Stephen L Lessnick

Summary

Affiliation: University of Utah
Country: USA

Publications

  1. pmc EWS/FLI mediates transcriptional repression via NKX2.2 during oncogenic transformation in Ewing's sarcoma
    Leah A Owen
    Department of Oncological Sciences, University of Utah, Salt Lake City, Utah, United States of America
    PLoS ONE 3:e1965. 2008
  2. pmc BCL11B is up-regulated by EWS/FLI and contributes to the transformed phenotype in Ewing sarcoma
    Elizabeth T Wiles
    Department of Oncological Sciences, University of Utah, Salt Lake City, Utah, United States of America
    PLoS ONE 8:e59369. 2013
  3. pmc Antibody detection of translocations in Ewing sarcoma
    Wen Luo
    The Department of Oncological Sciences, University of Utah School of Medicine, Salt Lake City, UT, USA
    EMBO Mol Med 4:453-61. 2012
  4. pmc Cell Cycle Deregulation in Ewing's Sarcoma Pathogenesis
    Ashley A Kowalewski
    Department of Oncological Sciences, University of Utah School of Medicine, 2000 Circle of Hope, Room 4242, Salt Lake City, UT 84112, USA
    Sarcoma 2011:598704. 2011
  5. pmc Glutathione s-transferases in pediatric cancer
    Wen Luo
    The Department of Oncological Sciences, University of Utah School of Medicine Salt Lake City, UT, USA
    Front Oncol 1:39. 2011
  6. pmc Mechanism and relevance of EWS/FLI-mediated transcriptional repression in Ewing sarcoma
    S Sankar
    Department of Oncological Sciences, Huntsman Cancer Institute, School of Medicine, Salt Lake City, UT, USA
    Oncogene 32:5089-100. 2013
  7. pmc Molecular pathogenesis of Ewing sarcoma: new therapeutic and transcriptional targets
    Stephen L Lessnick
    Center for Children s Cancer Research at Huntsman Cancer Institute, Department of Oncological Sciences, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA
    Annu Rev Pathol 7:145-59. 2012
  8. ncbi request reprint NR0B1 is required for the oncogenic phenotype mediated by EWS/FLI in Ewing's sarcoma
    Michelle Kinsey
    The Department of Oncological Sciences, University of Utah, Salt Lake City, Utah, USA
    Mol Cancer Res 4:851-9. 2006
  9. ncbi request reprint Expression profiling of EWS/FLI identifies NKX2.2 as a critical target gene in Ewing's sarcoma
    Richard Smith
    The Center for Children, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah 84112, USA
    Cancer Cell 9:405-16. 2006
  10. pmc EWS/FLI and its downstream target NR0B1 interact directly to modulate transcription and oncogenesis in Ewing's sarcoma
    Michelle Kinsey
    Department of Oncological Sciences, University of Utah School of Medicine, Salt Lake City, Utah, USA
    Cancer Res 69:9047-55. 2009

Research Grants

  1. Tumor Suppressors in Ewing's Sarcoma
    STEPHEN LESSNICK; Fiscal Year: 2007
  2. EWS/FLI AND ITS TARGETS IN EWING'S SARCOMA
    Stephen L Lessnick; Fiscal Year: 2010

