S L Letendre

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Correlates of HIV and malaria co-infection in Southern India
    Ajay R Bharti
    University of California San Diego, San Diego, CA, USA
    Malar J 11:306. 2012
  2. pmc Pathogenesis of HIV in the central nervous system
    Victor Valcour
    Memory and Aging Center, University of California San Francisco, 94143 1207, USA
    Curr HIV/AIDS Rep 8:54-61. 2011
  3. ncbi request reprint Lithium improves HIV-associated neurocognitive impairment
    Scott L Letendre
    Department of Medicine, University of California, San Diego, California 92103, USA
    AIDS 20:1885-8. 2006
  4. ncbi request reprint The effects of hepatitis C, HIV, and methamphetamine dependence on neuropsychological performance: biological correlates of disease
    Scott L Letendre
    Department of Medicine, University of California San Diego, CA 92103, USA
    AIDS 19:S72-8. 2005
  5. pmc Validation of the CNS Penetration-Effectiveness rank for quantifying antiretroviral penetration into the central nervous system
    Scott Letendre
    University of California, San Diego, 150 W Washington St, San Diego, CA 92103, USA
    Arch Neurol 65:65-70. 2008
  6. ncbi request reprint Cerebrospinal fluid beta chemokine concentrations in neurocognitively impaired individuals infected with human immunodeficiency virus type 1
    S L Letendre
    University of California, HIV Neurobehavioral Research Center, San Diego, California 92103, USA
    J Infect Dis 180:310-9. 1999
  7. pmc Chemokines in cerebrospinal fluid correlate with cerebral metabolite patterns in HIV-infected individuals
    Scott L Letendre
    University of California, San Diego, 220 Dickinson Street, Suite A, San Diego, CA 92103, USA
    J Neurovirol 17:63-9. 2011
  8. ncbi request reprint The role of cohort studies in drug development: clinical evidence of antiviral activity of serotonin reuptake inhibitors and HMG-CoA reductase inhibitors in the central nervous system
    Scott L Letendre
    University of California, 150 W Washington St, San Diego, CA 92103, USA
    J Neuroimmune Pharmacol 2:120-7. 2007
  9. ncbi request reprint The monocyte chemotactic protein-1 -2578G allele is associated with elevated MCP-1 concentrations in cerebrospinal fluid
    Scott Letendre
    Department of Medicine, The HIV Neurobehavioral Research Center, 150 West Washington Street, San Diego, CA 92103, USA
    J Neuroimmunol 157:193-6. 2004
  10. pmc Role of obesity, metabolic variables, and diabetes in HIV-associated neurocognitive disorder
    J A McCutchan
    University of California, San Diago, USA
    Neurology 78:485-92. 2012

Research Grants

Detail Information

Publications66

  1. pmc Correlates of HIV and malaria co-infection in Southern India
    Ajay R Bharti
    University of California San Diego, San Diego, CA, USA
    Malar J 11:306. 2012
    ..Plasmodium vivax contributes to almost half of the malaria cases in India, but the disease burden of HIV and P. vivax co-infection is unclear...
  2. pmc Pathogenesis of HIV in the central nervous system
    Victor Valcour
    Memory and Aging Center, University of California San Francisco, 94143 1207, USA
    Curr HIV/AIDS Rep 8:54-61. 2011
    ..This review highlights recent investigations of HIV-related CNS injury with emphasis on cART-era neuropathological mechanisms in the context of both US and international settings...
  3. ncbi request reprint Lithium improves HIV-associated neurocognitive impairment
    Scott L Letendre
    Department of Medicine, University of California, San Diego, California 92103, USA
    AIDS 20:1885-8. 2006
    ..To determine the effects of low-dose oral lithium on the neuropsychological performance of individuals diagnosed with HIV-associated neurocognitive impairment...
  4. ncbi request reprint The effects of hepatitis C, HIV, and methamphetamine dependence on neuropsychological performance: biological correlates of disease
    Scott L Letendre
    Department of Medicine, University of California San Diego, CA 92103, USA
    AIDS 19:S72-8. 2005
    ..To determine the effects of hepatitis C virus (HCV) infection on neuropsychological (NP) performance...
