Research Topics
Species | S L LetendreSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
Pathogenesis of HIV in the central nervous systemVictor Valcour
Memory and Aging Center, University of California San Francisco, 94143 1207, USA
Curr HIV/AIDS Rep 8:54-61. 2011..This review highlights recent investigations of HIV-related CNS injury with emphasis on cART-era neuropathological mechanisms in the context of both US and international settings...
Cerebrospinal fluid beta chemokine concentrations in neurocognitively impaired individuals infected with human immunodeficiency virus type 1S L Letendre
University of California, HIV Neurobehavioral Research Center, San Diego, California 92103, USA
J Infect Dis 180:310-9. 1999..Low, but detectable, levels of CSF MIP-1alpha were strongly associated with dementia, suggesting that higher levels may have neuroprotective effects...- The monocyte chemotactic protein-1 -2578G allele is associated with elevated MCP-1 concentrations in cerebrospinal fluidScott Letendre
Department of Medicine, The HIV Neurobehavioral Research Center, 150 West Washington Street, San Diego, CA 92103, USA
J Neuroimmunol 157:193-6. 2004..Our findings suggest that this MCP-1 promoter polymorphism influences HIV neuropathogenesis by regulating MCP-1 protein expression in the central nervous system (CNS)... - The effects of hepatitis C, HIV, and methamphetamine dependence on neuropsychological performance: biological correlates of diseaseScott L Letendre
Department of Medicine, University of California San Diego, CA 92103, USA
AIDS 19:S72-8. 2005..To determine the effects of hepatitis C virus (HCV) infection on neuropsychological (NP) performance... - Validation of the CNS Penetration-Effectiveness rank for quantifying antiretroviral penetration into the central nervous systemScott Letendre
University of California, San Diego, 150 W Washington St, San Diego, CA 92103, USA
Arch Neurol 65:65-70. 2008..To evaluate whether penetration of a combination regimen into the central nervous system (CNS), as estimated by the CNS Penetration-Effectiveness (CPE) rank, is associated with lower cerebrospinal fluid (CSF) viral load... - The role of cohort studies in drug development: clinical evidence of antiviral activity of serotonin reuptake inhibitors and HMG-CoA reductase inhibitors in the central nervous systemScott L Letendre
University of California, 150 W Washington St, San Diego, CA 92103, USA
J Neuroimmune Pharmacol 2:120-7. 2007..Some of these drugs, such as serotonin reuptake inhibitors (SRIs) and HMG-CoA reductase inhibitors (statins), may do so by reducing HIV replication in the CNS and are already widely used by HIV-infected individuals... - Chemokines in cerebrospinal fluid correlate with cerebral metabolite patterns in HIV-infected individualsScott L Letendre
University of California, San Diego, 220 Dickinson Street, Suite A, San Diego, CA 92103, USA
J Neurovirol 17:63-9. 2011.... - Lithium improves HIV-associated neurocognitive impairmentScott L Letendre
Department of Medicine, University of California, San Diego, California 92103, USA
AIDS 20:1885-8. 2006..To determine the effects of low-dose oral lithium on the neuropsychological performance of individuals diagnosed with HIV-associated neurocognitive impairment... - Role of obesity, metabolic variables, and diabetes in HIV-associated neurocognitive disorderJ A McCutchan
University of California, San Diago, USA
Neurology 78:485-92. 2012..To evaluate relationships between HIV-associated neurocognitive disorder and metabolic variables in a subgroup of HIV+ participants examined in a prospective, observational, multicenter cohort study... - Impact of long-term treatment with neurotoxic dideoxynucleoside antiretrovirals: implications for clinical care in resource-limited settingsC F Hung
University of California, San Diego, CA, USA
HIV Med 9:731-7. 2008..Therefore, we evaluated the safety of continuing d-drug therapy... - Variable patterns of neuropsychological performance in HIV-1 infectionS Dawes
Department of Psychiatry, HIV Neurobehavioral Research Center, University of California San Diego, San Diego, CA 92093 0603, USA
J Clin Exp Neuropsychol 30:613-26. 2008..Thus, there does not appear to be a single, prototypical pattern of neuropsychological impairment associated with HIV infection for this battery of representative neuropsychological tests... - HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER StudyR K Heaton