Collaborators

Detail Information

Publications29

  1. pmc EWS/FLI mediates transcriptional repression via NKX2.2 during oncogenic transformation in Ewing's sarcoma
    Leah A Owen
    Department of Oncological Sciences, University of Utah, Salt Lake City, Utah, United States of America
    PLoS ONE 3:e1965. 2008
    ..2 binding. These data demonstrate that the transcriptional repressive function of NKX2.2 is necessary, and sufficient, for the oncogenic phenotype of Ewing's sarcoma, and suggest a therapeutic approach to this disease...
  2. pmc BCL11B is up-regulated by EWS/FLI and contributes to the transformed phenotype in Ewing sarcoma
    Elizabeth T Wiles
    Department of Oncological Sciences, University of Utah, Salt Lake City, Utah, United States of America
    PLoS ONE 8:e59369. 2013
    ..These data define a new pathway downstream of EWS/FLI required for oncogenic maintenance in Ewing sarcoma...
  3. pmc Antibody detection of translocations in Ewing sarcoma
    Wen Luo
    The Department of Oncological Sciences, University of Utah School of Medicine, Salt Lake City, UT, USA
    EMBO Mol Med 4:453-61. 2012
    ..These results demonstrate that ADOT may be an effective approach for translocation analysis in clinical specimens with significant RNA degradation and may offer a novel diagnostic tool for translocation-based cancers...
  4. pmc Cell Cycle Deregulation in Ewing's Sarcoma Pathogenesis
    Ashley A Kowalewski
    Department of Oncological Sciences, University of Utah School of Medicine, 2000 Circle of Hope, Room 4242, Salt Lake City, UT 84112, USA
    Sarcoma 2011:598704. 2011
    ..This paper will summarize current published data associated with deregulation of the cell cycle in Ewing's sarcoma and highlight important questions that remain to be answered...
  5. pmc Glutathione s-transferases in pediatric cancer
    Wen Luo
    The Department of Oncological Sciences, University of Utah School of Medicine Salt Lake City, UT, USA
    Front Oncol 1:39. 2011
    ..This mini review focuses on studies related to GST epidemiology and functions related to pediatric cancer. Opportunities to exploit GST in pediatric cancer therapy are also discussed...
  6. pmc Mechanism and relevance of EWS/FLI-mediated transcriptional repression in Ewing sarcoma
    S Sankar
    Department of Oncological Sciences, Huntsman Cancer Institute, School of Medicine, Salt Lake City, UT, USA
    Oncogene 32:5089-100. 2013
    ....
  7. pmc Molecular pathogenesis of Ewing sarcoma: new therapeutic and transcriptional targets
    Stephen L Lessnick
    Center for Children s Cancer Research at Huntsman Cancer Institute, Department of Oncological Sciences, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA
    Annu Rev Pathol 7:145-59. 2012
    ....
  8. ncbi request reprint NR0B1 is required for the oncogenic phenotype mediated by EWS/FLI in Ewing's sarcoma
    Michelle Kinsey
    The Department of Oncological Sciences, University of Utah, Salt Lake City, Utah, USA
    Mol Cancer Res 4:851-9. 2006
    ..These studies define a new role for NR0B1 in oncogenic transformation and emphasize the utility of analyzing the function of EWS/FLI in Ewing's sarcoma cells...
  9. ncbi request reprint Expression profiling of EWS/FLI identifies NKX2.2 as a critical target gene in Ewing's sarcoma
    Richard Smith
    The Center for Children, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah 84112, USA
    Cancer Cell 9:405-16. 2006
    ..Thus, we developed a highly validated transcriptional profile for the EWS/FLI fusion protein and identified a critical target gene in Ewing's sarcoma development...
  10. pmc EWS/FLI and its downstream target NR0B1 interact directly to modulate transcription and oncogenesis in Ewing's sarcoma
    Michelle Kinsey
    Department of Oncological Sciences, University of Utah School of Medicine, Salt Lake City, Utah, USA
    Cancer Res 69:9047-55. 2009
    ..Taken together, these data suggest that EWS/FLI and NR0B1 physically interact, coordinately modulate gene expression, and mediate the transformed phenotype of Ewing's sarcoma...
  11. pmc EWS/FLI-responsive GGAA microsatellites exhibit polymorphic differences between European and African populations
    Robert Beck
    Center for Children s Cancer Research, Huntsman Cancer Institute, University of Utah, Salt Lake City, USA
    Cancer Genet 205:304-12. 2012
    ..These data suggest that GGAA microsatellite polymorphisms in the NR0B1 gene might influence disease susceptibility and prognosis in Ewing sarcoma in unanticipated ways...
  12. pmc A novel role for keratin 17 in coordinating oncogenic transformation and cellular adhesion in Ewing sarcoma
    Savita Sankar
    Department of Oncological Sciences, Huntsman Cancer Institute, School of Medicine, University of Utah
    Mol Cell Biol 33:4448-60. 2013
    ..Taken together, our data reveal previously unknown molecular functions for a cytoplasmic intermediate filament protein, KRT17, in coordinating EWS/FLI- and GLI1-mediated oncogenic transformation and cellular adhesion in Ewing sarcoma. ..
  13. ncbi request reprint Of mice and men: opportunities to use genetically engineered mouse models of synovial sarcoma for preclinical cancer therapeutic evaluation
    Kevin B Jones
    Department of Orthopaedic Surgery, The Center for Children s Cancer Research, at the University of Utah, Salt Lake City, Utah, USA
    Cancer Control 18:196-203. 2011
    ..The biological differences between sarcoma subtypes make inclusion of multiple types in general trials unsatisfactory as well...
  14. ncbi request reprint Identification of target genes in their native cellular context: an analysis of EWS/FLI in Ewing's sarcoma
    Leah A Owen
    The Department of Oncological Sciences, University of Utah School of Medicine, Salt Lake City, Utah, USA
    Cell Cycle 5:2049-53. 2006