  5. pmc Validation of the CNS Penetration-Effectiveness rank for quantifying antiretroviral penetration into the central nervous system
    Scott Letendre
    University of California, San Diego, 150 W Washington St, San Diego, CA 92103, USA
    Arch Neurol 65:65-70. 2008
    ..To evaluate whether penetration of a combination regimen into the central nervous system (CNS), as estimated by the CNS Penetration-Effectiveness (CPE) rank, is associated with lower cerebrospinal fluid (CSF) viral load...
  6. ncbi request reprint Cerebrospinal fluid beta chemokine concentrations in neurocognitively impaired individuals infected with human immunodeficiency virus type 1
    S L Letendre
    University of California, HIV Neurobehavioral Research Center, San Diego, California 92103, USA
    J Infect Dis 180:310-9. 1999
    ..Low, but detectable, levels of CSF MIP-1alpha were strongly associated with dementia, suggesting that higher levels may have neuroprotective effects...
  7. pmc Chemokines in cerebrospinal fluid correlate with cerebral metabolite patterns in HIV-infected individuals
    Scott L Letendre
    University of California, San Diego, 220 Dickinson Street, Suite A, San Diego, CA 92103, USA
    J Neurovirol 17:63-9. 2011
    ....
  8. ncbi request reprint The role of cohort studies in drug development: clinical evidence of antiviral activity of serotonin reuptake inhibitors and HMG-CoA reductase inhibitors in the central nervous system
    Scott L Letendre
    University of California, 150 W Washington St, San Diego, CA 92103, USA
    J Neuroimmune Pharmacol 2:120-7. 2007
    ..Some of these drugs, such as serotonin reuptake inhibitors (SRIs) and HMG-CoA reductase inhibitors (statins), may do so by reducing HIV replication in the CNS and are already widely used by HIV-infected individuals...
  9. ncbi request reprint The monocyte chemotactic protein-1 -2578G allele is associated with elevated MCP-1 concentrations in cerebrospinal fluid
    Scott Letendre
    Department of Medicine, The HIV Neurobehavioral Research Center, 150 West Washington Street, San Diego, CA 92103, USA
    J Neuroimmunol 157:193-6. 2004
    ..Our findings suggest that this MCP-1 promoter polymorphism influences HIV neuropathogenesis by regulating MCP-1 protein expression in the central nervous system (CNS)...
  10. pmc Role of obesity, metabolic variables, and diabetes in HIV-associated neurocognitive disorder
    J A McCutchan
    University of California, San Diago, USA
    Neurology 78:485-92. 2012
    ..To evaluate relationships between HIV-associated neurocognitive disorder and metabolic variables in a subgroup of HIV+ participants examined in a prospective, observational, multicenter cohort study...
  11. pmc Apolipoprotein E4 genotype does not increase risk of HIV-associated neurocognitive disorders
    E E Morgan
    University of California, San Diego, San Diego, CA, USA
    J Neurovirol 19:150-6. 2013
    ..Prospective, longitudinal studies are needed to examine APOE4 as a risk factor for neurocognitive decline, incident HAND at older ages, and potential associations with cerebrospinal fluid amyloid...
  12. pmc Impact of long-term treatment with neurotoxic dideoxynucleoside antiretrovirals: implications for clinical care in resource-limited settings
    C F Hung
    University of California, San Diego, CA, USA
    HIV Med 9:731-7. 2008
    ..Therefore, we evaluated the safety of continuing d-drug therapy...
  13. pmc Variable patterns of neuropsychological performance in HIV-1 infection
    S Dawes
    Department of Psychiatry, HIV Neurobehavioral Research Center, University of California San Diego, San Diego, CA 92093 0603, USA
    J Clin Exp Neuropsychol 30:613-26. 2008
    ..Thus, there does not appear to be a single, prototypical pattern of neuropsychological impairment associated with HIV infection for this battery of representative neuropsychological tests...
  14. pmc HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study
    R K Heaton
    University of California, San Diego, USA
    Neurology 75:2087-96. 2010
    ....
  15. pmc Negative mood and sexual behavior among non-monogamous men who have sex with men in the context of methamphetamine and HIV
    C A Bousman
    University of California San Diego, HIV Neurobehavioral Research Center, Department of Psychiatry, La Jolla, California 92103, USA
    J Affect Disord 119:84-91. 2009
    ..This study examined the contextual influence of METH, HIV-infection and their combination on mood states and sexual behavior...