University of California, San Diego, USA
Neurology 75:2087-96. 2010.... - White matter tract injury and cognitive impairment in human immunodeficiency virus-infected individualsAssawin Gongvatana
San Diego State University University of California, San Diego, Joint Doctoral Program in Clinical Psychology, San Diego and La Jolla, California, USA
J Neurovirol 15:187-95. 2009..The study also confirms that CNS injury is evident in persons infected with HIV despite effective antiretroviral treatment... - Negative mood and sexual behavior among non-monogamous men who have sex with men in the context of methamphetamine and HIVC A Bousman
University of California San Diego, HIV Neurobehavioral Research Center, Department of Psychiatry, La Jolla, California 92103, USA
J Affect Disord 119:84-91. 2009..This study examined the contextual influence of METH, HIV-infection and their combination on mood states and sexual behavior... - Genetic attributes of cerebrospinal fluid-derived HIV-1 envSatish K Pillai
University of California San Diego, Department of Medicine NCIRE, La Jolla, CA 94121, USA
Brain 129:1872-83. 2006..Furthermore, neurological impairment may be influenced by mutations within the viral V3 loop sequence... - Dynamics of monocyte chemoattractant protein type one (MCP-1) and HIV viral load in human cerebrospinal fluid and plasmaSergio Monteiro de Almeida
HIV Neurobehavioral Research Center, UCSD, 150 West Washington St, 2nd Flr, San Diego, CA 92103, USA
J Neuroimmunol 169:144-52. 2005..CONCLUSION: The close temporal relationship of the increase of MCP-1 and CSF VL suggests that they are co-regulated, or that one is a stimulus for the other... - Neurobehavioral effects of human immunodeficiency virus infection among former plasma donors in rural ChinaRobert K Heaton
HIV Neurobehavioral Research Center HNRC, Department of Psychiatry, University of California at San Diego, San Diego, California 92093 0603, USA
J Neurovirol 14:536-49. 2008..These findings indicate that HAND is likely to be an important feature of HIV infection in developing countries, underscoring the need for international efforts to develop CNS-relevant treatments... - Pleocytosis is associated with disruption of HIV compartmentalization between blood and cerebral spinal fluid viral populationsDavey M Smith
University of California San Diego, La Jolla, 92093, USA
Virology 385:204-8. 2009.... - Prospective memory in HIV infection: is "remembering to remember" a unique predictor of self-reported medication management?Steven Paul Woods
Department of Psychiatry, HIV Neurobehavioral Research Center, University of California, San Diego, School of Medicine, La Jolla, CA 92093, USA
Arch Clin Neuropsychol 23:257-70. 2008..The potential benefits of individualized remediation strategies that are informed by conceptual models of ProM and specifically target medication adherence warrant further exploration... - Meeting practical challenges of a trial involving a multitude of treatment regimens: an example of a multi-center randomized controlled clinical trial in neuroAIDSSusanne May
Division of Biostatistics and Bioinformatics, Department of Family and Preventive Medicine, and Department of Neurosciences, University of California, San Diego, 9500 Gilman Drive M C 0717, La Jolla, CA 92093 0717, USA
J Neuroimmune Pharmacol 2:97-104. 2007..A small pilot study demonstrated the feasibility and acceptability to providers. In conclusion, an innovative design can provide solutions to challenging practical issues in trials with multiple treatment options... - Psychometric characteristics of the memory for intentions screening testSteven Paul Woods
Department of Psychiatry, University of California, San Diego, CA, USA
Clin Neuropsychol 22:864-78. 2008..Recommendations are provided regarding future research to enhance the clinical usefulness of the MIST... - The semantic relatedness of cue-intention pairings influences event-based prospective memory failures in older adults with HIV infectionSteven Paul Woods
HIV Neurobehavioral Research Center, Department of Psychiatry, University of California, San Diego, CA 92103, USA
J Clin Exp Neuropsychol 32:398-407. 2010.... - HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictorsRobert K Heaton
