B Levant

Summary

Affiliation: University of Kansas Medical Center
Country: USA

Publications

  1. ncbi request reprint Diet (n-3) polyunsaturated fatty acid content and parity interact to alter maternal rat brain phospholipid fatty acid composition
    Beth Levant
    The Smith Mental Retardation Research Center, University of Kansas Medical Center, Kansas City, KS 66160, USA
    J Nutr 136:2236-42. 2006
  2. ncbi request reprint Sex-specific effects of brain LC-PUFA composition on locomotor activity in rats
    Beth Levant
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160 USA
    Physiol Behav 89:196-204. 2006
  3. pmc Dopamine receptor alterations in female rats with diet-induced decreased brain docosahexaenoic acid (DHA): interactions with reproductive status
    Paul F Davis
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center Kansas City, Kansas, USA
    Nutr Neurosci 13:161-9. 2010
  4. pmc N-3 (omega-3) Fatty acids in postpartum depression: implications for prevention and treatment
    Beth Levant
    Department of Pharmacology, Toxicology, and Therapeutics, Kansas Intellectual and Developmental Disabilities Research Center, The University of Kansas Medical Center, MS 1018, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Depress Res Treat 2011:467349. 2011
  5. pmc Streptozotocin-induced diabetes partially attenuates the effects of a high-fat diet on liver and brain fatty acid composition in mice
    Beth Levant
    Departments of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Mail Stop 1018, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    Lipids 48:939-48. 2013
  6. pmc N-3 (omega-3) polyunsaturated Fatty acids in the pathophysiology and treatment of depression: pre-clinical evidence
    Beth Levant
    Department of Pharmacology, University of Kansas Medical Center, MS 1018, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    CNS Neurol Disord Drug Targets 12:450-9. 2013
  7. ncbi request reprint Reduced brain DHA content after a single reproductive cycle in female rats fed a diet deficient in N-3 polyunsaturated fatty acids
    Beth Levant
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Biol Psychiatry 60:987-90. 2006
  8. ncbi request reprint Differential effects of modulation of docosahexaenoic acid content during development in specific regions of rat brain
    Beth Levant
    Department of Pharmacology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Lipids 41:407-14. 2006
  9. ncbi request reprint Specific brain regions of female rats are differentially depleted of docosahexaenoic acid by reproductive activity and an (n-3) fatty acid-deficient diet
    Beth Levant
    Departments of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA
    J Nutr 137:130-4. 2007
  10. ncbi request reprint Diet (n-3) polyunsaturated fatty acid content and parity affect liver and erythrocyte phospholipid fatty acid composition in female rats
    Beth Levant
    Department of Pharmacology, University of Kansas Medical Center, Kansas City, KS 66160, USA
    J Nutr 137:2425-30. 2007

Research Grants

  1. Brain DHA, Dopamine, and Behavior: Roles in ADHD
    Beth Levant; Fiscal Year: 2006
  2. Brain LC-PUFAs and Maternal Mental Health
    Beth Levant; Fiscal Year: 2006