  16. ncbi request reprint Genetic attributes of cerebrospinal fluid-derived HIV-1 env
    Satish K Pillai
    University of California San Diego, Department of Medicine NCIRE, La Jolla, CA 94121, USA
    Brain 129:1872-83. 2006
    ..Furthermore, neurological impairment may be influenced by mutations within the viral V3 loop sequence...
  17. pmc White matter tract injury and cognitive impairment in human immunodeficiency virus-infected individuals
    Assawin Gongvatana
    San Diego State University University of California, San Diego, Joint Doctoral Program in Clinical Psychology, San Diego and La Jolla, California, USA
    J Neurovirol 15:187-95. 2009
    ..The study also confirms that CNS injury is evident in persons infected with HIV despite effective antiretroviral treatment...
  18. ncbi request reprint Dynamics of monocyte chemoattractant protein type one (MCP-1) and HIV viral load in human cerebrospinal fluid and plasma
    Sergio Monteiro de Almeida
    HIV Neurobehavioral Research Center, UCSD, 150 West Washington St, 2nd Flr, San Diego, CA 92103, USA
    J Neuroimmunol 169:144-52. 2005
    ..Increased expression of monocyte chemoattractant protein type 1 (MCP-1) is associated with HIV CNS disease. This study evaluated the temporal relationships between MCP-1 expression and HIV replication in the CNS...
  19. pmc Pleocytosis is associated with disruption of HIV compartmentalization between blood and cerebral spinal fluid viral populations
    Davey M Smith
    University of California San Diego, La Jolla, 92093, USA
    Virology 385:204-8. 2009
    ....
  20. pmc Prospective memory in HIV infection: is "remembering to remember" a unique predictor of self-reported medication management?
    Steven Paul Woods
    Department of Psychiatry, HIV Neurobehavioral Research Center, University of California, San Diego, School of Medicine, La Jolla, CA 92093, USA
    Arch Clin Neuropsychol 23:257-70. 2008
    ..The potential benefits of individualized remediation strategies that are informed by conceptual models of ProM and specifically target medication adherence warrant further exploration...
  21. pmc Neurobehavioral effects of human immunodeficiency virus infection among former plasma donors in rural China
    Robert K Heaton
    HIV Neurobehavioral Research Center HNRC, Department of Psychiatry, University of California at San Diego, San Diego, California 92093 0603, USA
    J Neurovirol 14:536-49. 2008
    ..These findings indicate that HAND is likely to be an important feature of HIV infection in developing countries, underscoring the need for international efforts to develop CNS-relevant treatments...
  22. pmc The semantic relatedness of cue-intention pairings influences event-based prospective memory failures in older adults with HIV infection
    Steven Paul Woods
    HIV Neurobehavioral Research Center, Department of Psychiatry, University of California, San Diego, CA 92103, USA
    J Clin Exp Neuropsychol 32:398-407. 2010
    ....
  23. pmc Longer term improvement in neurocognitive functioning and affective distress among methamphetamine users who achieve stable abstinence
    Jennifer E Iudicello
    Department of Psychiatry, HIV Neurobehavioral Research Center, University of California, San Diego, School of Medicine, La Jolla, CA 92103, USA
    J Clin Exp Neuropsychol 32:704-18. 2010
    ..These results suggest partial recovery of neuropsychological functioning and improvement in affective distress upon sustained abstinence from MA that may extend beyond a year or more...
  24. pmc Cerebrospinal fluid human immunodeficiency virus viral load in patients with neurosyphilis
    Sergio Monteiro de Almeida
    HIV Neurobehavioral Research Center, University of California San Diego, San Diego, USA
    J Neurovirol 16:6-12. 2010
    ..Because elevated CSF VL is associated with subsequent neurocognitive decline, future studies should evaluate the impact of neurosyphilis on the course of central nervous system (CNS) HIV infection...
  25. pmc HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictors
    Robert K Heaton
    University of California, San Diego, CA, USA
    J Neurovirol 17:3-16. 2011
    ..Clinical trials targeting HAND prevention should specifically examine timing of ART initiation...
  26. pmc Neurocognitive functioning in acute or early HIV infection
    David J Moore
    Department of Psychiatry, University of California, San Diego UCSD, San Diego, CA, USA
    J Neurovirol 17:50-7. 2011
    ..Although a significant monotonic trend existed and patterns of the data suggest the AEH individuals may fall intermediate to HIV- and chronic participants, we were not able to statistically confirm this hypothesis...
