JACQUELINE LEUNG

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Does preoperative risk for delirium moderate the effects of postoperative pain and opiate use on postoperative delirium?
    Jacqueline M Leung
    University of California, San Francisco, CA Electronic address
    Am J Geriatr Psychiatry 21:946-56. 2013
  2. pmc Does using a femoral nerve block for total knee replacement decrease postoperative delirium?
    Sakura Kinjo
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143 0648, USA
    BMC Anesthesiol 12:4. 2012
  3. pmc Brief report: preoperative frailty in older surgical patients is associated with early postoperative delirium
    Jacqueline M Leung
    MPH, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA 94143 0648, USA
    Anesth Analg 112:1199-201. 2011
  4. pmc Does postoperative delirium limit the use of patient-controlled analgesia in older surgical patients?
    Jacqueline M Leung
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, 521 Parnassus, Room C 450, San Francisco, California 94143 0648, USA
    Anesthesiology 111:625-31. 2009
  5. ncbi request reprint Apolipoprotein E e4 allele increases the risk of early postoperative delirium in older patients undergoing noncardiac surgery
    Jacqueline M Leung
    Anesthesia and Perioperative Care, University of California, San Francisco, California 94143 0648, USA
    Anesthesiology 107:406-11. 2007
  6. ncbi request reprint Pilot clinical trial of gabapentin to decrease postoperative delirium in older patients
    J M Leung
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA 94143 0648, USA
    Neurology 67:1251-3. 2006
  7. ncbi request reprint Nitrous oxide does not change the incidence of postoperative delirium or cognitive decline in elderly surgical patients
    J M Leung
    Department of Anesthesia and Perioperative Care, University of California, 521 Parnassus, San Francisco, 94143 0648, USA
    Br J Anaesth 96:754-60. 2006
  8. ncbi request reprint Increases in P-wave dispersion predict postoperative atrial fibrillation after coronary artery bypass graft surgery
    Joby Chandy
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, USA
    Anesth Analg 98:303-10, table of contents. 2004
  9. ncbi request reprint Postoperative delirium: the importance of pain and pain management
    Linnea E Vaurio
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143 0648, USA
    Anesth Analg 102:1267-73. 2006
  10. ncbi request reprint Are preoperative depressive symptoms associated with postoperative delirium in geriatric surgical patients?
    Jacqueline M Leung
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143 0648, USA
    J Gerontol A Biol Sci Med Sci 60:1563-8. 2005

Research Grants

  1. AGING AND PERIOPERATIVE OUTCOMES
    JACQUELINE LEUNG; Fiscal Year: 2005
  2. Pathophysiology of postoperative delirium in older patients
    JACQUELINE LEUNG; Fiscal Year: 2009
  3. Pathophysiology of postoperative delirium in older patients
    Jacqueline M Leung; Fiscal Year: 2010