Collaborators

Detail Information

Publications38

  1. ncbi request reprint Diet (n-3) polyunsaturated fatty acid content and parity interact to alter maternal rat brain phospholipid fatty acid composition
    Beth Levant
    The Smith Mental Retardation Research Center, University of Kansas Medical Center, Kansas City, KS 66160, USA
    J Nutr 136:2236-42. 2006
    ....
  2. ncbi request reprint Sex-specific effects of brain LC-PUFA composition on locomotor activity in rats
    Beth Levant
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160 USA
    Physiol Behav 89:196-204. 2006
    ..This suggests that variation in brain DHA content produces sex-specific alterations in locomotor activity and that the neurochemical alterations underlying the observed behavioral changes vary depending on the degree of DHA depletion...
  3. pmc Dopamine receptor alterations in female rats with diet-induced decreased brain docosahexaenoic acid (DHA): interactions with reproductive status
    Paul F Davis
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center Kansas City, Kansas, USA
    Nutr Neurosci 13:161-9. 2010
    ..These receptor alterations are similar to those found in several rodent models of depression, and are consistent with the proposed hypodopaminergic basis for anhedonia and motivational deficits in depression...
  4. pmc N-3 (omega-3) Fatty acids in postpartum depression: implications for prevention and treatment
    Beth Levant
    Department of Pharmacology, Toxicology, and Therapeutics, Kansas Intellectual and Developmental Disabilities Research Center, The University of Kansas Medical Center, MS 1018, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Depress Res Treat 2011:467349. 2011
    ..These findings, and their implications for research and clinical practice, are discussed...
  5. pmc Streptozotocin-induced diabetes partially attenuates the effects of a high-fat diet on liver and brain fatty acid composition in mice
    Beth Levant
    Departments of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Mail Stop 1018, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    Lipids 48:939-48. 2013
    ..This indicates that the effects of a high-fat diet on liver and brain phospholipid fatty acid compositions are partially attenuated by concomitant hyperglycemia with hypoinsulinemia. ..
  6. pmc N-3 (omega-3) polyunsaturated Fatty acids in the pathophysiology and treatment of depression: pre-clinical evidence
    Beth Levant
    Department of Pharmacology, University of Kansas Medical Center, MS 1018, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    CNS Neurol Disord Drug Targets 12:450-9. 2013
    ..This evidence for a role for n-3 PUFA in the pathophysiology and treatment of depressive illness are reviewed. The implications of these finding for future pre-clinical research and clinical application are discussed. ..
  7. ncbi request reprint Reduced brain DHA content after a single reproductive cycle in female rats fed a diet deficient in N-3 polyunsaturated fatty acids
    Beth Levant
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Biol Psychiatry 60:987-90. 2006
    ..Low levels of n-3 polyunsaturated fatty acids (PUFAs), particularly docosahexaenoic acid (DHA, 22:6n3), are implicated in postpartum depression...
  8. ncbi request reprint Differential effects of modulation of docosahexaenoic acid content during development in specific regions of rat brain
    Beth Levant
    Department of Pharmacology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Lipids 41:407-14. 2006
    ..These differential effects may contribute to the specific neurochemical and behavioral effects observed in animals with variation in brain DHA content...
  9. ncbi request reprint Specific brain regions of female rats are differentially depleted of docosahexaenoic acid by reproductive activity and an (n-3) fatty acid-deficient diet
    Beth Levant
    Departments of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA
    J Nutr 137:130-4. 2007
    ..This pattern of changes in regional DHA and (n-6) DPA content suggests that specific neuronal systems may be differentially affected by depletion of brain DHA in the postpartum organism...
  10. ncbi request reprint Diet (n-3) polyunsaturated fatty acid content and parity affect liver and erythrocyte phospholipid fatty acid composition in female rats
    Beth Levant
    Department of Pharmacology, University of Kansas Medical Center, Kansas City, KS 66160, USA
    J Nutr 137:2425-30. 2007
    ..Changes in erythrocyte DHA were of similar magnitude and time course to those observed in liver, suggesting that this tissue may serve as a marker for liver DHA status...
  11. pmc Decreased brain docosahexaenoic acid content produces neurobiological effects associated with depression: Interactions with reproductive status in female rats
    Beth Levant
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Psychoneuroendocrinology 33:1279-92. 2008
    ..Furthermore, the data are consistent with findings in depressed humans, and thus support a role for DHA as a factor in the etiologies of depressive illnesses, particularly postpartum depression...
  12. pmc Developmental effects of dietary n-3 fatty acids on activity and response to novelty
    Beth Levant
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Physiol Behav 101:176-83. 2010
    ..The observation of this effect only in 2nd-litter rats fed the Deficient diet suggests that brain DHA content, rather than dietary n-3 PUFA content, likely underlies these effects...