  27. ncbi request reprint Increased human immunodeficiency virus loads in active methamphetamine users are explained by reduced effectiveness of antiretroviral therapy
    Ronald J Ellis
    Department of Neurosciences, University of California San Diego, San Diego, California, USA
    J Infect Dis 188:1820-6. 2003
    ..In contrast, abstinent former METH abusers (METH(+)Tox-) receiving HAART effectively suppressed viral replication. These data suggest that abstinence programs are a key component of effective treatment of HIV in METH-abusing populations...
  28. pmc Total raltegravir concentrations in cerebrospinal fluid exceed the 50-percent inhibitory concentration for wild-type HIV-1
    David Croteau
    HIV Neurobehavioral Research Center, University of California San Diego, 220 Dickinson, Suite B, 8208, San Diego, CA 92103, USA
    Antimicrob Agents Chemother 54:5156-60. 2010
    ..As a component of effective antiretroviral regimens or as the main antiretroviral, RAL likely contributes to the control of HIV replication in the nervous system...
  29. pmc Spontaneous strategy use protects against visual working memory deficits in older adults infected with HIV
    Steven Paul Woods
    Department of Psychiatry, University of California San Diego, La Jolla, USA
    Arch Clin Neuropsychol 25:724-33. 2010
    ....
  30. pmc Cytochrome P450-2D6 extensive metabolizers are more vulnerable to methamphetamine-associated neurocognitive impairment: preliminary findings
    Mariana Cherner
    Department of Psychiatry, University of California San Diego, La Jolla, California 92093 0847, USA
    J Int Neuropsychol Soc 16:890-901. 2010
    ..This preliminary study is the first to suggest that efficient meth metabolism is associated with worse neurocognitive outcomes in humans, and implicates the products of oxidative metabolism of meth as a possible source of brain injury...
  31. pmc Continued high prevalence and adverse clinical impact of human immunodeficiency virus-associated sensory neuropathy in the era of combination antiretroviral therapy: the CHARTER Study
    Ronald J Ellis
    HIV Neurobehavioral Research Center, Department of Neurosciences, University of California, San Diego, San Diego, CA 92103, USA
    Arch Neurol 67:552-8. 2010
    ..To provide updated estimates of the prevalence and clinical impact of human immunodeficiency virus-associated sensory neuropathy (HIV-SN) and neuropathic pain due to HIV-SN in the combination antiretroviral therapy (CART) era...
  32. pmc APOE epsilon4 and MBL-2 O/O genotypes are associated with neurocognitive impairment in HIV-infected plasma donors
    Stephen A Spector
    Department of Pediatrics, University of California San Diego, La Jolla, California 92093 0672, USA
    AIDS 24:1471-9. 2010
    ..This study examined associations of host genetic variants and neurocognitive impairment in Chinese individuals infected through contaminated blood products...
  33. ncbi request reprint Meeting practical challenges of a trial involving a multitude of treatment regimens: an example of a multi-center randomized controlled clinical trial in neuroAIDS
    Susanne May
    Division of Biostatistics and Bioinformatics, Department of Family and Preventive Medicine, and Department of Neurosciences, University of California, San Diego, 9500 Gilman Drive M C 0717, La Jolla, CA 92093 0717, USA
    J Neuroimmune Pharmacol 2:97-104. 2007
    ..A small pilot study demonstrated the feasibility and acceptability to providers. In conclusion, an innovative design can provide solutions to challenging practical issues in trials with multiple treatment options...
  34. ncbi request reprint Human immunodeficiency virus and the central nervous system
    Sergio Monteiro de Almeida
    Neurology Unit, Universidade Federal do Parana, Curitiba, PR, Brazil
    Braz J Infect Dis 10:41-50. 2006
    ..The neurological manifestations directly related to HIV are acute viral meningitis, chronic meningitis, HIV-associated dementia (HAD), vacuolar myelopathy, and involvement of the peripheral nervous system...
  35. ncbi request reprint Relationship of antiretroviral treatment to postmortem brain tissue viral load in human immunodeficiency virus-infected patients
    Dianne Langford
    Department of Pathology, University of California, San Diego, La Jolla, California 92093, USA
    J Neurovirol 12:100-7. 2006
    ..Furthermore, such strategies might help to prevent the development of ARV resistance...