University of California, San Diego, CA, USA
J Neurovirol 17:3-16. 2011..Clinical trials targeting HAND prevention should specifically examine timing of ART initiation... - Neurocognitive functioning in acute or early HIV infectionDavid J Moore
Department of Psychiatry, University of California, San Diego UCSD, San Diego, CA, USA
J Neurovirol 17:50-7. 2011..Although a significant monotonic trend existed and patterns of the data suggest the AEH individuals may fall intermediate to HIV- and chronic participants, we were not able to statistically confirm this hypothesis... - Total raltegravir concentrations in cerebrospinal fluid exceed the 50-percent inhibitory concentration for wild-type HIV-1David Croteau
HIV Neurobehavioral Research Center, University of California San Diego, 220 Dickinson, Suite B, 8208, San Diego, CA 92103, USA
Antimicrob Agents Chemother 54:5156-60. 2010..As a component of effective antiretroviral regimens or as the main antiretroviral, RAL likely contributes to the control of HIV replication in the nervous system... - Spontaneous strategy use protects against visual working memory deficits in older adults infected with HIVSteven Paul Woods
Department of Psychiatry, University of California San Diego, La Jolla, USA
Arch Clin Neuropsychol 25:724-33. 2010.... - Cytochrome P450-2D6 extensive metabolizers are more vulnerable to methamphetamine-associated neurocognitive impairment: preliminary findingsMariana Cherner
Department of Psychiatry, University of California San Diego, La Jolla, California 92093 0847, USA
J Int Neuropsychol Soc 16:890-901. 2010..This preliminary study is the first to suggest that efficient meth metabolism is associated with worse neurocognitive outcomes in humans, and implicates the products of oxidative metabolism of meth as a possible source of brain injury... 
Continued high prevalence and adverse clinical impact of human immunodeficiency virus-associated sensory neuropathy in the era of combination antiretroviral therapy: the CHARTER StudyRonald J Ellis
HIV Neurobehavioral Research Center, Department of Neurosciences, University of California, San Diego, San Diego, CA 92103, USA
Arch Neurol 67:552-8. 2010..To provide updated estimates of the prevalence and clinical impact of human immunodeficiency virus-associated sensory neuropathy (HIV-SN) and neuropathic pain due to HIV-SN in the combination antiretroviral therapy (CART) era...- APOE epsilon4 and MBL-2 O/O genotypes are associated with neurocognitive impairment in HIV-infected plasma donorsStephen A Spector
Department of Pediatrics, University of California San Diego, La Jolla, California 92093 0672, USA
AIDS 24:1471-9. 2010..This study examined associations of host genetic variants and neurocognitive impairment in Chinese individuals infected through contaminated blood products... - Longer term improvement in neurocognitive functioning and affective distress among methamphetamine users who achieve stable abstinenceJennifer E Iudicello
Department of Psychiatry, HIV Neurobehavioral Research Center, University of California, San Diego, School of Medicine, La Jolla, CA 92103, USA
J Clin Exp Neuropsychol 32:704-18. 2010..These results suggest partial recovery of neuropsychological functioning and improvement in affective distress upon sustained abstinence from MA that may extend beyond a year or more... - Cerebrospinal fluid human immunodeficiency virus viral load in patients with neurosyphilisSergio Monteiro de Almeida
HIV Neurobehavioral Research Center, University of California San Diego, San Diego, USA
J Neurovirol 16:6-12. 2010..Because elevated CSF VL is associated with subsequent neurocognitive decline, future studies should evaluate the impact of neurosyphilis on the course of central nervous system (CNS) HIV infection... - Valproic acid does not affect markers of human immunodeficiency virus disease progressionBeau M Ances
Department of Neurosciences, University of California, San Diego, California, USA
J Neurovirol 12:403-6. 2006..VPA patients had a trend towards lower CD4+ cells (P = .08) at follow-up. Concurrent antiretrovirals did not alter these relationships. VPA does not induce viremia or promote disease progression and may be safe for clinical intervention... - Brain mitochondrial injury in human immunodeficiency virus-seropositive (HIV+) individuals taking nucleoside reverse transcriptase inhibitorsBrian C Schweinsburg