  13. pmc Differences in methylphenidate dose response between periadolescent and adult rats in the familiar arena-novel alcove task
    Beth Levant
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Mail Stop 1018, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    J Pharmacol Exp Ther 337:83-91. 2011
    ....
  14. ncbi request reprint Sub-chronic antipsychotic drug treatment does not alter brain phospholipid fatty acid composition in rats
    Beth Levant
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Prog Neuropsychopharmacol Biol Psychiatry 30:728-32. 2006
    ....
  15. ncbi request reprint Differential distribution of D3 dopamine receptors in the brains of several mammalian species
    B Levant
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, KS 66160 7147, USA
    Brain Res 800:269-74. 1998
    ..These observations indicate significant inter-species differences in the distribution of D3 receptors...
  16. ncbi request reprint Novel drug interactions at D(2) dopamine receptors: modulation of [3H]quinpirole binding by monoamine oxidase inhibitors
    Beth Levant
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City 66160 7417, USA
    Life Sci 71:2691-700. 2002
    ....
  17. ncbi request reprint Differential effects of ibogaine on local cerebral glucose utilization in drug-naive and morphine-dependent rats
    Beth Levant
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160 7417, USA
    Brain Res 1003:159-67. 2004
    ..These findings indicate that ibogaine produces distinctly different effects on LCGU in drug-naive and morphine-dependent rats. This suggests that different mechanisms may underlie ibogaine's hallucinogenic and anti-addictive effects...
  18. ncbi request reprint Decreased brain docosahexaenoic acid during development alters dopamine-related behaviors in adult rats that are differentially affected by dietary remediation
    Beth Levant
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Mail Stop 1018, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    Behav Brain Res 152:49-57. 2004
    ..Some of these behavioral alterations were reversed by dietary remediation initiated at weaning...
  19. ncbi request reprint Modulation of [3H]quinpirole binding at striatal D2 dopamine receptors by a monoamine oxidaseA-like site: evidence from radioligand binding studies and D2 receptor- and MAO(A)-deficient mice
    B Levant
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City 66160 7417, USA
    Life Sci 70:229-41. 2001
    ..These data suggest that [3H]Ro-41-1049 labels multiple sites and that MAOIs modulate [3H]quinpirole binding to the D2 receptor via interactions at a novel, non-MAO binding site with MAO(A)-like pharmacology...
  20. ncbi request reprint D(3) dopamine receptors in rat spinal cord: implications for sensory and motor function
    B Levant
    Department of Pharmacology, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160 7417, USA
    Neurosci Lett 303:9-12. 2001
    ..Lowest densities of D(3) sites were detected in the ventral horn. These observations suggest that spinal D(3) receptors may play a role in sensory and/or motor function or contribute to the pharmacological effects of dopaminergic drugs...
  21. ncbi request reprint Alterations in local cerebral glucose utilization produced by D3 dopamine receptor-selective doses of 7-OH-DPAT and nafadotride
    B Levant
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160 7147, USA
    Brain Res 812:193-9. 1998
    ..These observations indicate that stimulation or blockade of D3 receptors alters LCGU and that produces a unique pattern of alterations in LCGU suggestive of potential antipsychotic activity...
  22. ncbi request reprint Inhibition of [3H]quinpirole binding by a monoamine oxidase inhibitor in subcellular fractions of rat striatum
    B Levant
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City 66160 7417, USA
    Life Sci 63:1643-51. 1998
    ..The subcellular distribution of MQB paralleled that of "D2-like" [3H]quinpirole binding. This suggests that "D2-like" [3H]quinpirole binding and MQB occur at a common membrane-bound binding site...
  23. pmc Basal local cerebral glucose utilization is not altered after behavioral sensitization to quinpirole
    Toni L Richards
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Neurosci Lett 429:165-8. 2007
    ....
  24. pmc Clorgyline-induced modification of behavioral sensitization to quinpirole: effects on local cerebral glucose utilization
    Toni L Richards
    Department of Pharmacology, University of Kansas Medical Center, Kansas City, KS 66160 7417, USA
    Brain Res 1160:124-33. 2007
    ..This implicates altered activity of the noradrenergic, serotonergic, olfactory, and limbic systems in the modified behavioral response to quinpirole with clorgyline pretreatment...
  25. ncbi request reprint Maternal parity and diet (n-3) polyunsaturated fatty acid concentration influence accretion of brain phospholipid docosahexaenoic acid in developing rats
    Marlies K Ozias
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA
    J Nutr 137:125-9. 2007
    ....
  26. ncbi request reprint Differences in quinpirole-induced local cerebral glucose utilization between naive and sensitized rats
    Toni L Carpenter
    Department of Pharmacology, Toxicology and Therapeutics, Mail Stop 1018, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160 7417, USA
    Brain Res 964:295-301. 2003
    ..This suggests that decreased neuronal activity in the nucleus accumbens and ventral pallidum may underlie the augmented behavioral response to quinpirole in sensitized animals...