  36. ncbi request reprint Valproic acid does not affect markers of human immunodeficiency virus disease progression
    Beau M Ances
    Department of Neurosciences, University of California, San Diego, California, USA
    J Neurovirol 12:403-6. 2006
    ..VPA patients had a trend towards lower CD4+ cells (P = .08) at follow-up. Concurrent antiretrovirals did not alter these relationships. VPA does not induce viremia or promote disease progression and may be safe for clinical intervention...
  37. ncbi request reprint Visual attention deficits are associated with driving accidents in cognitively-impaired HIV-infected individuals
    Thomas D Marcotte
    Department of Psychiatry, University of California, San Diego, CA 92103, USA
    J Clin Exp Neuropsychol 28:13-28. 2006
    ..Clinicians should attend to visual attention as well as general cognitive status in estimating which patients are at risk for impaired driving...
  38. pmc Psychometric characteristics of the memory for intentions screening test
    Steven Paul Woods
    Department of Psychiatry, University of California, San Diego, CA, USA
    Clin Neuropsychol 22:864-78. 2008
    ..Recommendations are provided regarding future research to enhance the clinical usefulness of the MIST...
  39. ncbi request reprint Brain mitochondrial injury in human immunodeficiency virus-seropositive (HIV+) individuals taking nucleoside reverse transcriptase inhibitors
    Brian C Schweinsburg
    VA San Diego Healthcare System, San Diego, California 92103, USA
    J Neurovirol 11:356-64. 2005
    ..Measurement of brain metabolites sensitive to impairments in energy metabolism, including NAA, may aid in early detection of subclinical NRTI-mediated mitochondrial toxicity...
  40. ncbi request reprint Lopinavir concentrations in cerebrospinal fluid exceed the 50% inhibitory concentration for HIV
    Edmund V Capparelli
    Pediatric Pharmacology Research Unit, University of California San Diego, La Jolla, California 92093 8214, USA
    AIDS 19:949-52. 2005
    ..However, even low lopinavir concentrations may be sufficient to inhibit HIV replication. Prior anecdotal reports indicated that lopinavir concentrations were below detection in cerebrospinal fluid (CSF)...
  41. ncbi request reprint CCR2 polymorphisms affect neuropsychological impairment in HIV-1-infected adults
    Kumud K Singh
    Department of Pediatrics, Division of Infectious Diseases, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0672, USA
    J Neuroimmunol 157:185-92. 2004
    ....
  42. ncbi request reprint Prediction of incident neurocognitive impairment by plasma HIV RNA and CD4 levels early after HIV seroconversion
    Thomas D Marcotte
    Department of Psychiatry, University of California San Diego, 92103, USA
    Arch Neurol 60:1406-12. 2003
    ..Neuropsychological (NP) impairment is a relatively common sequela in human immunodeficiency virus (HIV)-infected individuals with advanced disease. Early antecedents of NP dysfunction, however, remain poorly understood...
  43. ncbi request reprint Computerized reaction time battery versus a traditional neuropsychological battery: detecting HIV-related impairments
    Raul Gonzalez
    HIV Neurobehavioral Research Center HNRC, University of California, San Diego, 150 West Washington Street, 2nd Floor, San Diego, CA 92103, USA
    J Int Neuropsychol Soc 9:64-71. 2003
    ..44). Data from this study suggest that traditional NP batteries and computerized reaction time tests do not measure the same thing, and are not interchangeable in examining HIV-related NP impairments...
  44. ncbi request reprint Recurrent Kawasaki disease-like syndrome in a patient with acquired immunodeficiency syndrome
    Jennifer N Blanchard
    Department of Medicine, University of California San Diego School of Medicine, La Jolla, CA, USA
    Clin Infect Dis 36:105-11. 2003
    ..Analysis of a conjunctival tissue sample revealed endothelial cell damage with fibrin deposition and infiltration of immunoglobulin A-secreting plasma cells...
  45. ncbi request reprint Progression to neuropsychological impairment in human immunodeficiency virus infection predicted by elevated cerebrospinal fluid levels of human immunodeficiency virus RNA
    Ronald J Ellis
    HIV Neurobehavioral Research Center, University of California, San Diego, 150 W Washington St, 2nd Floor, San Diego, CA 92103, USA
    Arch Neurol 59:923-8. 2002
    ....