VA San Diego Healthcare System, San Diego, California 92103, USA
J Neurovirol 11:356-64. 2005..Measurement of brain metabolites sensitive to impairments in energy metabolism, including NAA, may aid in early detection of subclinical NRTI-mediated mitochondrial toxicity... - Human immunodeficiency virus and the central nervous systemSergio Monteiro de Almeida
Neurology Unit, Universidade Federal do Parana, Curitiba, PR, Brazil
Braz J Infect Dis 10:41-50. 2006..The neurological manifestations directly related to HIV are acute viral meningitis, chronic meningitis, HIV-associated dementia (HAD), vacuolar myelopathy, and involvement of the peripheral nervous system... - Relationship of antiretroviral treatment to postmortem brain tissue viral load in human immunodeficiency virus-infected patientsDianne Langford
Department of Pathology, University of California, San Diego, La Jolla, California 92093, USA
J Neurovirol 12:100-7. 2006..Furthermore, such strategies might help to prevent the development of ARV resistance... - Lopinavir concentrations in cerebrospinal fluid exceed the 50% inhibitory concentration for HIVEdmund V Capparelli
Pediatric Pharmacology Research Unit, University of California San Diego, La Jolla, California 92093 8214, USA
AIDS 19:949-52. 2005..However, even low lopinavir concentrations may be sufficient to inhibit HIV replication. Prior anecdotal reports indicated that lopinavir concentrations were below detection in cerebrospinal fluid (CSF)... - CCR2 polymorphisms affect neuropsychological impairment in HIV-1-infected adultsKumud K Singh
Department of Pediatrics, Division of Infectious Diseases, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0672, USA
J Neuroimmunol 157:185-92. 2004.... - Increased human immunodeficiency virus loads in active methamphetamine users are explained by reduced effectiveness of antiretroviral therapyRonald J Ellis
Department of Neurosciences, University of California San Diego, San Diego, California, USA
J Infect Dis 188:1820-6. 2003..In contrast, abstinent former METH abusers (METH(+)Tox-) receiving HAART effectively suppressed viral replication. These data suggest that abstinence programs are a key component of effective treatment of HIV in METH-abusing populations... - Prediction of incident neurocognitive impairment by plasma HIV RNA and CD4 levels early after HIV seroconversionThomas D Marcotte
Department of Psychiatry, University of California San Diego, 92103, USA
Arch Neurol 60:1406-12. 2003..Neuropsychological (NP) impairment is a relatively common sequela in human immunodeficiency virus (HIV)-infected individuals with advanced disease. Early antecedents of NP dysfunction, however, remain poorly understood... - Computerized reaction time battery versus a traditional neuropsychological battery: detecting HIV-related impairmentsRaul Gonzalez
HIV Neurobehavioral Research Center HNRC, University of California, San Diego, 150 West Washington Street, 2nd Floor, San Diego, CA 92103, USA
J Int Neuropsychol Soc 9:64-71. 2003..44). Data from this study suggest that traditional NP batteries and computerized reaction time tests do not measure the same thing, and are not interchangeable in examining HIV-related NP impairments... - Recurrent Kawasaki disease-like syndrome in a patient with acquired immunodeficiency syndromeJennifer N Blanchard
Department of Medicine, University of California San Diego School of Medicine, La Jolla, CA, USA
Clin Infect Dis 36:105-11. 2003..Analysis of a conjunctival tissue sample revealed endothelial cell damage with fibrin deposition and infiltration of immunoglobulin A-secreting plasma cells... - Progression to neuropsychological impairment in human immunodeficiency virus infection predicted by elevated cerebrospinal fluid levels of human immunodeficiency virus RNARonald J Ellis
HIV Neurobehavioral Research Center, University of California, San Diego, 150 W Washington St, 2nd Floor, San Diego, CA 92103, USA
Arch Neurol 59:923-8. 2002.... - Visual attention deficits are associated with driving accidents in cognitively-impaired HIV-infected individualsThomas D Marcotte
Department of Psychiatry, University of California, San Diego, CA 92103, USA