    ..We now put this model into a historical context, and describe the benefits (both perceived and observed) of this model over previous approaches using heterologous cell types...
  15. ncbi request reprint Expression of EWS-ETS fusions in NIH3T3 cells reveals significant differences to Ewing's sarcoma
    Chi L Braunreiter
    The Division of Pediatric Hematology Oncology, Huntsman Cancer Institute, Salt Lake City, Utah 84112, USA
    Cell Cycle 5:2753-9. 2006
    ..Thus, data derived from the NIH3T3 model system needs to be appropriately validated before they can be accepted as relevant to the human disease...
  16. ncbi request reprint A transcriptional profiling meta-analysis reveals a core EWS-FLI gene expression signature
    Jeffrey D Hancock
    The Division of Pediatric Hematology Oncology and The Center for Children, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah, USA
    Cell Cycle 7:250-6. 2008
    ..15) These results demonstrate the utility of using comparative analysis to validate model systems and emphasize the unique potential of this approach to identify both oncogenic and background cell signatures...
  17. ncbi request reprint A conditional mouse model of synovial sarcoma: insights into a myogenic origin
    Malay Haldar
    Department of Human Genetics, The Center for Children, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
    Cancer Cell 11:375-88. 2007
    ..We also show that early widespread expression of the fusion protein disrupts normal embryogenesis, causing lethality...
  18. pmc Molecular inversion probe analysis detects novel copy number alterations in Ewing sarcoma
    Mona S Jahromi
    Center for Children s Cancer Research C3R, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA
    Cancer Genet 205:391-404. 2012
    ..CNAs detected by microarray correlate with outcome and may be useful for risk stratification in future clinical trials...
  19. doi request reprint Small round cell sarcomas
    Stephen L Lessnick
    Huntsman Cancer Institute, Salt Lake City, UT, USA
    Semin Oncol 36:338-46. 2009
    ....
  20. ncbi request reprint Microsatellites are EWS/FLI response elements: genomic "junk" is EWS/FLI's treasure
    Kunal Gangwal
    Department of Oncological Sciences, University of Utah School of Medicine, Salt Lake City, Utah, USA
    Cell Cycle 7:3127-32. 2008
    ..The observation of microsatellites as transcriptional response elements for EWS/FLI suggest that these elements may not be "junk" after all...
  21. pmc Microsatellites as EWS/FLI response elements in Ewing's sarcoma
    Kunal Gangwal
    Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA
    Proc Natl Acad Sci U S A 105:10149-54. 2008
    ..These findings illustrate an unprecedented route to specificity for ETS proteins and use of microsatellites in tumorigenesis...
  22. pmc Complex genotype sarcomas display familial inheritance independent of known cancer predisposition syndromes
    Kevin B Jones
    Sarcoma Services, Department of Orthopaedics, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA
    Cancer Epidemiol Biomarkers Prev 20:751-7. 2011
    ..The low incidence of sarcomas in the general population makes heritable contribution to disease risk difficult to discern beyond highly penetrant Mendelian syndromes...
  23. pmc The clone wars - revenge of the metastatic rogue state: the sarcoma paradigm
    Holly L Spraker
    Division of Pediatric Hematology Oncology, Primary Children s Medical Center, University of Utah Salt Lake City, UT, USA
    Front Oncol 2:2. 2012
    ..These possibilities and the evidence base to support them are explored...
  24. pmc Potential for modulation of the fas apoptotic pathway by epidermal growth factor in sarcomas
    David E Joyner
    Department of Orthopaedics, Huntsman Cancer Institute, The University of Utah, Salt Lake City, UT 84112, USA
    Sarcoma 2011:847409. 2011
    ..Cells destined for elimination inhibit this prosurvival response via a presently undefined pathway. This scenario represents a novel role for EGF and CTGF as regulators of the Fas pathway in sarcomas...
  25. pmc Promiscuous partnerships in Ewing's sarcoma
    Savita Sankar
    Department of Oncological Sciences, University of Utah School of Medicine, Salt Lake City, UT, USA
    Cancer Genet 204:351-65. 2011
    ..Understanding the molecular mechanisms of action of the various different fusion oncogenes will provide better insights into the biology underlying this rare but important solid tumor...
  26. ncbi request reprint The potential for molecular therapeutic targets in Ewing's sarcoma
    Nancy R McAllister
    Huntsman Cancer Institute, Room 4242, 2000 Circle of Hope, Salt Lake City, UT 84112, USA
    Curr Treat Options Oncol 6:461-71. 2005
    ..Although a great deal of additional investigation is required before most of these approaches can be assessed in the clinic, we think that these potential new targets offer a great deal of hope for patients with Ewing's sarcoma...
  27. pmc Microsatellite instability in sarcoma: fact or fiction?
    Michael J Monument
    Sarcoma Services, Department of Orthopaedics, Huntsman Cancer Institute, University of Utah School of Medicine, 2000 Circle of Hope, Salt Lake City, UT 84112, USA
    ISRN Oncol 2012:473146. 2012
    ....
  28. pmc The EWS/FLI Oncogene Drives Changes in Cellular Morphology, Adhesion, and Migration in Ewing Sarcoma
    Aashi Chaturvedi
    Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA
    Genes Cancer 3:102-16. 2012
    ..In the case of Ewing sarcoma, it appears that the loss of cell adhesion needed to promote tumor cell dissemination might be induced by the EWS/FLI oncogene itself rather than via an accumulation of stepwise mutations...

Research Grants2

  1. Tumor Suppressors in Ewing's Sarcoma
    STEPHEN LESSNICK; Fiscal Year: 2007
    ..abstract_text> ..
  2. EWS/FLI AND ITS TARGETS IN EWING'S SARCOMA
    Stephen L Lessnick; Fiscal Year: 2010
    ....