Collaborators

Detail Information

Publications22

  1. pmc Does preoperative risk for delirium moderate the effects of postoperative pain and opiate use on postoperative delirium?
    Jacqueline M Leung
    University of California, San Francisco, CA Electronic address
    Am J Geriatr Psychiatry 21:946-56. 2013
    ..To investigate whether preoperative risk for delirium moderates the effect of postoperative pain and opioids on the development of postoperative delirium...
  2. pmc Does using a femoral nerve block for total knee replacement decrease postoperative delirium?
    Sakura Kinjo
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143 0648, USA
    BMC Anesthesiol 12:4. 2012
    ..abstract:..
  3. pmc Brief report: preoperative frailty in older surgical patients is associated with early postoperative delirium
    Jacqueline M Leung
    MPH, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA 94143 0648, USA
    Anesth Analg 112:1199-201. 2011
    ..42; 95% confidence interval=1.06-1.91; P=0.018) and the frailty score (odds ratio=1.84; 95% confidence interval=1.07-3.1; P=0.028) were independently associated with the development of postoperative delirium...
  4. pmc Does postoperative delirium limit the use of patient-controlled analgesia in older surgical patients?
    Jacqueline M Leung
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, 521 Parnassus, Room C 450, San Francisco, California 94143 0648, USA
    Anesthesiology 111:625-31. 2009
    ..BACKGROUNDPostoperative pain Is an independent predictor of postoperative delirium. Whether postoperative delirium limits patient-controlled analgesia (PCA) use has not been determined...
  5. ncbi request reprint Apolipoprotein E e4 allele increases the risk of early postoperative delirium in older patients undergoing noncardiac surgery
    Jacqueline M Leung
    Anesthesia and Perioperative Care, University of California, San Francisco, California 94143 0648, USA
    Anesthesiology 107:406-11. 2007
    ..Whether patients who subsequently develop early postoperative delirium have a genetic predisposition that renders them at risk for postoperative delirium has not been determined...
  6. ncbi request reprint Pilot clinical trial of gabapentin to decrease postoperative delirium in older patients
    J M Leung
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA 94143 0648, USA
    Neurology 67:1251-3. 2006
    ..Postoperative delirium occurred in 5/12 patients (42%) who received placebo vs 0/9 patients who received gabapentin, p = 0.045. The reduction in delirium appears to be secondary to the opioid-sparing effect of gabapentin...
  7. ncbi request reprint Nitrous oxide does not change the incidence of postoperative delirium or cognitive decline in elderly surgical patients
    J M Leung
    Department of Anesthesia and Perioperative Care, University of California, 521 Parnassus, San Francisco, 94143 0648, USA
    Br J Anaesth 96:754-60. 2006
    ..We hypothesized that in the elderly patients undergoing non-cardiac surgery, exposure to N(2)O resulted in an increased incidence of postoperative delirium than would be expected for patients not receiving N(2)O...
  8. ncbi request reprint Increases in P-wave dispersion predict postoperative atrial fibrillation after coronary artery bypass graft surgery
    Joby Chandy
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, USA
    Anesth Analg 98:303-10, table of contents. 2004
    ..03, 95% CI: 1.01-1.05, P = 0.01) to be independent predictors of postoperative AF. No surgical factor was identified to be responsible for this postoperative change in atrial electrophysiology...
  9. ncbi request reprint Postoperative delirium: the importance of pain and pain management
    Linnea E Vaurio
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143 0648, USA
    Anesth Analg 102:1267-73. 2006
    ..4; 95% CI 0.2 to 0.7). These results validate our hypothesis that pain and pain management strategies are important factors related to the development of postoperative delirium in elderly patients...
  10. ncbi request reprint Are preoperative depressive symptoms associated with postoperative delirium in geriatric surgical patients?
    Jacqueline M Leung
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143 0648, USA
    J Gerontol A Biol Sci Med Sci 60:1563-8. 2005
    ..Our study aimed to examine the prevalence and prognostic importance of preoperative depressive symptoms in older surgical patients...
  11. ncbi request reprint Preoperative electrocardiogram abnormalities do not predict postoperative cardiac complications in geriatric surgical patients
    Linda L Liu
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94143, USA
    J Am Geriatr Soc 50:1186-91. 2002
    ..This study was designed to determine whether abnormalities on preoperative ECGs were predictive of postoperative cardiac complications...
  12. ncbi request reprint The relative importance of left atrial function versus dimension in predicting atrial fibrillation after coronary artery bypass graft surgery
    Toshiko Nakai
    Department of Medicine, Section of Cardiac Electrophysiology, and Cardiovascular Research Institute, University of California, San Francisco 94143, USA
    Am Heart J 143:181-6. 2002
    ..The purpose of this study was to determine whether pre-existing left atrial dysfunction is a predictor of postoperative AF compared with other clinical predictors...