J Clin Exp Neuropsychol 28:13-28. 2006..Clinicians should attend to visual attention as well as general cognitive status in estimating which patients are at risk for impaired driving... - Prospective memory deficits are associated with unemployment in persons living with HIV infectionSteven Paul Woods
Department of Psychiatry, University of California, San Diego, USA
Rehabil Psychol 56:77-84. 2011..To determine whether deficits in prospective memory (i.e., "remembering to remember") confer an increased risk of unemployment in individuals living with chronic HIV infection... - Apolipoprotein E4 genotype does not increase risk of HIV-associated neurocognitive disordersE E Morgan
University of California, San Diego, San Diego, CA, USA
J Neurovirol 19:150-6. 2013..Prospective, longitudinal studies are needed to examine APOE4 as a risk factor for neurocognitive decline, incident HAND at older ages, and potential associations with cerebrospinal fluid amyloid... - Indinavir population pharmacokinetics in plasma and cerebrospinal fluid. The HIV Neurobehavioral Research Center GroupS L Letendre
HIV Neurobehavioral Research Center, University of California, San Diego, California 92103, USA
Antimicrob Agents Chemother 44:2173-5. 2000..We conclude that CSF indinavir concentrations are lower than levels in plasma but exceed the clinical 95% inhibitory concentration range... - Changing patterns in the neuropathogenesis of HIV during the HAART eraT D Langford
Department of Pathology, University of California San Diego, La Jolla 92093-0624, USA
Brain Pathol 13:195-210. 2003.... - Highlights of the 15th Conference on Retroviruses and Opportunistic Infections. Neurologic complications of HIV disease and their treatmentScott Letendre
Department of Medicine, Division of Infectious Diseases, University of California San Diego, San Diego, CA, USA
Top HIV Med 16:15-22. 2008.... - Neurologic complications of HIV disease and their treatmentsScott Letendre
Department of Medicine, University of California San Diego, CA, USA
Top HIV Med 14:21-6. 2006..Together, these findings heighten concern for persistent neurologic diseases in antiretroviral therapy-treated individuals but provide guidance for their improved identification and treatment... - Neurologic complications of HIV disease and their treatmentScott Letendre
Department of Medicine, Division of Infectious Diseases, University of California San Diego, San Diego, CA, USA
Top HIV Med 15:32-9. 2007..The conference also included an important focus on JC virus encephalitis (also known as progressive multifocal leukoencephalopathy)... - Differential expression of immunophilins FKBP51 and FKBP52 in the frontal cortex of HIV-infected patients with major depressive disorderErick T Tatro
Department of Psychiatry 0603, University of California at San Diego, La Jolla, San Diego, CA 92093 0603, USA
J Neuroimmune Pharmacol 4:218-26. 2009..Instead, an increase in FKBP51 at both the transcript (FKBP5) and protein level correlated with MDD. Increased FKBP4 expression of correlated to HIV(+)MDD but not to HIV without MDD... - Pathogenesis of hepatitis C virus coinfection in the brains of patients infected with HIVScott Letendre
Department of Medicine, University of California, San Diego, La Jolla, CA 92093 0624, USA
J Infect Dis 196:361-70. 2007..The results support the hypothesis that HCV traffics into the HIV-infected brain, where it might lead to a productive coinfection associated with cognitive impairment... - Implications of hepatitis C virus infection for behavioral symptoms and activities of daily livingCarolina Posada
San Diego State University University of California, San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA
J Clin Exp Neuropsychol 32:637-44. 2010..These results show that a subset of HCV-infected individuals report clinically elevated behavioral symptoms. Clinical implications for the assessment and management of elevated behavioral symptoms in HCV are discussed... - Increased accumulation of intraneuronal amyloid beta in HIV-infected patientsCristian L Achim
Department of Psychiatry, University of California, San Diego, CA 92093 0624, USA