  46. pmc Prospective memory deficits are associated with unemployment in persons living with HIV infection
    Steven Paul Woods
    Department of Psychiatry, University of California, San Diego, USA
    Rehabil Psychol 56:77-84. 2011
    ..To determine whether deficits in prospective memory (i.e., "remembering to remember") confer an increased risk of unemployment in individuals living with chronic HIV infection...
  47. ncbi request reprint Changing patterns in the neuropathogenesis of HIV during the HAART era
    T D Langford
    Department of Pathology, University of California San Diego, La Jolla 92093 0624, USA
    Brain Pathol 13:195-210. 2003
    ....
  48. pmc Indinavir population pharmacokinetics in plasma and cerebrospinal fluid. The HIV Neurobehavioral Research Center Group
    S L Letendre
    HIV Neurobehavioral Research Center, University of California, San Diego, California 92103, USA
    Antimicrob Agents Chemother 44:2173-5. 2000
    ..We conclude that CSF indinavir concentrations are lower than levels in plasma but exceed the clinical 95% inhibitory concentration range...
  49. ncbi request reprint Neurologic complications of HIV disease and their treatments
    Scott Letendre
    Department of Medicine, University of California San Diego, CA, USA
    Top HIV Med 14:21-6. 2006
    ..Together, these findings heighten concern for persistent neurologic diseases in antiretroviral therapy-treated individuals but provide guidance for their improved identification and treatment...
  50. ncbi request reprint Neurologic complications of HIV disease and their treatment
    Scott Letendre
    Department of Medicine, Division of Infectious Diseases, University of California San Diego, San Diego, CA, USA
    Top HIV Med 15:32-9. 2007
    ..The conference also included an important focus on JC virus encephalitis (also known as progressive multifocal leukoencephalopathy)...
  51. ncbi request reprint Highlights of the 15th Conference on Retroviruses and Opportunistic Infections. Neurologic complications of HIV disease and their treatment
    Scott Letendre
    Department of Medicine, Division of Infectious Diseases, University of California San Diego, San Diego, CA, USA
    Top HIV Med 16:15-22. 2008
    ....
  52. ncbi request reprint Pathogenesis of hepatitis C virus coinfection in the brains of patients infected with HIV
    Scott Letendre
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093 0624, USA
    J Infect Dis 196:361-70. 2007
    ..The results support the hypothesis that HCV traffics into the HIV-infected brain, where it might lead to a productive coinfection associated with cognitive impairment...
  53. pmc Implications of hepatitis C virus infection for behavioral symptoms and activities of daily living
    Carolina Posada
    San Diego State University University of California, San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA
    J Clin Exp Neuropsychol 32:637-44. 2010
    ..These results show that a subset of HCV-infected individuals report clinically elevated behavioral symptoms. Clinical implications for the assessment and management of elevated behavioral symptoms in HCV are discussed...
  54. pmc Differential expression of immunophilins FKBP51 and FKBP52 in the frontal cortex of HIV-infected patients with major depressive disorder
    Erick T Tatro
    Department of Psychiatry 0603, University of California at San Diego, La Jolla, San Diego, CA 92093 0603, USA
    J Neuroimmune Pharmacol 4:218-26. 2009
    ..Instead, an increase in FKBP51 at both the transcript (FKBP5) and protein level correlated with MDD. Increased FKBP4 expression of correlated to HIV(+)MDD but not to HIV without MDD...
  55. pmc Increased accumulation of intraneuronal amyloid beta in HIV-infected patients
    Cristian L Achim
    Department of Psychiatry, University of California, San Diego, CA 92093 0624, USA
    J Neuroimmune Pharmacol 4:190-9. 2009
    ..These findings suggest that long-term survival with HIV might interfere with clearance of proteins such as Abeta and worsen neuronal damage and cognitive impairment in this population...
  56. ncbi request reprint High-dose lopinavir/ritonavir in highly treatment-experienced HIV-1 patients: efficacy, safety, and predictors of response
    Daniel Podzamczer
    Infectious Disease Service, Hospital Universitari de Bellvitge, Barcelona, Spain
    HIV Clin Trials 8:193-204. 2007
    ..To investigate the efficacy and safety of high-dose lopinavir/ritonavir (LPV/r) therapy in multiple protease inhibitor, non-nucleoside reverse transcriptase inhibitor (NNRTI)-experienced subjects...
