Konstantin Levay

Summary

Affiliation: University of Miami
Country: USA

Publications

  1. pmc Tescalcin is an essential factor in megakaryocytic differentiation associated with Ets family gene expression
    Konstantin Levay
    Department of Molecular and Cellular Pharmacology and Neuroscience Program, University of Miami Miller School of Medicine, Miami, Florida 33101 6189, USA
    J Clin Invest 117:2672-83. 2007
  2. pmc Subcellular localization of regulator of G protein signaling RGS7 complex in neurons and transfected cells
    Evangelos Liapis
    Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL, USA
    J Neurochem 122:568-81. 2012
  3. pmc Molecular organization of the complex between the muscarinic M3 receptor and the regulator of G protein signaling, Gbeta(5)-RGS7
    Simone L Sandiford
    Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Biochemistry 49:4998-5006. 2010
  4. pmc Interaction of retinal guanylate cyclase with the alpha subunit of transducin: potential role in transducin localization
    Derek H Rosenzweig
    Department of Molecular and Cellular Pharmacology and Neuroscience Program University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Biochem J 417:803-12. 2009
  5. pmc Up- or downregulation of tescalcin in HL-60 cells is associated with their differentiation to either granulocytic or macrophage-like lineage
    Konstantin Levay
    Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL 33101 6189, USA
    Exp Cell Res 316:1254-62. 2010
  6. ncbi request reprint Characterization of tescalcin, a novel EF-hand protein with a single Ca2+-binding site: metal-binding properties, localization in tissues and cells, and effect on calcineurin
    Christina Gutierrez-Ford
    Department of Molecular and Cellular Pharmacology, University of Miami School of Medicine, Miami, Florida 33136, USA
    Biochemistry 42:14553-65. 2003
  7. ncbi request reprint Intramolecular interaction between the DEP domain of RGS7 and the Gbeta5 subunit
    Vijaya Narayanan
    Department of Molecular and Cellular Pharmacology and Neuroscience Program, University of Miami, Miami, Florida 33136, USA
    Biochemistry 46:6859-70. 2007
  8. pmc Evidence for multiple phototransduction pathways in a reef-building coral
    Benjamin Mason
    Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, Florida, United States of America
    PLoS ONE 7:e50371. 2012
  9. pmc Regulation of Cop9 signalosome activity by the EF-hand Ca2+-binding protein tescalcin
    Konstantin Levay
    Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    J Cell Sci 127:2448-59. 2014
  10. pmc Expression of olfactory signaling genes in the eye
    Alexey Pronin
    Department of Molecular and Cellular Pharmacology, University of Miami School of Medicine, Miami, Florida, United States of America Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, Florida, United States of America
    PLoS ONE 9:e96435. 2014

Collaborators

Detail Information

Publications12

  1. pmc Tescalcin is an essential factor in megakaryocytic differentiation associated with Ets family gene expression
    Konstantin Levay
    Department of Molecular and Cellular Pharmacology and Neuroscience Program, University of Miami Miller School of Medicine, Miami, Florida 33101 6189, USA
    J Clin Invest 117:2672-83. 2007
    ..Thus, tescalcin is essential for the coupling of ERK cascade activation with the expression of Ets family genes in megakaryocytic differentiation...
  2. pmc Subcellular localization of regulator of G protein signaling RGS7 complex in neurons and transfected cells
    Evangelos Liapis
    Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL, USA
    J Neurochem 122:568-81. 2012
    ..RGS7 also localized in centrosomes. Structure-function analysis showed that the punctate localization was mediated by the DEP/DHEX domains, and centrosomal localization was dependent on the DHEX domain...
  3. pmc Molecular organization of the complex between the muscarinic M3 receptor and the regulator of G protein signaling, Gbeta(5)-RGS7
    Simone L Sandiford
    Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Biochemistry 49:4998-5006. 2010
    ....
  4. pmc Interaction of retinal guanylate cyclase with the alpha subunit of transducin: potential role in transducin localization
    Derek H Rosenzweig
    Department of Molecular and Cellular Pharmacology and Neuroscience Program University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Biochem J 417:803-12. 2009
    ..Taken together, these results suggest that the protein-protein interaction between G(alphat) and retGC represents a novel mechanism regulating light-dependent translocation of transducin in rod photoreceptors...
  5. pmc Up- or downregulation of tescalcin in HL-60 cells is associated with their differentiation to either granulocytic or macrophage-like lineage
    Konstantin Levay
    Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL 33101 6189, USA
    Exp Cell Res 316:1254-62. 2010
    ..These studies indicate that tescalcin is one of the key gene products that is involved in switching differentiation program in some cell types...
  6. ncbi request reprint Characterization of tescalcin, a novel EF-hand protein with a single Ca2+-binding site: metal-binding properties, localization in tissues and cells, and effect on calcineurin
    Christina Gutierrez-Ford
    Department of Molecular and Cellular Pharmacology, University of Miami School of Medicine, Miami, Florida 33136, USA
    Biochemistry 42:14553-65. 2003
    ..Hence, tescalcin is a novel calcineurin B-like protein that binds a single Ca(2+) ion...
  7. ncbi request reprint Intramolecular interaction between the DEP domain of RGS7 and the Gbeta5 subunit
    Vijaya Narayanan
    Department of Molecular and Cellular Pharmacology and Neuroscience Program, University of Miami, Miami, Florida 33136, USA
    Biochemistry 46:6859-70. 2007
    ..The closed conformation appears to be less active with respect to its effect on Gq-mediated signaling than the open conformation...
  8. pmc Evidence for multiple phototransduction pathways in a reef-building coral
    Benjamin Mason
    Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, Florida, United States of America
    PLoS ONE 7:e50371. 2012
    ..This indicates that at least acropsins 1 and 3 can form functional photoreceptors and potentially may play a role in color preference during settlement, vertical positioning and other light-guided behaviors observed in coral larvae...
  9. pmc Regulation of Cop9 signalosome activity by the EF-hand Ca2+-binding protein tescalcin
    Konstantin Levay
    Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    J Cell Sci 127:2448-59. 2014
    ..These effects are consistent with the hypothesis that tescalcin might play a role as a negative regulator of CSN activity towards Cul1 in the process of induced cell differentiation. ..
  10. pmc Expression of olfactory signaling genes in the eye
    Alexey Pronin
    Department of Molecular and Cellular Pharmacology, University of Miami School of Medicine, Miami, Florida, United States of America Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, Florida, United States of America
    PLoS ONE 9:e96435. 2014
    ..To advance our understanding how the outer eye interacts with its environment, we asked which cellular receptors are expressed in the cornea, focusing on G protein-coupled receptors...
  11. pmc Targeted deletion of one or two copies of the G protein β subunit Gβ5 gene has distinct effects on body weight and behavior in mice
    Qiang Wang
    Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, Florida, 33136, USA
    FASEB J 25:3949-57. 2011
    ..Our data on Gβ5 haploinsufficient mice may explain earlier observations of genetic linkage between R7 family mutations and obesity in humans...
  12. ncbi request reprint Spinal cord injury induces expression of RGS7 in microglia/macrophages in rats
    Oliver N Hausmann
    The Miami Project to Cure Paralysis, Miami, Florida, USA
    Eur J Neurosci 15:602-12. 2002
    ..This expression might contribute to the post-traumatic inflammatory responses in the central nervous system...