  13. ncbi request reprint Does intraoperative evaluation of left ventricular contractile reserve predict myocardial viability? A clinical study using dobutamine stress echocardiography in patients undergoing coronary artery bypass graft surgery
    Jacqueline M Leung
    Department of Anesthesia and Perioperative Care, University of California San Francisco, 521 Parnassus Ave, San Francisco, CA 94143 0648, USA
    Anesth Analg 99:647-54, table of contents. 2004
    ..The majority of new postbypass regional wall motion abnormalities appear to be related to stunned myocardium...
  14. ncbi request reprint Impairment of left atrial function predicts post-operative atrial fibrillation after coronary artery bypass graft surgery
    Jacqueline M Leung
    Department of Anesthesia and Perioperative Care, University of California, 521 Parnassus Avenue, San Francisco, CA 94143 0648, USA
    Eur Heart J 25:1836-44. 2004
    ..This study sought to determine the relationship between LA function and post-operative AF...
  15. ncbi request reprint Comparison of left atrial dimensions by transesophageal and transthoracic echocardiography
    Matthew Block
    Department of Medicine, California Pacific Medical Center, San Francisco, CA, USA
    J Am Soc Echocardiogr 15:143-9. 2002
    ..86; bias 0.37 +/- 1 cm). Overall, TEE underestimated the LA dimension by 9% compared with TTE. These results suggest that the short-axis view at the level of the aortic valve is the preferred site for measuring the LA dimension by TEE...
  16. ncbi request reprint Association between intraoperative blood transfusions and early postoperative delirium in older adults
    Matthias Behrends
    Department of Anesthesia and Perioperative Care, University of California at San Francisco, San Francisco, CA 94143, USA
    J Am Geriatr Soc 61:365-70. 2013
    ....
  17. ncbi request reprint Prognostic significance of postoperative in-hospital complications in elderly patients. II. Long-term quality of life
    Kawalpreet Manku
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, USA
    Anesth Analg 96:590-4, table of contents. 2003
    ..The important independent predictors are co-morbid conditions, age, and new hospitalization after discharge...
  18. ncbi request reprint The role of postoperative analgesia in delirium and cognitive decline in elderly patients: a systematic review
    Harold K Fong
    Department of Anesthesia and Perioperative Care, School of Medicine, University of California, San Francisco, California 94143 0648, USA
    Anesth Analg 102:1255-66. 2006
    ..However, future investigations of sufficient study size and more standardized methods of defining outcomes are necessary to confirm the current findings...
  19. ncbi request reprint The prevalence of preoperative diastolic filling abnormalities in geriatric surgical patients
    Bridget Phillip
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94143 1605, USA
    Anesth Analg 97:1214-21. 2003
    ..These results suggest that evaluation of LV systolic function alone is not discriminatory in comprehensively characterizing LV function in geriatric surgical patients...
  20. ncbi request reprint Prognostic significance of postoperative in-hospital complications in elderly patients. I. Long-term survival
    Kawalpreet Manku
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, California, USA
    Anesth Analg 96:583-9, table of contents. 2003
    ..9, P = 0.023). An effort to improve perioperative care delivery to elderly surgical patients must include measures to minimize in-hospital postoperative complications, particularly those involving the pulmonary and renal systems...
  21. ncbi request reprint Histologic assessment of right atrial appendage myocardium in patients with atrial fibrillation after coronary artery bypass graft surgery
    Toshiko Nakai
    Division of Cardiovascular Medicine, Nihon University School of Medicine, Tokyo, Japan
    Cardiology 108:90-6. 2007
    ..85). These results suggest that the age-related atrial fibrosis rather than cellular hypertrophy may be important in the pathogenesis of AF after CABG surgery and should be further investigated...
  22. ncbi request reprint The effects of postoperative pain and its management on postoperative cognitive dysfunction
    Yun Wang
    Department of Statistics, Purdue University, West Lafayette, Indiana 47907 2069, USA
    Am J Geriatr Psychiatry 15:50-9. 2007
    ..Those at least risk of experiencing POCD were those who received postoperative analgesia orally...

Research Grants3

  1. AGING AND PERIOPERATIVE OUTCOMES
    JACQUELINE LEUNG; Fiscal Year: 2005
    ..We believe that our studies will provide important results contributing ultimately to the improvement of perioperative outcomes in geriatric patients. ..
  2. Pathophysiology of postoperative delirium in older patients
    JACQUELINE LEUNG; Fiscal Year: 2009
    ..Our proposal meets with the major mission of the National Institute of Aging to reduce the burden of illness and disability in the elderly. ..
  3. Pathophysiology of postoperative delirium in older patients
    Jacqueline M Leung; Fiscal Year: 2010
    ..Our proposal meets with the major mission of the National Institute of Aging to reduce the burden of illness and disability in the elderly. ..