J Neuroimmune Pharmacol 4:190-9. 2009..These findings suggest that long-term survival with HIV might interfere with clearance of proteins such as Abeta and worsen neuronal damage and cognitive impairment in this population... - Hepatitis C virus infection is associated with reduced white matter N-acetylaspartate in abstinent methamphetamine usersMichael J Taylor
University of California, San Diego, San Diego, California, USA
J Int Neuropsychol Soc 10:110-3. 2004 - Is the glass three-quarters full or one-quarter empty?Justin C McArthur
J Infect Dis 194:1628-31. 2006 - Population pharmacokinetics of abacavir in plasma and cerebrospinal fluidEdmund V Capparelli
Pediatric Pharmacology Research Unit PPRU, University of California, San Diego, 200 West Arbor Drive, MC 8214, San Diego, CA 92103 8214, USA
Antimicrob Agents Chemother 49:2504-6. 2005..The abacavir CSF/plasma ratio averaged 36% and increased throughout the dose interval. Abacavir penetrates into the CSF in adequate concentrations to inhibit local human immunodeficiency virus replication... - Severe, demyelinating leukoencephalopathy in AIDS patients on antiretroviral therapyT Dianne Langford
Department of Pathology, University of California, San Diego, CA, USA
AIDS 16:1019-29. 2002..This condition warrants further study and increased vigilance among those who provide care for HIV-infected individuals... - Effects of human immunodeficiency virus and methamphetamine on cerebral metabolites measured with magnetic resonance spectroscopyMichael J Taylor
VA San Diego Healthcare System, San Diego, California, USA
J Neurovirol 13:150-9. 2007..This evidence indicates when HIV is poorly suppressed, METH may modify the effects of the virus on neuronal integrity... - Is hepatitis C infection associated with increased risk of depression in persons with methamphetamine dependence?Ofilio Vigil
Department of Psychiatry, School of Medicine, University of California San Diego, La Jolla, CA, USA
Am J Addict 16:418-23. 2007..Results from this study suggest that HCV infection does not confer an additive effect on the severity of depressive symptoms or the prevalence of major depression in persons with MA dependence... - Role of psychiatric medications as adjunct therapy in the treatment of HIV associated neurocognitive disordersBeau M Ances
Department of Neurosciences, University of California, San Diego, California, USA
Int Rev Psychiatry 20:89-93. 2008..The present brief review focuses on these drugs and assesses their possible adjunct roles in the treatment of HIV-infected individuals... - Markers of macrophage activation and axonal injury are associated with prospective memory in HIV-1 diseaseSteven Paul Woods
Department of Psychiatry, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
Cogn Behav Neurol 19:217-21. 2006..To use clinical specimens to better understand the neuropathogenesis of prospective memory (ProM) functioning in persons with HIV-1 infection... - Frequency and predictors of self-reported prospective memory complaints in individuals infected with HIVSteven Paul Woods
Department of Psychiatry, University of California, San Diego 92103, USA
Arch Clin Neuropsychol 22:187-95. 2007.... - Enhancing antiretroviral therapy for human immunodeficiency virus cognitive disordersScott L Letendre
HIV Neurobehavioral Research Center, University of California at San Diego, San Diego, CA 92103, USA
Ann Neurol 56:416-23. 2004..Including CSF-penetrating drugs in the ART regimen and monitoring CSF viral load may be indicated for individuals with HIV-associated cognitive impairment... - High-dose lopinavir/ritonavir in highly treatment-experienced HIV-1 patients: efficacy, safety, and predictors of responseDaniel Podzamczer
Infectious Disease Service, Hospital Universitari de Bellvitge, Barcelona, Spain
HIV Clin Trials 8:193-204. 2007..To investigate the efficacy and safety of high-dose lopinavir/ritonavir (LPV/r) therapy in multiple protease inhibitor, non-nucleoside reverse transcriptase inhibitor (NNRTI)-experienced subjects...
Research Grants
- Neurocognitive Effects of HCV, HIV, and Drug UseScott Letendre; Fiscal Year: 2004..The findings of this research will be used to evaluate the feasibility of an interventional study, and to assist in its design. ..
- Clinical Trial of CNS Penetrating ART to Prevent NeuroAIDS in ChinaScott L Letendre; Fiscal Year: 2010..S., China, and elsewhere and ultimately lead to preservation of normal neurocognitive functioning in people afflicted with HIV/AIDS. ..