorg Med Chem Lett 17:2594-7. 2007
    ..Thus, a constrained tetrahydroisoquinoline ring system is key to the exceptional sigma(2) receptor binding affinity and selectivity of this active series...
  13. pmc Effect of structural modification in the amine portion of substituted aminobutyl-benzamides as ligands for binding σ1 and σ2 receptors
    Kuo Hsien Fan
    Department of Chemistry, University of Missouri Columbia, Columbia, MO, USA
    Bioorg Med Chem 19:1852-9. 2011
    ..Thus, location of the nitrogen within a constrained ring is confirmed to be key to the exceptional σ(2) receptor binding affinity and selectivity for this active series...
  14. ncbi request reprint Synthesis and structure-activity relationships of N-(3-phenylpropyl)-N'-benzylpiperazines: Potent ligands for sigma1 and sigma2 receptors
    Roger I Nahas
    Department of Chemistry, University of Missouri Columbia, Columbia, MO 65212, USA
    Bioorg Med Chem 16:755-61. 2008
    ..The hydrophobicity term is negative for sigma(1) binding but positive for sigma(2) binding, indicating a major difference between the pharmacophores...
  15. doi request reprint Development of high-specific-activity (68)Ga-labeled DOTA-rhenium-cyclized alpha-MSH peptide analog to target MC1 receptors overexpressed by melanoma tumors
    Melchor V Cantorias
    University of Missouri Research Reactor Center, Columbia, 65211, USA
    Nucl Med Biol 36:505-13. 2009
    ....
  16. pmc Bombesin functionalized gold nanoparticles show in vitro and in vivo cancer receptor specificity
    Nripen Chanda
    Department of Radiology, Harry S Truman Veterans Administration Medical Center, Columbia, MO, USA
    Proc Natl Acad Sci U S A 107:8760-5. 2010
    ....
  17. doi request reprint Labeling of dopamine transporter transmembrane domain 1 with the tropane ligand N-[4-(4-azido-3-[125I]iodophenyl)butyl]-2beta-carbomethoxy-3beta-(4-chlorophenyl)tropane implicates proximity of cocaine and substrate active sites
    M Laura Parnas
    Department of Biochemistry and Molecular Biology, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND 58202, USA
    Mol Pharmacol 73:1141-50. 2008
    ..These results directly establish the proximity of TMs 1 and 6 in DAT and suggest that the mechanism of transport inhibition by cocaine involves close interactions with multiple regions of the substrate permeation pathway...
  18. ncbi request reprint Localization of cocaine analog [125I]RTI 82 irreversible binding to transmembrane domain 6 of the dopamine transporter
    Roxanne A Vaughan
    Department of Biochemistry and Molecular Biology, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota 58203 9037, USA
    J Biol Chem 282:8915-25. 2007
    ..Cocaine binding near TM6 may thus overlap the dopamine translocation pathway and function to inhibit TM6 structural rearrangements necessary for transport...
  19. ncbi request reprint Design and synthesis of a novel photoaffinity ligand for the dopamine and serotonin transporters based on 2beta-carbomethoxy-3beta-biphenyltropane
    Amy Hauck Newman
    Medicinal Chemistry and Psychobiology Sections, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health DHHS, Baltimore, MD, USA
    J Med Chem 49:6621-5. 2006
    ..Moreover, this compound showed moderate binding affinity for the serotonin transporter (SERT, K(i) = 109 +/- 14 nM), suggesting the potential utility of [(125)I]11 in both DAT and SERT protein structure studies...