  57. pmc Severe, demyelinating leukoencephalopathy in AIDS patients on antiretroviral therapy
    T Dianne Langford
    Department of Pathology, University of California, San Diego, CA, USA
    AIDS 16:1019-29. 2002
    ....
  58. doi request reprint Role of psychiatric medications as adjunct therapy in the treatment of HIV associated neurocognitive disorders
    Beau M Ances
    Department of Neurosciences, University of California, San Diego, California, USA
    Int Rev Psychiatry 20:89-93. 2008
    ..The present brief review focuses on these drugs and assesses their possible adjunct roles in the treatment of HIV-infected individuals...
  59. ncbi request reprint Effects of human immunodeficiency virus and methamphetamine on cerebral metabolites measured with magnetic resonance spectroscopy
    Michael J Taylor
    VA San Diego Healthcare System, San Diego, California, USA
    J Neurovirol 13:150-9. 2007
    ..This evidence indicates when HIV is poorly suppressed, METH may modify the effects of the virus on neuronal integrity...
  60. ncbi request reprint Hepatitis C virus infection is associated with reduced white matter N-acetylaspartate in abstinent methamphetamine users
    Michael J Taylor
    University of California, San Diego, San Diego, California, USA
    J Int Neuropsychol Soc 10:110-3. 2004
  61. ncbi request reprint Enhancing antiretroviral therapy for human immunodeficiency virus cognitive disorders
    Scott L Letendre
    HIV Neurobehavioral Research Center, University of California at San Diego, San Diego, CA 92103, USA
    Ann Neurol 56:416-23. 2004
    ..Including CSF-penetrating drugs in the ART regimen and monitoring CSF viral load may be indicated for individuals with HIV-associated cognitive impairment...
  62. pmc Frequency and predictors of self-reported prospective memory complaints in individuals infected with HIV
    Steven Paul Woods
    Department of Psychiatry, University of California, San Diego 92103, USA
    Arch Clin Neuropsychol 22:187-95. 2007
    ....
  63. ncbi request reprint Is the glass three-quarters full or one-quarter empty?
    Justin C McArthur
    J Infect Dis 194:1628-31. 2006
  64. pmc Population pharmacokinetics of abacavir in plasma and cerebrospinal fluid
    Edmund V Capparelli
    Pediatric Pharmacology Research Unit PPRU, University of California, San Diego, 200 West Arbor Drive, MC 8214, San Diego, CA 92103 8214, USA
    Antimicrob Agents Chemother 49:2504-6. 2005
    ..The abacavir CSF/plasma ratio averaged 36% and increased throughout the dose interval. Abacavir penetrates into the CSF in adequate concentrations to inhibit local human immunodeficiency virus replication...
  65. pmc Markers of macrophage activation and axonal injury are associated with prospective memory in HIV-1 disease
    Steven Paul Woods
    Department of Psychiatry, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    Cogn Behav Neurol 19:217-21. 2006
    ..To use clinical specimens to better understand the neuropathogenesis of prospective memory (ProM) functioning in persons with HIV-1 infection...
  66. ncbi request reprint Is hepatitis C infection associated with increased risk of depression in persons with methamphetamine dependence?
    Ofilio Vigil
    Department of Psychiatry, School of Medicine, University of California San Diego, La Jolla, CA, USA
    Am J Addict 16:418-23. 2007
    ..Results from this study suggest that HCV infection does not confer an additive effect on the severity of depressive symptoms or the prevalence of major depression in persons with MA dependence...

Research Grants6

  1. Neurocognitive Effects of HCV, HIV, and Drug Use
    Scott Letendre; Fiscal Year: 2002
    ..The findings of this research will be used to evaluate the feasibility of an interventional study, and to assist in its design. ..
  2. Neurocognitive Effects of HCV, HIV, and Drug Use
    Scott Letendre; Fiscal Year: 2003
    ..The findings of this research will be used to evaluate the feasibility of an interventional study, and to assist in its design. ..
  3. Neurocognitive Effects of HCV, HIV, and Drug Use
    Scott Letendre; Fiscal Year: 2004
    ..The findings of this research will be used to evaluate the feasibility of an interventional study, and to assist in its design. ..
  4. Clinical Trial of CNS Penetrating ART to Prevent NeuroAIDS in China
    Scott L Letendre; Fiscal Year: 2010
    ..S., China, and elsewhere and ultimately lead to preservation of normal neurocognitive functioning in people afflicted with HIV/AIDS. ..