  27. ncbi request reprint Altered quinpirole-induced local cerebral glucose utilization in anterior cortical regions in rats after sensitization to quinpirole
    Toni L Richards
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160 7417, USA
    Brain Res 1042:53-61. 2005
    ....
  28. pmc Reduced numbers of dopamine neurons in the substantia nigra pars compacta and ventral tegmental area of rats fed an n-3 polyunsaturated fatty acid-deficient diet: a stereological study
    S Omar Ahmad
    Department of Occupational Therapy Education, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Neurosci Lett 438:303-7. 2008
    ....
  29. ncbi request reprint Detection of dopamine receptor subtypes in the rat diaphragm
    Janet D Pierce
    School of Nursing, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Heart Lung 36:58-63. 2007
    ..The administration of dopamine using an in vivo animal model has been shown to prevent and treat diaphragm fatigue...
  30. ncbi request reprint Dopamine receptor binding and quantitative autoradiographic study
    Beth Levant
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS, USA
    Methods Mol Med 79:297-313. 2003
  31. ncbi request reprint Signaling mechanisms of the D3 dopamine receptor
    Joy A Ahlgren-Beckendorf
    Department of Pharmacology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Recept Signal Transduct Res 24:117-30. 2004
    ..Finally, D3-preferring drugs modulate expression of c-fos in neuronal cultures and brain. Signaling mechanisms of the D3 receptor in brain, however, remain to be definitively determined...
  32. ncbi request reprint Altered behavioral response to dopamine D3 receptor agonists 7-OH-DPAT and PD 128907 following repetitive amphetamine administration
    Neil M Richtand
    Department of Psychiatry V 116A, Cincinnati Veterans Affairs Medical Center, Cincinnati, OH 45220, USA
    Neuropsychopharmacology 28:1422-32. 2003
    ..These findings suggest a persistent release of D3 receptor-mediated inhibitory influence contributes to the expression of behavioral sensitization to amphetamine...
  33. pmc Altered dopamine D2-like receptor binding in rats with behavioral sensitization to quinpirole: effects of pre-treatment with Ro 41-1049
    Kirsten E Culver
    School of Nursing, McMaster University, Hamilton, Ontario, Canada
    Eur J Pharmacol 592:67-72. 2008
    ....
  34. pmc Design, synthesis, and evaluation of potent and selective ligands for the dopamine 3 (D3) receptor with a novel in vivo behavioral profile
    Jianyong Chen
    Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Med Chem 51:5905-8. 2008
    ..Our in vivo functional assays showed that this compound is a partial agonist at the D3 receptor with no detectable activity at the D2 receptor...
  35. ncbi request reprint Enantiomerically pure hexahydropyrazinoquinolines as potent and selective dopamine 3 subtype receptor ligands
    Ke Ding
    Department of Internal Medicine and Medicinal Chemistry, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, Michigan 48109 0934, USA
    J Med Chem 48:3171-81. 2005
    ..7 nM to the D(3) receptor and selectivity greater than 10000- and 1600-fold over the D(1)-like and D(2)-like receptors, respectively, and thus is one of the most selective D(3) ligands reported to date...
  36. ncbi request reprint Design, synthesis, and evaluation of hexahydrobenz[f]isoquinolines as a novel class of dopamine 3 receptor ligands
    Xihan Wu
    Departments of Internal Medicine and Medicinal Chemistry, University of Michigan, CCGC 3316, 1500 East Medical Center Drive, Ann Arbor, MI 48109 0934, USA
    Bioorg Med Chem Lett 14:5813-6. 2004
    ..Thus, compound 4 h represents a promising new lead compound for further design and optimization toward achieving highly potent and selective D(3) ligands...
  37. ncbi request reprint Molecular modeling of the three-dimensional structure of dopamine 3 (D3) subtype receptor: discovery of novel and potent D3 ligands through a hybrid pharmacophore- and structure-based database searching approach
    Judith Varady
    Departments of Internal Medicine and Medicinal Chemistry, University of Michigan, 3 316 CCGC Box 0934, 1500 East Medical Center Drive, Ann Arbor, MI 48109 0934, USA
    J Med Chem 46:4377-92. 2003
    ..Furthermore, the employed hybrid approach may be more effective for lead discovery from a large chemical database than either pharmacophore-based or structure-based database screening alone...
  38. ncbi request reprint Design, synthesis and structure-activity relationship studies of hexahydropyrazinoquinolines as a novel class of potent and selective dopamine receptor 3 (D3) ligands
    Min Ji
    Department of Internal Medicine, University of Michigan, CCGC 3316, 1500 East Medical Center Drive, Ann Arbor, MI 48109 0934, USA
    Bioorg Med Chem Lett 15:1701-5. 2005
    ..Among them, compound 12d has a Ki value of 2.6 nM for its binding affinity to the D3 receptor and has >2000- and 99-fold selectivity over the D1-like and D2-like receptors, respectively, representing a potent and selective D3 ligand...

Research Grants2

  1. Brain DHA, Dopamine, and Behavior: Roles in ADHD
    Beth Levant; Fiscal Year: 2006
    ..Such insights may identify a means by which certain risk factors for ADHD may be reduced or eliminated or the severity of the disease may be reduced through appropriate pre- and postnatal nutrition. [unreadable] [unreadable]..
  2. Brain LC-PUFAs and Maternal Mental Health
    Beth Levant; Fiscal Year: 2006
    ..These findings will also suggest novel treatments for such illnesses when they occur. ..